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    41.
    发明专利
    未知

    公开(公告)号：DE69820552D1

    公开(公告)日：2004-01-29

    申请号：DE69820552

    申请日：1998-08-31

    Applicant: OREAL

    Inventor： VIDAL LAURENT ,  MALLE GERARD ,  GARSON JEAN-CLAUDE

    IPC: C07D231/14 ,  A61K8/00 ,  A61K8/49 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q5/06 ,  A61Q5/10 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  C07D231/28 ,  C07D231/40 ,  C07D231/52 ,  A61K7/13

    Abstract: 4,4-dihydroxy pyrazolin-5-one is new. 4,4-dihydroxy pyrazolin-5-ones of formula (I) are new. In (I): R1 = H, 1-18C alkyl optionally substituted, cyclohexyl, cyclopentyl, -(CH2)m-O-(CHX)n-Y, -(CH2)p-OR', -(CH2)q-R", naphthyl, thienyl, furyl, pyridyl, piperidyl, a group of any three formulae (a)-(c), phenyl optionally substituted, naphthyl optionally substituted by -SO3H, benzyl optionally substituted by -COOH, -OCH3, or -SO3H, pyridyl, pyrimidinyl, pyrazinyl, triazinyl, benzotriazolyl, benzimidazolyl, thienyl, imidazolyl, thiazolyl, 1,2,4-triazolyl, indazolyl, indolyl, quinolyl, or isoquinolyl; m = 1, 2 or 3; n = 1, 2 or 3; X = H or methyl; Y = methyl, OH, or 1-5C alkoxy; R' = phenyl or naphthyl optionally substituted; p = 1 or 2; q = 1, 2 or 3; R" = optionally substituted phenyl; R2 = H, 1-18C alkyl optionally substituted, phenyl substituted by halogen, nitro or CF3, phenyl substituted by up to three 1-4C alkyl, alkoxy, or dialkylamino groups or 1-2C alkylthio, benzyl optionally substituted, -(CH2)r-R4, methoxy carbonyl, ethoxy carbonyl, phenyl, 1-4C alkoxy, phenoxy optionally substituted by halogens, CF3, acetamido, 1-4C dialkylamino, carboxy, methoxy carbonyl or ethoxy carbonyl, -NH-CO-R5; r = 1, 2 or 3; R4 = -SO3H, 1 or 2C alkylthio, or benzylthio; and R5 = 1-18C alkyl, 3-18C alkenyl thienyl, furyl, pyridyl, pyrazolyl or halogen.

    45.
    发明专利
    未知

    公开(公告)号：FR2758083B1

    公开(公告)日：1999-02-05

    申请号：FR9700033

    申请日：1997-01-03

    Applicant: OREAL

    Inventor： BAZIN ROLAND ,  BERNARDET LAURENT ,  CANDAU DIDIER ,  MALLE GERARD ,  GARSON JEAN CLAUDE

    IPC: A61K8/72 ,  A61K8/00 ,  A61K8/64 ,  A61K8/65 ,  A61K8/86 ,  A61K8/87 ,  A61K8/96 ,  A61K8/97 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/48

    Abstract: PCT No. PCT/FR97/02461 Sec. 371 Date Nov. 17, 1998 Sec. 102(e) Date Nov. 17, 1998 PCT Filed Dec. 30, 1997 PCT Pub. No. WO98/29091 PCT Pub. Date Jul. 9, 1998The present invention relates to an anti-wrinkle composition containing a dispersion of a polymer system comprising at least one polymer of natural origin, and to the use of this polymer system as a tensioning agent in a cosmetic or dermatological composition. In particular, a soybean protein commercial product Profam 972. The polymer used must characteristically have a molecular weight of greater than 670,000 daltons and the polymer system obtained must be capable of forming a steam-permeable film, it must have a Young's modulus ranging from 108 to 9x109 N/m2 and it must produce, at a concentration of 7%, a greater than 1.5% retraction of isolated stratum corneum at 30 DEG C. and at a relative humidity of 40%. The composition obtained is used in particular for the immediate treatment of wrinkles and fine lines on the skin.

    48.
    发明专利
    未知

    公开(公告)号：FR2752524A1

    公开(公告)日：1998-02-27

    申请号：FR9610449

    申请日：1996-08-26

    Applicant: OREAL

    Inventor： VIDAL LAURENT ,  MALLE GERARD

    IPC: A61K8/00 ,  A61K8/22 ,  A61K8/33 ,  A61K8/34 ,  A61K8/38 ,  A61K8/41 ,  A61K8/49 ,  A61Q5/10 ,  A61K7/13

    Abstract: The invention concerns a composition for dyeing keratin fibres, in particular human hair, containing in a medium suitable for dyeing: as coupler at least one compound of formula (I) in which R1 represents in particular hydrogen, halogen, aryloxy, alcoxy, acyloxy, arylthio, alkythio, acetamide; one NR R radical with R and R representing one C1-C4 alkyl....;Za, Zb, Zc represent independently from one another, a nitrogen atom or a carbon atom bearing one R2, R3 or R4 radical; except that: when Za represents a carbon atom bearing a R2 radical, Zb represents a nitrogen atom and Zc represents a carbon atom bearing one R3 radical; when Za represents a nitrogen atom, Zb represents a carbon atom bearing one R4 radical and Zc represents a nitrogen atom; R2, R3 or R4 represent in particular hydrogen; C1-C4 alkyl, linear or branched; aryl optionally substituted....; n is equal to 1 or 2; at least one oxidation base. The invention also concerns the dyeing method using such a composition.

