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    IMPROVED SAMPLE TUBE HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION
    52.
    发明申请
    IMPROVED SAMPLE TUBE HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION 审中-公开
    具有特异性实用性的改良样品管用于核酸放大

    公开(公告)号：WO2012145662A1

    公开(公告)日：2012-10-26

    申请号：PCT/US2012/034506

    申请日：2012-04-20

    Applicant: STRECK, INC. ,  VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  TERMAAT, Joel, R. ,  KREIFELS, Matthew, Robert

    Inventor： VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  TERMAAT, Joel, R. ,  KREIFELS, Matthew, Robert

    IPC: B01L3/00

    CPC classification number: B01L3/50825 ,  B01L7/52 ,  B01L2300/022 ,  B01L2300/043 ,  B01L2300/123 ,  B01L2300/168

    Abstract: An improved tube (10) including a closure portion (12), a strap (18) integrally connected to the closure portion (12) and being configured for defining a living hinge, a body portion (20) having a longitudinal axis and an outer wall generally circumscribing the longitudinal ax is, and being integrally and hingedly connected with the closure portion (12) by way of the strap (18), the body portion (20) including a head portion (13) that has an opening (26) through which a sample is dispensed, and a sample portion (28) having a first outer wall dimension (OWD1) and including a closed distal end (30) and a wall structure (32) that includes an outer wall (34) and an inner wall structure (36) that defines a hollow cavity (38) within which the sample resides as a sample volume after is dispensed through the head portion (13), the sample portion (28) being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wail dimension (OWD1) of the sample portion (28) reduces to a smaller second outer wall dimension (OWD2).

    Abstract translation: 一种改进的管（10），包括封闭部分（12），一体地连接到封闭部分（12）并且构造成用于限定活动铰链的带子（18），具有纵向轴线的外部部分（20） 所述主体部分（20）包括具有开口（26）的头部（13），所述头部（13）具有开口（26），所述主体部分 通过其分配样品和具有第一外壁尺寸（OWD1）并包括封闭的远端（30）的样品部分（28）和包括外壁（34）和内壁（34）的壁结构 壁结构（36），其限定空心空腔（38），在所述中空空腔（38）中，所述样品部分（28）沿着所述纵向轴线大致伸长，所述样品部分（28）在所述中空空腔（38）中被分配通过所述头部部分（13） 弹性变形沿其长度的一部分，包括在a 方向，其通常横向于纵向轴线，使得壁结构的至少一部分压缩和弹性变形并且接合限定聚合酶链式反应放大装置的样品块中的开口的壁，并且与第一外壁尺寸（OWD1 ）减小到较小的第二外壁尺寸（OWD2）。

    PROCESS, COMPOSITION AND KIT FOR PROVIDING A STABLE WHOLE BLOOD CALIBRATOR/CONTROL
    54.
    发明申请
    PROCESS, COMPOSITION AND KIT FOR PROVIDING A STABLE WHOLE BLOOD CALIBRATOR/CONTROL 审中-公开
    用于提供稳定的全血校准器/控制的过程，组成和工具

    公开(公告)号：WO2006091918A2

    公开(公告)日：2006-08-31

    申请号：PCT/US2006/006787

    申请日：2006-02-23

    Applicant: STRECK, INC.

    Inventor： RYAN, Wayne, L.

    IPC: C12Q1/54

    CPC classification number: C12Q1/54 ,  G01N33/80 ,  Y10T436/10 ,  Y10T436/104998 ,  Y10T436/106664 ,  Y10T436/108331 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2525

    Abstract: The present invention is directed toward a stable calibrator and/or control, kit and process for using in a glucose monitoring instrumentation. Principally, the instant invention teaches a glycolyzed red blood cell component which has been treated with a glycolysis stabilizing effective amount of at least one non- cross linking aldehyde compound which may be added to fresh plasma along with an amount of glucose to form a simulated whole blood glucose control product, effective for maintaining a particular and essentially stable glucose concentration over a period of time sufficient for accurate measurement and calibration of a glucose measuring instrument.

