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    DIETARY OMEGA-3 FATTY ACID DERIVED GLYCEROPHOSPHOLIPIDS TO TREAT NEUROPATHIC PAIN
    53.
    发明公开
    DIETARY OMEGA-3 FATTY ACID DERIVED GLYCEROPHOSPHOLIPIDS TO TREAT NEUROPATHIC PAIN 审中-公开
    DIYTETISCHE GLYCEROPHOSPHOLIPIDE AUS OMEGA-3-FETTSÄUREZUR BEHANDLUNG VON NEUROPATHISCHEN SCHMERZEN

    公开(公告)号：EP3003331A1

    公开(公告)日：2016-04-13

    申请号：EP14807965.0

    申请日：2014-06-06

    Applicant: Loma Linda University

    Inventor： DE LEON, Marino ,  FIGUEROA, Johnny, D.

    IPC: A61K35/60

    CPC classification number: A61K31/202 ,  A23L33/12 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/164 ,  A61K35/00 ,  A61K45/06 ,  A23V2200/322 ,  A23V2250/1882

    Abstract: Disclosed are methods and dietary compositions for the treatment and prevention of neuropathic pain and for pain prognosis. Some embodiments may include the administration of a diet rich in omega-3 fatty acids. Methods for the treatment and prevention of neuropathic pain by administering a diet rich in omega-3 fatty acids, N-acylated ethanolamines, or N-acylated ethanolamine precursors are also provided. Compositions for the treatment and prevention of neuropathic pain are also provided.

    Abstract translation: 公开了用于治疗和预防神经性疼痛和疼痛预后的方法和饮食组合物。 一些实施方案可以包括施用富含ω-3脂肪酸的饮食。 还提供了通过施用富含ω-3脂肪酸，N-酰化的乙醇胺或N-酰化的乙醇胺前体的饮食来治疗和预防神经性疼痛的方法。 还提供了用于治疗和预防神经性疼痛的组合物。

    SYSTEMS, DEVICES AND METHODS RELATED TO CALIBRATION OF A PROTON COMPUTED TOMOGRAPHY SCANNER
    55.
    发明公开
    SYSTEMS, DEVICES AND METHODS RELATED TO CALIBRATION OF A PROTON COMPUTED TOMOGRAPHY SCANNER 审中-公开
    与质子计算机断层扫描仪校准相关的系统，装置和方法

    公开(公告)号：EP2684034A2

    公开(公告)日：2014-01-15

    申请号：EP12789981.3

    申请日：2012-03-06

    Applicant: Loma Linda University Medical Center

    Inventor： SCHULTE, Reinhard W. ,  HURLEY, R. Ford

    IPC: G01N23/04

    CPC classification number: G01T7/005 ,  A61B6/032 ,  A61B6/035 ,  A61B6/4258 ,  A61B6/548 ,  A61B6/583 ,  A61B6/585 ,  G01N23/04 ,  G01N23/046 ,  G01N35/00693 ,  G01N2223/107 ,  G01T1/169 ,  G01T1/2985

    Abstract: Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.

    Abstract translation: 公开了与校准基于离子的成像设备（例如质子计算机断层摄影扫描仪）有关的系统，设备和方法。 在一些实施方式中，具有已知的水当量厚度（WET）值的能量降级板可被引入离子束以引入不同的能量降级设置。 可以获得受到这种能量退化设置的个体离子的能量检测器响应。 根据已知的WET值，这些响应可以归一化并与离子的水当量路径长度（WEPL）相关。 使用降级板的这种校准可以相对较快地执行并且可以产生精确的WEPL值，这有助于例如基于对象的相对阻止功率来估计CT图像。

    Apoptotic cell-mediated transfection of mammalian cells with interfering RNA
    56.
    发明授权
    Apoptotic cell-mediated transfection of mammalian cells with interfering RNA 有权
    用干扰RNA凋亡细胞介导的哺乳动物细胞转染

    公开(公告)号：EP2069375B1

    公开(公告)日：2012-03-28

    申请号：EP07843470.1

    申请日：2007-09-28

    Applicant: LOMA LINDA UNIVERSITY

    Inventor： LI, Fengchun ,  ESCHER, Alan, P.

    IPC: C12N15/87 ,  C12N15/113

    CPC classification number: C12N5/0602 ,  A61K31/7088 ,  A61K35/12 ,  A61K39/001 ,  A61K2035/122 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

    Abstract: Mammalian host cells for use in a cell-mediated transfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of down-regulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs down-regulates the expression of the target gene in living cells.

    Abstract translation: 用于细胞介导的转染过程的哺乳动物宿主细胞，其含有RNAi分子和促凋亡蛋白的表达载体。 该方法包括在含有能够下调所选靶基因的RNAi分子的哺乳动物细胞中诱导凋亡细胞（AC）死亡。 然后将表达靶基因的活细胞暴露于AC。 AC由活细胞处理，并且AC中的RNAi分子下调活细胞中靶基因的表达。

    VASCULAR WOUND CLOSURE DEVICE
    57.
    发明授权
    VASCULAR WOUND CLOSURE DEVICE 有权
    DEVICE FOR闭幕血管伤口

    公开(公告)号：EP1656069B1

    公开(公告)日：2011-03-23

    申请号：EP04781320.9

    申请日：2004-08-16

    Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

    Inventor： ZHU, Yong, Hua ,  KIRSCH, Wolff, M.

    IPC: A61B17/00

    CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B17/02 ,  A61B2017/00637 ,  A61B2017/00654

    Abstract: An apparatus (430) for closing a vascular wound includes an apparatus that can be threaded over a guidewire(458) into place at or adjacent the wound. The apparatus includes a chamber(520) that encloses a hemostatic material (270) therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

    DNA VACCINES AND METHODS FOR THE PREVENTION OF TRANSPLANTATION REJECTION
    59.
    发明公开
    DNA VACCINES AND METHODS FOR THE PREVENTION OF TRANSPLANTATION REJECTION 有权
    DNA-IMPFSTOFFE UND VERFAHREN ZUR VERHINDERUNG DER ABSTOSSUNG VON TRANSPLANTATIONEN

    公开(公告)号：EP2249645A1

    公开(公告)日：2010-11-17

    申请号：EP09719482.3

    申请日：2009-03-12

    Applicant: LOMA LINDA UNIVERSITY

    Inventor： LI, Fengchun ,  ESCHER, Alan, P.

    IPC: A01N43/04

    CPC classification number: A61K39/001 ,  A61K2039/53 ,  A61K2039/55561

    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipeint, as described herein, can induce a donor specific tolerogenic response.

    Abstract translation: 使用DNA疫苗预防，延迟同种异体移植物的发作或治疗排斥反应的方法，其中疫苗可以包含编码前凋亡蛋白的多核苷酸，如BAX和/或编码自身抗原或供体抗原的多核苷酸，如分泌的 谷氨酸脱羧酶55.如本文所述，将DNA疫苗之一施用于移植物质，可以诱导供体特异性耐受性反应。

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