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    GONOCOCCAL VACCINES
    53.
    发明申请
    GONOCOCCAL VACCINES 审中-公开

    公开(公告)号：WO2010027729A3

    公开(公告)日：2010-06-03

    申请号：PCT/US2009054749

    申请日：2009-08-24

    Applicant: CREATV MICROTECH INC ,  ZHU PEIXUAN

    Inventor： ZHU PEIXUAN

    IPC: A61K39/095 ,  C07K14/22 ,  C12N15/31 ,  G01N33/53

    CPC classification number: G01N33/571 ,  A61K39/00 ,  C07K14/22

    Abstract: The present invention relates to immunogenic compositions comprising a recombinant Neisseria gonorrhoeae OpcA and methods of eliciting an immune response in a mammal by administering a formulation comprising N. gonorrhoeae OpcA or a portion or fragment of N. gonorrhoeae OpcA. The invention also provides for methods and kits for diagnosing N. gonorrhoeae infection using said recombinant N. gonorrhoeae OpcA.

    Abstract translation: 本发明涉及包含重组淋病奈瑟氏球菌OpcA的免疫原性组合物和通过施用包含淋病奈瑟氏球菌OpcA或淋病奈瑟氏球菌OpcA的部分或片段的制剂在哺乳动物中引发免疫应答的方法。 本发明还提供了使用所述重组淋病奈瑟菌OpcA诊断淋病奈瑟氏球菌感染的方法和试剂盒。

    FLOW-THROUGH CHEMICAL AND BIOLOGICAL SENSOR
    55.
    发明申请
    FLOW-THROUGH CHEMICAL AND BIOLOGICAL SENSOR 审中-公开
    流通化学和生物传感器

    公开(公告)号：WO2005086703A3

    公开(公告)日：2007-06-28

    申请号：PCT/US2005007121

    申请日：2005-03-04

    Applicant: CREATV MICROTECH INC ,  TANG CHA-MEI ,  AMSTUTZ PLATTE T III

    Inventor： TANG CHA-MEI ,  AMSTUTZ PLATTE T III

    IPC: G01N21/00 ,  B01F5/06 ,  B01F13/00 ,  G01N21/05 ,  G01N21/17 ,  G01N21/29 ,  G01N21/31 ,  G01N21/41 ,  G01N21/47 ,  G01N21/62 ,  G01N21/63 ,  G01N21/65

    CPC classification number: G01N21/05 ,  B01F5/0603 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/086 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/54373 ,  G01N2021/0346

    Abstract: The invention provides a mixing flow apparatus. The mixing flow apparatus consists of a waveguide and a mixing flow chamber; the waveguide having a higher index of refraction material than its surroundings for propagation of a signal, and the mixing flow chamber having a body forming a flow chamber with an inlet, an outlet, a radiation transmissive wall and a surface positioned to disrupt flow regularity of a sample fluid, the body of the mixing flow chamber surrounding at least a portion of the waveguide, wherein constituents of a sample fluid entering the inlet are mixed by disruption of sample fluid flow regularity prior to discharge at the outlet. Also provided is a detection apparatus. The detection apparatus consists of a waveguide, a mixing flow chamber and a radiation detector; the waveguide having a higher index of refraction material than its surroundings for propagation of a signal; the mixing flow chamber having a body forming a flow chamber with an inlet, an outlet, a radiation transmissive wall and a surface positioned to disrupt flow regularity of a sample fluid, the body of the mixing flow chamber surrounding at least a portion of the waveguide, wherein constituents of a sample fluid entering the inlet are mixed by disruption of sample fluid flow regularity prior to discharge at the outlet, and the radiation detector being disposed facing the direction of oncoming propagated signal from the waveguide. The detection apparatus can include an illumination source.

    Abstract translation: 本发明提供一种混合流动装置。 混合流动装置由波导和混合流动室构成; 所述波导具有比其周围的更高的折射率折射材料以传播信号，并且所述混合流动室具有形成流动室的主体，所述主体具有入口，出口，辐射透射壁和定位成破坏流动规则性的表面 样品流体，混合流动室的主体围绕波导的至少一部分，其中进入入口的样品流体的组分通过在出口排放之前破坏样品流体流动规则性而混合。 还提供了检测装置。 检测装置由波导管，混合流室和放射线检测器构成， 波导具有比其周围更高的折射材料折射率以传播信号; 所述混合流动室具有形成具有入口，出口，辐射透射壁和定位成破坏样品流体的流动规则的流动室的主体，所述混合流动室的主体围绕所述波导的至少一部分 其中进入入口的样品流体的组分通过在出口处排出之前破坏样品流体流动规则性而被混合，并且辐射检测器被布置为面对来自波导的迎面传播信号的方向。 检测装置可以包括照明源。

