公开(公告)号：WO2016172365A1

公开(公告)日：2016-10-27

申请号：PCT/US2016/028686

申请日：2016-04-21

Applicant: PURDUE RESEARCH FOUNDATION OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： RICKUS, Jenna Leigh ,  HARBIN, Sherry L. ,  KAHN, Jennifer L.

IPC: C12N11/04 ,  C12N11/14

CPC classification number: C07K14/78 ,  C12N5/0012 ,  C12N5/0697 ,  C12N11/04 ,  C12N11/14

Abstract: Soluble, self-assembling collagens derived from tissues are extensively characterized such that one can predict and customize the final collagen-fibril matrix with respect to fibril microstructure (i.e.,fibril density, interfibril branching), viscoelasticity, and proteolytic degradability. As shown herein these matrices template and direct the deposition of mesoporous silica at the level of individual collagen fibrils. The fibril density, silicic acid concentration, and time of exposure to silicifying solution were varied and the resulting hybrid materials were analyzed by scanning electron microscopy, energy-dispersive x-ray spectroscopy, and rheology. Microstructural properties of the collagen-fibril template are preserved in the silica surface of hybrid materials. Results for three different collagen fibril densities, corresponding to shear storage moduli of 200 Pa, 1000 Pa, and 1600 Pa, indicate that increased fibril density increases the absolute amount of templated silica when all other silica synthesis conditions are kept constant. The mechanical properties of the hybrid material are dominated by the presence of the silica coating rather than the starting collagen matrix stiffness.

Abstract translation: 衍生自组织的可溶性自组装胶原蛋白被广泛地表征，使得人们可以相对于原纤维微结构（即原纤维密度，纤丝分支），粘弹性和蛋白水解降解性来预测和定制最终的胶原纤维基质。 如本文所示，这些基质模拟并引导介孔二氧化硅在单个胶原原纤维水平的沉积。 改变原纤维密度，硅酸浓度和暴露于硅化溶液的时间，通过扫描电子显微镜，能量色散X射线光谱和流变学分析所得的杂化材料。 胶原纤维模板的微观结构性质保留在混合材料的二氧化硅表面。 对应于200 Pa，1000 Pa和1600 Pa的剪切储存模量的三种不同胶原纤维密度的结果表明，当所有其他二氧化硅合成条件保持恒定时，增加的原纤维密度增加模板二氧化硅的绝对量。 杂化材料的机械性能由二氧化硅涂层的存在主导，而不是起始胶原基质刚度。

公开(公告)号：WO2016154715A1

公开(公告)日：2016-10-06

申请号：PCT/CA2015/000211

申请日：2015-03-31

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION (CIMTEC) ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： BEN-LAVI, Eliezer Azi ,  FENSTER, Aaron

IPC: A61B6/03 ,  A61B8/13 ,  G06T7/00

CPC classification number: G06T7/33 ,  G06T3/0068 ,  G06T5/20 ,  G06T15/08 ,  G06T2207/10081 ,  G06T2207/10136 ,  G06T2207/20024 ,  G06T2207/30056 ,  G06T2207/30101

Abstract: A method for registering ultrasound (US) and computed tomography (CT) images, comprising: receiving US and CT images representative of a body portion comprising blood vessels and an initial approximate transform; enhancing the blood vessels in the US and CT images, thereby obtaining an enhanced US and CT images; creating a point-set for a given one of the enhanced US and CT images; determining a final transform between the point-set and the other one of the enhanced US and CT images using the initial transform; applying the final transform to a given one of the US and CT images to align together a coordinate system of the US image and a coordinate system of the CT image, thereby obtaining a transformed image; and outputting the transformed image.

Abstract translation: 一种用于记录超声（US）和计算机断层摄影（CT）图像的方法，包括：接收代表包括血管的身体部分和初始近似变换的US和CT图像; 增强美国血管和CT图像，从而获得增强的美国和CT图像; 为给定的一个增强的美国和CT图像创建一个点集; 使用初始变换确定增强的US和CT图像中的点集和另一个之间的最终变换; 将最终变换应用于美国和CT图像中的给定的一个，以将美国图像的坐标系和CT图像的坐标系对准，从而获得变换的图像; 并输出变换后的图像。

公开(公告)号：WO2016154714A1

公开(公告)日：2016-10-06

申请号：PCT/CA2015/000210

申请日：2015-03-31

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： BEN-LAVI, Eliezer, Azi ,  FENSTER, Aaron

