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公开(公告)号：JP2013249303A
公开(公告)日：2013-12-12
申请号：JP2013155969
申请日：2013-07-26
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTY KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LU HSIENG SEN , LAWSON ALASTAIR , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: A61K39/395 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P5/14 , A61P5/18 , A61P7/00 , A61P7/06 , A61P15/00 , A61P17/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/08 , A61P29/00 , C07K16/26 , C12N15/02 , C12N15/09
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition that contains an antibody capable of binding to Sclerostin as a protein.SOLUTION: A pharmaceutical composition contains an antibody having a light chain variable domain consisting of an amino acid sequence shown by SEQ ID No. 376 and a heavy chain variable domain consisting of an amino acid sequence shown by SEQ ID No. 378. The antibody binds to Sclerostin as SEQ ID No. 1 with a binding affinity (Kd) lower than, or equal to, 1×10M. or bonds to the sucre loss Canis familiaris var. domesticus of SEQ ID NO 1 by binding affinity (Kd) equal to 1×10M. The pharmaceutical composition can be used for treatment or prevention of a pathologic disorder developed through the medium of Sclerostin or associated with a rise in the Sclerostin level.
Abstract translation: 要解决的问题：提供含有能够结合硬皮蛋白作为蛋白质的抗体的药物组合物。溶液：药物组合物含有具有由SEQ ID No.366所示的氨基酸序列组成的轻链可变结构域的抗体 和由SEQ ID No.378所示的氨基酸序列组成的重链可变结构域。抗体以低于或等于1×10M的结合亲和力（Kd）与SEQ ID No.1结合至硬化蛋白。 或结合到苏必莱失去犬科家族变种。 通过结合亲和力（Kd）等于1×10M的SEQ ID NO 1的家蚕。 该药物组合物可用于治疗或预防通过硬化性白细胞介素发展或与硬皮蛋白血症水平升高相关的病理学疾病。
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公开(公告)号：JP2014012001A
公开(公告)日：2014-01-23
申请号：JP2013155968
申请日：2013-07-26
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： PASZTY CHRISTOPHER , MARTYN KIM ROBINSON , KEVIN GRAHAM , ALISTAIR JAMES HENRY , KELLY SUE HOFFMANN , JOHN LATHAM , LU HSIENG SEN , ALASTAIR LAWSON , ANDY POPPLEWELL , SHEN WENYAN , DAVID WINKLER , AARON GEORGE WINTERS
IPC: C12N15/09 , A61K39/395 , A61P19/08 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/08
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: PROBLEM TO BE SOLVED: To provide epitopes of sclerostin protein, including human sclerostin protein, and binding agents (such as antibodies) capable of binding to sclerostin or fragments thereof.SOLUTION: An antibody includes a light chain variable domain of a specific amino acid sequence and a heavy chain variable domain of another specific amino acid sequence, and binds to sclerostin with a binding affinity (Kd) less than or equal to 1×10M. Also provided are a method of producing the antibody, and a pharmaceutical composition containing the antibody.
Abstract translation: 要解决的问题：提供包含人类硬化蛋白的软骨素蛋白质表位，以及能够结合硬化蛋白酶或其片段的结合剂（例如抗体）。解决方案：抗体包括特定氨基酸序列的轻链可变结构域 和另一个特定氨基酸序列的重链可变结构域，并以小于或等于1×10M的结合亲和力（Kd）结合硬化蛋白。 还提供了产生抗体的方法和含有该抗体的药物组合物。
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公开(公告)号：JP2014061000A
公开(公告)日：2014-04-10
申请号：JP2013245908
申请日：2013-11-28
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： PASZTY CHRISTOPHER , MARTYN KIM ROBINSON , KEVIN GRAHAM , ALISTAIR JAMES HENRY , KELLY SUE HOFFMANN , JOHN LATHAM , LU HSIENG SEN , ALASTAIR LAWSON , ANDY POPPLEWELL , SHEN WENYAN , DAVID WINKLER , AARON GEORGE WINTERS
IPC: C12N15/09 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/02 , A61P3/04 , A61P3/10 , A61P5/14 , A61P5/18 , A61P7/06 , A61P15/00 , A61P17/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/32 , A61P29/00 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: PROBLEM TO BE SOLVED: To provide therapeutic substances that can be used to enhance bone formation and bone density of animals including humans.SOLUTION: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding action substances such as antibodies capable of binding to sclerostin are provided.
Abstract translation: 要解决的问题：提供可用于增强包括人类在内的动物的骨形成和骨密度的治疗物质。解决方案：与硬皮蛋白的表位有关的组合物和方法，以及硬结蛋白结合作用物质，例如能结合硬化蛋白的抗体 被提供。
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公开(公告)号：JP2014177470A
公开(公告)日：2014-09-25
申请号：JP2014095921
申请日：2014-05-07
Applicant: Amgen , アムジエン・インコーポレーテツド , Ucb Pharma Sa , ユーシービー ファーマ ソシエテ アノニム
Inventor： LU HSIENG SEN , PASZTY CHRISTOPHER , MARTYN KIM ROBINSON , ALISTAIR JAMES HENRY , KELLY SUE HOFFMANN , JOHN LATHAM , ALASTAIR LAWSON , DAVID WINKLER , AARON GEORGE WINTERS
IPC: C07K14/47 , A61K39/00 , A61P19/08 , A61P19/10 , C07K1/12 , C07K16/18 , C12N15/09 , C12P21/06 , C12P21/08
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
Abstract: PROBLEM TO BE SOLVED: To provide compositions and methods that can be used to increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength.SOLUTION: The invention provides compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin.
Abstract translation: 要解决的问题：提供可用于增加骨形成，骨矿物质密度，骨矿物质含量，骨量，骨质量和骨强度中的至少一种的组合物和方法。解决方案：本发明提供了与 硬骨素蛋白表位和硬化蛋白结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：HRP20211904T3
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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Patent Agency Ranking
公开(公告)号：HRP20211904T1
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：PL3670528T3
公开(公告)日：2022-01-31
申请号：PL19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：EA021539B1
公开(公告)日：2015-07-30
申请号：EA200702402
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Изобретениеотноситсяк связывающимсклеростинагентам, такимкакантитела, иихприменению.
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公开(公告)号：AU2006242431B2
公开(公告)日：2012-11-08
申请号：AU2006242431
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： SHEN WENYAN , LATHAM JOHN , PASZTY CHRISTOPHER , POPPLEWELL ANDY , WINTERS AARON GEORGE , ROBINSON MARTYN KIM , HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , LU HSIENG SEN , GRAHAM KEVIN , WINKLER DAVID , LAWSON ALASTAIR
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：AU2006242476B2
公开(公告)日：2012-05-31
申请号：AU2006242476
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , WINTERS AARON GEORGE , WINKLER DAVID , ROBINSON MARTYN KIM , LU HSIENG SEN , LAWSON ALASTAIR , PASZTY CHRISTOPHER , LATHAM JOHN
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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