公开(公告)号：WO1989003386A1

公开(公告)日：1989-04-20

申请号：PCT/US1988003513

申请日：1988-10-14

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GOLDBERG, Eugene, P. ,  LI, Fu-Mian ,  LUO, Ching-Wang

IPC: C07D279/22

CPC classification number: A61L27/16 ,  A61F2002/16965 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  C07D279/22 ,  C07D279/30 ,  C07D513/04 ,  C08F20/38 ,  C08F20/60 ,  G02B1/04 ,  G02B1/043 ,  A61F2/16 ,  A61F2/14 ,  C08L33/24 ,  C08L33/14

Abstract: Ultraviolet light absorbing, polymerizable phenothiazine and azaphenothiazine monomers, copolymers thereof and articles of manufacture, including lenses, optical devices, plastic films and hydrogels, constructed therefrom.

Abstract translation: 紫外光吸收，可聚合吩噻嗪和氮杂噻嗪单体，其共聚物和制品，包括由其构成的透镜，光学装置，塑料膜和水凝胶。

公开(公告)号：WO1989003205A1

公开(公告)日：1989-04-20

申请号：PCT/US1988003452

申请日：1988-10-12

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GOLDBERG, Eugene, P.; ,  YALON, Moshe;

IPC: A61K09/06

CPC classification number: A61L31/145 ,  A61K9/0048 ,  A61K31/79 ,  A61L31/041 ,  A61L31/048 ,  A61L2430/16 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/915 ,  A61F9/00 ,  C08L39/06 ,  C08L5/08 ,  C08L1/28

Abstract: A composition and surgical method involving the use as an ophthalmic viscoelastic surgical material of an aqueous solution containing at least 1.5 %, by weight, of a water soluble polyvinylpyrrolidone or polyvinylpyrrolidone copolymer having a molecular weight greater than 500,000 and a viscosity greater than 5,000 centipoises.

Abstract translation: 一种组合物和手术方法，其涉及用作含有至少1.5重量％的分子量大于500,000并且粘度大于5,000厘泊的水溶性聚乙烯吡咯烷酮或聚乙烯吡咯烷酮共聚物的水溶液的眼用粘弹性手术材料。

公开(公告)号：WO1989002737A1

公开(公告)日：1989-04-06

申请号：PCT/US1988003302

申请日：1988-09-28

Applicant: UNIVERSITY OF FLORIDA ,  FREGLY, Melvin, J. ,  CADE, James, Robert

Inventor： UNIVERSITY OF FLORIDA

IPC: A61K31/405

CPC classification number: A61K31/405

Abstract: A composition and method for treating hypertension, cardiac or renal hypertrophy, polydipsia, polyuria, stroke or atherosclerosis based on chronic administration of L-tryptophan or L-5-hydroxytryptophan.

Abstract translation: 基于慢性施用L-色氨酸或L-5-羟色氨酸治疗高血压，心脏或肾脏肥大，多饮，多尿，中风或动脉粥样硬化的组合物和方法。

公开(公告)号：WO1986002717A1

公开(公告)日：1986-05-09

申请号：PCT/US1985002056

申请日：1985-10-22

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  KURZWEG, Ulrich, H.

IPC: F28D15/00

CPC classification number: F25B9/145 ,  F03G7/002 ,  F25B2309/1413 ,  F25B2309/1417 ,  F25B2309/1419 ,  F25B2309/1426 ,  F28D15/00 ,  F28F13/10 ,  G21C15/257 ,  Y02E30/35

Abstract: A device for the transport of large conduction heat flux between two locations of differing temperature includes a pair of fluid reservoirs (12, 14) for positioning at the respective locations connected by at least one duct (24), and preferably a plurality of ducts (24), having walls of a material which conducts heat. A heat transfer fluid, preferably a liquid, and preferably a liquid metal such as mercury, lithium or sodium, fills both reservoirs and the connecting ducts. An oscillatory axial movement or flow of working fluid is established within the ducts, with the extent of fluid movement being less than the duct length. Preferably the oscillatory movement is sinusoidal. Heat is transferred radially between the fluid and the duct walls and thence axially along the ducts. The rate of heat transfer is greatly enhanced by a physical mechanism which may be described as a high time-dependent radial temperature gradient produced by fluid oscillations. During most of each sinusoidal cycle, fluid in wall-near region has a temperature different from the core of the fluid column, with most of the temperature difference concentrated across a relatively thin boundary layer.

