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    Whole blood preparation for cytometric analysis of cellular signal transduction pathways
    2.
    发明专利
    Whole blood preparation for cytometric analysis of cellular signal transduction pathways 审中-公开
    全身血细胞计数细胞信号转导途径的细胞分析

    公开(公告)号：JP2012022007A

    公开(公告)日：2012-02-02

    申请号：JP2011229883

    申请日：2011-10-19

    Applicant: Beckman Coulter Inc ,  Univ Health Network ,  ベックマン コールター, インコーポレイテッド ,  ユニバーシティー ヘルス ネットワーク

    Inventor： SI CHOU ,  DAVID HEDLEY ,  T VINCENT SHANKEY ,  PATRICIA GROM

    IPC: G01N33/48 ,  C12Q1/02 ,  G01N33/543

    CPC classification number: G01N33/80 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375

    Abstract: PROBLEM TO BE SOLVED: To provide a method for preparing a biological sample for the measurement of protein epitopes that enables intracellular protein epitopes to be preserved and signal transduction pathways to be detected based on the ability to capture the transient active state of the epitopes.SOLUTION: The present invention enables a biological sample including erythrocytes to be fixed quickly to ensure that epitopes of signal transduction molecules and other intracellular protein epitopes are preserved in an active state. The method of the invention enables erythrocyte lysis and can be useful for the cytometric analysis of a biological sample, for example, whole blood, bone marrow aspirate, ascites, and other sample including erythrocytes. The invention also provides a method for recovering or unmasking epitopes on intracellular antigens adapted to make crosslinking fixative inapproachable which is necessary to fix the sample. The invention enables the preservation and analysis of phosphate-epitope level in a biological sample collected directly from a patient to determine disease-specific characteristics.

    Abstract translation: 要解决的问题：提供一种制备用于测量蛋白质表位的生物样品的方法，其使得能够保留细胞内蛋白质表位和基于捕获瞬时活性状态的能力来检测信号转导途径 表位。 解决方案：本发明能够使包含红细胞的生物样品快速固定，以确保信号转导分子和其它细胞内蛋白质表位的表位保持在活性状态。 本发明的方法使红细胞溶解，并且可用于生物样品例如全血，骨髓抽吸物，腹水和包括红细胞在内的其它样品的细胞计数分析。 本发明还提供了一种用于在细胞内抗原上恢复或揭开表位的方法，该方法适于制备固定样品所必需的交联固定剂。 本发明能够保存和分析从患者直接收集的生物样品中的磷酸盐表位水平，以确定疾病特异性特征。 版权所有（C）2012，JPO＆INPIT

    Method and apparatus for high resolution coherent optical imaging
    3.
    发明专利
    Method and apparatus for high resolution coherent optical imaging 有权
    用于高分辨相关光学成像的方法和装置

    公开(公告)号：JP2012145588A

    公开(公告)日：2012-08-02

    申请号：JP2012045571

    申请日：2012-03-01

    Applicant: Univ Health Network ,  ユニヴァーシティー ヘルス ネットワークUniversity Health Network

    Inventor： VICTOR XIAO DONG YANG ,  ALEX VITKIN I ,  LOUIE WONGKEESONG ,  SHARON KATZ ,  MARGARET LESLIE GORDON ,  BRIAN C WILSON ,  ALVIN HO KWAN MOK

    IPC: G01N21/17 ,  A61B1/00 ,  A61B1/05 ,  A61B5/00 ,  G01N21/47 ,  G02B6/04 ,  G02B23/26

    CPC classification number: A61B5/6852 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/05 ,  A61B5/0066 ,  G01N21/4795

    Abstract: PROBLEM TO BE SOLVED: To provide an endomicroscope with OCT employing multiple fibers (i.e., channels) to allow different parts of the image to be scanned in parallel, instead of in series as is currently implemented in existing in vivo or ex vivo OCT/OCM systems.SOLUTION: Radiation from a plurality of optical radiation sources (21, 22, 23) travels along a first optical path. In the first optical path, a device focuses the optical radiation from the optical sources into respective focal points (21a, 22a, 23a) along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within selected length extending into the sample is scanned along the selected portion of the first optical path.

