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    CRYSTAL STRUCTURE OF SMYD3 PROTEIN
    51.
    发明申请
    CRYSTAL STRUCTURE OF SMYD3 PROTEIN 审中-公开
    SMYD3蛋白的晶体结构

    公开(公告)号：WO2008137834A2

    公开(公告)日：2008-11-13

    申请号：PCT/US2008/062636

    申请日：2008-05-05

    Applicant: OSI PHARMACEUTICALS, INC. ,  SGX PHARMACEUTICALS, INC. ,  FOREMAN, Kenneth, William ,  PARK, Frances, E. ,  ARNOLD, Lee

    Inventor： FOREMAN, Kenneth, William ,  PARK, Frances, E. ,  ARNOLD, Lee

    IPC: C12N9/10 ,  C12Q1/48 ,  G01N33/68 ,  A61K38/43

    CPC classification number: C12N9/1007 ,  C07K2299/00 ,  G01N2500/04

    Abstract: The invention relates to SMYD3 methyltransferase (SMYD3), SMYD3 binding pockets or SMYD3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to SMYD3 methyltransferase protein, complexes of SMYD3 methyltransferase protein, homologues thereof, or SMYD3-like protein or protein complexes.

    Abstract translation: 本发明涉及SMYD3甲基转移酶（SMYD3），SMYD3结合口袋或SMYD3样结合口袋。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标来筛选和设计结合SMYD3甲基转移酶蛋白质的化合物，SMYD3甲基转移酶蛋白质的复合物，其同源物或SMYD3样蛋白质或蛋白质复合物的方法。

    FUSED BICYCLIC PYRIMIDINE DERIVATIVES
    58.
    发明申请
    FUSED BICYCLIC PYRIMIDINE DERIVATIVES 审中-公开
    熔化的双相吡啶衍生物

    公开(公告)号：WO1998023613A1

    公开(公告)日：1998-06-04

    申请号：PCT/IB1997001393

    申请日：1997-11-05

    Applicant: PFIZER INC. ,  ARNOLD, Lee, Daniel ,  MOYER, Mikel, Paul ,  SOBOLOV-JAYNES, Susan, Beth

    Inventor： PFIZER INC.

    IPC: C07D471/04

    CPC classification number: C07D471/04 ,  C07D487/04

    Abstract: The invention relates to compounds of formula (I) and to pharmaceutically acceptable salts thereof, wherein R , R and Z are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula (I) and to methods of using said compounds in the treatment of hyperproliferative diseases such as cancer.

    Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2和Z如本文所定义。 本发明还涉及含有式（I）化合物的药物组合物以及使用所述化合物治疗过度增殖性疾病如癌症的方法。

    COFLUORONS AND METHODS OF MAKING AND USING THEM
    59.
    发明申请
    COFLUORONS AND METHODS OF MAKING AND USING THEM 审中-公开
    COFLORONS AND METHODS OF MAKING AND USING THEM

    公开(公告)号：WO2012154213A1

    公开(公告)日：2012-11-15

    申请号：PCT/US2012/000198

    申请日：2012-04-09

    Applicant: CORNELL UNIVERSITY ,  PURDUE RESEARCH FOUNDATION ,  COFERON, INC. ,  BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald ,  GIARDINA, Sarah, F. ,  ARNOLD, Lee, Daniel

    Inventor： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald ,  GIARDINA, Sarah, F. ,  ARNOLD, Lee, Daniel

    IPC: C40B30/04 ,  C40B30/06 ,  C40B40/04

    CPC classification number: G01N33/573 ,  C07D211/26 ,  C07D263/06 ,  C07D401/06 ,  C07D405/06 ,  C07D491/107 ,  C07F5/025 ,  C40B30/04 ,  C40B30/06 ,  C40B50/10 ,  C40B50/16

    Abstract: The present invention is directed to method of using a collection of monomers capable of forming multimers as a fluorescence reporter in different applications such as ligand detection/screening, disease diagnosis, drug discovery or screening, fluorescent labeling and imaging, or other fluorescent methodologies. Each monomer in the collection includes one or more ligand elements useful for binding to a target molecule with a dissociation constant of less than 300 μΜ and a linker element connected to the ligand elements directly or indirectly through a connector. Association of linker elements of different combinations of monomers, with their ligand elements bound to the target molecule to form a multimer, will generate a unique fluorescent signature different from that produced by those monomers either alone or in association with each other in the absence of the target molecule, when subjected to electromagnetic excitement.

    Abstract translation: 本发明涉及在不同应用如配体检测/筛选，疾病诊断，药物发现或筛选，荧光标记和成像或其它荧光方法中使用能够形成多聚体的单体的集合的方法。 收集物中的每个单体包括一个或多个配体元件，其用于结合靶分子，解离常数小于300μ？ 以及通过连接器直接或间接连接到配体元件的连接体元件。 不同单体组合的连接体元件与其与靶分子结合以形成多聚体的连接体元件的关联将产生独特的荧光特征，其不同于单独或彼此相关联的单体，不存在 目标分子，当受到电磁兴奋时。

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