公开(公告)号：JPS61233631A

公开(公告)日：1986-10-17

申请号：JP7489885

申请日：1985-04-09

Applicant: KAO CORP

Inventor： ICHII YUJI ,  KAMIYA TETSURO ,  HARA KENJI

IPC: A61K8/00 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/55 ,  A61K8/58 ,  A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/70 ,  A61K47/00 ,  A61K47/24 ,  A61Q5/00 ,  A61Q19/00

Abstract: PURPOSE:To provide the titled agent containing a specific monoalkylphosphoric acid ester and an active drug component, giving high transcutaneous absorbability of the drug component, exhibiting mild action to the skin and mucosa and having high safety. CONSTITUTION:The objective agent contains (A) the compound of formula I [R1 and R2 are alkyl and the total carbon number of the branched alkyl (formula II) is 8-40; X1 and X2 are H, alkali metal, ammonium, mono, di or trialkanol (2-3C) ammonium, mono, di, tri or tetraalkyl (1-4C) ammonium, basic amino acid or morpholine salt] and (B) an active drug component which can be administered by transcutaneous or transumucous absorption. The amount of the compound A is preferably 0.5-30 wt%, especially 1-20 wt% based on the whole agent. EFFECT:A sufficient effect can be attained at a low concentration of the drug component compared with conventional method, and accordingly, the side effect of the drug can be mitigated.

公开(公告)号：JP2000044482A

公开(公告)日：2000-02-15

申请号：JP21545998

申请日：1998-07-30

Applicant: KAO CORP

Inventor： KANAZAWA SATOSHI ,  OHASHI YUKIHIRO ,  NISHIZAWA YOSHINORI ,  SATO MAYUMI ,  MORI SHINOBU ,  ICHII YUJI ,  KUDOU MICHIMASA

IPC: A61K9/06 ,  A61K8/00 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61P3/04 ,  A61P3/06 ,  A61Q11/00 ,  A61Q19/00 ,  A61K35/78 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a lipolysis promoter and a preparation for external use for skin containing the promoter, capable of promoting the degradation of accumulated adipose tissue in vivo and of adequately inhibit, prevent and remedy obesity. SOLUTION: This lipolysis promoter and the other objective preparation for external use for skin each contains banana skin or an extract derived therefrom; wherein the banana skin is usable either directly, after dried, or after solvent extraction, pref. being in the form of extract; in this case, an extraction solvent to be used is e.g. water, a lower alcohol such as ethanol, propanol or butanol, a polyol such as propylene glycol, 1,3-butylene glycol or glycerol, or a mixture thereof; among them, water singly, or ethanol or a mixture of water and 1,3-butylene glycol is more preferable, and a mixture of ethanol or 1,3-butylene glycol and water in the vol. ratio of (1:1) to (99:1) is especially preferable.

公开(公告)号：JPH10147516A

公开(公告)日：1998-06-02

申请号：JP30793896

申请日：1996-11-19

Applicant: KAO CORP

Inventor： SUZUKI JUNKO ,  MORI SHINOBU ,  ICHII YUJI

IPC: A61K8/00 ,  A61K8/46 ,  A61K8/97 ,  A61K36/18 ,  A61K36/28 ,  A61P17/00 ,  A61Q19/10 ,  A61K7/50 ,  A61K35/78

Abstract: PROBLEM TO BE SOLVED: To obtain a composition for a bubble bath capable of providing an excellent foam-touch feeling and a moist feeling to the skin after taking the bath by including a specific surfactant and a specified plant in combination. SOLUTION: This composition comprises (A) an anionic surfactant of the formula [R is a 8-18C alkyl; M is a counter anion; (n) is 0-10] and (B) one or more than two kinds of plant selected from Piperaceae, Cephalonoplos and Cirsium in combination. The plant of component B is exemplified by Piper nigrum L., Piper longum L., Piper rangustifolium R. et P., Cephalonoplos segetum, Cephalonoplos setosum (Bieb)Kitam, Cirsium borealinipponense Kitam. The formulating amount of the component A is 5-90wt.% and the formulating amount of the component B is 0.01-20wt.% expressed in terms of a dried material of a solvent extract.

