公开(公告)号：CA2535346A1

公开(公告)日：2005-03-03

申请号：CA2535346

申请日：2004-08-11

Applicant: MEDTRONIC INC

Inventor： HOBOT CHRISTOPHER M ,  LYU SUPING ,  DANG KIEM ,  SPARER RANDALL V ,  DINH THOMAS Q

IPC: A61L27/34 ,  A61K9/00 ,  A61K47/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

Abstract: An active agent delivery system that includes two or more active agents in a layer of a miscible polymer blend having at least two miscible polymers; wherein delivery of at least one of the active agents occurs predominantly under permeation control; and further wherein the permeability of the active agent that is to be released faster is greater than the permeability of the other one or more active agents.

公开(公告)号：CA2518374A1

公开(公告)日：2004-09-23

申请号：CA2518374

申请日：2004-03-08

Applicant: MEDTRONIC INC

Inventor： EBERT MICHAEL J ,  HOBOT CHRISTOPHER M ,  STOKES KENNETH B

IPC: A61L27/54 ,  A61L31/16 ,  A61N1/05

Abstract: A biostable polymeric substrate of an implantable medical device unit includ es a demand-release bioactive composition including one or more bioactive agent s covalently bound to surface-modifying end groups of the substrate. Certain cellular activities, in proximity to the polymeric substrate, release substances reacting with the end groups such that the end groups release the one or more bioactive agents, which modify the certain cellular activities.

公开(公告)号：AU2003258209A1

公开(公告)日：2004-02-25

申请号：AU2003258209

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： UDIPI KISHORE ,  SPARER RANDALL V ,  HOBOT CHRISTOPHER M ,  LYU SUPING

IPC: A61K9/00 ,  A61L27/26 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/16 ,  A61L27/34

Abstract: The present invention provides active agent delivery systems for use in medical devices, wherein the active agent delivery systems include an active agent and a miscible polymer blend.

公开(公告)号：CA2494188A1

公开(公告)日：2004-02-19

申请号：CA2494188

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： SPARER RANDALL V ,  HOBOT CHRISTOPHER M ,  CHENG PEIWEN ,  LYU SUPING ,  DANG KIEM

IPC: A61L27/26 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16

Abstract: The present invention provides active agent delivery systems for use in medical devices, wherein the active agent delivery systems include an active agent and a miscible polymer blend that includes a hydrophobic cellulose derivative and a polyvinyl homopolymer or copolymer selected from the group consisting of a polyvinyl alkylate homopolymer or copolymer, a polyvinyl alk yl ether homopolymer or copolymer, a polyvinyl acetal homopolymer or copolymer, and combinations thereof.

公开(公告)号：DE68928020D1

公开(公告)日：1997-06-05

申请号：DE68928020

申请日：1989-09-29

Applicant: MEDTRONIC INC

Inventor： COURY ARTHUR J ,  HOBOT CHRISTOPHER M

IPC: C07C271/16 ,  C08G18/32 ,  C08G18/38 ,  C08G18/50 ,  C08G18/61 ,  C08G71/04 ,  C08G18/46

公开(公告)号：CA2023703C

公开(公告)日：1995-05-16

申请号：CA2023703

申请日：1990-08-21

Applicant: MEDTRONIC INC

Inventor： DI DOMENICO EDWARD D ,  HOBOT CHRISTOPHER M ,  STOKES KENNETH B ,  COURY ARTHUR J ,  DOAN PHONG D ,  SANDSTROM RICHARD D

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/70 ,  A61K47/34 ,  A61M37/00 ,  A61N1/05 ,  A61N1/02 ,  A61N1/375

Abstract: A cardiac pacing lead or other stimulation lead carrying a steroid compounded within a polymer matrix. The steroid is dispersed in thermoplastic or thermoset polyurethane or polyurea forming monomers or prepolymers. The mixture is then chain extended by addition of the appropriate difunctional or multifunctional isocyanate, hydroxyl or amine curing agent to form a solid polymer. The resulting formulation is molded or cast into a desired shape, and incorporated in the distal end of a medical electrical lead, adjacent to or within the electrode. In a preferred embodiment, the medical lead employs an extendable helix which is screwed into body tissue, and the polymer containing the drug takes the form of a generally dimensionally stable annular member mounted to the lead, encircling the helix.

公开(公告)号：DE68910279T2

公开(公告)日：1994-02-17

申请号：DE68910279

申请日：1989-09-29

Applicant: MEDTRONIC INC

Inventor： COURY ARTHUR J ,  HOBOT CHRISTOPHER M

IPC: C07C271/16 ,  C08G18/32 ,  C08G18/38 ,  C08G18/50 ,  C08G18/61 ,  C08G71/04 ,  C07C271/12 ,  C07C269/04 ,  C07D295/205

公开(公告)号：DE68910279D1

公开(公告)日：1993-12-02

申请号：DE68910279

申请日：1989-09-29

Applicant: MEDTRONIC INC

Inventor： COURY ARTHUR J ,  HOBOT CHRISTOPHER M

IPC: C07C271/16 ,  C08G18/32 ,  C08G18/38 ,  C08G18/50 ,  C08G18/61 ,  C08G71/04 ,  C07C271/12 ,  C07C269/04 ,  C07D295/205

公开(公告)号：CA3063458A1

公开(公告)日：2020-06-10

申请号：CA3063458

申请日：2019-12-02

Applicant: MEDTRONIC INC

Inventor： HOBOT CHRISTOPHER M ,  GERBER MARTIN T

IPC: A61M1/28

Abstract: The invention relates to devices, systems, and methods for performing a precision or personalized Peritoneal Dialysis (PD) therapy session or cycle based on dialysis adequacy measurements in patients undergoing peritoneal dialysis treatment. The settings for the precision peritoneal dialysis therapy session can be obtained using one or more flow sensors and one or more uremic solute sensors that measure the uremic solute concentration and volume of the peritoneal dialysate removed from the patient. The desired dialysis adequacy for a specific patient, group of patients, or class of patients, can then be calculated based on the measured peritoneal dialysate concentration and volume. Using the calculated dialysis adequacy, the system and methods can then set one or more peritoneal dialysis parameters for subsequent cycles or sessions.

公开(公告)号：BRPI0905073A2

公开(公告)日：2015-07-07

申请号：BRPI0905073

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC

Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  SHAW KATARA ,  MCDONALD PHILIP EDWARD ,  MCKAY WILLIAM F ,  REMSEN KATHY L

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/4162 ,  A61K47/34