公开(公告)号：JP2004091495A

公开(公告)日：2004-03-25

申请号：JP2003377620

申请日：2003-11-06

Applicant: Pharmacyclics Inc ,  Univ Texas Syst ,  ファーマサイクリクス,インコーポレイテッド ,  ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents,The University Of Texas System

Inventor： SESSLER JONATHAN L ,  HARRIMAN ANTHONY M ,  MILLER RICHARD A ,  MODY TARAK D ,  HEMMI GREGORY W ,  KRAAL VLADIMIR A ,  MAGDA DARREN

IPC: A61K31/40 ,  A61K31/407 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/00 ,  A61K51/04 ,  A61L2/00 ,  A61P35/02 ,  A61P43/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00

CPC classification number: A61K51/0485 ,  A61K41/0038 ,  A61K41/0057 ,  A61K41/0076 ,  A61K47/546 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/085 ,  A61K49/10 ,  A61K49/106 ,  A61K49/126 ,  A61L2/0011 ,  B01J31/061 ,  B01J31/1658 ,  B01J31/1805 ,  B01J31/1815 ,  B01J2531/025 ,  B01J2531/23 ,  B01J2531/26 ,  B01J2531/27 ,  B01J2531/28 ,  B01J2531/36 ,  B01J2531/37 ,  B01J2531/38 ,  B01J2531/72 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  B01J2531/96 ,  C07D487/22 ,  C07H21/00

Abstract: PROBLEM TO BE SOLVED: To obtain texaphyrin for radiosensitization. SOLUTION: A medicinal composition used for a radiosensitizer is prepared by using the texaphyrin. The texaphyrin is an aromatic 5 position (and heptacyclic) macrocycle (enlarged porphyrin) and, may be due to its inherent lipophilic property, shows larger biolocalization in non-neoplasm organs and non-atheroma plaque in neoplasm organ and atheroma each possible to be a malignant or benign tumor. The texaphyrin improves radiation damage and overcomes many defects of conventional radiosensitizers. COPYRIGHT: (C)2004,JPO

公开(公告)号：WO2013010136A3

公开(公告)日：2013-07-04

申请号：PCT/US2012046779

申请日：2012-07-13

Applicant: PHARMACYCLICS INC ,  CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  WANG LONGCHENG

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D

IPC: A61K31/52 ,  A61K31/433 ,  A61P17/00 ,  A61P29/00 ,  C07D473/32 ,  C07D473/34

CPC classification number: C07D487/04 ,  A61K31/52 ,  C07D473/34

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

Abstract translation: 本文描述的是激酶抑制剂化合物，合成这种抑制剂的方法，以及在治疗疾病中使用这些抑制剂的方法。 本文进一步描述了用于确定包括激酶在内的蛋白质的适当抑制剂的方法，测定和系统。

公开(公告)号：WO2011153514A9

公开(公告)日：2012-04-05

申请号：PCT/US2011039190

申请日：2011-06-03

Applicant: PHARMACYCLICS INC ,  BUGGY JOSEPH J ,  ELIAS LAURENCE ,  FYFE GWEN ,  HEDRICK ERIC ,  LOURY DAVID J ,  MODY TARAK D

Inventor： BUGGY JOSEPH J ,  ELIAS LAURENCE ,  FYFE GWEN ,  HEDRICK ERIC ,  LOURY DAVID J ,  MODY TARAK D

IPC: A61K31/519 ,  A61K31/505 ,  A61P35/00 ,  A61P35/02

CPC classification number: A61K31/519 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0048 ,  A61K9/0056 ,  A61K9/007 ,  A61K9/06 ,  A61K31/195 ,  A61K31/337 ,  A61K31/4184 ,  A61K31/436 ,  A61K31/437 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/573 ,  A61K31/606 ,  A61K31/664 ,  A61K31/675 ,  A61K31/69 ,  A61K31/7032 ,  A61K31/704 ,  A61K31/7076 ,  A61K39/395 ,  A61K39/39533 ,  A61K39/3955 ,  A61K45/06 ,  C07D487/04 ,  A61K2300/00

Abstract: Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

公开(公告)号：WO2011046964A3

公开(公告)日：2011-08-25

申请号：PCT/US2010052377

申请日：2010-10-12

Applicant: PHARMACYCLICS INC ,  CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

Abstract translation: 本文描述的是激酶抑制剂化合物，用于合成这种抑制剂的方法，以及在治疗疾病中使用这些抑制剂的方法。 本文进一步描述了用于测定包括激酶在内的蛋白质的适当抑制剂的方法，测定和系统。

公开(公告)号：WO2004050716A3

公开(公告)日：2006-03-16

申请号：PCT/US0337888

申请日：2003-11-24

Applicant: PHARMACYCLICS INC ,  DOUGLAS CARY ,  FU LEI ,  MODY TARAK D

Inventor： DOUGLAS CARY ,  FU LEI ,  MODY TARAK D

IPC: C07D487/22 ,  C07F3/02 ,  C07F3/04 ,  C07F5/00 ,  C08F20060101 ,  C08F2/00 ,  C08F8/42 ,  C07B47/00

CPC classification number: C07D487/22

Abstract: The present invention provides a process for replacing a metal cation, M 1 , from a compound of Formula (I).