公开(公告)号：JPH09110672A

公开(公告)日：1997-04-28

申请号：JP26742095

申请日：1995-10-16

Applicant: KAO CORP

Inventor： MORI SHINOBU ,  ICHII YUJI ,  YOROZU HIDENORI

IPC: A61K8/96 ,  A61K8/00 ,  A61K8/36 ,  A61K8/41 ,  A61K8/49 ,  A61K8/92 ,  A61K8/97 ,  A61Q19/10 ,  A61K7/50 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a composition, which is applied to the body by means of coating or patching before bathing and has excellent effects of giving the skin firmed-up feeling and good after-bathing skin touch feeling, by compounding green pepper, an unripe fruit of pepper. SOLUTION: This composition contains green pepper [unripe fruit of pepper Piper nigrum L.) of pepper family], for example, at 0.01-20wt.%. Furthermore, the composition contains preferably an inorganic salt (e.g. sodium chloride, etc.), organic acid (e.g. succinic acid, etc.), carbonate (e.g. sodium bicarbonate, etc.), oily substance (e.g. myristic glyceride, etc.), xanthine derivative such as aminophylline, β-adrenergic stimultant such as isoproterenol, α2 -adrenergic depressant such as yohimbine, and bipyridine derivative such as amurinone.

公开(公告)号：JPH0834724A

公开(公告)日：1996-02-06

申请号：JP17500894

申请日：1994-07-27

Applicant: KAO CORP

Inventor： KAMIYA TETSURO ,  TEZUKA YOKO ,  WATANABE ISAMU ,  ICHII YUJI ,  YOROZU HIDENORI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61K8/63 ,  A61K8/68 ,  A61K8/92 ,  A61Q19/00 ,  A61Q19/10 ,  A61K7/50 ,  A61K7/00 ,  A61K7/48

Abstract: PURPOSE:To obtain a bathing agent composition which is excellent in the humectant effect for skin and inhibits skin dryness and roughness, moreover sustains moisture retention effect on skin without greasy touch after bathing. CONSTITUTION:This bathing agent composition comprises (A) at least one selected from the group consisting of ceramides of formula I (R , R are each an 8-26C straight or branched, saturated or unsaturated hydrocarbon group which may be substituted with one or more hydroxyl groups) and compounds having a ceride-like structure of formula II (R is a 10C-26C straight or branched, saturated or unsaturated hydrocarbon; R is a 9-25C straight or branched, saturated or unsaturated hydrocarbon group), (B) at least one of monoesters between cholesterol and a dicarboxylic acid of formula III (R is a 2-20C straight or branched alkylene or alkenylene; R is a residue after OH proton is removed from cholesterol) wherein the amounts of A and B are each 0.01-50wt.%, particularly 0.1-10wt.%, A:B is 1/10-10/1. This agent composition may also contain other oil components than components A and B and an emulsifier for these oil components.

公开(公告)号：JPH0826962A

公开(公告)日：1996-01-30

申请号：JP15997894

申请日：1994-07-12

Applicant: KAO CORP

Inventor： TANAKA NORIHIRO ,  ICHII YUJI ,  MORI SHINOBU ,  YOROZU HIDENORI

IPC: C07D473/06 ,  A61K8/00 ,  A61K8/30 ,  A61K8/34 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K45/06 ,  A61Q19/00 ,  C07D213/64 ,  C07D213/72 ,  C07D213/82 ,  A61K7/48 ,  A61K7/00

Abstract: PURPOSE:To obtain a skin external agent containing a compound selected from a xanthine derivative, a beta-adrenalin action-stimulating medicine, an alpha2-adrenalin action-inhibiting medicine and a bipyridine derivative, a polyol and an amino acid, and excellent in the improvement of the roughness of skin. CONSTITUTION:The skin external agent composition contains one or two kinds of compounds selected from a xanthine derivative of formula I (R is methyl, H; R is H, 1-12C alkyl) (e.g. aminophylline), a beta-adrenalin action-stimulating medicine (e.g. isoproterenol), an (alpha2-adrenalin action-inhibiting medicine (e.g. yohinbine), and a bipyridine derivative of formula II (R is H, alkyl; Q is NH2, NC, H2NCO, etc.) (e.g. amrinone) in an amount of >=0.005wt.% based on the whole amount of the composition, a polyol (e.g. glycerol) in an amount of 0.1-90wt.%, and an amino acid (e.g. alanine) in an amount of 0.1-90wt.%. The composition can be prepared in the preparation forms of creams, gels, ointments, solutions, pastes, cataplasms, plasters, etc.

公开(公告)号：JPH06287130A

公开(公告)日：1994-10-11

申请号：JP22388592

申请日：1992-08-24

Applicant: KAO CORP

Inventor： ICHII YUJI ,  TEZUKA YOKO ,  SUZUKI JUNKO ,  YOROZU HIDENORI

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/37 ,  A61K8/72 ,  A61Q19/10 ,  A61K7/50

Abstract: PURPOSE:To provide a bath liquid composition excellent in emulisifiablity, exhibiting an excellent effect on moisture retention of the skin and improvement of dryness of the skin and capable of giving a moist and soft touch free from stickiness after bathing. CONSTITUTION:There is provided a bath liquid composition containing (A) a synthetic diglyceride and/or a synthetic triglyceride exhibiting a liquid state at room temperatures, (B) a univalent alcohol ester of a 3 to 34C fatty acid and (C) a nonionic surfactant containing a polyoxyethylene chain in the molecule and having >=10 HLB. The total amount of the components (A) and (B) is 75 to 95wt.% and the weight ratio of (A) to (B) is 10:40 to 40:10.

