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公开(公告)号：KR1020130048986A
公开(公告)日：2013-05-13
申请号：KR1020110113947
申请日：2011-11-03
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A manufacturing method of an amphiphilic block copolymer is provided to simplify synthesis of a RAFT polymerization method which can accurately control molecular weight without a metallic catalyst, and to obtain uniform size distribution. CONSTITUTION: An amphiphilic block copolymer comprises polyester as a hydrophobic block, and polyphosphoryl choline as a hydrophilic block. A manufacturing method of the amphiphilic block copolymer comprises: a step of polymerizing a polyester block through ring-opening polymerization; a step of adding a chain-moving reactant into the polyester block; and a step of adding phosphoryl choline into the polyester block, and polymerizing a polyester-polyphosphoryl chlorine block copolymer by a living radical method.
Abstract translation: 目的：提供两亲嵌段共聚物的制造方法，以简化无需金属催化剂即可精确控制分子量并获得均匀尺寸分布的RAFT聚合方法的合成。 构成：两亲嵌段共聚物包含作为疏水嵌段的聚酯和作为亲水嵌段的聚磷酰胆碱。 两亲嵌段共聚物的制造方法包括：通过开环聚合聚合聚酯嵌段的步骤; 将链移动反应物添加到聚酯嵌段中的步骤; 以及将磷酰胆碱添加到聚酯嵌段中，通过活性自由基聚合聚酯多聚磷酰氯嵌段共聚物的工序。
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公开(公告)号：KR101040393B1
公开(公告)日：2011-06-09
申请号：KR1020080075927
申请日：2008-08-04
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 해조류 섬유를 유효성분으로 함유하는 화장료 조성물에 관한 것으로, 보다 상세하게는 해조류 섬유를 함유함으로써 피부 보습을 향상시키며, 유해물질을 흡착하고, 해조류의 천연 영양 성분을 피부에 전달할 수 있으며 화장료의 점도와 경도를 향상시킬 수 있는 화장료 조성물에 관한 것이다.
해조류 섬유, 해조류 펄프, 화장품, 스킨케어, 보습, 황사, 흡착, 세정제, 천연 다공성 섬유-
公开(公告)号：KR2020100004810U
公开(公告)日：2010-05-11
申请号：KR2020080014566
申请日：2008-10-31
Applicant: (주)아모레퍼시픽
CPC classification number: A61H23/006 , A61H23/004 , A61H2201/1215 , A61H2201/5023 , A61N2005/1087
Abstract: 본 고안은 충격파 미용기기에 관한 것으로, 구동모터에 의한 연속적인 회전 구동에 의해 단속적으로 탄성 압착되는 탄성스프링의 탄성력에 의해 충격해머가 일정 주기로 충격전달부를 타격하도록 구성됨으로써, 기계적인 메카니즘에 의해 충격파가 발생되어 구조가 단순하고 부품수 및 제작 비용이 감소하며 제작이 용이하고, 특히 충격파에 의한 지방세포 파괴 능력이 우수한 형태의 충격파 미용기기를 제공한다.
충격파, 미용기기, 탄성스프링, 충격해머-
公开(公告)号：KR1020100015042A
公开(公告)日：2010-02-12
申请号：KR1020080075927
申请日：2008-08-04
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition containing sea algae fiber as an active ingredient is provided to remove harmful materials by adsorbing and transfer natural nutrition ingredients. CONSTITUTION: A cosmetic composition contains 0.01-20 weight% of sea algae fiber as an active ingredient. The sea algae fiber is obtained from green laver, chlorella, cosmarium, closterium, hearing and green laver including gelidium amansii, gracilaria, the nose soil. The supino island, gigartina, laver, injury, the glue plant, pterocladia, acanthopeltis japonica, gracilaria, visible gelidium jelly, ceramium kondoi, brown seaweed, laminaria japonica, gulfweed, ecklonia cava, and ecklonia stolonifera. The cosmetic composition is used in the form of skin softener, massage cream, lotion, ointment, gel, lipstick, mascara, cleansing oil, cleansing cream, spray, powder, foundation, eye shadow, foam cleanser or shampoo.