    INTEGRATED MULTISTEP BIOSENSOR
    56.
    发明申请
    INTEGRATED MULTISTEP BIOSENSOR 审中-公开
    集成多媒体生物传感器

    公开(公告)号：WO2006025866A2

    公开(公告)日：2006-03-09

    申请号：PCT/US2005/007122

    申请日：2005-03-04

    Applicant: CREATV MICROTECH, INC. ,  TANG, Cha-Mei

    Inventor： TANG, Cha-Mei

    IPC: C12Q1/68 ,  C12M1/34

    CPC classification number: G01N33/54373 ,  B82Y15/00 ,  B82Y30/00

    Abstract: The invention provides an integrated biosensor. The integrated bioprocessor consists of an integrated capture chamber having an analyte recognition coating and a structure supporting analyte detection, analyte growth and target nucleic acid detection. The integrated capture chamber can consist of a waveguide, a capillary tube, a mixing flow chamber or an integrated combination thereof. The integrated capture chamber also can contain an antibody or other recognition species as an analyte recognition coating, an illumination source, a radiation detector, a microfluidics handling system, a second chamber for target nucleic acid detection or a combination thereof. Also provided is an integrated biosensor. The integrated biosensor consists of an integrated capture chamber having an analyte recognition coating, an illumination source, a radiation detector and a structure supporting analyte detection, analyte growth and target nucleic acid detection. The integrated capture chamber can consist of a waveguide, a capillary tube, a mixing flow chamber or an integrated combination thereof. The integrated capture chamber also can contain an antibody as an analyte recognition coating, a microfluidics handling system, a second chamber for target nucleic acid detection or a combination thereof.

    Abstract translation: 本发明提供一种集成的生物传感器。 集成的生物处理器由具有分析物识别涂层和支持分析物检测，分析物生长和靶核酸检测的结构的集成捕获室组成。 集成捕获室可以由波导，毛细管，混合流动室或其一体化组合组成。 集成捕获室还可以包含抗体或其他识别物质作为分析物识别涂层，照射源，放射线检测器，微流体处理系统，用于靶核酸检测的第二室或其组合。 还提供了一个集成的生物传感器。 集成生物传感器由具有分析物识别涂层，照明源，辐射检测器和支持分析物检测，分析物生长和靶核酸检测的结构的集成捕获室组成。 集成捕获室可以由波导，毛细管，混合流动室或其一体化组合组成。 集成捕获室还可以含有抗体作为分析物识别涂层，微流体处理系统，用于靶核酸检测的第二室或其组合。

    tNTI-SCATTER GRIDS AND COLLIMATOR DESIGNS, AND THEIR MOTION, FABRICATION AND ASSEMBLY
    57.
    发明申请
    tNTI-SCATTER GRIDS AND COLLIMATOR DESIGNS, AND THEIR MOTION, FABRICATION AND ASSEMBLY 审中-公开
    tNTI散热器网格和收集器设计及其运动，制造和组装

    公开(公告)号：WO2002065480A1

    公开(公告)日：2002-08-22

    申请号：PCT/US2002/002711

    申请日：2002-02-01

    Applicant: CREATV MICROTECH, INC. ,  TANG, Cha-Mei ,  MAKAROVA, Olga

    Inventor： TANG, Cha-Mei ,  MAKAROVA, Olga

    IPC: G21K1/00

    CPC classification number: G21K1/025

    Abstract: Grids (30) and collimators, for use with electromagnetic energy emitting devices (61), include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls (32). Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings (31) extending entirely through the layer. At least some of the walls (32) also can include projections extending into the respective openings formed by the walls (32). The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid (30) is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid (30) at any distance from the edge. Methods to fabricate these grids (30) using copper, lead, nickel, gold, any other electroplating/electroforming materials or low melting temperature metals are described.

    Abstract translation: 与电磁能发射装置（61）一起使用的格栅（30）和准直器至少包括通过例如电镀/电铸或铸造形成的金属层。 金属层包括顶表面和底表面，以及多个固体一体化壁（32）。 每个固体一体化壁从顶部到底部表面延伸并且具有多个侧表面。 固体一体化壁的侧表面布置成限定完全延伸穿过该层的多个开口（31）。 至少一些壁（32）还可以包括延伸到由壁（32）形成的相应开口中的突起。 突起可以是各种形状和尺寸，并且被布置成使得沿着沿着格栅（30）的边缘的方向传播的线相交的壁材料的总量基本上与另外的总量的壁材料相交 通过在与边缘任何距离处基本上平行于栅格（30）的边缘的另一方向上传播的另一条线。 描述了使用铜，铅，镍，金，任何其它电镀/电铸材料或低熔点金属制造这些栅极（30）的方法。

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