Abstract translation: 本发明提供从式（I）的化合物代替金属阳离子M 1的方法。

公开(公告)号：WO9746262A2

公开(公告)日：1997-12-11

申请号：PCT/US9709501

申请日：1997-06-04

Applicant: PHARMACYCLICS INC ,  UNIV TEXAS ,  YOUNG STUART W ,  WRIGHT MEREDITH ,  SESSLER JONATHAN L ,  MODY TARAK D ,  MAGDA DARREN

Inventor： YOUNG STUART W ,  WRIGHT MEREDITH ,  SESSLER JONATHAN L ,  MODY TARAK D ,  MAGDA DARREN

IPC: C07D487/22 ,  A61K9/127 ,  A61K9/50 ,  A61K31/40 ,  A61K31/409 ,  A61K35/18 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00

CPC classification number: A61K49/1896 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/5068 ,  A61K41/0076 ,  A61K47/554 ,  A61K47/6901 ,  A61K47/6911 ,  A61K49/085

Abstract: Compositions having a texaphyrin-lipophilic molecule conjugate loaded into a biological vesicle and methods for imaging, diagnosis and treatment using the loaded vesicle are provided. For example, liposomes or red blood cells loaded with a paramagnetic texaphyrin-lipophilic molecule conjugate have utility as a blood pool contrast agent, facilitating the enhancement of normal tissues, magnetic resonance angiography, and marking areas of damaged endothelium by their egress through fenestrations or damaged portions of the blood vascular system. Liposomes or cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate can be photolysed, allowing for a photodynamic therapy effect at the site of lysis. Availability of red blood cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate provides a method for delivering a photodynamic therapeutic agent to a desired site with a high concentration of oxygen. By presenting the agent in this way, it is expected that a patient will experience less toxicity.

Abstract translation: 提供了具有加载到生物囊泡中的泰克萨菲瑞 - 亲脂性分子缀合物的组合物以及使用加载的囊泡进行成像，诊断和治疗的方法。 例如，装载有顺磁性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或红细胞具有作为血液池造影剂的效用，有助于正常组织的增强，磁共振血管造影术，以及通过开窗口或损伤的出口来损伤内皮的标记区域 部分血管系统。 可以光密化具有感光性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或细胞，从而在裂解部位产生光动力学治疗效果。 载有感光性泰克萨菲瑞 - 亲脂性分子缀合物的红细胞的可获得性提供了一种将光动力治疗剂递送至具有高浓度氧的所需部位的方法。 通过以这种方式呈现代理，预期患者的毒性将较低。

公开(公告)号：EP2731612A4

公开(公告)日：2015-04-08

申请号：EP12811600

申请日：2012-07-13

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  WANG LONGCHENG

IPC: A61K31/52 ,  A61K31/433 ,  A61P17/00 ,  A61P29/00 ,  C07D473/32 ,  C07D473/34

CPC classification number: C07D487/04 ,  A61K31/52 ,  C07D473/34

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

公开(公告)号：EP2814493A4

公开(公告)日：2015-07-22

申请号：EP13748860

申请日：2013-02-15

Applicant: PHARMACYCLICS INC

Inventor： BALASUBRAMANIAN SRIRAM ,  MODY TARAK D

IPC: A61K31/506 ,  A61K31/343 ,  A61P35/00

CPC classification number: A61K31/343 ,  A61K31/506 ,  A61K45/06 ,  A61N5/10 ,  A61K2300/00

公开(公告)号：EP2755648A4

公开(公告)日：2015-03-11

申请号：EP11872389

申请日：2011-09-13

Applicant: PHARMACYCLICS INC ,  SERVIER SAS LAB

Inventor： LOURY DAVID J ,  BUGGY JOSEPH J ,  MODY TARAK D ,  VERNER ERIK J ,  PURRO NORBERT ,  BALASUBRAMANIAN SRIRAM ,  KLOOS IOANA ,  DEPIL STÉPHANE

IPC: A61K31/343 ,  A61K31/16 ,  A61K31/166 ,  A61P35/00

CPC classification number: A61K31/343 ,  A61K9/14 ,  A61K9/28 ,  A61K9/70 ,  A61K31/4184 ,  A61K2300/00

公开(公告)号：EP2393816A4

公开(公告)日：2011-12-14

申请号：EP10823966

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D487/04 ,  C07D519/00