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41.发明申请METHODS OF DETECTING METHYL TRANSFERASE ACTIVITY AND METHODS OF SCREENING FOR METHYL TRANSFERASE ACTIVITY MODULATORS 审中-公开检测甲基转移酶活性的方法和甲基转移酶活性调节剂筛选方法
公开(公告)号：WO2005071102A3
公开(公告)日：2005-11-17
申请号：PCT/JP2005001172
申请日：2005-01-21
Applicant: ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , FURUKAWA YOICHI
Inventor： NAKAMURA YUSUKE , FURUKAWA YOICHI
IPC: C12Q1/48 , G01N33/574
CPC classification number: C12Q1/48 , G01N33/57419 , G01N33/57438 , G01N2333/91011 , G01N2500/02
Abstract: The invention features a method for determining methyl transferase activity of a polypeptide and screening for modulators of methyl transferase activity. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer or hepatocellular carcinoma using the modulator.
Abstract translation: 本发明的特征在于确定多肽的甲基转移酶活性并筛选甲基转移酶活性调节剂的方法。 本发明还提供了一种使用该调节剂预防或治疗结肠直肠癌或肝细胞癌的方法或药物组合物。
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公开(公告)号：WO2005028676A3
公开(公告)日：2005-09-15
申请号：PCT/JP2004014438
申请日：2004-09-24
Applicant: ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKATSURU SHUICHI
IPC: C07K14/47 , C12N9/10 , C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
Abstract: Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
Abstract translation: 本文描述了用于检测和诊断乳腺癌（BRC）的客观方法。 在一个实施方案中，诊断方法包括确定区分BRC细胞和正常细胞的BRC相关基因的表达水平。 在另一个实施方案中，诊断方法包括确定在DCIS和IDC细胞之间区分BRC细胞的BRC相关基因的表达水平。 本发明进一步提供了用于在具有淋巴结转移的乳腺癌细胞中使用具有独特改变的表达模式的BRC相关基因来预测和预防乳腺癌转移的手段。 最后，本发明提供筛选可用于治疗乳腺癌的治疗剂的方法，治疗乳腺癌的方法和用于针对乳腺癌接种受试者的方法。
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公开(公告)号：WO2004001072A3
公开(公告)日：2005-04-07
申请号：PCT/JP0212760
申请日：2002-12-05
Applicant: ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , FURUKAWA YOICHI
Inventor： NAKAMURA YUSUKE , FURUKAWA YOICHI
IPC: G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C12N15/09 , C12Q1/02 , C12Q1/26 , C12Q1/32 , C12Q1/34 , C12Q1/37 , C12Q1/42 , C12Q1/44 , C12Q1/48 , C12Q1/527 , C12Q1/533 , C12Q1/68 , G01N33/574 , G01N37/00 , C12Q1/00 , G01N33/50
CPC classification number: G01N33/57446 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
Abstract: The invention provides objective methods for detecting and diagnosing colorectal cancers and pre-malignant lesions. For example, the methods disclosed herein can reliably detect very early-stage colorectal cancers. In one embodiment, the diagnostic method involves the scoring of gene expression profiles that discriminate between adenomas and carcinomas. The profile score calculated acts as diagnostic indicator that can objectively indicate whether a sample tissue is non-cancerous, pre-cancerous, or cancerous. The present invention further provides methods of diagnosing colorectal tumors in a subject, methods of screening for therapeutic agents useful in the treatment of colorectal tumors, methods of treating colorectal tumors and method of vaccinating a subject against colorectal tumors.
Abstract translation: 本发明提供了用于检测和诊断结肠直肠癌和恶性前病变的客观方法。 例如，本文公开的方法可以可靠地检测非常早期的结肠直肠癌。 在一个实施方案中，诊断方法包括区分腺瘤和癌的基因表达谱的评分。 计算出的分布分数作为诊断指标，可以客观地指示样品组织是否为非癌性，癌前或癌性。 本发明还提供诊断受试者的结肠直肠肿瘤的方法，筛选用于治疗结肠直肠肿瘤的治疗剂的方法，治疗结肠直肠肿瘤的方法和接种受试者抵抗结肠直肠肿瘤的方法。
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公开(公告)号：WO2004031413A3
公开(公告)日：2005-02-24
申请号：PCT/JP0312072
申请日：2003-09-22
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , DAIGO YATARO , NAKATSURU SHUICHI
Inventor： NAKAMURA YUSUKE , DAIGO YATARO , NAKATSURU SHUICHI
CPC classification number: G01N33/57423 , A61K31/7088 , C07K14/47 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , G01N2800/50
Abstract: Disclosed are methods for detecting non-small cell lung cancer using differentially expressed genes. Furthermore, novel human genes whose expression is elevated in non-small cell lung cancer compared to no-cancerous tissues are provided. Also disclosed are methods of identifying compounds for treating and preventing non-small cell lung cancer.
