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    RAPID THERMOCYCLER SYSTEM FOR RAPID AMPLIFICATION OF NUCLEIC ACIDS AND RELATED METHODS
    2.
    发明申请
    RAPID THERMOCYCLER SYSTEM FOR RAPID AMPLIFICATION OF NUCLEIC ACIDS AND RELATED METHODS 审中-公开
    用于快速放大核酸的快速热分解系统及相关方法

    公开(公告)号：WO2012166913A1

    公开(公告)日：2012-12-06

    申请号：PCT/US2012/040201

    申请日：2012-05-31

    Applicant: STRECK, INC. ,  TERMAAT, Joel, R. ,  WHITNEY, Scott, E. ,  VILJOEN, Hendrik, J. ,  KREIFELS, Matthew, R.

    Inventor： TERMAAT, Joel, R. ,  WHITNEY, Scott, E. ,  VILJOEN, Hendrik, J. ,  KREIFELS, Matthew, R.

    IPC: C12Q1/68 ,  G01N35/00 ,  B01L7/00

    CPC classification number: B01L7/52 ,  B01L2200/14 ,  B01L2300/0627 ,  B01L2300/0858 ,  B01L2300/1805 ,  B01L2300/1822 ,  C12Q1/6844 ,  G01N2035/00366

    Abstract: A thermocycling device (10) and method of operating in which at least one first temperature sensor (1060) monitors a first temperature condition within the sample holder (64) and is adapted to provide a first electrical signal corresponding with the first temperature condition. In addition, at least one second temperature sensor (87) monitors a second temperature condition of a component external of the sample holder and is adapted to provide a second signal corresponding with the second temperature condition. At least one control device is adapted to interface with a power supply (1010) to control the delivery of power to a first thermal cycling element (60) and a second thermal cycling element (62), (both of which may sandwich a sample holder) and optionally an air mover (54); adapted to be in signaling communication with the first temperature sensor and the second temperature sensor; is configured for analysis of signals from the first temperature sensor and the second temperature sensor and; is configured such that, based upon such analysis, the at least one control device alters the power that is delivered to one or more of the first thermal cycling element and second thermal cycling element, and/or the air mover. The device Is controllably operated to account for thermal inertia effects.

    Abstract translation: 一种热循环装置（10）和操作方法，其中至少一个第一温度传感器（1060）监测样品保持器（64）内的第一温度条件，并适于提供对应于第一温度条件的第一电信号。 此外，至少一个第二温度传感器（87）监测样品保持器外部的部件的第二温度条件，并且适于提供对应于第二温度条件的第二信号。 至少一个控制装置适于与电源（1010）接口，以控制向第一热循环元件（60）和第二热循环元件（62）的输送，（两者都可以夹持样品架 ）和任选的鼓风机（54）; 适于与第一温度传感器和第二温度传感器进行信令通信; 被配置用于分析来自第一温度传感器和第二温度传感器的信号; 被配置为使得基于这种分析，所述至少一个控制装置改变被输送到第一热循环元件和第二热循环元件和/或鼓风机中的一个或多个的功率。 该装置可控地操作以考虑热惯性效应。

    IMPROVED SAMPLE TUBE HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION
    5.
    发明申请
    IMPROVED SAMPLE TUBE HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION 审中-公开
    具有特异性实用性的改良样品管用于核酸放大

    公开(公告)号：WO2012145662A1

    公开(公告)日：2012-10-26

    申请号：PCT/US2012/034506

    申请日：2012-04-20

    Applicant: STRECK, INC. ,  VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  TERMAAT, Joel, R. ,  KREIFELS, Matthew, Robert

    Inventor： VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  TERMAAT, Joel, R. ,  KREIFELS, Matthew, Robert

    IPC: B01L3/00

    CPC classification number: B01L3/50825 ,  B01L7/52 ,  B01L2300/022 ,  B01L2300/043 ,  B01L2300/123 ,  B01L2300/168

    Abstract: An improved tube (10) including a closure portion (12), a strap (18) integrally connected to the closure portion (12) and being configured for defining a living hinge, a body portion (20) having a longitudinal axis and an outer wall generally circumscribing the longitudinal ax is, and being integrally and hingedly connected with the closure portion (12) by way of the strap (18), the body portion (20) including a head portion (13) that has an opening (26) through which a sample is dispensed, and a sample portion (28) having a first outer wall dimension (OWD1) and including a closed distal end (30) and a wall structure (32) that includes an outer wall (34) and an inner wall structure (36) that defines a hollow cavity (38) within which the sample resides as a sample volume after is dispensed through the head portion (13), the sample portion (28) being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wail dimension (OWD1) of the sample portion (28) reduces to a smaller second outer wall dimension (OWD2).

    Abstract translation: 一种改进的管（10），包括封闭部分（12），一体地连接到封闭部分（12）并且构造成用于限定活动铰链的带子（18），具有纵向轴线的外部部分（20） 所述主体部分（20）包括具有开口（26）的头部（13），所述头部（13）具有开口（26），所述主体部分 通过其分配样品和具有第一外壁尺寸（OWD1）并包括封闭的远端（30）的样品部分（28）和包括外壁（34）和内壁（34）的壁结构 壁结构（36），其限定空心空腔（38），在所述中空空腔（38）中，所述样品部分（28）沿着所述纵向轴线大致伸长，所述样品部分（28）在所述中空空腔（38）中被分配通过所述头部部分（13） 弹性变形沿其长度的一部分，包括在a 方向，其通常横向于纵向轴线，使得壁结构的至少一部分压缩和弹性变形并且接合限定聚合酶链式反应放大装置的样品块中的开口的壁，并且与第一外壁尺寸（OWD1 ）减小到较小的第二外壁尺寸（OWD2）。

    SAMPLE PROCESSING METHOD AND DEVICE
    8.
    发明申请
    SAMPLE PROCESSING METHOD AND DEVICE 审中-公开
    样品处理方法和装置

    公开(公告)号：WO2011153244A1

    公开(公告)日：2011-12-08

    申请号：PCT/US2011/038766

    申请日：2011-06-01

    Applicant: STRECK, INC. ,  VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  FREIFELD, Alison ,  BOOTH, Christine ,  ZHAO, Xing

    Inventor： VILJOEN, Hendrik, J. ,  WHITNEY, Scott, E. ,  FREIFELD, Alison ,  BOOTH, Christine ,  ZHAO, Xing

    IPC: B01L3/00 ,  C12Q1/68 ,  G01N1/40

    CPC classification number: C12Q1/6806 ,  B01L3/5023 ,  B01L3/5029 ,  B01L3/505 ,  B01L2300/0825

    Abstract: The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to release or create one or more biological indicators from the biological specimen. The biological specimen is further contacted with a treated polymeric material so that at least a portion of the polymeric material binds to the one or more biological indicators.

    Abstract translation: 本发明提供一种用于处理和分析生物样本的方法和装置。 将生物样品引入处理装置中并在加工装置内热处理，机械地，化学地或其任何组合进行处理，以改变生物样本的至少一个构成特征并从生物样品中释放或产生一个或多个生物指示剂。 生物样品进一步与经处理的聚合材料接触，使得至少一部分聚合物材料与一种或多种生物指示剂结合。

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