公开(公告)号：WO2006121740A2

公开(公告)日：2006-11-16

申请号：PCT/US2006017053

申请日：2006-05-04

Applicant: STRYKER CORP ,  WU CHUNWU

Inventor： WU CHUNWU

CPC classification number: A61B5/06 ,  A61B5/062 ,  A61B5/7257 ,  A61B34/20 ,  A61B90/36 ,  A61B2034/2051 ,  A61B2090/397

Abstract: A system and method for performing object localization based on the emission of electromagnetic fields. The electromagnetic fields are simultaneously emitted from different transmitters. One electromagnetic field is emitted at a base frequency; the remaining waves are emitted at frequencies that are harmonics of the base frequency. The composite magnetic fields are measured by sensors. The signal generated by each sensor is subject to a Fourier analysis to determine the strengths of the individual electromagnetic fields forming the composite electromagnetic field. These individual measure field strength data are then used to determine the position and orientation of the sensors relative to the transmitters.

Abstract translation: 一种基于电磁场发射进行物体定位的系统和方法。 电磁场同时从不同的发射器发射。 一个电磁场以基频发射; 剩余的波在基频的谐波频率处发射。 复合磁场由传感器测量。 由每个传感器产生的信号经历傅立叶分析以确定形成复合电磁场的各个电磁场的强度。 然后使用这些单独的测量场强数据来确定传感器相对于发射器的位置和方向。

公开(公告)号：WO2006029406A3

公开(公告)日：2006-06-22

申请号：PCT/US2005032521

申请日：2005-09-09

Applicant: STRYKER CORP ,  LEE JOHN C ,  TOTH CAROL A

Inventor： LEE JOHN C ,  TOTH CAROL A

IPC: A61K38/18

CPC classification number: A61K38/1875 ,  A61K48/00

Abstract: The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

Abstract translation: 本发明提供了通过施用药学有效量的骨形态发生蛋白或编码骨的核酸来治疗骨癌，诱导骨肿瘤细胞分化，抑制骨肿瘤生长，诱导骨肿瘤消退或治疗过度增殖性细胞病症的方法 形态发生蛋白。

公开(公告)号：WO2004006787A3

公开(公告)日：2004-04-08

申请号：PCT/US0321656

申请日：2003-07-10

Applicant: STRYKER CORP ,  CARUSILLO STEVEN ,  HENNIGES BRUCE ,  ALVAREZ EDGARDO ,  BARNES MILTON

Inventor： CARUSILLO STEVEN ,  HENNIGES BRUCE ,  ALVAREZ EDGARDO ,  BARNES MILTON

IPC: A61B17/00 ,  A61B17/24 ,  A61B17/32 ,  A61M1/00 ,  A61B17/22

CPC classification number: A61B17/32002 ,  A61B17/24 ,  A61B2017/00477 ,  A61B2217/005 ,  A61B2217/007 ,  A61M1/0058

Abstract: A surgical tool system comprising a handpiece and a cutting accessory that is releasable secured to the handpiece. The handpiece has a gear assembly with two drive heads. The gear assembly turns the drive heads at different rotational speeds relative to each other. The cutting accessory is provided with one of two drive hubs. If the cutting accessory is provided with a first drive hub, the drive hub mates to a first one of the drive heads so as to turn of the speed of that head. If the cutting accessory is provided with a second drive hub, the drive hub mates to the second drive head so as to turn at the speed of that head. Thus, the speed at which the cutting accessory is actuated is a function of the associated drive head.

Abstract translation: 一种手术工具系统，包括手持件和可拆卸地固定到手持件的切割配件。 手机具有带两个驱动头的齿轮组件。 齿轮组件以不同的转速相对于彼此转动驱动头。 切割附件配有两个驱动轮毂中的一个。 如果切割附件设置有第一驱动毂，则驱动毂配合到驱动头中的第一个，以便转动该头的速度。 如果切割附件设置有第二驱动毂，则驱动毂配合到第二驱动头以便以该头的速度转动。 因此，切割配件被致动的速度是相关驱动头的功能。

公开(公告)号：WO0160261A9

公开(公告)日：2002-10-24

申请号：PCT/US0105378

申请日：2001-02-17

Applicant: STRYKER CORP ,  WALEN JAMES

Inventor： WALEN JAMES

IPC: A61B17/00 ,  A61B17/16 ,  A61B17/32

CPC classification number: A61B17/1633 ,  A61B17/1615 ,  A61B17/162 ,  A61B17/32002 ,  A61B2017/00464 ,  A61B2017/00477

Abstract: A set of removable cutting attachments (550, 650, 740 and 840). The attachments are of different lengths. The coupling members (578, 802) internal to the attachments are all spaced a substantially identical distances from the distal ends of the attachments. This makes it possible to employ cutting accessories (40a) that have shafts (44a) of a common length in each attachment. The accessory shafts have plural, linearly aligned retention features (530) are formed on the shaft. This makes it possible to longitudinally adjust the position of the cutting accessory relative to the attachment with which the accessory is used.

