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    T CELL RECEPTORS AND METHODS OF USE THEREOF
    41.
    发明专利
    T CELL RECEPTORS AND METHODS OF USE THEREOF 未知

    公开(公告)号：CA3146298A1

    公开(公告)日：2021-02-04

    申请号：CA3146298

    申请日：2020-07-29

    Applicant: UNIV HEALTH NETWORK

    Inventor： HIRANO NAOTO ,  SUGATA KENJI ,  SASO KAYOKO

    IPC: C12N15/867 ,  A61K35/17 ,  A61P35/00 ,  C07K14/725

    Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a CCND1 epitope and nucleic acid molecules encoding the same. In some aspects, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some aspects, the methods comprise treating a cancer in a subject in need thereof.

    MHC CLASS II MOLECULES AND METHODS OF USE THEREOF
    42.
    发明专利
    MHC CLASS II MOLECULES AND METHODS OF USE THEREOF 未知

    公开(公告)号：CA3146296A1

    公开(公告)日：2021-02-04

    申请号：CA3146296

    申请日：2020-07-29

    Applicant: UNIV HEALTH NETWORK

    Inventor： HIRANO NAOTO ,  SUGATA KENJI ,  GUO TINGXI

    IPC: C07K14/74

    Abstract: The present disclosure is directed to HLA class II molecules having a higher affinity for CD4 than naturally occurring HLA class II molecules. In certain aspects, the HLA class II molecule comprises a DR beta chain having (i) an amino acid other than leucine at a position corresponding to amino acid residue 114 of SEQ ID NO: 1, (ii) an amino acid other than valine at a position corresponding to amino acid residue 143 of SEQ ID NO: 1, (iii) or both (i) and (ii). Certain aspects of the present disclosure are directed to nucleic acid molecules encoding the HLA class II molecules, vectors comprising the nucleic acid molecule, cells comprising the same, and methods of use thereof.

    PEPTIDE-HLA COMPLEXES AND METHODS OF PRODUCING SAME
    44.
    发明专利
    PEPTIDE-HLA COMPLEXES AND METHODS OF PRODUCING SAME 未知

    公开(公告)号：CA3022227A1

    公开(公告)日：2017-11-02

    申请号：CA3022227

    申请日：2017-04-27

    Applicant: UNIV HEALTH NETWORK UHN

    Inventor： HIRANO NAOTO ,  NAKATSUGAWA MUNEHIDE ,  RAHMAN MUHAMMED AASHIQ ,  MURATA KENJI

    IPC: C07K14/74 ,  C12N5/10 ,  C12N15/12 ,  G01N33/53 ,  G01N33/569

    Abstract: There is provided herein, the use of mammalian derived HLA class I molecule for in vitro peptide exchange. For example, there is provided a method of producing an HLA class I molecule complexed to a pre-selected peptide comprising: (a) providing a mammalian derived HLA class 1 molecule complexed to an existing peptide; (b) incubating, in vitro, the HLA class I molecule complexed to the existing peptide with the pre-selected peptide, wherein the pre-selected peptide is at a concentration sufficient to replace the existing peptide to produce the HLA class I molecule complexed to the pre-selected peptide; and the HLA class I molecule comprises a1, a1, a2, a3 and ß2m domains.

    Receptores de células t e métodos de uso dos mesmos
    45.
    发明专利
    Receptores de células t e métodos de uso dos mesmos 未知

    公开(公告)号：BR112022001697A2

    公开(公告)日：2022-06-07

    申请号：BR112022001697

    申请日：2020-07-29

    Applicant: UNIV HEALTH NETWORK

    Inventor： SASO KAYOKO ,  SUGATA KENJI ,  HIRANO NAOTO

    IPC: C07K14/725 ,  A61K35/17 ,  A61P35/00 ,  C12N15/113 ,  C12N15/12 ,  C12N15/63 ,  C12N15/867

    Abstract: receptores de células t e métodos de uso dos mesmos. a presente invenção refere-se aos receptores de células t recombinantes capazes de ligar um epítopo mage-a2 e moléculas de ácido nucleico que codificam os mesmos. em alguns aspectos, as moléculas de ácido nucleico compreendem ainda uma segunda sequência de nucleotídeos, em que a segunda sequência de nucleotídeos ou o polipeptídeo codificado pela segunda sequência de nucleotídeos inibe a expressão de um tcr endógeno. outros aspectos da invenção são dirigidos a vetores que compreendem a molécula de ácido nucleico e células que compreendem o tcr recombinante, a molécula de ácido nucléico, ou o vetor. ainda outros aspectos da invenção são dirigidos a métodos de utilização dos mesmos. em alguns aspectos, os métodos compreendem o tratamento de um câncer em um indivíduo em necessidade do mesmo.

    T cell receptors and methods of use thereof
    47.
    发明专利
    T cell receptors and methods of use thereof 未知

    公开(公告)号：AU2020320445A1

    公开(公告)日：2022-03-03

    申请号：AU2020320445

    申请日：2020-07-29

    Applicant: UNIV HEALTH NETWORK

    Inventor： HIRANO NAOTO ,  SUGATA KENJI ,  SASO KAYOKO

    IPC: C12N15/867 ,  A61K35/17 ,  A61P35/00 ,  C07K14/725

    Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a CCND1 epitope and nucleic acid molecules encoding the same. In some aspects, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some aspects, the methods comprise treating a cancer in a subject in need thereof.

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