公开(公告)号：WO1996038865A1

公开(公告)日：1996-12-05

申请号：PCT/US1996007437

申请日：1996-05-22

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  LE, Dinh, Ba ,  SMYRL, William, H. ,  OWENS, Boone, B. ,  PASSERINI, Stefano

IPC: H01M04/36

CPC classification number: C01G31/02 ,  C01G31/00 ,  C01P2002/20 ,  C01P2004/80 ,  C01P2006/12 ,  C01P2006/40 ,  C01P2006/60 ,  H01M4/485 ,  H01M2004/023

Abstract: A method for manufacturing a novel composition V2O4.5(OH) and the composition per se, wherein the materials are suitable for intercalation of greater than 2.4 Li per V2O5 to yield theoretical energy density of greater than 970 Wh/kg of cathode active material, the intercalation being completely reversible, and synthesis of these materials from sol and gels. Devices incorporating these materials are also disclosed.

Abstract translation: 制备新型组合物V2O4.5（OH）的方法及其组合物本身，其中该材料适合于每V 2 O 5插入大于2.4Li，以产生大于970Wh / kg阴极活性材料的理论能量密度， 插层是完全可逆的，并且从溶胶和凝胶合成这些材料。 还公开了并入这些材料的装置。

公开(公告)号：WO1996030492A1

公开(公告)日：1996-10-03

申请号：PCT/US1996003316

申请日：1996-03-21

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  HU, Wei-Shou ,  CERRA, Frank, Bernard

IPC: C12M03/06

CPC classification number: C12M21/08 ,  A61F2/022 ,  A61K2035/126 ,  A61M1/1625 ,  A61M1/3475 ,  A61M1/3489 ,  C12M25/10 ,  C12M29/16 ,  C12N5/0671 ,  C12N2500/02 ,  C12N2500/90 ,  C12N2510/00 ,  C12N2533/30 ,  C12N2533/54

Abstract: A filter device containing cell masses and single cells is described. The device contains porous hollow fibers and hepatocytes entrapped within a contracted gel matrix.

Abstract translation: 描述了包含细胞块和单细胞的过滤装置。 该装置包含多孔中空纤维和包埋在收缩凝胶基质内的肝细胞。

公开(公告)号：WO1996005310A1

公开(公告)日：1996-02-22

申请号：PCT/US1995010075

申请日：1995-08-09

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  EL HALAWANI, Mohamed, E.

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA

IPC: C12N15/16

CPC classification number: C07K14/57563

Abstract: The present invention provides an isolated and purified DNA molecule comprising a single coding region encoding (a) a turkey vasoactive intestinal peptide (VIP); (b) a turkey prepro vasoactive intestinal peptide or (c) a biologically active subunit of (a) or (b).

Abstract translation: 本发明提供了分离和纯化的DNA分子，其包含编码（a）火鸡血管活性肠肽（VIP）的单个编码区; （b）火鸡原生血管活性肠肽或（c）（a）或（b）的生物活性亚单位。

公开(公告)号：WO1996002969A1

公开(公告)日：1996-02-01

申请号：PCT/US1995007641

申请日：1995-06-16

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  MOHAN, Ned ,  RASTOGI, Mukul

IPC: H02J01/02

CPC classification number: H02J3/01 ,  G05F1/12 ,  H02M1/12 ,  Y02E40/40 ,  Y10T307/445

Abstract: An apparatus (10) and method for reducing distortion currents present in an alternating current power system (12) supplying power to a load (16) includes a passive filter (26, 152) and an active filter (24, 150). In a first embodiment, the passive filter (26) is operably connected to the power system (12) across the load (16) by a switching device (30). The active filter (24) is then connected across the switching device (30) and operated to draw a current equal to the current through the passive filter (26). The active filter (24) and the passive filter (26) are thereby connected in series across the load (16). The active filter (24) is controlled to draw a fundamental frequency component and to provide distortion currents required by the load (16). In a second embodiment, the active filter (150) is connected in parallel with a first circuit (154), the parallel combination of which is connected in series with a second circuit (156) across the load (16).

Abstract translation: 用于减少向负载（16）供电的交流电力系统（12）中存在的失真电流的装置（10）和方法包括无源滤波器（26,152）和有源滤波器（24,150）。 在第一实施例中，无源滤波器（26）通过开关装置（30）可操作地连接到负载（16）上的电力系统（12）。 然后，有源滤波器（24）跨越开关装置（30）连接并且被操作以绘制等于通过无源滤波器（26）的电流的电流。 因此，有源滤波器（24）和无源滤波器（26）串联连接在负载（16）上。 有源滤波器（24）被控制以绘制基频分量并提供负载（16）所需的失真电流。 在第二实施例中，有源滤波器（150）与第一电路（154）并联连接，第一电路与第二电路（156）串联连接跨过负载（16）。

公开(公告)号：WO1995020666A2

公开(公告)日：1995-08-03

申请号：PCT/US1995001088

申请日：1995-01-27

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  HSIAO, Karen ,  BORCHELT, David, R. ,  SISODIA, Sangra, M.