公开(公告)号：WO1986000897A1

公开(公告)日：1986-02-13

申请号：PCT/US1985001333

申请日：1985-07-15

Applicant: UNIVERSITY OF FLORIDA ,  BODOR, Nicholas, S.

Inventor： UNIVERSITY OF FLORIDA

IPC: C07D213/220

CPC classification number: C07D213/53 ,  C07C323/00 ,  C07D213/82 ,  C07D277/04 ,  C07D285/00 ,  C07F13/005 ,  C07K5/06026

Abstract: A dihydropyridine pyridinium salt type of redox, or chemical, delivery system for the site-specific and/or site-enhanced delivery of a radio-nuclide to the brain. A chelating agent capable of chelating with a radionuclide and having a primary, secondary or tertiary amino function can be converted to the corresponding analogue in which said function is replaced with a dihydropyridine pyridinium salt redox system and then complexed with a radionuclide to provide a new radiopharmaceutical that, in its lipoidal dihydropyridine form, penetrates the blood-brain barrier ("BBB") and allows increased levels of radionuclide concentration in the brain, particularly since oxidation of the dihydropyridine moiety in vivo to the ionic pyridinium salt retards elimination from the brain while elimination from the general circulation is accelerated. This radionuclide delivery system is well suited for use in scintigraphy and similar radiographic techniques.

Abstract translation: 二氢吡啶标记的吡啶鎓盐类型的氧化还原或化学递送系统，用于放射性核素向大脑的位点特异性和/或位点增强的递送。 能够与放射性核素螯合并具有伯，仲或叔氨基官能团的螯合剂可以转化为相应的类似物，其中所述功能被二氢吡啶吡啶鎓盐氧化还原体系所取代，然后与放射性核素络合以提供 特别是由于二氢吡啶部分在体内氧化成离子型吡啶鎓盐，所以放射性核素在脂质二氢吡啶形式中渗入血脑屏障（“BBB”）并允许增加脑内放射性核素浓度， 大脑从总体循环中消除加速。 该放射性核素输送系统非常适用于闪烁扫描和类似放射照相技术。

公开(公告)号：WO1998013050A1

公开(公告)日：1998-04-02

申请号：PCT/US1997016673

申请日：1997-09-24

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GOLDBERG, Eugene, P.

IPC: A61K31/785

CPC classification number: A61L27/34 ,  A61F2/16 ,  C08L39/06 ,  C08L33/14 ,  C08L33/02

Abstract: Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma-irradiation induced polymerized and chemically grafted coatings on plastic surfaces of articles adapted for contacting living tissue, the improvement comprising carrying out the graft polymerization in an aqueous solution under specific combinations of the following conditions: (a) monomer concentration in the range of from about 0.1 % to about 50 %, by weight; (b) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad; and (c) gamma dose rate in the range of from above about 2,500 to about 10 rads/minute.

Abstract translation: 改进的医疗装置和仪器通过改进的在适于接触生物体组织的制品的塑料表面上产生亲水性γ射线诱导聚合和化学接枝涂层的方法制备，改进包括在水溶液中进行接枝聚合， 以下条件：（a）单体浓度在约0.1％至约50％的范围内; （b）在约0.001至小于约0.5Mrad范围内的总伽马剂量; 和（c）在约2,500至约10 8rad / min以上范围内的γ剂量率。