    Abstract translation: 本发明涉及用于在葡萄糖监测仪器中使用的稳定的校准器和/或控制，试剂盒和方法。 原则上，本发明教导了糖酵解的红细胞成分，其已经用糖酵解稳定有效量的至少一种非交联醛化合物处理，该化合物可与一定量的葡萄糖一起添加到新鲜血浆中以形成模拟的整体 血糖控制产品，对于在足以准确测量和校准葡萄糖测量仪器的时间段内维持特定且基本稳定的葡萄糖浓度是有效的。

    SUSPENSION COMPOSITION FOR HEMATOLOGY ANALYSIS CONTROL
    55.
    发明申请
    SUSPENSION COMPOSITION FOR HEMATOLOGY ANALYSIS CONTROL 审中-公开
    血液学分析控制的悬浮组合物

    公开(公告)号：WO2018022991A1

    公开(公告)日：2018-02-01

    申请号：PCT/US2017/044368

    申请日：2017-07-28

    Applicant: STRECK, INC.

    Inventor： HUNSLEY, Brad ,  SCHOLL, John

    IPC: G01N33/50 ,  C12N5/078

    CPC classification number: G01N33/5094 ,  C12N5/0634 ,  C12N2501/90 ,  C12N2501/999

    Abstract: A suspension composition for a hematology analysis control particularly useful for preserving relevant detectable characteristics of blood cells for a prolong stability period. The suspension may include at least one polysaccharide, which may include or derive from chitosan and/or chitin, as a stabilizing agent.

    Abstract translation: 用于血液学分析控制的悬浮液组合物特别用于在延长的稳定期保持血细胞的相关可检测特征。 该悬浮液可以包括至少一种多糖，其作为稳定剂可以包含壳聚糖和/或几丁质或来源于壳聚糖和/或几丁质。

    IMMATURE RETICULOCYTE FRACTION REFERENCE CONTROL AND RELATED METHODS
    57.
    发明申请
    IMMATURE RETICULOCYTE FRACTION REFERENCE CONTROL AND RELATED METHODS 审中-公开
    参考控制和相关方法

    公开(公告)号：WO2013019290A3

    公开(公告)日：2013-04-11

    申请号：PCT/US2012034434

    申请日：2012-04-20

    Applicant: STRECK INC ,  RYAN WAYNE L ,  SCHOLL JOHN W

    Inventor： RYAN WAYNE L ,  SCHOLL JOHN W

    IPC: G01N33/96

    CPC classification number: G01N33/96

    Abstract: A composition (and associated methods) including a plurality of treated red blood cells for simulating reticulocytes, and particularly an immature reticulocyte fraction, of whole blood when processed as a sample in an automated analyzer capable of detecting reticulocytes. A method for making the composition or other simulated reticuolcyte may include steps of contacting a suspension of a plurality of red blood cells each having a membrane in an initial state that surrounds an interior volume of a cell with an effective amount of a hypertonic permeabilizing solution including dimethyl sulfoxide and a hypotonic loading agent delivery solution including a loading agent, for a sufficient time to form a plurality of pores in the membrane, for permitting the loading agent to enter into the interior volume of the cells, and, after entry of a desired amount of the loading agent into the interior volume of the cell, for sealing the pores for substantially restoring the membrane to the initial state while substantially encapsulating the loading agent within the resulting cell, and preferably also retaining within the resulting cell a substantial amount of hemoglobin from the original starting red blood cell.

