公开(公告)号：US20030169421A1

公开(公告)日：2003-09-11

申请号：US10303335

申请日：2002-11-25

Inventor： Peter Ehbets

IPC: G01J003/42

CPC classification number: G01J3/50 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/501 ,  G01N21/251 ,  G01N21/255 ,  G01N2021/4757 ,  G01N2201/062

Abstract: A spectrophotometer for measuring light received from a sample is disclosed. The spectrophotometer includes a measurement head housing a sample and an illumination arrangement having a light source essentially continuous in the visible spectral range, formed by light-emitting diodes. The measurement head includes an illumination channel for each light emitting diode directing the light from each diode at a defined angle of incidence onto a measurement spot on the sample and a collecting arrangement capturing the light originating from the measurement spot. A spectrometer is optically connected to the collecting arrangement for splitting the captured light into its spectral components and for generating corresponding electrical signals. An electronic circuit, constructed for selectively controlling the light emitting diodes, controls the illumination arrangement and the spectrometer and processes the electrical measurement signals. A color densitometer, a variant of a spectorphotometer constructed in accordance with the subject disclosure, is also disclosed.

Abstract translation: 公开了一种用于测量从样品接收的光的分光光度计。 分光光度计包括容纳样品的测量头和具有由可见光谱范围内基本上连续的光源的照明装置，其由发光二极管形成。 测量头包括用于每个发光二极管的照明通道，其将来自每个二极管的光以规定的入射角度引导到样品上的测量点上，以及收集装置捕获源自测量点的光。 光谱仪光学连接到采集装置，用于将捕获的光分解成其光谱分量并产生相应的电信号。 构造用于选择性地控制发光二极管的电子电路控制照明装置和光谱仪并处理电测量信号。 还公开了彩色浓度计，根据本公开内容构造的分光光度计的变体。

公开(公告)号：US20030081204A1

公开(公告)日：2003-05-01

申请号：US10226592

申请日：2002-08-23

Inventor： Paul J. Cronin ,  Peter J. Miller

IPC: G01J003/42 ,  G01J003/00 ,  G01N021/64

CPC classification number: G01N21/645 ,  G01N21/31 ,  G01N2021/6421

Abstract: A method is described that includes measuring, at each of a set of W wavelength bins, a spectral response of at least one region of a sample stained with multiple stains, and determining the concentration of at least one of the stains in the region of the sample based in part on the spectral responses, the wavelength bins being chosen so that a matrix of elements that represent the responses of the stains at the wavelength bin has an inverse for which a mathematical stability is maximum relative to the inverses of other matrices of elements that represent the responses of the stains for other possible sets of wavelength bins.

Abstract translation: 描述了一种方法，其包括在一组W波长区段中的每一个处测量被多个污渍染色的样品的至少一个区域的光谱响应，以及确定在多个污渍区域中的至少一个污渍的浓度 样品部分地基于光谱响应，选择波长区，使得表示波长箱上的污点的响应的元素矩阵具有相对于元素的其它矩阵的逆的数学稳定性最大的逆矩阵 其代表着对于其它可能的波长箱组的污渍的响应。

公开(公告)号：US20020193948A1

公开(公告)日：2002-12-19

申请号：US10172563

申请日：2002-06-13

Applicant: CARL ZEISS JENA GmbH

Inventor： Dietrich Schweitzer ,  Lutz Leistritz ,  Martin Hammer ,  Karl-Heinz Donnerhacke

IPC: G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  G06K009/00 ,  G01J003/42 ,  G01J003/427

CPC classification number: A61B3/12

Abstract: An arrangement and method for determining the two-dimensional distribution of fundus pigments, particularly of the xanthophyll macular pigment. The arrangement for carrying out the method comprises an illumination unit which illuminates the retina via an illumination beam path directed to the ocular fundus, observation optics located in the observation beam path proceeding from the ocular fundus, an image processing unit, elements for beam deflection and a central controlling and evaluating unit. In the method, a two-dimensional reflection image of the retina is recorded in a selected narrow-band wavelength region. In evaluating this two-dimensional reflection image, site-specific areas are established for determining the optical density and comparison values. The optical density of the fundus pigment at every fundus location is calculated from the negative logarithmic value of the quotient of the intensity value of the reflection image IR(null) at this fundus site to a comparison intensity value of the reflection image IR(null)Comparison. The suggested solution for the objective detection of the two-dimensional distribution of the optical density of the macular pigment xanthophyll is also suitable in principle for determining the distribution of other fundus pigments.

Abstract translation: 用于确定眼底颜料，特别是黄叶黄斑色素的二维分布的布置和方法。 用于执行该方法的装置包括：照明单元，其经由指向眼底的照明光束照射视网膜，位于观察光束路径中的观察光学器件，从眼底进入，图像处理单元，用于光束偏转的元件， 中央控制评估单位。 在该方法中，将视网膜的二维反射图像记录在所选择的窄带波长区域中。 在评估这种二维反射图像时，建立位置特定区域以确定光密度和比较值。 每个眼底位置的眼底颜料的光密度由该眼底位置的反射图像IR（lambd）的强度值的商数的负对数值与反射图像IR（lambd）的比较强度值计算， 比较。 用于目标检测黄斑色素叶黄素光密度二维分布的解决方案在原理上也适用于确定其他眼底颜料的分布。

公开(公告)号：US20020137052A1

公开(公告)日：2002-09-26

申请号：US09907795

申请日：2001-07-17

Applicant: Lynx Therapeutics, Inc.