公开(公告)号：JPH0680557A

公开(公告)日：1994-03-22

申请号：JP23361092

申请日：1992-09-01

Applicant: KAO CORP

Inventor： ICHII YUJI ,  TEZUKA YOKO ,  YOROZU HIDENORI

IPC: A61K8/00 ,  A61K8/68 ,  A61K8/89 ,  A61K8/891 ,  A61Q19/10 ,  C08L83/04 ,  A61K7/50

Abstract: PURPOSE:To obtain a bathing agent composition having excellent effect to keep the moisture and prevent the dryness of the skin, free from tacky feeling of the skin after bathing and giving moist skin by using an interkeratocytic lipid or a substance having similar structure and a silicone as active components. CONSTITUTION:The objective composition contains (A) 0.1-60wt.% of an interkeratocytic lipid (e.g. ceramide or cholesteryl ester) or a substance having similar structure and (B) 1-50wt.% of a silicone oil (e.g. methylphenylpolysiloxane) based on the total composition as active components. The active components are compounded with oily component, dispersing agent or emulsifying agent for the oily component and conventional component for ordinary bathing agent and formed in the form of powder, granule, tablet, liquid, etc. The agent is thrown into bath water before bathing. The amount of the agent is selected to give the bath water containing 0.1-500ppm (preferably 0.2-400ppm) each of the components A and B.

公开(公告)号：JPH03109317A

公开(公告)日：1991-05-09

申请号：JP24615089

申请日：1989-09-21

Applicant: KAO CORP

Inventor： YOROZU HIDENORI ,  FUKUDA KAZUYUKI ,  ICHII YUJI

IPC: A61K8/00 ,  A61K8/04 ,  A61K8/31 ,  A61K8/36 ,  A61K8/362 ,  A61K8/37 ,  A61Q13/00 ,  A61Q19/10 ,  C11D7/06 ,  C11D7/12 ,  C11D17/00

Abstract: PURPOSE:To obtain a bathing agent containing an organic acid containing adipic acid at a specific ratio or above, carbonate and perfume ingredient and capable of preventing both gaseous carbon dioxide from foaming and the perfume from volatilizing sustaining aroma for a long period and further providing comfortable bathing effects. CONSTITUTION:A bathing agent obtained by regulating the adipic acid content in an organic acid to >=70wt.% and containing at least one or more 10C terpenic hydrocarbons or formic acid, acetic acid or propionic acid esters of 5-10C terpenic hydrocarbons or 5-10C alcohols as a perfume ingredient. The objective substance is obtained by blending 10-80wt.% aforementioned organic acid with 0.001-2wt.% highly volatile perfume and 5-80wt.% carbonate and further suitably blending a coloring matter, vitamins, active ingredients of hot springs, proteolytic enzymes, seaweed extract, crude drugs, etc., therewith and preparing a formulation. The aforementioned agent can be prepared in the form of tablet and further grain, granule, etc.

公开(公告)号：JPH09208453A

公开(公告)日：1997-08-12

申请号：JP1391596

申请日：1996-01-30

Applicant: KAO CORP

Inventor： ICHII YUJI ,  MORI SHINOBU ,  YOROZU HIDENORI

IPC: A61K8/19 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/92 ,  A61K8/96 ,  A61K8/97 ,  A61K36/18 ,  A61Q19/00 ,  A61Q19/10 ,  A61K7/50 ,  A61K7/00 ,  A61K7/48 ,  A61K35/78

Abstract: PROBLEM TO BE SOLVED: To obtain a bathing material composition excellent in refreshed feeling of the skin and warm feeling of the body by blending a plant of the family Menispermaceae. SOLUTION: This bathing material composition contains a plant of the family Menishpermaceae and preferably contains inorganic salts, organic acids, carbonates and oil-based components. The composition is used for bathing by applying or sticking it to the body. As the plant of the family Menispermaceae, Sinomenium actum Rehder et Wilson, Ccculus trilobus DC, Cocculus laurifolius DC., etc., are preferable. Especially Sinomeni Caulis et Rgizoma, which are roots and stems of Sinomenium actum Rehder et Wilson, are preferable. The plant is used in an untreated state, a squeezed juice, a solvent extract, etc. The blending amount of the plant is preferably >=0.005wt.%, especially 0.01-20wt.% of the dried solvent extract based on the composition.