IPC: A61B8/13 ,  G06T5/50 ,  G06T11/60

CPC classification number: A61B8/5253 ,  A61B8/0891 ,  A61B8/4477 ,  A61B8/483 ,  A61B8/5223 ,  G06T3/4038 ,  G06T7/12 ,  G06T7/32 ,  G06T2207/10136 ,  G06T2207/20016 ,  G06T2207/20048 ,  G06T2207/20076 ,  G06T2207/20221 ,  G06T2207/30101

Abstract: A computer-implemented method for combining two 3 -dimensional ultrasound images of a patient's body part containing blood vessels into a single 3 -dimensional ultrasound image of that body part with a greater field of view. Blood vessels within the body part are used for registration. The two ultrasound images are preprocessed using a vessel enhancement algorithm to derive two corresponding enhanced images. The enhanced images can undergo a registration process based upon minimizing a mean-square-difference metric to derive an enhanced rigid transform, which represents a transform that maps the first enhanced image onto the second enhanced image. The two enhanced images are seamlessly combined via a blending process (via the use of a distance transform based weighting of the voxel values) to derive an output image.

Abstract translation: 一种计算机实现的方法，用于将包含血管的患者身体部分的两个3维超声图像组合成具有更大视场的该身体部位的单个3维超声图像。 身体部位的血管用于登记。 使用血管增强算法对两个超声图像进行预处理，以导出两个相应的增强图像。 增强图像可以基于最小化均方差度量来进行注册过程，以导出增强的刚性变换，其表示将第一增强图像映射到第二增强图像上的变换。 两个增强图像通过混合处理（通过使用基于距离变换的体素值的加权）无缝地组合以导出输出图像。

公开(公告)号：WO2015117218A1

公开(公告)日：2015-08-13

申请号：PCT/CA2014/000101

申请日：2014-02-07

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION (CIMTEC)

Inventor： BAX, Jeffrey Scott ,  WARING, Christopher Stanley Robert ,  FENSTER, Aaron

IPC: B65G9/00 ,  A61B19/00 ,  B25J17/00 ,  B25J18/00 ,  B25J19/00 ,  F16M13/04

CPC classification number: B25J19/0016 ,  A61B34/30 ,  A61B90/11 ,  A61B90/50 ,  A61B2090/374 ,  A61B2090/5025 ,  A61B2090/506 ,  F16M2200/041 ,  F16M2200/044 ,  F16M2200/063

Abstract: Disclosed is a modular base link for use in a counterbalancing arm. The base link includes two base plates and four connection points. Two stabilizing members are connected to and extend between the base plates. Two resilient members, one of which is hingeably connected to and in communication with the two connection points, the other resilient member is hingeably connected to and in communication with the other connection points. The connection points are eccentrically and orthogonally disposed relative to each other. The resilient members are sufficiently resilient to permit movement of the base plates relative to each other so as to counterbalance the arm when a load is applied to either base plate.

Abstract translation: 公开了一种用于平衡臂的模块化基座连杆。 基座连接件包括两个基板和四个连接点。 两个稳定构件连接到基板之间并在基板之间延伸。 两个弹性构件，其中一个可铰接地连接到两个连接点并与两个连接点连通，另一个弹性构件可铰接地连接到其它连接点并与其连接点连通。 连接点相对于彼此偏心地且正交地设置。 弹性构件具有足够的弹性，以允许基板相对于彼此移动，以便当将负载施加到任一基板时抵抗臂的平衡。

公开(公告)号：WO2008073439A2

公开(公告)日：2008-06-19

申请号：PCT/US2007/025351

申请日：2007-12-10

Applicant: THE CITY UNIVERSITY OF NEW YORK TECHNOLOGY COMMERCIALIZATION OFFICE ,  CROUSE, David Thomas ,  KESHAVAREDDY, Pavan Kumar Reddy

Inventor： CROUSE, David Thomas ,  KESHAVAREDDY, Pavan Kumar Reddy

IPC: G01J3/18

CPC classification number: G02B5/008 ,  B82Y20/00 ,  G02B5/203

Abstract: Grating structures adapted to support cavity modes ("CMs"), including CMs produced by waveguide modes (WGs) of TE -polarized radiation; and those produced by WGs or vertically-oriented surface plasmons (VSPs) on the groove walls of incident TM- polarized radiation are provided. Such grating structures include those that provide enhanced transmission for a predetermined polarization state at a predetermined wavelength, simultaneous TM and TE transmission, and those that provide light circulation and weaving. The grating structures can include wires, or arrays of holes in thin (metallic) films, and include multiple-groove-per-period structures. Methods for optimizing such grating structures are also provided.