    49.
    发明专利
    未知

    公开(公告)号：DE69600054T2

    公开(公告)日：1998-01-15

    申请号：DE69600054

    申请日：1996-05-03

    Applicant: OREAL

    Inventor： VIDAL LAURENT ,  BURANDE AGNES ,  MALLE GERARD ,  HOCQUAUX MICHEL

    IPC: A61K8/35 ,  A61K8/00 ,  A61K8/19 ,  A61K8/23 ,  A61K8/33 ,  A61K8/34 ,  A61K8/41 ,  A61K8/49 ,  A61Q5/10 ,  B65D81/32 ,  C07D231/38 ,  C09B57/00 ,  C09B67/42 ,  D06P3/08 ,  A61K7/13 ,  A61K7/00

    Abstract: Oxidn. dye compsns. for dyeing keratinic fibres, esp. human hair, contain 3-substd. 4,5-diamino-pyrazoles of formula (I) or their acid-addn. salts as developers. R1-R5 = H; 1-6C alkyl; 2-4C hydroxyalkyl or aminoalkyl; phenyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, NO2, CF3, NH2 or 1-4C alkylamino; benzyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, methylenedioxy or NH2; or (CH2)mX(CHY)nZ; or R3 can also = NH2 or 1-4C alkylamino when R2 = H; m, n = 1-3; X = O or NH; Y = H or Me; Z = Me, OR or NRR'; R, R' = H, Me or Et; R6 = 1-6C alkyl; 1-4C hydroxyalkyl, 1-4C aminoalkyl; mono- or di(1-4C alkyl)amino(1-4C alkyl); (1-4C hydroxyalkyl)amino(1-4C alkyl); (1-4C alkoxy)methyl; phenyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, NO2, CF3, NH2 or 1-4C alkylamino; benzyl opt. substd. by halo, 1-4C alkyl, 1-4C alkoxy, methylenedioxy or NH2; thienyl, furyl or pyridyl; or (CH2)pO(CH2)qOR"; p, q = 1-3; R" = H or Me; provided that: (a) at least one of R2-R5 = H; (b) only one of R2 and R3, and only one of R4 and R5, can be opt. substd. phenyl, benzyl or (CH2)mX(CHY)nZ; (c) when R4 = R5 = H, then R1+R2+R3 can form a hexahydropyrimidine or tetrahydroimidazole ring opt. substd. by 1-4C alkyl or 1,2,4-tetrazolyl; and (d) when R2-R5 = H or 1-6C alkyl, then R1 or R6 may also = 2-, 3- or 4-pyridyl, 2- or 3-thienyl or 2- or 3-furyl gp. opt. substd. by Me or a cyclohexyl gp. Cpds. (I) are new when: (i) R6 is not hydroxymethyl, isobutyloxymethyl, methoxyethoxymethyl, cyclohexyl, thienyl, pyridyl, phenyl, methylphenyl, trifluoromethylphenyl or chlorophenyl when R1 = Me, R2, R4 and R5 = H and R3 = H or Me; (ii) R6 is not Ph when R1 = Ph and R2-R5 = H; (iii) R3 is not H, Me or Ph when R1 = Ph, R2, R4 and R5 = H and R6 = Me; (iv) R3 is not Ph when R1 = Ph, R2 = Me or Et, R4 and R5 = H and R6 = Me; (v) R4 is not Me when R1 = Ph, R2, R3 and R5 = H and R6 = Me; (vi) R1 is not chlorophenyl, trifluoroethyl-phenyl, nitrophenyl or pyridyl when R2-R5 = H and R6 = Me; (vii) R3 is not H, 1-4C alkyl or Ph when R1, R2, R3 and R5 = H and R6 = phenyl opt. substd. by Cl, Me or OMe; (viii) R6 is not Me when R1-R5 = H; (ix) R6 is not Me or Ph when R1 = beta -hydroxyethyl and R2-R5 = H; (x) R6 is not phenyl opt. substd. by Me, Et, OMe or Cl when R4 = Me, R5 = Ph, R2 and R3 = H and R1 = H or Me; (xi) R6 is not Me when R1 = t-Bu and R2-R5 = H; (xii) R6 is not Me or Ph when R1 = pyridyl, R2, R4 and R5 = H and R3 = H or Me; (xiii) R6 is not Me when R1 = Me, Et or 4-aminophenyl, R2, R4 and R5 = H and R3 = H or Ph; (xiv) R3 and/or R6 is not Me when R1 = i-Pr and R2, R4 and R5 = H; and (xv) R6 is not Me or Ph when R1 = H or Ph, R2, R4 and R5 = H and R3 = benzyl, methylphenyl or chlorophenyl.

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