公开(公告)号：KR810000759B1

公开(公告)日：1981-07-02

申请号：KR770000809

申请日：1977-04-02

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MITSURU SHIRAISHI ,  YAMAOKA MASAYOSHI ,  NISHIMURA TATSUO ,  NUMATA MITSUO ,  MINAMIDA ISAO

IPC: C07D501/36

Abstract: Cephalosporin derivatives [ Ib; X = hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, etc. and their salts or their ester having activity to gram negative and positive bacteria were prepd. Thus, compds Ia or their salts or their ester was reacted with hydroxylamine to give title compds.

公开(公告)号：KR800001569B1

公开(公告)日：1980-12-28

申请号：KR750000661

申请日：1975-03-29

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： YAMAOKA MASAYOSHI ,  NUMATA MITSUO ,  MINAMIDA ISAO ,  SHIRAISHI MICHURU ,  MIYAWAKI TOSHIO

IPC: C07D277/34 ,  C07D277/36 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/20

Abstract: 7-(4-halogeno-3-oxobutyrylamide)-cephalosporin derivs. I; Y = H, acyloxy, =SR1 (R1 is N comprised heterocyclic group); X= halogen, useful as bactericides, were prepd. by reaction of 4-halogeno-3-oxobutyrylhalogenide(II) and 7-aminocephalosporin derivs.(III). The compd(III) was obtained by treating same mole of diketene and halogen.

公开(公告)号：US3455956A

公开(公告)日：1969-07-15

申请号：US3455956D

申请日：1966-02-23

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HIRANO HIROSHI ,  MASUDA KATSUTADA ,  NUMATA MITSUO ,  OKA YOSHIKAZU

IPC: C07D307/10 ,  C07D307/38 ,  C07D309/04 ,  C07D309/20 ,  C07D63/04 ,  C07D7/04 ,  C07D65/04

CPC classification number: C07D307/38 ,  C07D307/10 ,  C07D309/04 ,  C07D309/20

公开(公告)号：US3544574A

公开(公告)日：1970-12-01

申请号：US3544574D

申请日：1968-03-04

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HIRANO HIROSHI ,  NUMATA MITSUO ,  SHIMAHARA NOBORU ,  KAWAI KIYOHISA

IPC: C07D415/00 ,  C07D51/42

CPC classification number: C07D415/00 ,  Y10S514/916

公开(公告)号：JPH0526793B2

公开(公告)日：1993-04-19

申请号：JP9921183

申请日：1983-06-02

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TAKANOHASHI KUNIO ,  FUJII TOMOYUKI ,  NUMATA MITSUO

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C68/02 ,  C07D501/36 ,  C07D501/38 ,  C07D501/56

Abstract: A compound of the formula:wherein R is 2-methylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, n-pentyl, an alkyl group of 6 or 7 carbon atoms, or an alkenyl group of 2 to 7 carbon atoms, or a pharmaceutically acceptable salt thereof and processes for preparing the same are provided. The compound can orally be applied as antibiotics having improved absorbability.

公开(公告)号：JPS6067482A

公开(公告)日：1985-04-17

申请号：JP17549683

申请日：1983-09-21

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MIYAKE AKIO ,  YOSHIMURA YOSHINOBU ,  NUMATA MITSUO

IPC: C07D501/36 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04

Abstract: NEW MATERIAL:A compound shown by the formula I (R1 is 5-7C cycloalkyl; R2 is

公开(公告)号：JPS5334794A

公开(公告)日：1978-03-31

申请号：JP10810176

申请日：1976-09-08

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  TSUSHIMA SUSUMU

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D257/04 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D499/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

Abstract: PURPOSE:2-Hydroxyimino (syn isomer) acetamides of formula I (Y is H or nucleophilic compound residue), e.g. 7-(4-bromo-2-hydroxyimino-3oxobutyrylamino)-3-methyl-3-cephem-4-carbox ylic acid (syn isomer).

公开(公告)号：JPS52122389A

公开(公告)日：1977-10-14

申请号：JP3737476

申请日：1976-04-02

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  YAMAOKA MASAYOSHI ,  MINAMIDA ISAO ,  SHIRAISHI MITSURU ,  NISHIMURA TATSUO

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

Abstract: PURPOSE:Cephalosporin derivatives I [X is H, OH, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or -SR (R is heterocyclic ring containing nitrogen atom)], e.g. 7-[2-(2-imino-e-hydroxy-4-thiazoline-4-yl) acetamido] -3-acetoxymethyl-3-cephem-4-carboxylic acid sodium salt.

公开(公告)号：JPS5283865A

公开(公告)日：1977-07-13

申请号：JP125076

申请日：1976-01-01

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TERAO SHINJI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO ,  MINAMIDA ISAO ,  NUMATA MITSUO ,  YAMAOKA MASAYOSHI

IPC: C07D501/24 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/38

Abstract: PURPOSE:3-Morpholylalkyloxyiminomethyl-cephalosporin derivatives of formula I(R is acyl, R is alkylene); for example, 7beta-(2-thienylacetamido)-3(2-morpholinoethoxy)iminomethyl-3cephem-4- carboxylic acid.

公开(公告)号：JPS5946237B2

公开(公告)日：1984-11-10

申请号：JP3737476

申请日：1976-04-02

Applicant: Takeda Chemical Industries Ltd

Inventor： NUMATA MITSUO ,  YAMAOKA MASAYOSHI ,  MINAMIDA ISAO ,  SHIRAISHI MITSURU ,  NISHIMURA TATSUO

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

CPC classification number: C07D501/20 ,  C07D501/24