Inventor： John Bridgham ,  Kevin P. Corcoran ,  George S. Golda ,  Sydney Brenner ,  Michael C. Pallas

IPC: C12Q001/68 ,  C12M001/34 ,  G01J003/42

CPC classification number: G01N21/6452 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00317 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2400/0403 ,  B01L2400/0475 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12Q1/6874 ,  C40B60/14 ,  G01N15/1456 ,  G01N15/1475 ,  G01N15/1484 ,  G01N21/05 ,  G01N21/253 ,  G01N21/6428 ,  G01N2015/0015 ,  G01N2015/149 ,  G01N2021/0346 ,  C12Q2565/518 ,  C12Q2521/313 ,  C12Q2525/191 ,  C12Q2525/161

Abstract: An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

Abstract translation: 提供了一种用于同时分析锚定到微粒的多个分析物的装置和系统。 每个具有单一类型分析物的均匀群体的微粒被布置为在流动室内部基本上固定的平面阵列，其中分析过程的步骤通过将一系列处理试剂通过流体系统递送到微粒进行， 微处理器控制。 响应于这样的处理步骤，在每个微粒的表面上产生光信号，其特征在于由微粒携带的分析物与递送的处理试剂之间的相互作用。多个分析物同时通过收集和记录 由平面阵列中的所有微粒产生的光信号。 本发明的一个关键特征是在分析过程中由平面阵列中的每个微粒产生的光信号序列的相关性。

公开(公告)号：US20020109842A1

公开(公告)日：2002-08-15

申请号：US09782089

申请日：2001-02-12

Applicant: Engelhard Corp.

Inventor： James B. Carroll JR. ,  Charles Willard

IPC: G01J003/42

CPC classification number: G01J3/50 ,  G01J3/463 ,  G01J3/504 ,  G01N21/05 ,  G01N21/251 ,  G01N21/45 ,  G01N21/85 ,  G01N2021/0346

Abstract: An apparatus and a method for objectively ascertaining a color match between a selected standard color and the color exhibited by an interference effect pigment during processing thereof and terminating the process upon achieving a match. The invention provides a spectrophotometer attached to a flow cell to monitor the color of a platy effect pigment to monitor pigment color and ascertain completion of the coating reaction process involved in interference pigment production.

Abstract translation: 一种用于客观地确定所选标准颜色与干涉效应颜料在其处理期间展现的颜色之间的颜色匹配的装置和方法，并且在实现匹配时终止处理。 本发明提供一种附着在流动池上的分光光度计，以监测片状效应颜料的颜色，以监测颜料颜色，并确定涉及干涉颜料生产的涂层反应过程的完成。

公开(公告)号：US20020102595A1

公开(公告)日：2002-08-01

申请号：US10059754

申请日：2002-01-29

Inventor： Lloyd Mervyn Davis

IPC: C12Q001/68 ,  C12M001/34 ,  G01J003/42 ,  G01J003/427

CPC classification number: G01N15/14 ,  C12Q1/6869 ,  G01N2015/1415 ,  G01N2015/1438 ,  C12Q2533/101

Abstract: Methods and devices for detecting the incorporation of NTPs into immobilized enzyme-nucleic acid complexes are disclosed. The methods and devices can be used to genotype or sequence nucleic acids, including DNA and RNA, and are capable, in preferred embodiments, of detecting single incorporation events.

Abstract translation: 公开了用于检测NTPs结合到固定化酶 - 核酸复合物中的方法和装置。 方法和装置可用于对核酸（包括DNA和RNA）进行基因型或序列测定，并且在优选实施方案中能够检测单一掺入事件。

公开(公告)号：US20020067481A1

公开(公告)日：2002-06-06

申请号：US09899706

申请日：2001-07-05

Inventor： Udo Wolf ,  Friedrich-Karl Bruder ,  Jurgen Diefendahl ,  Andreas Elschner ,  Uwe Hucks ,  Detlef Riesebeck ,  Bodo Schnittka ,  Manfred Schraut ,  Lutz Spauschus

IPC: G01J003/42

CPC classification number: G01N21/85 ,  G01N21/31

Abstract: An apparatus for the spectroscopic analysis of the composition of the contents of vessels, especially of conduits, by recording transmission spectra is described. The apparatus comprises at least a radiation source for generating the measuring radiation, and a spectral analyzer for measuring the transmitted radiation, two windows which are disposed opposite one another on the vessel and are transparent to the measuring radiation, and two collimators which are designed to spread the measuring radiation within the range of the measuring section and are disposed opposite one another in front of the windows, characterized in that the collimators are positioned relative to one another in a mounting joined to the vessel and the collimators can, while their relative alignment is maintained, be swung out in parallel from the range of the measuring section in the vessel or be displaced and/or be fixed to the mounting, so that the measuring section bypasses the vessel.