Abstract translation: 公开了使用差异表达基因检测非小细胞肺癌的方法。 此外，提供了与非癌性组织相比在非小细胞肺癌中表达升高的新型人类基因。 还公开了鉴定用于治疗和预防非小细胞肺癌的化合物的方法。
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公开(公告)号：WO2004031774A3
公开(公告)日：2004-10-14
申请号：PCT/JP0310338
申请日：2003-08-14
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , FURUKAWA YOICHI
Inventor： NAKAMURA YUSUKE , FURUKAWA YOICHI
CPC classification number: C07K14/4748 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/5023 , G01N33/57419 , G01N2500/04
Abstract: Disclosed are methods of detecting metastasis of colorectal cancer using differentially expressed genes. Also disclosed are methods of identifying agents for treating colorectal cancer or preventing metastasis of colorectal cancer.
Abstract translation: 公开了使用差异表达基因检测结肠直肠癌转移的方法。 还公开了鉴定用于治疗结肠直肠癌或预防结肠直肠癌转移的药剂的方法。
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Patent Agency Ranking
公开(公告)号：WO2004021010A3
公开(公告)日：2004-10-14
申请号：PCT/JP0310436
申请日：2003-08-19
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , FURUKAWA YOICHI
Inventor： NAKAMURA YUSUKE , FURUKAWA YOICHI
IPC: G01N33/50 , A61K31/7088 , A61K31/7105 , A61K35/12 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/113 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N37/00 , C07K14/00 , C07K16/30 , C12N15/11
CPC classification number: C07K14/47 , A61K38/00 , C07K14/4748 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/57419 , G01N33/57446 , G01N2500/00
Abstract: Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer -associated gene that discriminate between colon or gastric cancer and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of colonic cancer and method of vaccinating a subject against colon or gastric cancer.
Abstract translation: 本文描述了用于检测和诊断结直肠癌和胃癌的客观方法。 在一个实施方案中，诊断方法包括确定区分结肠癌或胃癌与正常细胞的结肠或胃癌相关基因的表达水平。 本发明进一步提供了筛选用于治疗结肠癌的治疗剂的方法以及针对结肠癌或胃癌接种受试者的方法。
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公开(公告)号：WO2004031411A3
公开(公告)日：2004-09-30
申请号：PCT/JP0311713
申请日：2003-09-12
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC: A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/574 , C07K14/82
CPC classification number: G01N33/57438 , A61K38/00 , C07K14/47 , C07K14/82 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
Abstract: The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of pancreatic cancer, and as target molecules for developing drugs against the disease.
Abstract translation: 本申请提供了新的人类基因C1958V1或C1958V2，与相应的非癌性组织相比，其表达在胰腺癌中显着升高。 由这些基因编码的基因和多肽可以用于例如胰腺癌的诊断以及作为开发针对该疾病的药物的靶分子。
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公开(公告)号：WO2004031414A3
公开(公告)日：2004-07-08
申请号：PCT/JP0312073
申请日：2003-09-22
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , NAKAGAWA HIDEWAKI , NAKATSURU SHUICHI
CPC classification number: C07K14/47 , C12Q1/6886 , C12Q2600/136
Abstract: Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
Abstract translation: 本文描述了用于检测和诊断前列腺癌（PRC）或前列腺上皮内瘤变（PIN）的客观方法。 在一个实施方案中，诊断方法涉及确定区分PRC或PIN和正常细胞的PRC相关基因的表达水平。 本发明还提供筛选用于治疗PRC和PIN中的任一者或两者的治疗剂的方法，治疗PRC和PIN中的任一者或两者的方法以及针对PRC和PIN中的任一者或两者接种受试者的方法。
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公开(公告)号：WO2004031410A3
公开(公告)日：2004-07-08
申请号：PCT/JP0311711
申请日：2003-09-12
Applicant: ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
Inventor： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
Abstract: Objective methods for detecting and diagnosing testicular seminoma (TS) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of TS -associated gene that discriminate between TS and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of TS, methods of treating TS and method of vaccinating a subject against TS.
Abstract translation: 本文描述了用于检测和诊断睾丸精原细胞瘤（TS）的客观方法。 在一个实施方案中，诊断方法涉及确定区分TS和正常细胞的TS相关基因的表达水平。 本发明进一步提供筛选用于治疗TS的治疗剂，治疗TS的方法和接种个体接种TS的方法的方法。
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公开(公告)号：MX381489B
公开(公告)日：2025-03-12
申请号：MX2018003903
申请日：2018-03-28
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： SATYANARAYANA ARVAPALLI VENKATA , CHAKRABARTI ANJAN , HISADA SHOJI , DECORNEZ HÉLÈNE , MATSUO YO , RAWAT MANISH , NAKAMURA YUSUKE , RAI SANJAY , RAVULA SRINIVAS , TALUKDAR ARINDAM , DUAN ZHIYONG
IPC: C07D487/04 , A61K31/4745 , A61P35/00 , C07D451/00 , C07D471/04 , C07D519/00
Abstract: La presente invención se refiere a un compuesto representado por la fórmula (I). (ver Fórmula).
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