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA

IPC: C12N15/63

CPC classification number: C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  A61K38/00 ,  A61K49/0008 ,  C07K14/4711 ,  C12N2830/008

Abstract: Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage. In mice, an age-related CNS disorder characterized by agitation, neophobia, seizures, inactivity, diminished cerebral glucose utilization, cortico-limbic gliosis, and death, develops. An acceleration of this disorder occurs in transgenic mice expressing human and mouse Alzheimer amyloid precursor proteins (APP) produced using a hamster prion protein gene-derived cosmid vector that confers position-independent, copy number-dependent expression. In transgenic mice the disorder develops in direct relationship to brain levels of transgenic APP, but mutant APP confers the phenotype at lower levels of expression than wild-type APP. The disorder occurs in the absence of extracellular amyloid deposition, indicating that some pathogenic activities of APP are dissociated from amyloid formation.

Abstract translation: 提供了一种转基因非人类真核动物，其生殖细胞和体细胞在胚胎期含有引入动物或动物祖先的淀粉样蛋白前体蛋白序列。 在小鼠中，发展为以激动，恐惧症，癫痫发作，不活动，脑葡萄糖利用减少，皮层边缘胶质增生和死亡为特征的年龄相关的中枢神经系统疾病。 这种疾病的加速发生在使用赋予位置无关的拷贝数依赖性表达的仓鼠朊蛋白基因衍生的粘粒载体产生的表达人和小鼠阿尔茨海默氏淀粉样蛋白前体蛋白（APP）的转基因小鼠中。 在转基因小鼠中，病症与转基因APP的脑水平直接相关，但是突变体APP赋予表型低于野生型APP的表型。 该疾病发生在没有细胞外淀粉样蛋白沉积的情况下，表明APP的一些致病活性与淀粉样蛋白形成解离。

公开(公告)号：WO1995007712A1

公开(公告)日：1995-03-23

申请号：PCT/US1994009903

申请日：1994-09-06

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  SLUNGARD, Arne

IPC: A61K38/36

CPC classification number: A61K38/195 ,  A61K31/00 ,  A61K38/366 ,  A61K38/4833 ,  A61K2300/00

Abstract: A method of inhibiting blood coagulation in a patient is provided. This method involves administering to the patient an effective anticoagulant amount of a cationic protein; wherein the cationic protein has an isoelectric point of at least about 7.4, and is capable of enhancing the production of activated protein C by a thrombomodulin-thrombin complex by a factor of at least about two. A particularly preferred cationic protein is purified Platelet Factor 4.

Abstract translation: 提供一种抑制患者血液凝固的方法。 该方法包括向患者施用有效的抗凝剂量的阳离子蛋白质; 其中所述阳离子蛋白具有至少约7.4的等电点，并且能够通过血栓调节蛋白 - 凝血酶复合物增强至少约两倍的活性蛋白C的产生。 特别优选的阳离子蛋白是纯化的血小板因子4。

公开(公告)号：WO1994025231A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004775

申请日：1994-04-28

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  SCHMIDT, Elmer, L. ,  AMBURGEY, Terry, L.

IPC: B27K05/02

CPC classification number: B27K3/16 ,  B27K3/0271 ,  Y10S428/907 ,  Y10T83/0405 ,  Y10T428/662 ,  Y10T428/8305

Abstract: Methods for preventing non-fungal discoloration of logs, wood and wood products that are free of non-fungal discolorations are provided. The wood is treated with a phytotoxic agent in order to prevent enzyme-mediated discoloration of the wood. The wood subsequently may be monitored to determine viability of parenchyma cells. This invention also relates to unmilled wood that is substantially free of non-fungal discolorations and has nonviable parenchyma cells.

Abstract translation: 提供了防止没有非真菌变色的原木，木材和木制品的非真菌变色的方法。 用植物毒素处理木材，以防止酶介导的木材变色。 随后可以监测木材以确定实质细胞的活力。 本发明还涉及基本上没有非真菌变色并且具有不可见的薄壁组织细胞的未磨碎木材。

公开(公告)号：WO1994017822A1

公开(公告)日：1994-08-18

申请号：PCT/US1994001405

申请日：1994-02-08

Applicant: T CELL SCIENCES, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA ,  LEVIN, James, L. ,  REGAL, Jean, F. ,  TOTH, Carol, A.