Abstract translation: 一组可拆卸的切割附件（550,650,740和840）。 附件长度不同。 连接件内部的连接件（578,802）的距离与附件的远端基本相同。 这使得可以在每个附件中采用具有公共长度的轴（44a）的切割附件（40a）。 附件轴在轴上形成有多个直线对准的保持特征（530）。 这使得可以纵向地调整切割附件相对于使用附件的附件的位置。

公开(公告)号：WO0020449A9

公开(公告)日：2002-08-22

申请号：PCT/US9923372

申请日：1999-10-07

Applicant: STRYKER CORP

Inventor： OPPERMANN HERMANN ,  TAI MEI-SHENG ,  MCCARTNEY JOHN

IPC: C12P21/02 ,  A61K38/00 ,  A61P19/00 ,  A61P21/00 ,  C07K14/47 ,  C07K14/495 ,  C07K19/00 ,  C12N15/09 ,  C12N15/62

CPC classification number: C07K14/51 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/75

Abstract: The invention provides modified TGF- beta family proteins having altered biological or biochemical properties, and methods for making them. Specific modified protein constructs include TGF- beta family member proteins that have N-terminal truncations, "latent" proteins, fusion proteins and heterodimers.

Abstract translation: 本发明提供具有改变的生物或生物化学性质的修饰的TGF-β家族蛋白质及其制备方法。 特异性修饰的蛋白质构建体包括具有N-末端截短的“潜在”蛋白质，融合蛋白质和异二聚体的TGF-β家族成员蛋白质。

公开(公告)号：WO0144514A3

公开(公告)日：2002-07-18

申请号：PCT/US0034114

申请日：2000-12-15

Applicant: STRYKER CORP

Inventor： YEH LEE-CHUAN C ,  LEE JOHN C

IPC: C12N15/09 ,  A61F2/02 ,  A61F2/08 ,  A61F2/28 ,  A61K38/00 ,  A61K45/00 ,  A61L27/00 ,  A61P19/04 ,  A61P21/00 ,  A61P25/00 ,  A61P43/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68

CPC classification number: C12N15/1086 ,  C12Q1/6897 ,  Y10S530/84

Abstract: The present invention relates generally to methods and compositions for identifying morphogenic protein analogs. In one embodiment, this invention relates to an osteogenic protein reponsive transcription inhibitory element. This invention also relates to the identified morphogenic protein analogs which can mimic the biological effects of morphogenic proteins, particularly those relating to the BMP family such as osteogenic protein (OP-1), on the regulation of gene expression and tissue inductive capabilities.

Abstract translation: 本发明一般涉及用于鉴定形态发生蛋白类似物的方法和组合物。 在一个实施方案中，本发明涉及成骨蛋白反应转录抑制元件。 本发明还涉及可以模拟形态发生蛋白质，特别是与BMP家族（例如成骨蛋白质（OP-1）相关的那些）对调节基因表达和组织诱导能力的生物学效应的鉴定的形态发生蛋白类似物。

公开(公告)号：WO0123563A3

公开(公告)日：2001-10-04

申请号：PCT/US0026528

申请日：2000-09-27

Applicant: STRYKER CORP

Inventor： LEE JOHN C ,  YEH LEE-CHUAN C

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K38/18 ,  A61K38/20 ,  A61K38/22 ,  A61P9/00 ,  A61P17/00 ,  A61P19/00 ,  A61P19/04 ,  A61P43/00 ,  C07K14/51 ,  C07K14/715 ,  C12N15/12 ,  A61K48/00 ,  C07K14/54

CPC classification number: A61K38/204 ,  A61K35/32 ,  A61K38/1793 ,  A61K38/1875 ,  A61K38/39 ,  A61K2300/00

Abstract: This invention features devices and methods for inducing tissue formation in a mammal, involving the use of a morphogenic protein, a hormone and a soluble receptor of the hormone. The hormone and receptor thereof are used to enhance the tissue inductive activity of the morphogenic protein.

Abstract translation: 本发明的特征在于在哺乳动物中诱导组织形成的装置和方法，涉及使用形态发生蛋白，激素和激素的可溶性受体。 激素及其受体用于增强形态发生蛋白的组织诱导活性。

公开(公告)号：WO2018145096A1

公开(公告)日：2018-08-09

申请号：PCT/US2018/017078

申请日：2018-02-06

Applicant: STRYKER CORP.

Inventor： KAISER, William ,  KOVACEVICH, Ian ,  GRAUL, Jeremy ,  PARKER, John ,  BANSASINE, Nouphone ,  FLOM, James

IPC: A61F5/05 ,  A61G13/12 ,  A61F5/37

Abstract: An anatomical gripping system comprising: a binding comprising: a substantially rigid spine; a calf shell mounted to the substantially rigid spine; an anterior shell; and a clamping mechanism connecting the anterior shell to the calf shell; wherein the calf shell comprises a flexible portion configured to selectively engage the superior portion of the calcaneus bone of a patient; and further wherein when the clamping mechanism applies a force to the flexible portion of the calf shell, the flexible portion of the calf shell is drawn into engagement with the superior portion of the calcaneus bone of the patient.