Abstract translation: 适用于支持腔模（“CM”）的光栅结构，包括由TE极化辐射的波导模（WG）产生的CM; 并提供由WG或垂直取向表面等离子体（VSP）在入射TM偏振辐射的凹槽壁上产生的那些。 这种光栅结构包括为预定波长的预定偏振状态提供增强透射，同时TM和TE透射以及提供光循环和编织的那些光栅结构。 光栅结构可以包括导线或薄（金属）薄膜中的孔阵列，并且包括多周期多槽结构。 还提供了用于优化这种光栅结构的方法。

公开(公告)号：WO2017177190A1

公开(公告)日：2017-10-12

申请号：PCT/US2017/026692

申请日：2017-04-07

Applicant: UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： JAMESON, Noel J. ,  AZARIAN, Michael,

IPC: G06F11/00

Abstract: A system that is a target of health monitoring via a computational system, the computational system, and corresponding method for determining health indicators using rank correlation analysis are disclosed. The target system includes a computational system that includes a computing device that acquires data from the target system, generate at least two features from the data acquired from the target system, computes, for each feature, rank correlation of the feature with time, computes the absolute value of each rank correlation coefficient for each feature, confining the range of the absolute value rank correlation coefficients to that from 0 to 1; and chooses at least one feature with a higher relative absolute value rank correlation coefficient as a health or condition indicator for the target system. The target system or the computational system or the method may perform health or condition monitoring on the target system.

Abstract translation: 公开了一种系统，该系统是经由计算系统进行健康监测的目标，该计算系统以及使用等级相关分析来确定健康指标的相应方法。 目标系统包括计算系统，该计算系统包括计算装置，该计算装置从目标系统获取数据，根据从目标系统获取的数据生成至少两个特征，针对每个特征计算特征与时间的相关性，计算 每个特征的每个等级相关系数的绝对值，将绝对值等级相关系数的范围限制为从0到1的范围; 并选择具有较高的相对绝对值等级相关系数的至少一个特征作为目标系统的健康或状况指标。 目标系统或计算系统或方法可以在目标系统上执行健康状况或状况监视。

公开(公告)号：WO2016154713A1

公开(公告)日：2016-10-06

申请号：PCT/CA2015/000209

申请日：2015-03-31

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： BAX, Jeffrey ,  WARING, Christopher ,  FENSTER, Aaron ,  CEPEK, Jeremy

IPC: F16D49/00 ,  F16D65/14 ,  F16D71/00

CPC classification number: F16D71/04 ,  A61N7/02 ,  F16D49/00 ,  F16D65/14 ,  F16D71/00 ,  F16D2121/14 ,  F16D2125/28 ,  F16D2125/48 ,  F16D2125/582 ,  F16D2127/06

Abstract: A self-locking brake mechanism, which utilises a cantilever to engage a brake drum to prevent the brake drum from rotating, thereby resulting in braking behaviour. Further, locking mechanisms are provided that are useful for applications involving multiple brakes. The locking mechanism, through suitable use of indexing via Geneva mechanisms, allows multiple brakes to be engaged and/or disengaged from a single point of adjustment. The multiple brakes may be engaged or disengaged in a variety of combinations to achieve a particular desired braking configuration. The user can turn a single knob to engage or disengage varying combinations of brakes so as to achieve the desired braking configuration.

Abstract translation: 一种自锁制动机构，其使用悬臂来接合制动鼓以防止制动鼓旋转，从而导致制动行为。 此外，提供了可用于涉及多个制动器的应用的锁定机构。 锁定机构通过适当地使用通过日内瓦机构的分度，允许多个制动器从单个调节点接合和/或脱离。 多个制动器可以以各种组合接合或分离以实现特定的期望的制动配置。 用户可以转动单个旋钮以接合或分离制动器的各种组合，以便实现期望的制动配置。

公开(公告)号：WO2016033322A1

公开(公告)日：2016-03-03

申请号：PCT/US2015/047176

申请日：2015-08-27

Applicant: PURDUE RESEARCH FOUNDATION OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： VOYTIK-HARBIN, Sherry

IPC: A61L31/04

CPC classification number: A61L27/24 ,  A61K9/0024 ,  A61K9/19 ,  A61K38/18 ,  A61K47/42 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2400/06