Inventor： T CELL SCIENCES, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

IPC: A61K37/64

CPC classification number: A61K9/0078 ,  A61K38/00 ,  C07K14/705

Abstract: The present invention relates to formulations for pulmonary administration by inhalation that comprise a complement inhibitory protein, and uses thereof in the prophylactic or therapeutic treatment of diseases or disorders involving complement, especially diseases or disorders of the lung. In particular, the proteins are complement receptors of fragments thereof or soluble members of the complement receptor family that contain the conserved SCR motif and that are able to inhibit complement activity. More particularly the present invention relates to the direct treatment of certain complement related lung disorders by administering complement receptor proteins via the pulmonary route, in particular, direct delivery to the lungs of a complement receptor protein by aerosolization and subsequent inhalation. The invention also relates to use of a complement inhibitory protein to treat bronchoconstriction or anaphylaxis, or both.

Abstract translation: 本发明涉及包含补体抑制蛋白的吸入肺给药制剂及其在预防或治疗性治疗涉及补体，特别是肺疾病或病症的疾病或病症中的用途。 特别地，蛋白质是其片段的补体受体或补体受体家族的可溶性成员，其含有保守的SCR基序并能够抑制补体活性。 更具体地，本发明涉及通过经由肺途径施用补体受体蛋白质，特别是通过气雾化和随后的吸入直接递送至补体受体蛋白质的肺部来直接治疗某些补体相关性肺病。 本发明还涉及补体抑制蛋白用于治疗支气管收缩或过敏反应或两者的用途。

公开(公告)号：WO1994008616A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009041

申请日：1993-09-22

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  HALAWANI, Mohamed, El

IPC: A61K39/00

CPC classification number: A61K39/0005 ,  A61K38/2278

Abstract: The present method of increasing egg production in laying turkey hens includes actively immunizing the hens with vasoactive intestinal peptide. The peptide is conjugated to a protein to induce an antibody response in the hens. The resulting antibodies tie up vasoactive intestinal peptide naturally produced in the turkey. This lack of naturally produced VIP in the turkey in turn prevents the secretion of the hormone prolactin from the pituitary gland of the hens to eliminate the onset of broody behavior. The hens are immunized prior to the laying season and subsequently boosted with immunizations approximately once per month during the laying season.

Abstract translation: 目前在铺鸡肉母鸡中增加产蛋的方法包括用血管活性肠肽主动免疫母鸡。 该肽与蛋白质缀合以在母鸡中诱导抗体应答。 所产生的抗体结合在火鸡中天然产生的血管活性肠肽。 这种在土耳其自然产生的VIP的缺乏反过来又防止了从母鸡脑垂体分泌激素催乳素，以消除体内发生的行为。 母鸡在铺设季节之前免疫，随后在铺设季节每月大约一次免疫接种。

公开(公告)号：WO1993012576A1

公开(公告)日：1993-06-24

申请号：PCT/US1992010780

申请日：1992-12-14

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  MOHAN, Ned

IPC: H02M01/12

CPC classification number: H02M1/12 ,  H02J3/01 ,  Y02E40/40

Abstract: A circuit (30) is provided for generating a current that is a harmonic of the frequency of the utility system (12, 34, 160, 220) and which is of a selected amplitude and phase to reduce the total harmonic distortion of a system (10, 42, 136, 170, 236) that converts alternating current to direct current, or vice versa. The DC signal is sampled and by controlling switches (68, 70; 130, 132; 204, 208, 294, 296), a sinusoidal current at the desired harmonic is generated, and is provided to an impedance network (71, 71H, 71K, 150, 218) that injects this current into the multiphase AC system used (260) by the utility in a very low cost, easily controlled, and highly effective manner. The impedance network, (71, 71H, 71K, 150, 218, 260) comprises a single inductor (73A, 73B, 73C) and capacitance (75A, 75B, 75C, 75H, 75I, 75J) connected in series through each of the phases of the utility, with the current signal having an amplitude that is selected to substantially eliminate harmonics which cause high distortion of the utility signal.

Abstract translation: 提供电路（30），用于产生作为公用事业系统（12,34,160,220）的频率的谐波的电流并且其具有选定的幅度和相位，以减少系统的总谐波失真（ 10,22,136,170,236），其将交流电转换为直流电，或反之亦然。 对DC信号进行采样并通过控制开关（68,70; 130,132; 204,208,294,296）产生所需谐波的正弦电流，并将其提供给阻抗网络（71,71H，71K ，150,218），其以非常低成本，易于控制和高效的方式由该实用程序将该电流注入所使用的多相AC系统（260）。 阻抗网络（71,71H，71K，150,218,260）包括单个电感器（73A，73B，73C）和电容（75A，75B，75C，75H，75I，75J） 电力系统的相位，其中当前信号具有被选择的幅度，以基本上消除导致效用信号的高失真的谐波。