公开(公告)号：WO2016145279A3

公开(公告)日：2016-10-27

申请号：PCT/US2016021933

申请日：2016-03-11

Applicant: STC UNM ,  THE OFFICE OF INNOVATION COMMERCIALIZATION ,  HALL PAMELA R ,  DALY SETH MICHAEL ,  OBERLIES NICHOLAS HUNTER ,  RAJA HUZEFA A ,  FIGUEROA-SALDIVAR MARIO A ,  HORSWILL ALEXANDER ROBERT ,  KAVANAUGH JEFFREY SCOTT

Inventor： HALL PAMELA R ,  DALY SETH MICHAEL ,  OBERLIES NICHOLAS HUNTER ,  RAJA HUZEFA A ,  FIGUEROA-SALDIVAR MARIO A ,  HORSWILL ALEXANDER ROBERT ,  KAVANAUGH JEFFREY SCOTT

IPC: A61K31/122 ,  A61K31/7056 ,  A61P3/10 ,  A61P29/00 ,  A61P31/00

CPC classification number: A61K31/122

Abstract: This disclosure describes pharmaceutical compositions and methods that involve the use of a polyhydroxyanthraquinone to inhibit quorum sensing in a microbe. In some embodiments, the polyhydroxyanthraquinone may be effective to antagonize AgrA function in a microbe. In other embodiments, the polyhydroxyanthraquinone may be effective for prophylactic and/or therapeutic treatment of a skin and soft tissue infection (SSTI) of a subject by a microbe. In still other embodiments, the polyhydroxyanthraquinone may be effective to reduce, limit progression, ameliorate, or resolve, to any extent, a symptom or clinical sign of infection by a microbe

Abstract translation: 本公开描述了涉及使用多羟基蒽醌抑制微生物群体感应的药物组合物和方法。 在一些实施方案中，多羟基蒽醌可有效拮抗微生物中的AgrA功能。 在其它实施方案中，多羟基蒽醌可有效用于通过微生物预防和/或治疗受试者的皮肤和软组织感染（SSTI）。 在其它实施方案中，多羟基蒽醌可以有效地减少，限制进行，改善或解决微生物感染的症状或临床症状的任何程度

公开(公告)号：WO2015081294A2

公开(公告)日：2015-06-04

申请号：PCT/US2014067764

申请日：2014-11-26

Applicant: STC UNM ,  BRUECK STEVEN R J ,  EDWARDS JEREMY SCOTT ,  NEUMANN ALEXANDER ,  KUZNETSOVA YULIYA ,  MENDOZA EDGAR A

Inventor： BRUECK STEVEN R J ,  EDWARDS JEREMY SCOTT ,  NEUMANN ALEXANDER ,  KUZNETSOVA YULIYA ,  MENDOZA EDGAR A

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0896 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2400/0421 ,  C12Q1/6869 ,  C23C16/345 ,  C23C16/45525 ,  C23C16/50 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/061 ,  C12Q2563/155 ,  C12Q2565/631

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (> wavelength), ~ 1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

公开(公告)号：WO2012154944A3

公开(公告)日：2013-04-18

申请号：PCT/US2012037300

申请日：2012-05-10

Applicant: STC UNM ,  DERETIC VOJO ,  CASTILLO ELISEO ,  BRADFUTE STEVEN

Inventor： DERETIC VOJO ,  CASTILLO ELISEO ,  BRADFUTE STEVEN

IPC: A61K39/395 ,  A61P29/00

CPC classification number: A61K31/436 ,  A61K31/12 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  A61K31/65 ,  C07K16/18 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/9015

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

Abstract translation: 本发明提供了治疗自噬介导的疾病和病症以及相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明提供了一种通过评估LC3水平来确定受试者是否患有或有发展风险和自噬介导的疾病状态和/或状况的方法。

公开(公告)号：WO2012088503A3

公开(公告)日：2012-10-18

申请号：PCT/US2011067152

申请日：2011-12-23

Applicant: STC UNM ,  SIBBETT SCOTT ,  LAU CAROLIN ,  CINICIATO GUSTAVO PIO MARCHESI KRALL ,  ATANASSOV PLAMEN

Inventor： SIBBETT SCOTT ,  LAU CAROLIN ,  CINICIATO GUSTAVO PIO MARCHESI KRALL ,  ATANASSOV PLAMEN

IPC: H01M8/16 ,  H01M8/02

CPC classification number: H01M8/04216 ,  H01M8/004 ,  H01M8/023 ,  H01M8/0247 ,  H01M8/0252 ,  H01M8/08 ,  H01M8/1009 ,  H01M8/16 ,  H01M8/2455 ,  Y02E60/527

Abstract: The present disclosure provides biological fuel cells comprising a paper-based fuel delivery layer which delivery fuel to the biological anode and cathode via capillary action and/or evaporation. In some embodiments the paper-based fuel delivery layer incorporates an outwardly extending fan-shaped region which enables a constant volumetric flow rate through the cell.