公开(公告)号：WO2017011619A4

公开(公告)日：2017-03-09

申请号：PCT/US2016042193

申请日：2016-07-14

Applicant: STRYKER CORP

Inventor： DOWNEY ADAM DARWIN

IPC: A61B17/32

CPC classification number: A61B17/320068 ,  A61B2017/00017 ,  A61B2017/0015

Abstract: Systems (10) and methods (12) of controlling an ultrasonic surgical tool (20) with a console (22) are provided. A first drive signal (40) is applied to the ultrasonic surgical tool (20). A characteristic of a harmonic signal (44) resulting from application of the first drive signal (40) to the ultrasonic surgical tool (20) is acquired. A cancellation signal (70) is generated based on the characteristic of the harmonic signal (44). The first drive signal (40) and the cancellation signal (70) are combined to produce a second drive signal (80) that is sinusoidal. The second drive signal (80) is applied to the ultrasonic surgical tool (20) such that presence of the harmonic signal (44) resulting from application of the second drive signal (80) is reduced relative to presence of the harmonic signal (44) resulting from application of the first drive signal (40).

Abstract translation: 提供了用控制台（22）控制超声波手术工具（20）的系统（10）和方法（12）。 第一驱动信号（40）被施加到超声波手术工具（20）。 获取由将第一驱动信号（40）应用于超声波手术工具（20）而产生的谐波信号（44）的特性。 基于谐波信号（44）的特性产生消除信号（70）。 第一驱动信号（40）和消除信号（70）被组合以产生正弦曲线的第二驱动信号（80）。 第二驱动信号（80）被施加到超声波手术工具（20），使得由施加第二驱动信号（80）而产生的谐波信号（44）的存在相对于谐波信号（44）的存在而减小， 由施加第一驱动信号（40）导致。

公开(公告)号：WO2016138443A3

公开(公告)日：2016-11-24

申请号：PCT/US2016019880

申请日：2016-02-26

Applicant: STRYKER CORP

Inventor： WALEN JAMES G ,  DEENY BRYAN G ,  NUNAN GERARD

IPC: A61M25/01 ,  A61B17/00 ,  A61B17/16 ,  A61B17/22 ,  A61B17/29 ,  A61B17/32 ,  A61B17/3207 ,  A61M1/00

CPC classification number: A61B17/32002 ,  A61B17/1622 ,  A61B17/1631 ,  A61B17/320758 ,  A61B17/3421 ,  A61B2017/00309 ,  A61B2017/22079 ,  A61B2017/2905 ,  A61B2017/2908 ,  A61B2017/2927 ,  A61B2017/320032 ,  A61B2217/005 ,  A61M25/0138 ,  A61M25/0147

Abstract: A surgical instrument (10, 110, 210) includes an articulating tube assembly (20, 120, 220) having a proximal end and a distal end, an articulating region (23, 123, 223) disposed between the proximal end and the distal end, and a proximal axis axially extending from the proximal end to the articulating region (23, 123, 223). The articulating tube assembly (20, 120, 220) includes an inner tube (24, 124, 224) and an outer tube (26, 126, 226) each having the articulating region (23, 123, 223). The inner tube (24, 124, 224) and the outer tube (26, 126, 226) being movable relative to each other proximal to the articulating region (23, 123, 223) and fixed axially relative one another distal to the articulating region (23, 123, 223). The surgical instrument (10, 110, 210) also includes an actuation assembly (22, 122, 222a) coupled to the articulating tube assembly (20, 120, 220) for moving the inner tube (24, 124, 224) and the outer tube (26, 126, 226) axially relative to each other for articulating the articulating region (23, 123, 223) of the articulating tube assembly (20, 120, 220) between a first configuration and a second configuration, wherein the articulating region (23, 123, 223) is rigid in the first configuration and the second configuration.

Abstract translation: 手术器械（10,110,210）包括具有近端和远端的关节运动管组件（20,120,220），设置在近端和远端之间的关节运动区域（23,123,223） ，以及从近端轴向延伸到关节运动区域（23,123,223）的近轴。 铰接管组件（20,120,220）包括每个具有铰接区域（23,123,223）的内管（24,124,224）和外管（26,126,226）。 内管（24,124,224）和外管（26,126,226）可相对于彼此相对于关节部分（23,123,223）相对移动并且相对于铰接区域远离另一个轴向固定 （23,123,223）。 手术器械（10,110,210）还包括联接到铰接管组件（20,120,220）的致动组件（22,122,222a），用于移动内管（24,124,224）和外管 管（26,126,226）相对于彼此轴向地铰接在第一构造和第二构造之间的铰接管组件（20,120,220）的铰接区域（23,123,223），其中所述铰接区域 （23,123,223）在第一构造和第二构造中是刚性的。