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    콜라겐 조절용 조성물
    52.
    发明授权
    콜라겐 조절용 조성물 有权
    用于调节胶原的组合物

    公开(公告)号：KR101309335B1

    公开(公告)日：2013-09-16

    申请号：KR1020110064247

    申请日：2011-06-30

    Applicant: (주)아모레퍼시픽

    Inventor： 김규한 ,  심중현 ,  신동욱 ,  최현 ,  노민수 ,  이태룡

    IPC: A61K38/16 ,  A61K31/7105 ,  A61P17/00

    Abstract: 본 발명은 miRNA-526b 기능의 저해제(inhibitor)로 작용하는 올리고뉴클레오티드 또는 모방체(mimic)로 작용하는 올리고뉴클레오티드를 포함하는 콜라겐 조절용 조성물을 제공한다. 본 발명의 조성물은 콜라겐 분해효소(collagenase) 중의 하나인 MMP1(matrix metalloproteinase 1)의 발현을 조절하여 진피층을 채우는 콜라겐 생성을 조절하므로 노화 개선, 예방 또는 치료에 사용될 수 있다.

    인간 중간엽줄기세포의 분화 촉진용 조성물
    53.
    发明公开
    인간 중간엽줄기세포의 분화 촉진용 조성물 有权
    促进人类间质干细胞分化的组合物

    公开(公告)号：KR1020130030833A

    公开(公告)日：2013-03-28

    申请号：KR1020110094352

    申请日：2011-09-20

    Applicant: (주)아모레퍼시픽

    Inventor： 신동욱 ,  노민수

    IPC: A61K36/9066 ,  C12N5/0775 ,  A61P17/00

    Abstract: PURPOSE: An external use skin composition is provided to promote differentiation of mesenchymal stem cells into adipocytes, to enhance skin elasticity, and to improve anti-wrinkling effect. CONSTITUTION: An external use skin composition for promoting differentiation into adipocytes contains 0.0001-30 wt% of a Curcuma longa extract as an active ingredient. The composition promotes differentiation of mesenchymal stem cells into adipocytes. The mesenchymal stem cell is a human mesenchymal stem cell. A pharmaceutical composition for promoting differentiation into adipocytes contains the Curcuma longa extract as an active ingredient. [Reference numerals] (AA) Relative differentiation rate; (BB) Negative control group; (CC) Borneolum; (DD) Achuranthis Radix; (EE) Curcumae longae Rhizoma

    Abstract translation: 目的：提供外用皮肤组合物，以促进间充质干细胞分化为脂肪细胞，增强皮肤弹性，改善抗皱效果。 构成：用于促进脂肪细胞分化的外用皮肤组合物含有0.0001-30重量％的姜黄提取物作为活性成分。 该组合物促进间充质干细胞分化为脂肪细胞。 间充质干细胞是人间充质干细胞。 用于促进脂肪细胞分化的药物组合物含有姜黄提取物作为活性成分。 （附图标记）（AA）相对分化率; （BB）阴性对照组; （CC）冰片; （DD）Achuranthis Radix; （EE）Curcumae longae Rhizoma

    비피더스균 추출물을 함유하는 지방유래 줄기세포의 줄기세포성 증진용 및 피부세포 증식용 조성물
    54.
    发明公开
    비피더스균 추출물을 함유하는 지방유래 줄기세포의 줄기세포성 증진용 및 피부세포 증식용 조성물 有权
    用于促进ADIPOSE衍生的干细胞和增加含有双歧杆菌提取物的皮肤细胞的稳定性的化妆品组合物

    公开(公告)号：KR1020120058864A

    公开(公告)日：2012-06-08

    申请号：KR1020100120371

    申请日：2010-11-30

    Applicant: (주)아모레퍼시픽

    Inventor： 심중현 ,  김지현 ,  조성아 ,  민대진 ,  김한곤 ,  이태룡 ,  노민수 ,  신동욱

    IPC: A61K35/745 ,  A61K35/28 ,  A61K8/99 ,  A61K8/06 ,  A61K9/06 ,  A61Q19/08

    CPC classification number: A61K35/745 ,  A61K8/06 ,  A61K8/99 ,  A61K9/06 ,  A61K35/28 ,  A61Q19/08

    Abstract: PURPOSE: A composition containing Bifidobacteria extract is provided to enhance the stemness of stem cells and to enhance adipose for beauty. CONSTITUTION: A composition for enhancing the stemness of adipose-derived stem cells contains 0.0001-10 wt% of Bifidobacteria extract as an active ingredient. The stem cell is human adipose-derived stem cells(hADSCs). A composition for enhancing skin cells contains 0.0001-10 wt% of extract as an active ingredient. The skin cells are keratinocyte stem cells(KSCs) or transit-amplifying cells(TA cells). The extract is prepared by culturing and crushing the bacteria with a homogenizer.