公开(公告)号：WO1998010246A1

公开(公告)日：1998-03-12

申请号：PCT/US1997015649

申请日：1997-09-05

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  ALEXANDER, John

IPC: G01C11/02

CPC classification number: G01C11/00 ,  G01C11/02 ,  G01C21/00 ,  G01S19/53

Abstract: The subject invention provides devices and methods for efficiently and accurately gathering image and other field data using a handheld portable Geographic Data Manager (GDMs). The subject GDMs can utilize a combination of GPS antennas and receivers, digital compasses, inclinometers, gyroscopes, and digital cameras to gather, process, and/or store data which can provide the position and other geographic data and information pertaining to objects of study. The subject GDMs can have application to fields including environmental sampling, surveying, agriculture field data collection, property appraisal, law enforcement, and construction inspection.

Abstract translation: 本发明提供了使用手持便携式地理数据管理器（GDM）来有效且准确地收集图像和其他现场数据的设备和方法。 主题GDM可以利用GPS天线和接收器，数字罗盘，倾斜仪，陀螺仪和数码相机的组合来收集，处理和/或存储可以提供与研究对象有关的位置和其他地理数据和信息的数据。 主题GDM可以应用于环境抽样，测量，农业现场数据收集，财产评估，执法和施工检查等领域。

公开(公告)号：WO1998010082A1

公开(公告)日：1998-03-12

申请号：PCT/US1996014244

申请日：1996-09-05

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GIROUX, Michael ,  HANNAH, L., Curtis

IPC: C12N15/82

CPC classification number: C12N9/1241 ,  C12N15/8245 ,  C12N15/8261 ,  Y02A40/146

Abstract: The subject invention pertains to novel variants of the maize gene, Shrunken2(Sh2) and a method of using that gene. The variant gene, Sh2-m1Rev6, encodes a subunit of the ADP-glucose pyrophosphorylase (AGP) enzyme that has additional amino acids inserted in or near the allosteric binding site of the protein. Corn seed expressing the Sh2-m1Rev6 gene has a 15 % weight increase over wild type seed. The increase in seed weight is not associated simply with an increase in percentage starch content of the seed.

Abstract translation: 本发明涉及玉米基因Shrunken2（Sh2）的新变体和使用该基因的方法。 变体基因Sh2-m1Rev6编码ADP-葡萄糖焦磷酸化酶（AGP）酶的亚基，其具有插入蛋白质的变构结合位点内或附近的附加氨基酸。 表达Sh2-m1Rev6基因的玉米种子比野生型种子具有15％的重量增加。 种子重量的增加与种子淀粉含量百分比的增加不相关。

公开(公告)号：WO1998004006A1

公开(公告)日：1998-01-29

申请号：PCT/US1997006434

申请日：1997-04-18

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  SIMMONS, Joseph, H.

IPC: H01L31/04

CPC classification number: H01L31/18 ,  H01L31/022466 ,  H01L31/0352 ,  H01L31/0384 ,  H01L31/04 ,  Y02E10/50

Abstract: A method and structure for a photo-active region (20) for generation of free carriers when a first surface is exposed to optical radiation. The photo-active region (20) includes a conducting transparent matrix (24) and clusters (22, 26, 28, 30) of semiconductor materials embedded within the conducting transparent matrix (24). The clusters are arranged in the matrix material so as to define at least a first distribution of cluster sizes ranging from those with the highest bandgap energy near a light incident surface of the photo-active region to those with the smallest bandgap energy near an opposite second surface of the photo-active region. Also disclosed is a method and structure for a solar cell. The solar cell includes a photo-active region (20) containing a plurality of semiconductor clusters (22, 26, 28, 30) of varying sizes as described.