    Abstract translation: 要解决的问题：为了提供使用多个纤维（即，通道）的OCT的内窥镜，以允许图像的不同部分并行扫描，而不是如现在在体内或离体中实施的那样串联 OCT / OCM系统。 解决方案：来自多个光辐射源（21,22,23）的辐射沿第一光路行进。 在第一光路中，设备将来自光源的光辐射沿着第一光路聚焦到相应的焦点（21a，22a，23a）中，以提供对第一光路的选定部分的基本上连续的覆盖。 然后，沿着第一光路的选定部分扫描延伸到样品中的选定长度内的第一光路上的样品。 版权所有（C）2012，JPO＆INPIT

    FIBER OPTIC LIGHT DELIVERY, MONITORING AND APPARATUS THEREFORE
    5.
    发明专利
    FIBER OPTIC LIGHT DELIVERY, MONITORING AND APPARATUS THEREFORE 未知

    公开(公告)号：CA3001273A1

    公开(公告)日：2017-04-13

    申请号：CA3001273

    申请日：2016-10-10

    Applicant: THERALASE TECH INC ,  UNIV HEALTH NETWORK ,  UNIV HEALTH NETWORK

    Inventor： LIGLE LOTHAR ,  DUMOULIN-WHITE ROGER ,  EMBREE WAYNE ,  LEM DON ,  MANDEL ARKADY ,  WU JENNY

    IPC: A61N5/06 ,  A61B1/07 ,  A61B1/307 ,  G02B6/42

    Abstract: Apparatus for illuminating comprises one or more fibers, the one or more fibers including fiber portions meeting at an apex and a bottom location to form a three dimensional cage; a detector attached to each of the fiber portions for receiving light and transmitting light along each of the fiber portions, respectively; and an illumination member situated within the cage. A method for illuminating a hollow member includes the steps of inserting one or more fibers into the hollow member, wherein one or more fibers include fiber portions that meet at a location to form a three-dimensional cage; permitting light to emit from within the three-dimensional cage and towards the fiber portions; receiving light at distinct locations on each of said fibers; and allowing each of the fibers to transmit the light received on each of the fiber portions out of the hollow member.

    TREATMENT OF EGF-RECEPTOR DEPENDENT PATHOLOGIES
    7.
    发明申请
    TREATMENT OF EGF-RECEPTOR DEPENDENT PATHOLOGIES 审中-公开
    EGF受体依赖性病理学的治疗

    公开(公告)号：WO2014100602A8

    公开(公告)日：2015-05-07

    申请号：PCT/US2013076954

    申请日：2013-12-20

    Applicant: HOSPITAL FOR SPECIAL SURGERY ,  UNIV HEALTH NETWORK

    Inventor： BLOBEL CARL ,  MARETZKY THORSTEN ,  MCILWAIN DAVID ,  MAK TAK WAH

    IPC: C12N15/113 ,  A01K67/027 ,  C07K16/18

    CPC classification number: G01N33/5032 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/507 ,  C07K16/18 ,  C12N15/113 ,  C12N2310/14 ,  G01N2500/02

    Abstract: Disclosed are methods for treating a subject with an EGFR dependent pathology. The method comprises the step of administering to the subject an effective amount of an agent ("First Agent") that decreases the biological activity of iRhoml and an effective amount of an agent ("Second Agent") that decreases the biological activity of iRhom2. Alternatively, the method comprises the step of administering to the subject an effective amount of an agent ("First Agent") that modulates formation of a complex between iRhom 1 and TACE and an effective amount of an agent ("Second Agent") that modulates formation of a complex between TACE and iRhom2. Also disclosed are assays for identifying such agents.

    Abstract translation: 公开了用EGFR依赖性病理学治疗受试者的方法。 该方法包括向受试者施用有效量的减少iRhoml的生物活性的试剂（“First Agent”）和有效量的降低iRhom2生物活性的试剂（“第二剂”）。 或者，该方法包括向受试者施用有效量的调节iRhom1和TACE之间的复合物形成的试剂（“第一剂”）和有效量的调节剂（“第二剂”） 形成TACE和iRhom2之间的复合物。 还公开了用于鉴定这种试剂的测定法。

    METHODS OF ADMINISTERING DANTROLENE FOR THE ACUTE TREATMENT OF CARDIAC ARRHYTHMIAS
    8.
    发明申请
    METHODS OF ADMINISTERING DANTROLENE FOR THE ACUTE TREATMENT OF CARDIAC ARRHYTHMIAS 审中-公开
    用于治疗心脏病的急性心肌梗死的方法

    公开(公告)号：WO2014191837A2

    公开(公告)日：2014-12-04

    申请号：PCT/IB2014001748

    申请日：2014-05-05

    Applicant: UNIV HEALTH NETWORK

    Inventor： NANTHAKUMAR KUMARASWAMY

    IPC: A61K31/4178

    CPC classification number: A61K31/4178 ,  A61K31/422 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.

    Abstract translation: 本说明书涉及施用有效量的抗心律失常药物（例如丹曲林，azumolene或其药学上可接受的盐）用于急性治疗心律失常的方法，例如心房颤动，室性早搏，室性心动过速或室性心律失常 原纤维化和预防随后的心律失常，其中所述方法降低发病率和死亡率。

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