Abstract: A collagen-based therapeutic delivery device includes an insoluble synthetic collagen-fibril matrix comprising a polymerization product of soluble oligomeric collagen or a polymerization product of a mixture of soluble oligomeric collagen with one or more type of non-oligomeric soluble collagen molecules, such as, for example, soluble telocollagen and/or soluble atelocollagen, and an active agent dispersed throughout the collagen-fibril matrix or within a portion of the collagen-fibril matrix. A pre-matrix composition includes an aqueous solution including soluble collagen-fibril building blocks and an active agent in the aqueous solution. The soluble collagen-fibril building blocks include soluble oligomeric collagen or a mixture of soluble oligomeric collagen with non-oligomeric soluble collagen molecules. The building blocks are operable to self-assemble into a macromolecular synthetic collagen-fibril matrix in the absence of an exogenous cross-linking agent. Methods of making and using the pre-matrix composition and the device are also provided.

Abstract translation: 基于胶原的治疗递送装置包括不溶性合成胶原纤维基质，其包含可溶性低聚胶原的聚合产物或可溶性低聚胶原与一种或多种类型的非低聚可溶性胶原分子的混合物的聚合产物， 例如可溶性胶原蛋白和/或可溶性胶原蛋白，以及分散在整个胶原 - 原纤维基质或胶原 - 原纤维基质的一部分内的活性剂。 前体基质组合物包括在水溶液中包含可溶性胶原 - 原纤维结构单元和活性剂的水溶液。 可溶性胶原纤维结构单元包括可溶性低聚胶原蛋白或可溶性低聚胶原蛋白与非低聚可溶性胶原分子的混合物。 在不存在外源交联剂的情况下，构建块可操作以自组装成大分子合成胶原原纤维基质。 还提供了制备和使用前基质组合物和装置的方法。

公开(公告)号：WO2015077742A3

公开(公告)日：2015-05-28

申请号：PCT/US2014/067215

申请日：2014-11-25

Applicant: UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： DIEHN, Kevin ,  ARYA, Chandamany ,  ENGEL, Karl ,  FURSTENBURG, Matthew ,  RAGHAVAN, Srinivasa

IPC: C09J101/02 ,  C09J105/08 ,  C09K3/14

Abstract: A formulation for coating surfaces, for example gloves, with a tacky film comprises a hydrophobically modified biopolymer, where the hydrophobic modifications of the biopolymer correspond to between 1 and 90% of available functional groups, a plasticizer, and a volatile solvent. The formulation quickly dries into a tacky film that provides an enhanced friction of the surface.

公开(公告)号：WO2012162647A1

公开(公告)日：2012-11-29

申请号：PCT/US2012/039672

申请日：2012-05-25

Applicant: UNIVERSITY OF CINCINNATI ,  CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER, CENTER FOR TECHNOLOGY COMMERCIALIZATION ,  CLARK, Joseph, F. ,  PYNE-GEITHMAN, Gail ,  KUROSAWA, Yuko ,  ZHANG, Kejian ,  ZHANG, Wenying ,  KEDDACHE, Mehdi

Inventor： CLARK, Joseph, F. ,  PYNE-GEITHMAN, Gail ,  KUROSAWA, Yuko ,  ZHANG, Kejian ,  ZHANG, Wenying ,  KEDDACHE, Mehdi

IPC: C12P19/34 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/156 ,  C12Q2531/113 ,  C12Q2537/143

Abstract: Amplification primers, sequencing primers, kits for screening, and screening methods for identifying a SLC6A8 creatine transporter gene mutation are disclosed. The screening method includes treating a sample of DNA with polymerase chain reaction amplification primers for amplifying regions of the DNA having SLC6A8 to produce a first, second, and third amplification product, sequencing the first, second, and third amplification products with sequencing primer pairs to provide a DNA sequence of SLC6A8 in the sample, and comparing the DNA sequence of SLC6A8 with a reference DNA sequence of SLC6A8 .

Abstract translation: 公开了扩增引物，测序引物，筛选试剂盒和鉴定SLC6A8肌酸转运蛋白基因突变筛选方法。 筛选方法包括用聚合酶链式反应扩增引物处理DNA样品，扩增具有SLC6A8的DNA的区域以产生第一，第二和第三扩增产物，测序第一，第二和第三扩增产物，测序引物对 在样品中提供SLC6A8的DNA序列，并比较SLC6A8的DNA序列与SLC6A8的参考DNA序列。