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公开(公告)号：HK1204452A1
公开(公告)日：2015-11-20
申请号：HK15105022
申请日：2015-05-27
Applicant: UCB PHARMA SA
Inventor： ROBINSON MARTYN KIM
IPC: A61K20060101 , C07K20060101
Abstract: The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to 5 anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some 10 instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.
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公开(公告)号：AU2008232409B2
公开(公告)日：2013-06-20
申请号：AU2008232409
申请日：2008-03-21
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： GARBER ELLEN A , POPPLEWELL ANDREW GEORGE , TAYLOR FREDERICK R , ROBINSON MARTYN KIM , SU LIHE , FERRANT-ORGETTAS JANINE L , ADAMS RALPH , SHOCK ANTHONY , BURKLY LINDA C , HSU YEN-MING , BROWN DEREK THOMAS , TYSON KERRY LOUISE
IPC: C07K16/28 , A61K39/395 , C12N15/13 , C12N15/63
Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
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公开(公告)号：UA100513C2
公开(公告)日：2013-01-10
申请号：UAA200910650
申请日：2008-03-21
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： BURKLY LINDA , FERRANT-ORGETTAS JANINE L , GARBER ELLEN A , HSU YEN-MING , SU LIHE , TAYLOR FREDERICH R , ADAMS RALPH , BROWN DEREK THOMAS , POPPLEWELL ANDREW GEORGE , ROBINSON MARTYN KIM , SHOK ANTHONY , TYSON KERRY LOUISE
IPC: C07K16/28 , A61K39/395 , A61P37/00 , C12N15/13 , C12P21/08
Abstract: Изобретениеотноситсяк CD 154-связывающемубелку (антитела), молекуленуклеиновойкислоты, котораяегокодирует, вектору, клетке-хозяину, способуполученияантитела, композициии применениюданногобелкав приготовлениилекарственногосредствадлялеченияилипрофилактикисостояния, нарушенияилизаболеваниячеловека, опосредствованногов целомиличастичносигнальнымпутемприучастии CD40.
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公开(公告)号：GEP20125594B
公开(公告)日：2012-08-10
申请号：GEAP2006010403
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWEL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: There are represented sclerostin binding sequences or amino acid sequences determining segments complementarity in (CDR) antibodies blocking binding and isolated coding polynucleotide sequences thereof, pharmaceutical compositions containing said antibodies and their usage at the treatment of diseases associated with sclerostin, particularly, with bone mineralization related diseases.
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公开(公告)号：CO6231038A2
公开(公告)日：2010-12-20
申请号：CO09113723
申请日：2009-10-14
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： TYSON KERRY , BURKLY LINDA C , FERRANT-ORGETTAS JANINE , GARBER ELLEN , SHU YEN-MING , SU LIHE , TAYLOR FREDERICH , ADAMS RALPH , POPPLEWELL ANDREW GEORGE , ROBINSON MARTYN KIM , SHOCK ANTHONY
IPC: A61K39/395 , C07K16/28 , C12N15/13 , C12N15/63
Abstract: 1.- Una proteína de unión CD154 que comprende secuencias CDR1. CDR2 y CDR3 de cadena pesada seleccionadas de: (a) SEQ ID NO: 3, SEQ ID NO: 4 y SEQ ID NO: 5, respectivamente; (b) SEQ ID NO: 42, SEQ ID NO: 43 y SEQ ID NO: 44, respectivamente; y (c) SEQ ID NO: 48, SEQ ID NO: 49 y SEQ ID NO: 50, respectivamente; o que comprende secuencias CDR1, CDR2 y CDR3 de cadena liviana seleccionadas de: (a) SEQ ID NO: 6, SEQ ID NO: 7 y SEQ ID NO: 8, respectivamente; (b) SEQ ID NO: 45, SEQ ID NO: 46 y SEQ ID NO: 47, respectivamente; y (c) SEQ ID NO: 51, SEQ ID NO: 52 y SEQ ID NO: 53, respectivamente. 2.- La proteína de unión CD154 de la reivindicación 1 que comprende secuencias CDR1, CDR2 y CDR3 de cadena pesada y secuencias CDR1, CDR2 y CDR3 de cadena liviana seleccionadas de: (a) SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 y SEQ ID NO: 8, respectivamente; (b) SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46 y SEQ ID NO: 47, respectivamente; y (c) SEQ ID NO: 48, SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO. 51, SEQ ID NO: 52 y SEQ ID NO: 53, respectivamente.
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Patent Agency Ranking
公开(公告)号：CA2681530A1
公开(公告)日：2008-10-02
申请号：CA2681530
申请日：2008-03-21
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： TAYLOR FREDERICK R , BURKLY LINDA C , BROWN DEREK THOMAS , ADAMS RALPH , TYSON KERRY LOUISE , POPPLEWELL ANDREW GEORGE , ROBINSON MARTYN KIM , SHOCK ANTHONY , SU LIHE , HSU YEN-MING , FERRANT-ORGETTAS JANINE L , GARBER ELLEN A
IPC: C07K16/28 , A61K39/395 , C12N15/13 , C12N15/63
Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) p rotein. This invention also provides a chimeric, humanized or fully human an tibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy cha in sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding protein s of this invention may elicit reduced effector function relative to a secon d anti-CD154 antibody. CD154 binding proteins of this invention are useful i n diagnostic and therapeutic methods, such as in the treatment and preventio n of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
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公开(公告)号：MA29528B1
公开(公告)日：2008-06-02
申请号：MA30433
申请日：2007-11-29
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: L'INVENTION CONCERNE DES COMPOSITIONS ET DES PROCÉDÉS AYANT TRAIT AUX ÉPITOPES DE LA PROTÉINE SCLÉROSTINE, ET DES AGENTS DE FIXATION À LA SCLÉROSTINE TELS QUE DES ANTICORPS POUVANT SE FIXER À LA SCLÉROSTINE
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公开(公告)号：NO20201120A1
公开(公告)日：2008-01-30
申请号：NO20201120
申请日：2020-10-16
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： LATHAM JOHN , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: A61K39/395 , A61P19/08 , A61P19/10 , C07K14/51 , C07K16/18
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公开(公告)号：CA2947080A1
公开(公告)日：2006-11-09
申请号：CA2947080
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALASTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: C07K16/22 , A61K39/395 , A61P19/08 , C07K14/475 , C07K14/51 , C07K19/00 , C12N15/13 , C12P21/08 , G01N33/50
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：AU2006242476A1
公开(公告)日：2006-11-09
申请号：AU2006242476
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , WINTERS AARON GEORGE , WINKLER DAVID , ROBINSON MARTYN KIM , LU HSIENG SEN , LAWSON ALASTAIR , PASZTY CHRISTOPHER , LATHAM JOHN
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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