Abstract translation: 本公开提供了包括纸基燃料输送层的生物燃料电池，其通过毛细作用和/或蒸发将燃料输送到生物阳极和阴极。 在一些实施例中，基于纸的燃料输送层包括向外延伸的扇形区域，其能够通过电池的恒定体积流量。

公开(公告)号：WO2012099843A2

公开(公告)日：2012-07-26

申请号：PCT/US2012021493

申请日：2012-01-17

Applicant: STC UNM ,  SEN PRADEEP ,  DARABI ALIAKBAR

Inventor： SEN PRADEEP ,  DARABI ALIAKBAR

IPC: G06T5/00 ,  G06T15/00

CPC classification number: G06T5/001 ,  G06T5/00 ,  G06T5/50 ,  G06T15/503 ,  G06T2200/12 ,  G06T2207/20221

Abstract: The invention produces a higher quality image from a rendering system based on a relationship between the output of a rendering system and the parameters used to compute them. Specifically, noise is removed in rendering by estimating the functional dependency between sample features and the random inputs to the system. Mutual information is applied to a local neighborhood of samples in each part of the image. This dependency is then used to reduce the importance of certain scene features in a cross-bilateral filter, which preserves scene detail. The results produced by the invention are computed in a few minutes thereby making it reasonably robust for use in production environments.

Abstract translation: 本发明基于渲染系统的输出和用于计算它们的参数之间的关系从渲染系统产生更高质量的图像。 具体而言，通过估计样本特征和系统的随机输入之间的函数依赖性来消除渲染中的噪声。 互信息被应用于图像每个部分的局部样本邻域。 然后，这种依赖性被用来降低跨双边滤波器中的某些场景特征的重要性，这保留了场景细节。 在几分钟内计算出本发明产生的结果，从而使其在生产环境中使用相当健壮。

公开(公告)号：WO2012037397A2

公开(公告)日：2012-03-22

申请号：PCT/US2011051827

申请日：2011-09-15

Applicant: STC UNM ,  PAUL SUROJIT

Inventor： PAUL SUROJIT

IPC: C07K14/47 ,  A61K38/17 ,  A61P25/00 ,  C07K19/00

CPC classification number: C12N9/16 ,  A61K38/00 ,  A61K38/465 ,  C12Y301/03048

Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

Abstract translation: 显示和描述了作为神经元特异性酪氨酸磷酸酶的修饰衍生物的新型肽序列。 具体来说，新肽序列是纹状体富含酪氨酸磷酸酶的修饰衍生物（STEP）。 肽序列已被修饰，以便能够改善和治疗由过量的谷氨酸释放和/或氧化应激引起的脑损伤。 目前公开的肽序列可用于治疗的脑损伤类型的实例包括由中风或创伤性脑损伤引起的急性脑损伤和慢性疾病如亨廷顿氏舞蹈症和精神分裂症。 此外，目前描述的肽序列还可用于治疗和改善与恐惧记忆相关的疾病，例如创伤后应激障碍。

公开(公告)号：WO2011103428A3

公开(公告)日：2012-01-05

申请号：PCT/US2011025438

申请日：2011-02-18

Applicant: STC UNM ,  SUBHADRA BOBBAN

Inventor： SUBHADRA BOBBAN

IPC: C12N1/13 ,  C10G3/00 ,  C12N9/42 ,  C12N15/56 ,  C12P7/00

CPC classification number: C12N9/2437 ,  C10G2300/1014 ,  C10L1/02 ,  C10L1/026 ,  C12N1/12 ,  C12P7/649 ,  Y02E50/13 ,  Y02E50/17 ,  Y02P30/20

Abstract: A method for producing hemicellulase and cellulase for use in processing cellulosic materials for biofuel production. The method involves transforming algal feedstock to express hemicellulase and cellulase and then collecting hemicellulase and cellulase that has been secreted into a culture medium by the algae. The method may further involve transforming the algal feedstock to express other recombinant products and/or processing the alga feedstock to produce biofuels.