Abstract translation: 一种用于当第一表面暴露于光辐射时产生自由载流子的光有源区（20）的方法和结构。 光活性区域（20）包括导电透明矩阵（24）和嵌入导电透明矩阵（24）内的半导体材料的簇（22,26,28,30）。 簇被布置在矩阵材料中，以便限定从具有最大带隙能量的那些在光有源区的光入射表面附近的簇的尺寸的至少第一分布与具有最小带隙能的那些具有接近相反的第二分布 光活性区域的表面。 还公开了一种用于太阳能电池的方法和结构。 太阳能电池包括含有如上所述的各种尺寸的多个半导体簇（22,26,28,30）的光有源区（20）。

公开(公告)号：WO1997008201A1

公开(公告)日：1997-03-06

申请号：PCT/US1996014032

申请日：1996-08-27

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  MACLAREN, Noel, K. ,  SONG, Yao-Huo

IPC: C07K14/47

CPC classification number: C07K14/4713 ,  A61K38/00 ,  C07K16/18

Abstract: Acquired hypoparathyroidism (AH) occurs frequently as a component of type I autoimmune polyglandular diseases (APS-I) or as a sporadic isolated disease in adults. Whereas autoantibodies to the parathyroid glands have been reported in AH, their very existence remains controversial. We report here the detection of autoantibodies as identified through immunoblotting using sera from AH patients. The antibodies were specific to parathyroid autoantigens obtained through differential centrifugation of fresh human hypercellular parathyroid glands, obtained shortly after their surgical removal for tertiary hyperparathyroidism in patients with renal failure. Autoantibodies were detected against several parathyroid specific proteins in the 17 AH sera tested. Twelve (70 %) reacted to a protein of 70 kDa, while 16 (94 %) reacted to a protein of 80 kDa, and 3 (18 %) reacted to a protein of 120-140 kDa, respectively. The 70 and 80 kDa proteins were localized to the cytosolic fraction of the parathyroid extract, and the 120-140 kDa protein to the membrane fraction. The autoantibodies were also detectable using a dog parathyroid gland as an antigen source. However, they could not be identified using cultured human melanocytes or in rat pituitary cells as antigen sources. Sera from 50 patients with various other autoimmune diseases as well as 22 normal controls were also tested, and none reacted with any of the above specific parathyroid proteins. It is concluded that autoantibodies to 3 major autoantigens in the human parathyroid gland extract have been detected in AH patients. Furthermore, our data indicates that the 120-140 kDa autoantigen is the calcium sensing receptor and that the reactive epitope largely resides in its extracellular domain. These data confirm the autoimmune nature of AH, and the invention provides a method for detecting AH or propensity for AH as well as a method for treating AH.

Abstract translation: 获得性甲状旁腺功能减退症（AH）经常作为I型自身免疫多腺性疾病（APS-1）的组成部分或作为成人散发性孤立性疾病发生。 而甲状旁腺的自身抗体已被报道在AH中，它们的存在仍然是有争议的。 我们在这里报告通过使用来自AH患者的血清的免疫印迹鉴定的自身抗体的检测。 抗体对于通过差异离心新鲜的人类超细胞甲状旁腺获得的甲状旁腺自身抗原特异性，其在肾功能衰竭患者的手术切除后不久即获得三级甲状旁腺功能亢进。 在17个AH血清测试中检测到几种甲状旁腺特异性蛋白的自身抗体。 十二（70％）与70kDa的蛋白质反应，而16（94％）反应于80kDa的蛋白质，3（18％）分别与120-140kDa的蛋白质反应。 70和80 kDa蛋白质定位于甲状旁腺提取物的胞质部分，并将120-140 kDa的蛋白质定位于膜级分。 使用狗甲状旁腺作为抗原来检测自身抗体。 然而，它们不能使用培养的人类黑素细胞或大鼠垂体细胞作为抗原来识别。 还测试了50例患有各种其他自身免疫性疾病的患者和22例正常对照的血清，并且没有任何一种与上述特定甲状旁腺蛋白反应。 得出结论：在AH患者中已经检测到人类甲状旁腺提取物中3种主要自身抗原的自身抗体。 此外，我们的数据表明，120-140 kDa自身抗原是钙敏感受体，并且反应性表位主要存在于细胞外结构域中。 这些数据证实了AH的自身免疫性质，本发明提供了一种检测AH或AH倾向的方法以及治疗AH的方法。