公开(公告)号：EP2484780A1

公开(公告)日：2012-08-08

申请号：EP12000245.6

申请日：2005-07-25

Applicant: The University of North Carolina At Chapel Hill

Inventor： Diatchenko, Luda B. ,  Maixner, William ,  Slade, Gary D. ,  Nackley, Andrea Gail

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6881 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  C12Y201/01006 ,  G06F19/18 ,  Y02A90/24 ,  Y02A90/26

Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.

Abstract translation: 体感治疗病症和通过施用以有效量的COMT调制器的，ADRB2调制器，调制器ADRB3或组合的受试者中提供其调制促炎性细胞因子的方法。 预测有效的药理学疗法，用于通过确定性采矿的病症体感关于选自COMT，ADRB2，ADRB3，以及它们的组合进一步提供了选择的基因的受试者的基因型折磨的受试者的方法。 确定性采矿疼痛反应或疼痛感和主题的预测敏感性制定相关的疾病，：如躯体感觉障碍和躯体，以确定开采主体的基因型对于基因选自COMT，ADRB2，ADRB3的选择方法， 和其组合是更提供。

公开(公告)号：EP2328909A4

公开(公告)日：2012-04-04

申请号：EP09815553

申请日：2009-09-08

Applicant: UNIV HONG KONG

Inventor： HO SHULEONG ,  RAMSDEN DAVID BOYER ,  HO WINGLOK

IPC: C07K7/08 ,  C07K14/47 ,  C07K16/40 ,  C07K16/44 ,  C12N9/10 ,  G01N33/573

CPC classification number: C07K16/44 ,  C07K7/08 ,  C07K16/40 ,  C07K2319/40 ,  C12N9/1011 ,  C12Y201/01006 ,  G01N33/573 ,  G01N2333/91022 ,  Y10S435/975

公开(公告)号：EP1782321A4

公开(公告)日：2009-11-04

申请号：EP05858041

申请日：2005-07-25

Applicant: UNIV NORTH CAROLINA

Inventor： SLADE GARY D ,  NACKLEY ANDREA GAIL ,  DIATCHENKO LUDA B ,  MAIXNER WILLIAM

IPC: G01N33/48 ,  A01N33/18 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6881 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  C12Y201/01006 ,  G06F19/18 ,  Y02A90/24 ,  Y02A90/26

Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.

公开(公告)号：EP1826265A2

公开(公告)日：2007-08-29

申请号：EP07005020.8

申请日：1999-10-06

Applicant: ARBORGEN, LLC

Inventor： Bloksberg, Leonard Nathan ,  Havukkala, Ilkka Jaakko

IPC: C12N9/00 ,  C12N9/02 ,  C12N9/08 ,  C12N9/10 ,  C12N9/32 ,  C12N9/42 ,  C12N9/86 ,  C12N15/82

CPC classification number: C12N9/0004 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0059 ,  C12N9/0061 ,  C12N9/0065 ,  C12N9/0071 ,  C12N9/0083 ,  C12N9/1007 ,  C12N9/1011 ,  C12N9/1051 ,  C12N9/2422 ,  C12N9/2445 ,  C12N9/86 ,  C12N9/93 ,  C12N15/8255 ,  C12Y110/03001 ,  C12Y110/03002 ,  C12Y114/13011 ,  C12Y201/01006 ,  C12Y302/01001 ,  C12Y302/01021

Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.

Abstract translation: 提供了与木质素生物合成途径相关的新型分离的多核苷酸和多肽以及包括这些序列的构建体。 还公开了调节靶生物体中木质素含量，木质素结构和木质素组成的方法，所述方法包括将本发明的一种或多种多核苷酸掺入靶生物体的基因组中。

公开(公告)号：EP1121421A1

公开(公告)日：2001-08-08

申请号：EP99954500.7

申请日：1999-10-06

Applicant: Genesis Research & Development Corporation Limited ,  Fletcher Challenge Forests Limited

Inventor： BLOKSBERG, Leonard Nathan ,  HAVUKKALA, Ilkka Jaakko

IPC: C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10

CPC classification number: C12N9/0004 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0059 ,  C12N9/0061 ,  C12N9/0065 ,  C12N9/0071 ,  C12N9/0083 ,  C12N9/1007 ,  C12N9/1011 ,  C12N9/1051 ,  C12N9/2422 ,  C12N9/2445 ,  C12N9/86 ,  C12N9/93 ,  C12N15/8255 ,  C12Y110/03001 ,  C12Y110/03002 ,  C12Y114/13011 ,  C12Y201/01006 ,  C12Y302/01001 ,  C12Y302/01021

Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.