公开(公告)号：KR840000912B1

公开(公告)日：1984-06-28

申请号：KR810000762

申请日：1981-03-09

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN

IPC: C07D307/52

公开(公告)号：US3876632A

公开(公告)日：1975-04-08

申请号：US38686373

申请日：1973-08-09

Applicant: HOECHST AG

Inventor： STURM KARL ,  STAREY FRANZ

IPC: C07D295/12 ,  A61K20060101 ,  A61K31/495 ,  A61K31/63 ,  C07D20060101 ,  C07D207/08 ,  C07D207/32 ,  C07D211/18 ,  C07D213/24 ,  C07D307/10 ,  C07D307/38 ,  C07D401/12 ,  C07D403/10 ,  C07D405/12 ,  C07D51/70

Abstract: Basically substituted 4-piperazino-benzene-1,3-disulfonamides, their non toxic salts and a process for their manufacture which process comprises introducing either the piperazino radical in 4position or the basic group in 6-position into corresponding 1,3benzene sulfonamides having an appropriate group in 4- or 6position in usual manner or by oxidizing compounds containing an allyl group which is interrupted by an S or an SO-group.

公开(公告)号：US3557153A

公开(公告)日：1971-01-19

申请号：US3557153D

申请日：1967-06-27

Applicant: HOECHST AG

Inventor： STURM KARL ,  SIEDEL WALTER

IPC: C07D307/14 ,  C07D307/68 ,  C07C143/82

CPC classification number: C07D307/14 ,  C07D307/68 ,  Y10S514/869

Abstract: N-ACYLATED HALOBENZENE-2,4-DISULFONAMIDE OF THE FORMULA

1-X,2-(NH2-SO2-),4-(R1-CO-N(-R)-SO2-)BENZENE

IN WHICH X IS CHLORINE OR BROMINE; R IS METHYL, ETHYL OR TETRAHYDROFURFURYL; AND R1 IS ALKYL OF UP TO 8 CARBON ATOMS, CHLOROMETHYL, BROMOMETHYL, ALLYL, FURYL, CYCLOPENTYLMETHYL, PHENYL, BENZYL OR PHENYLETHYL, HAVE BEEN FOUND TO HAVE VALUABLE DIURETIC AND SALURETIC ACTIVITY.

公开(公告)号：US3483291A

公开(公告)日：1969-12-09

申请号：US3483291D

申请日：1965-12-06

Applicant: HOECHST AG

Inventor： VOGEL GERHARD ,  GEIGER ROLF ,  STURM KARL

IPC: A61K38/35 ,  A61K17/16

CPC classification number: A61K38/35 ,  Y10S514/805

公开(公告)号：HU187300B

公开(公告)日：1985-12-28

申请号：HU41581

申请日：1981-02-20

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN

IPC: A61K31/18 ,  A61K31/63 ,  A61P13/02 ,  A61P15/00 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C317/36 ,  C07D307/52 ,  C07D333/20 ,  C07C147/12

Abstract: What are disclosed are compounds of the formula I in which R denotes alkyl, alkenyl, cycloalkyl or cycloalkylalkyl, each of which has up to 10 C atoms, or phenyl and Ar denotes phenyl, thienyl or furyl and salts thereof, the preparation of these compounds and their use as medicaments and also medicaments of this type as such.

公开(公告)号：CA1178279A

公开(公告)日：1984-11-20

申请号：CA389540

申请日：1981-11-05

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN ,  HROPOT MAX

IPC: C07D251/18 ,  A61K31/41 ,  A61P7/10 ,  C07D257/04 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  C07D407/12

Abstract: The invention relates to a 5-phenyltetrazole of the formula I (I) in which R denotes furyl or thienyl, to a physiologically acceptable salt thereof, to its preparation, to agents composed of or containing this compound and to its use as a drug.

公开(公告)号：AU7712081A

公开(公告)日：1982-05-13

申请号：AU7712081

申请日：1981-11-05

Applicant: HOECHST AG

Inventor： STURM KARL ,  MUSCHAWECK ROMAN ,  HROPOT MAX

IPC: C07D251/18 ,  A61K31/41 ,  A61P7/10 ,  C07D257/04 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12

Abstract: What are disclosed are salidiuretic compounds of the formula and physiologically acceptable salts thereof, wherein R is phenyl, furyl or thienyl, intermediates of said compounds, methods for making said compounds, salidiuretic pharmaceutical preparations containing said compounds or salts, and methods for treating humans and other mammals with such compounds or salts.

公开(公告)号：HU171908B

公开(公告)日：1978-04-28

申请号：HUHO001767

申请日：1975-02-11

Applicant: HOECHST AG

Inventor： STURM KARL

IPC: C07D333/20 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D213/38 ,  C07D307/14 ,  C07D307/52 ,  C07C143/80 ,  C07D307/22 ,  C07D213/36 ,  C07D309/14

Abstract: Process for the preparation of sulfamoylantranilic acids of the general formula i ** (see formula) ** Wherein ph means a phenyl radical optionally substituted with 1-2 halogen atoms, alkyl groups or etherified hydroxy groups and r means aralcohyl, heteroaralkyl or cycloalkohilalcoyl radicals which in the aliphatic portion may be unsaturated, interrupted by oxygen or sulfur and/or in the aromatic portion they can be substituted with halogen atoms, alkyl or alkoxy radicals, characterized in that carboxylic acids of the general formula iv are reacted ** (see formula) ** At temperatures above 120º c, with at least one molar equivalent of an amine of the general formula r-nh2, wherein r has the above meanings. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：AU7813075A

公开(公告)日：1976-08-12

申请号：AU7813075

申请日：1975-02-12

Applicant: HOECHST AG

Inventor： STURM KARL

IPC: C07D333/20 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D213/38 ,  C07D307/14 ,  C07D307/52 ,  C07C143/78 ,  C07C143/80 ,  C07D5/04 ,  C07D31/42 ,  C07D63/12 ,  C07D5/16 ,  C07D13/10

Abstract: Process for the preparation of sulfamoylantranilic acids of the general formula i ** (see formula) ** Wherein ph means a phenyl radical optionally substituted with 1-2 halogen atoms, alkyl groups or etherified hydroxy groups and r means aralcohyl, heteroaralkyl or cycloalkohilalcoyl radicals which in the aliphatic portion may be unsaturated, interrupted by oxygen or sulfur and/or in the aromatic portion they can be substituted with halogen atoms, alkyl or alkoxy radicals, characterized in that carboxylic acids of the general formula iv are reacted ** (see formula) ** At temperatures above 120º c, with at least one molar equivalent of an amine of the general formula r-nh2, wherein r has the above meanings. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：FI752472A

公开(公告)日：1976-03-07

申请号：FI752472

申请日：1975-09-03

Applicant: HOECHST AG

Inventor： STURM KARL ,  STAREY FRANZ

IPC: C07D295/10 ,  C07D295/155 ,  C07D

Abstract: Antihypertensively-active 3-sulfamoyl-4-piperazinyl-benzoic acids, optionally substituted in the 2-position by halogen or alkyl, and the esters, amides, and nitriles of these acids are disclosed, as is a method for making these compounds by the reaction of the corresponding 4-halogeno- or 4-alkyl-(or 4-aryl-) sulfonyloxy-benzoic acids (or their esters etc.) with piperazines.