    Abstract translation: 目的：提供含有双歧杆菌提取物的组合物，以增强干细胞的干性和增强美容的脂肪。 构成：用于增强脂肪干细胞的干性的组合物含有0.0001-10重量％的双歧杆菌提取物作为活性成分。 干细胞是人类脂肪来源的干细胞（hADSCs）。 用于增强皮肤细胞的组合物含有0.0001-10重量％的提取物作为活性成分。 皮肤细胞是角质形成细胞干细胞（KSC）或转运扩增细胞（TA细胞）。 通过用均化器培养和破碎细菌来制备提取物。

    인간 중간엽줄기세포의 분화 촉진용 조성물
    56.
    发明公开
    인간 중간엽줄기세포의 분화 촉진용 조성물 无效
    促进人类间质干细胞分化的组合物

    公开(公告)号：KR1020120026689A

    公开(公告)日：2012-03-20

    申请号：KR1020100088716

    申请日：2010-09-10

    Applicant: (주)아모레퍼시픽

    Inventor： 신동욱 ,  최현 ,  노민수

    IPC: A61K36/282 ,  A61K8/97 ,  C12N5/077 ,  A61Q19/08

    CPC classification number: A61K36/282 ,  A61K8/97 ,  A61K2800/86 ,  A61Q19/08 ,  C12N5/0669 ,  C12N2506/1353

    Abstract: PURPOSE: A composition for promoting human mesenchymal stem cell differentiation is provided to enhance skin volume and elasticity and to improve anti-wrinkling. CONSTITUTION: An external use skin composition for promoting adipocytes contains 0.0001-30 wt% of Artemisia asiatica extract as an active ingredient. The composition promotes differentiation of mesenchymal stem cells into adipocytes. The mesenchymal stem cells are derived from human body. A pharmaceutical composition for promoting differentiation into adipocytes contains the extract as an active ingredient. The dose of the extract is 0.001 mg/kg/day-2,000 mg/kg/day.

    Abstract translation: 目的：提供促进人间质干细胞分化的组合物，以增强皮肤体积和弹性，并改善抗皱纹。 构成：用于促进脂肪细胞的外用皮肤组合物含有0.0001-30重量％的亚洲艾蒿提取物作为活性成分。 该组合物促进间充质干细胞分化为脂肪细胞。 间充质干细胞来源于人体。 用于促进脂肪细胞分化的药物组合物含有提取物作为活性成分。 提取物的剂量为0.001mg / kg /天-2000mg / kg /天。

    인간 중간엽줄기세포의 분화 촉진용 조성물
    57.
    发明公开
    인간 중간엽줄기세포의 분화 촉진용 조성물 无效
    促进人类间充质干细胞分化的组成

    公开(公告)号：KR1020120009183A

    公开(公告)日：2012-02-01

    申请号：KR1020100071135

    申请日：2010-07-23

    Applicant: (주)아모레퍼시픽

    Inventor： 신동욱 ,  노민수 ,  심중현 ,  최현

    IPC: A61K36/53 ,  A61K8/97 ,  A61P17/00 ,  A61Q19/00

    Abstract: PURPOSE: A composition containing Potulacae Grandiflorae Herba extract is provided to promote differentiation of human mesenchymal stem cells into adipocytes. CONSTITUTION: An external use skin composition for promoting differentiation of human mesenchymal stem cells into adipocytes contains 0.0001-30 wt% of Potulacae Grandiflorae Herba extract as an active ingredient. A pharmaceutical composition for promoting the differentiation contains the Potulacae Grandiflorae Herba extract as an active ingredient. The dose of the Potulacae Grandiflorae Herba extract is 0.001mg/kg-2000mg/kg per day.

    Abstract translation: 目的：提供含有甘草提取物的组合物，以促进人间充质干细胞分化为脂肪细胞。 构成：用于促进人类间充质干细胞分化为脂肪细胞的外用皮肤组合物含有0.0001-30重量％的Pot草提取物作为活性成分。 用于促进分化的药物组合物含有大戟草作为活性成分。 Pot草提取物的剂量为0.001mg / kg-2000mg / kg /天。

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