公开(公告)号：IN162660B

公开(公告)日：1988-06-25

申请号：IN117CA1987

申请日：1987-02-10

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NISHIMURA TATSUO ,  YOSHIMURA YOSHINOBU ,  NUMATA MITSUO

IPC: C07D99/10

公开(公告)号：DK151339C

公开(公告)日：1988-05-30

申请号：DK669174

申请日：1974-12-20

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D277/34 ,  C07D277/36 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36

Abstract: A compound of the formula: wherein R1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR2 (where R2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R1), and Y represents acetoxy group or a group of formula -SR3 (where R3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

公开(公告)号：AU566096B2

公开(公告)日：1987-10-08

申请号：AU2874884

申请日：1984-05-28

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NISHIMURA TATSUO ,  YOSHIMURA YOSHINOBU ,  NUMATA MITSUO

IPC: C07D501/36 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C67/08 ,  C07D20060101 ,  C07D257/04 ,  C07D277/22 ,  C07D499/42 ,  C07D501/00 ,  C07D501/02 ,  C07D501/04 ,  C07D501/20 ,  C07D501/34 ,  C07D501/46 ,  C07D501/56

Abstract: A compound of the formula:wherein R. is a hydrogen atom or a lower alkyl group; R 2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C 3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.

公开(公告)号：CA1215355A

公开(公告)日：1986-12-16

申请号：CA460608

申请日：1984-08-09

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MIYAKE AKIO ,  YAMAOKA MASAYOSHI ,  NUMATA MITSUO

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/36 ,  C07D501/56

Abstract: CEPHALOSPORIN ESTERS, THEIR PRODUCTION AND USE A compound of the formula: wherein R1 stands for n-propyl or isopropyl; and R2 stands for n-butyl, isobutyl, n-pentyl, n-hexyl or 2-ethylbutyl, or a pharmaceutically acceptable salt thereof, processes for preparing the same, and a pharmaceutical composition thereof, are provided. The compound can orally be applied as an antibiotic having improved bioavailability.

公开(公告)号：NO153259B

公开(公告)日：1985-11-04

申请号：NO771111

申请日：1977-03-29

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  YAMAOKA MASAYOSHI ,  MINAMIDA ISAO ,  SHIRAISHI MITSURU ,  NISHIMURA TATSUO

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

Abstract: A novel cephalosporin derivative of the formula: [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula -SR1 (where R1 is a nitrogen-containing heterocyclic group)] or a pharmaceutically acceptable salt or ester thereof is found to have potent antibiotic activity against various bacteria, particularly against gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri and Citrobacter freundii.

公开(公告)号：HU185670B

公开(公告)日：1985-03-28

申请号：HU340881

申请日：1981-11-13

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  YAMAOKA MASAYOSKI ,  NICHIMURA TATSOU ,  MATSUMOTO NORICHIKA

IPC: C07C205/42 ,  C07D205/08 ,  C07D205/085 ,  C07D403/04 ,  C07D477/00 ,  C07D499/00 ,  C07D403/12

Abstract: 2-Oxoazetidine derivatives represented by the formula; (I) wherein R1 stands for phthalimido group, benzyloxycarbonylamino group, a halogen on an alkyl group which may have hydroxyl group, R2 stands for hydrogen, an alkyl group, an alkylthio group or an arylthio group, and R3 and R4 independently stand for an acyl group or cyano group, and a method of preparing them, which is shown by the following reaction scheme; wherein R5 stands for a carboxyl-protective group, and R1, R2, R3 and R4 are of the same meanings as defined above. This compound (I) can be utilized as intermediates for carba-2-penem compounds having excellent anti-bacterial activity and beta -lactamase inhibitory activity.

公开(公告)号：FI842210A

公开(公告)日：1984-12-03

申请号：FI842210

申请日：1984-06-01

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NISHIMURA TATSUO ,  YOSHIMURA YOSHINOBU ,  NUMATA MITSUO

IPC: C07D501/36 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C67/08 ,  C07D20060101 ,  C07D257/04 ,  C07D277/22 ,  C07D499/42 ,  C07D501/00 ,  C07D501/02 ,  C07D501/04 ,  C07D501/20 ,  C07D501/34 ,  C07D501/46 ,  C07D501/56 ,  C07D

Abstract: A compound of the formula:wherein R. is a hydrogen atom or a lower alkyl group; R 2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C 3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.

公开(公告)号：DK273784A

公开(公告)日：1984-12-03

申请号：DK273784

申请日：1984-06-01

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NISHIMURA TATSUO ,  YOSHIMURA YOSHINOBU ,  NUMATA MITSUO

IPC: C07D501/36 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C67/08 ,  C07D20060101 ,  C07D257/04 ,  C07D277/22 ,  C07D499/42 ,  C07D501/00 ,  C07D501/02 ,  C07D501/04 ,  C07D501/20 ,  C07D501/34 ,  C07D501/46 ,  C07D501/56 ,  C07D

Abstract: A compound of the formula:wherein R. is a hydrogen atom or a lower alkyl group; R 2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C 3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.

公开(公告)号：NO150083C

公开(公告)日：1984-08-22

申请号：NO744527

申请日：1974-12-16

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D20060101 ,  C07D501/34 ,  C07D501/36

公开(公告)号：FI842210A0

公开(公告)日：1984-06-01

申请号：FI842210

申请日：1984-06-01

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NISHIMURA TATSUO ,  YOSHIMURA YOSHINOBU ,  NUMATA MITSUO

IPC: C07D501/36 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C67/08 ,  C07D20060101 ,  C07D257/04 ,  C07D277/22 ,  C07D499/42 ,  C07D501/00 ,  C07D501/02 ,  C07D501/04 ,  C07D501/20 ,  C07D501/34 ,  C07D501/46 ,  C07D501/56 ,  C07D

Abstract: A compound of the formula:wherein R. is a hydrogen atom or a lower alkyl group; R 2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C 3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.