Abstract translation: 一种生产半纤维素酶和纤维素酶的方法，用于加工用于生物燃料生产的纤维素材料。 该方法包括转化藻类原料以表达半纤维素酶和纤维素酶，然后收集通过藻类分泌到培养基中的半纤维素酶和纤维素酶。 该方法还可以包括转化藻类原料以表达其他重组产物和/或加工藻类原料以生产生物燃料。

公开(公告)号：WO2011050165A3

公开(公告)日：2011-08-18

申请号：PCT/US2010053553

申请日：2010-10-21

Applicant: STC UNM ,  LEE SEUNG-CHANG ,  KRISHNA SANJAY ,  BRUECK STEVEN

Inventor： LEE SEUNG-CHANG ,  KRISHNA SANJAY ,  BRUECK STEVEN

IPC: G01J5/28

CPC classification number: H01L31/035236 ,  B82Y20/00 ,  G01J5/0853 ,  G02B6/1226 ,  H01L27/1446 ,  H01L31/03046 ,  H01L31/1035 ,  Y02E10/544 ,  Y02P70/521

Abstract: A plasmonic detector is described which can resonantly enhance the performance of infrared detectors. More specifically, the disclosure is directed to enhancing the quantum efficiency of semiconductor infrared detectors by increasing coupling to the incident radiation field as a result of resonant coupling to surface plasma waves supported by the metal/semiconductor interface, without impacting the dark current of the device, resulting in an improved detectivity over the surface plasma wave spectral bandwidth.

Abstract translation: 描述了可以共振地增强红外检测器的性能的等离子体激元检测器。 更具体地，本公开涉及通过增加与入射辐射场的耦合来提高半导体红外检测器的量子效率，这是由于与由金属/半导体界面支撑的表面等离子体波的谐振耦合而不影响器件的暗电流 ，导致比表面等离子体波谱带宽更好的检测性。

公开(公告)号：WO2011041500A3

公开(公告)日：2011-08-18

申请号：PCT/US2010050850

申请日：2010-09-30

Applicant: STC UNM ,  LUAN SHUANG ,  MA LIJUN ,  CHEN ZHE

Inventor： LUAN SHUANG ,  MA LIJUN ,  CHEN ZHE

IPC: A61N5/10 ,  A61B5/05 ,  A61B6/00

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

Abstract translation: 基于光子的放射外科广泛用于治疗局部和区域肿瘤。 提高放射外科手术质量的关键是增加肿瘤内高剂量区域的剂量衰减率到附近健康组织和结构的低剂量区域。 动态光子喷涂（DPP）通过沿着动态轨迹移动光束源来处理目标，从而进一步提高剂量衰减率，其中在照射期间光源的速度，方向和剂量率恒定不变。 DPP制造的剂量梯度可以与质子布拉格峰相媲美，并且胜过伽玛刀放射外科手术。

公开(公告)号：WO2011005380A2

公开(公告)日：2011-01-13

申请号：PCT/US2010036686

申请日：2010-05-28

Applicant: STC UNM ,  MIAO YUBIN ,  YANG JIANQUAN

Inventor： MIAO YUBIN ,  YANG JIANQUAN

IPC: A61K38/06 ,  A61K38/08 ,  A61K38/22 ,  A61P17/00 ,  A61P35/00

CPC classification number: C07K14/68 ,  A61K38/00 ,  A61K51/082 ,  A61K51/086 ,  A61K51/088 ,  C12N9/88

Abstract: The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及包含混合环肽的新型非侵入性诊断和治疗工具/化合物，其使用环肽螯合基团，其中所述化合物结合MSH受体以成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤 体内。 本发明代表了目前依靠组织活检诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌性黑素瘤细胞以及它们在组织中的转移性扩散。 这代表了使用非侵入性分子成像技术在黑色素瘤诊断和治疗方面迈出的一大步，包括转移性黑色素瘤。 本发明的新型探针也可用于启动黑素瘤治疗以及监测患者对化疗治疗和用于治疗黑素瘤/转移性黑素瘤的其他干预或疗法的反应。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。