    Abstract translation: 包括用于模拟网织红细胞的多种处理红细胞的组合物（和相关方法），特别是在能够检测网织红细胞的自动分析仪中作为样品处理时，全血的未成熟网织红细胞部分。 用于制备组合物或其它模拟的蛋白质的方法可以包括以下步骤：将具有包围细胞内部体积的初始状态的膜的多个红细胞的悬浮液与有效量的高渗渗透溶液接触，包括 二甲基亚砜和包含负载剂的低渗加载剂递送溶液足够的时间以在膜中形成多个孔，以允许负载剂进入细胞的内部体积，并且在进入期望的 负载剂进入电池的内部容积的量，用于密封用于基本上将膜恢复到初始状态的孔，同时基本上将所述负载剂封装在所得电池内，并且优选地还在所得电池内保留大量的血红蛋白 从原来的红血球开始。

    SAMPLE PROCESSING METHOD AND DEVICE
    58.
    发明申请
    SAMPLE PROCESSING METHOD AND DEVICE 审中-公开
    样品处理方法和装置

    公开(公告)号：WO2011153244A1

    公开(公告)日：2011-12-08

    申请号：PCT/US2011/038766

    申请日：2011-06-01

    Applicant: STRECK, INC. ,  VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  FREIFELD, Alison ,  BOOTH, Christine ,  ZHAO, Xing

    Inventor： VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  FREIFELD, Alison ,  BOOTH, Christine ,  ZHAO, Xing

    IPC: B01L3/00 ,  C12Q1/68 ,  G01N1/40

    CPC classification number: C12Q1/6806 ,  B01L3/5023 ,  B01L3/5029 ,  B01L3/505 ,  B01L2300/0825

    Abstract: The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to release or create one or more biological indicators from the biological specimen. The biological specimen is further contacted with a treated polymeric material so that at least a portion of the polymeric material binds to the one or more biological indicators.

    Abstract translation: 本发明提供一种用于处理和分析生物样本的方法和装置。 将生物样品引入处理装置中并在加工装置内热处理，机械地，化学地或其任何组合进行处理，以改变生物样本的至少一个构成特征并从生物样品中释放或产生一个或多个生物指示剂。 生物样品进一步与经处理的聚合材料接触，使得至少一部分聚合物材料与一种或多种生物指示剂结合。

    PROCESS, COMPOSITION AND KIT FOR PROVIDING A STABLE WHOLE BLOOD CALIBRATOR/CONTROL
    60.
    发明申请
    PROCESS, COMPOSITION AND KIT FOR PROVIDING A STABLE WHOLE BLOOD CALIBRATOR/CONTROL 审中-公开
    用于提供稳定的全血校准器/控制的过程，组成和工具

    公开(公告)号：WO2006091918A3

    公开(公告)日：2009-04-16

    申请号：PCT/US2006006787

    申请日：2006-02-23

    Applicant: STRECK INC

    Inventor： RYAN WAYNE L

    IPC: G01N33/48

    CPC classification number: C12Q1/54 ,  G01N33/80 ,  Y10T436/10 ,  Y10T436/104998 ,  Y10T436/106664 ,  Y10T436/108331 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2525

    Abstract: The present invention is directed toward a stable calibrator and/or control, kit and process for using in a glucose monitoring instrumentation. Principally, the instant invention teaches a glycolyzed red blood cell component which has been treated with a glycolysis stabilizing effective amount of at least one non-cross linking aldehyde compound which may be added to fresh plasma along with an amount of glucose to form a simulated whole blood glucose control product, effective for maintaining a particular and essentially stable glucose concentration over a period of time sufficient for accurate measurement and calibration of a glucose measuring instrument.

    Abstract translation: 本发明涉及用于在葡萄糖监测仪器中使用的稳定的校准器和/或控制，试剂盒和方法。 原则上，本发明教导了糖酵解的红细胞成分，其已用糖酵解稳定有效量的至少一种非交联醛化合物进行处理，该化合物可与一定量的葡萄糖一起加入到新鲜血浆中以形成模拟的整体 血糖控制产品，对于在足以准确测量和校准葡萄糖测量仪器的时间段内维持特定且基本稳定的葡萄糖浓度是有效的。

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