Abstract translation: 描述了通过记录透射光谱对容器的内容物，特别是导管的成分进行光谱分析的装置。 该装置至少包括用于产生测量辐射的辐射源，以及用于测量透射辐射的光谱分析仪，在容器上彼此相对设置并对测量辐射透明的两个窗口，以及两个准直器，其被设计为 将测量辐射扩展到测量部分的范围内，并且在窗口前方彼此相对设置，其特征在于，准直器在连接到容器的安装件中相对于彼此定位，并且准直器可以在其相对对准 被保持，从容器中的测量部分的范围平行摆动或移位和/或固定到安装件，使得测量部分绕过容器。

公开(公告)号：US20020024664A1

公开(公告)日：2002-02-28

申请号：US09922845

申请日：2001-08-07

Applicant: Shimadzu Corporation

Inventor： Kazumi Yokota ,  Kaori Kinoshita

IPC: G01J003/42

CPC classification number: G01J3/36 ,  G01J1/04 ,  G01J3/0254 ,  G01N2201/065

Abstract: In a detector for spectrometry attached to an integrating sphere, a plurality of detection elements having different spectral sensitivity characteristics is arranged side by side in the same plane on a base, and a side cover is provided such that the detection elements receive light. Thus, the measurement light is directly irradiated to the respective detection elements. Accordingly, the detector for spectrometry has a fast response speed and is excellent in the sensitivity characteristics in a wide wavelength region in the near-infrared area.

Abstract translation: 在附着于积分球的光谱测定装置中，具有不同光谱灵敏度特性的多个检测元件并排设置在基座的同一平面上，并且设置侧盖，使得检测元件接收光。 因此，测量光直接照射到各个检测元件。 因此，用于光谱测定的检测器具有快速的响应速度，并且在近红外区域的宽波长区域中的灵敏度特性优异。

公开(公告)号：US20010052979A1

公开(公告)日：2001-12-20

申请号：US09800953

申请日：2001-03-07

Inventor： Patrick J. Treado ,  Arjun Bangalore ,  Matthew P. Nelson ,  Christopher T. Zugates

IPC: G01J003/42 ,  G01B009/02

CPC classification number: G02B21/365 ,  G01B11/2545 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/447

Abstract: An apparatus incorporated within a spectroscopic imaging system, typically a microscope, but also applicable to other image gathering platforms, namely fiberscopes, macrolens imaging systems and telescopes employing a polarizing beam splitting element is disclosed. The apparatus allows simultaneous spectroscopic (i.e. chemical) imaging and rapid acquisition spectroscopy to be performed without the need for moving mechanical parts or time sequenced sampling and without introducing significant optical signal loss or degradation to the spectroscopic imaging capability. In addition, the apparatus affords a more compact design, an improved angular field of view and an improved overall ruggedness of optical design at a lower manufacturing and maintenance cost compared to previous devices.

Abstract translation: 公开了一种结合在分光成像系统（通常为显微镜）内的装置，但也适用于采用偏振分束元件的其它图像采集平台，即纤维内窥镜，宏观成像系统和望远镜。 该装置允许执行同时分光（即化学）成像和快速采集光谱，而不需要移动机械部件或时间顺序采样，并且不会对光谱成像能力引入显着的光信号损失或劣化。 此外，与先前的设备相比，该设备以更低的制造和维护成本提供更紧凑的设计，改进的角视场和改进的光学设计的整体耐用性。

公开(公告)号：US20010013931A1

公开(公告)日：2001-08-16

申请号：US09752732

申请日：2001-01-03

Applicant: SHIMADZU CORPORATION

Inventor： Tatsumi Sato

IPC: G01J003/42

CPC classification number: G01J3/08

Abstract: In a double beam spectrophotometer, a sample beam is irradiated to a large-sized sample in a substantially vertical direction, and the beam upwardly transmitted through the large-sized sample is reflected by a reflecting mirror and sent to an integrating sphere including a detector. A reference beam irradiated parallel to the sample beam is deflected by reflecting mirrors such that the reference beam goes around the large-sized sample, and guided to the integrating sphere. Thus, a holder is not required to correspond to a size or shape of the sample, and measurement position can be freely changed by moving the sample. Also, in case of utilizing a conventional standard sample chamber, movable reflecting mirrors are inserted in the optical paths to transfer the beams to the standard sample chamber.

Abstract translation: 在双光束分光光度计中，将样品光束在大致垂直方向上照射到大尺寸样品上，并且向上透射通过大尺寸样品的光束被反射镜反射并发送到包括检测器的积分球。 平行于样品光束照射的参考光束通过反射镜偏转，使得参考光束绕大尺寸样品并被引导到积分球。 因此，保持器不需要对应于样品的尺寸或形状，并且通过移动样品可以自由地改变测量位置。 此外，在利用传统的标准样品室的情况下，将可动反射镜插入到光路中以将光束传送到标准样品室。