公开(公告)号：WO2002076986A1

公开(公告)日：2002-10-03

申请号：PCT/US2002/008996

申请日：2002-03-22

Applicant: ABBOTT GMBH & CO. KG ,  HIRST, Gavin C., ,  RAFFERTY, Paul ,  RITTER, Kurt ,  CALDERWOOD, David ,  WISHART, Neil ,  ARNOLD, Lee D., ,  FRIEDMAN, Michael M.,

Inventor： HIRST, Gavin C., ,  RAFFERTY, Paul ,  RITTER, Kurt ,  CALDERWOOD, David ,  WISHART, Neil ,  ARNOLD, Lee D., ,  FRIEDMAN, Michael M.,

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein.

Abstract translation: 本发明提供式I化合物，包括其药学上可接受的盐和/或前药，其中G，R a，R 2和R 3如本文所述定义。

公开(公告)号：WO0119829A2

公开(公告)日：2001-03-22

申请号：PCT/US0025468

申请日：2000-09-15

Applicant: BASF AG ,  HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RAFFERTY PAUL ,  RITTER KURT ,  ARNOLD LEE D ,  FRIEDMAN MICHAEL M

Inventor： HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RAFFERTY PAUL ,  RITTER KURT ,  ARNOLD LEE D ,  FRIEDMAN MICHAEL M

IPC: A61K31/519 ,  A61K31/5377 ,  A61K38/22 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/12 ,  A61P15/16 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/22 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561

CPC classification number: C07D487/04 ,  C07F9/6561

Abstract: The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, R3 are defined as described herein.

Abstract translation: 本发明提供式（I）化合物，包括其药学上可接受的盐和/或前药，其中G，R a，R 2，R 3如本文所述定义。

公开(公告)号：WO2002080926A1

公开(公告)日：2002-10-17

申请号：PCT/US2002/009104

申请日：2002-03-22

Applicant: ABBOTT GMBH & CO. KG ,  HIRST, Gavin, C. ,  RAFFERTY, Paul ,  RITTER, Kurt ,  CALDERWOOD, David ,  WISHART, Neil ,  ARNOLD, Lee, D. ,  FRIEDMAN, Michael, M.

Inventor： HIRST, Gavin, C. ,  RAFFERTY, Paul ,  RITTER, Kurt ,  CALDERWOOD, David ,  WISHART, Neil ,  ARNOLD, Lee, D. ,  FRIEDMAN, Michael, M.

IPC: A61K31/519

CPC classification number: C07D487/04 ,  C07F9/6561

Abstract: The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R 2 , and R 3 are defined as described herein.

Abstract translation: 本发明提供式（I）化合物，其包括其药学上可接受的盐和/或前药，其中G，R 2和R 3如本文所述定义。

公开(公告)号：WO2005110410A3

公开(公告)日：2007-03-29

申请号：PCT/US2005016903

申请日：2005-05-13

Applicant: ABBOTT LAB ,  CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  WISHART NEIL ,  YU ZHENGTIAN

Inventor： CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  WISHART NEIL ,  YU ZHENGTIAN

IPC: C07D471/02 ,  A61K31/4743 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

公开(公告)号：WO2005110410A2

公开(公告)日：2005-11-24

申请号：PCT/US2005/016903

申请日：2005-05-13

Applicant: ABBOTT LABORATORIES ,  CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

Inventor： CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

IPC: A61K31/4743

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  Y02A50/481

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。