公开(公告)号：AT260121T

公开(公告)日：2004-03-15

申请号：AT97927923

申请日：1997-06-04

Applicant: PHARMACYCLICS INC ,  UNIV TEXAS

Inventor： YOUNG STUART W ,  WRIGHT MEREDITH ,  SESSLER JONATHAN L ,  MODY TARAK D ,  MAGDA DARREN

IPC: C07D487/22 ,  A61K9/127 ,  A61K9/50 ,  A61K31/40 ,  A61K31/409 ,  A61K35/18 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61P35/00

公开(公告)号：NO315185B1

公开(公告)日：2003-07-28

申请号：NO961436

申请日：1996-04-11

Applicant: PHARMACYCLICS INC

Inventor： SESSLER JONAHAN L ,  HARRIMAN ANTHONY M ,  MILLER RICHARD A ,  MODY TARAK D ,  HEMMI GREGORY W ,  KRAL VLADIMIR A ,  MAGDA DARREN

IPC: A61K31/40 ,  A61K31/407 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/00 ,  A61K51/04 ,  A61L2/00 ,  A61P35/02 ,  A61P43/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00

Abstract: Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.

公开(公告)号：AT217874T

公开(公告)日：2002-06-15

申请号：AT95911776

申请日：1995-02-15

Applicant: UNIV TEXAS ,  PHARMACYCLICS INC

Inventor： SESSLER JONATHAN L ,  MODY TARAK D ,  HEMMI GREGORY W

IPC: A61K31/40 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/00 ,  A61K51/04 ,  A61L2/00 ,  A61P35/00 ,  C07D487/22 ,  C07H21/00 ,  C07D259/00 ,  C07D209/00

Abstract: Texaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18 and/or 21 contribute electrons to the aromatic pi system of the macrocycle which stabilizes the metal complex to demetallation and the imine bonds to hydrolysis. The addition of substituents to the 12 and 21 positions of the macrocycle offer steric protection for the imine bonds against possible in vivo enzyme hydrolysis. Electron-withdrawing groups at positions 15 and/or 18 render the macrocycle more readily reduced, i.e. the redox potential is lower and the macrocycle more readily gains an electron to form a radical. Such texaphyrins having a low redox potential and imine bond stabilization are useful in a variety of applications.

公开(公告)号：AU8848401A

公开(公告)日：2002-03-13

申请号：AU8848401

申请日：2001-08-28

Applicant: PHARMACYCLICS INC

Inventor： MODY TARAK D ,  GALANTER JOSHUA

IPC: A61K41/00 ,  C07D487/22 ,  A61K31/335

公开(公告)号：AU8844801A

公开(公告)日：2002-03-13

申请号：AU8844801

申请日：2001-08-28

Applicant: PHARMACYCLICS INC

Inventor： MODY TARAK D ,  SESSLER JONATHAN L ,  YOUNG STUART W

IPC: A61K31/355 ,  A61K41/00 ,  A61P35/00 ,  C07D487/22

Abstract: Compounds, pharmaceutical formulations and methods for use in neutron capture therapy are provided, useful for treating diseases characterized by neoplastic tissue and arteriosclerosis.

公开(公告)号：NO20006155L

公开(公告)日：2001-02-02

申请号：NO20006155

申请日：2000-12-04

Applicant: PHARMACYCLICS INC ,  UNIV TEXAS

Inventor： SESSLER JONAHAN L ,  MODY TARAK D ,  MAGDA DARREN ,  ANZENBACHER PAVEL ,  CARVALHO JOAN F

IPC: A61K47/48 ,  A61K31/409 ,  A61K41/00 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  A61K

Abstract: Texaphyrin/chemotherapeutic drug conjugates, optionally including a platinum(II) or platinum(IV) metal chelating site and/or complex, are useful for treating atheroma, tumors and other neoplastic tissue, neovascular-related diseases, as well as other conditions that are typically responsive to chemotherapy, radiation sensitization and photodynamic therapy.

公开(公告)号：AU709951B2

公开(公告)日：1999-09-09

申请号：AU3727095

申请日：1995-09-21

Applicant: UNIV TEXAS ,  PHARMACYCLICS INC

Inventor： MAGDA DARREN ,  SESSLER JONATHAN L ,  IVERSON BRENT L ,  SANSOM PETRA I ,  WRIGHT MEREDITH ,  MODY TARAK D ,  HEMMI GREGORY W

IPC: C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K38/22 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/04 ,  A61L2/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/11

Abstract: Methods of cleavage of a polymer of deoxyribonucleic acid using photosensitive texaphyrins are disclosed. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.

公开(公告)号：NO985645D0

公开(公告)日：1998-12-03

申请号：NO985645

申请日：1998-12-03

Applicant: PHARMACYCLICS INC ,  UNIV TEXAS

Inventor： YOUNG STUART W ,  WRIGHT MEREDITH ,  SESSLER JONATHAN L ,  MODY TARAK D ,  MAGDA DARREN

IPC: C07D487/22 ,  A61K9/127 ,  A61K9/50 ,  A61K31/40 ,  A61K31/409 ,  A61K35/18 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K

公开(公告)号：FI971176A

公开(公告)日：1997-05-19

申请号：FI971176

申请日：1997-03-20

Applicant: UNIV TEXAS ,  PHARMACYCLICS INC

Inventor： MAGDA DARREN ,  SESSLER JONATHAN L ,  IVERSON BRENT L ,  SANSOM PETRA I ,  WRIGHT MEREDITH ,  MODY TARAK D ,  HEMMI GREGORY W

IPC: C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K38/22 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/04 ,  A61L2/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  C07H

Abstract: Methods of cleavage of a polymer of deoxyribonucleic acid using photosensitive texaphyrins are disclosed. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.

公开(公告)号：NO971317A

公开(公告)日：1997-05-16

申请号：NO971317

申请日：1997-03-20

Applicant: UNIV TEXAS ,  PHARMACYCLICS INC

Inventor： MAGDA DARREN ,  SESSLER JONATHAN L ,  IVERSON BRENT L ,  SANSOM PETRA I ,  WRIGHT MEREDITH ,  MODY TARAK D ,  HEMMI GREGORY W

IPC: C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K38/22 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/04 ,  A61L2/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  A61K48/00

CPC classification number: C12N15/113 ,  A61K41/0038 ,  A61K41/0042 ,  A61K41/0076 ,  A61K47/54 ,  A61K47/546 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/06 ,  A61K49/085 ,  A61K49/10 ,  A61K51/0485 ,  A61L2/0011 ,  B01J31/061 ,  B01J31/1658 ,  B01J31/1815 ,  B01J2531/025 ,  B01J2531/38 ,  C07D487/22 ,  C07H21/00 ,  C12N2310/15 ,  C12N2310/321 ,  C12N2310/3511 ,  Y10T436/147777 ,  C12N2310/3521