Abstract translation: 目的：提供含有海藻纤维作为活性成分的化妆品组合物，通过吸收和转移天然营养成分来除去有害物质。 构成：化妆品组合物含有0.01-20重量％的海藻纤维作为活性成分。 海藻纤维由绿色紫菜，小球藻，海藻，ium ium，听觉和绿色紫菜获得，包括枸杞子，江ia，鼻土。 上野岛，吉格加特，紫菜，伤害，胶水植物，蕨类植物，j ica，江楂，可见的枸杞，檀香，棕色海藻，aria粳，草甘膦，ecklonia cava和ecklonia stolonifera。 化妆品组合物以皮肤柔软剂，按摩霜，洗剂，软膏，凝胶，口红，睫毛膏，清洁油，清洁霜，喷雾剂，粉剂，粉底，眼影，泡沫清洁剂或洗发剂的形式使用。
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公开(公告)号：KR100851044B1
公开(公告)日：2008-08-12
申请号：KR1020070083905
申请日：2007-08-21
Applicant: (주)아모레퍼시픽
Abstract: 3,5-Dihydroxy benzamide derivatives are provided to whiten the skin due to a depigmenting activity and improve stability in aqueous solution and organic solvent in formulation by inhibiting structure change. A cosmetic composition for whitening the skin comprises 0.01-20 wt.% of 3,5-dihydroxy benzamide derivatives represented by a formula(1), wherein a hydroxyl group is located in the 2,3-, 2,4-, 2,5-, 3,4- or 3,5-site, and is used in forms of emulsion, cream, cosmetic lotion, essence, pack, gel, powder, makeup base, foundation, lotion, ointment, patch, beauty solution, cleansing foam, cleansing cream, cleansing water, body lotion, body cream, body oil, body essence, shampoo, rinse, body cleanser, soap, hair dye or spray.
Abstract translation: 提供3,5-二羟基苯甲酰胺衍生物，由于脱色活性而使皮肤变白，并通过抑制结构变化提高配方中水溶液和有机溶剂的稳定性。 用于使皮肤美白的化妆品组合物包含0.01-20重量％的由式（1）表示的3,5-二羟基苯甲酰胺衍生物，其中羟基位于2,3-，2,4-， 5-，3,4-或3,5-位，并以乳液，霜剂，化妆水，精华，包装，凝胶，粉末，化妆底，粉底，洗剂，软膏，贴片，美容液，清洁剂的形式使用 泡沫，清洁霜，清洁水，身体乳液，身体霜，身体油，身体精华，洗发水，漂洗，身体清洁剂，肥皂，染发剂或喷雾剂。
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Patent Agency Ranking
公开(公告)号：KR100845511B1
公开(公告)日：2008-07-10
申请号：KR1020070029253
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07D317/68 , A61K31/357
Abstract: A hydroxamic acid derivative is provided to induce the activity increase of each promoter of IDH3alpha and CPT1 involving with energy consumption metabolism, thereby being usefully used for preventing or treating diseases related to dyslipidemia such as obesity, hyperlipidemia and diabetes. A hydroxamic acid is represented by a formula(1), wherein R1 is CONH, NHCO, CONR4 or NR4CO(where R4 is H or C1-10 alkyl); R2 is -(CH2)n-(where n is 0 or 1); and R3 is H or C1-10 alkyl. A method for preparing the hydroxamic acid comprises the steps of: (a) reacting an anhydrous compound synthesized by reacting ethyl chloroformate with piperonic acid using pyridine or N-methyl morpholine as a solvent with methyl 4-amino benzoate or 4-amino phenyl acetic acid ethyl ester at a temperature of 10-20 deg.C using pyridine or N-methyl morpholine as a solvent to prepare a benzamide compound; (b) reacting the benzamide with an alkyl halide selected from the group consisting of bromomethane, bromoethane, bromopropane, bromo isopropane, bromo butane, and bromo tert-butane to substitute an amide bond of the benzamide with an alkyl group; (c) hydrolyzing methyl ester in the benzamide obtained from the step(a) or the benzamide compound obtained from the step(b) to prepare an acid and reacting the acid with ethyl chloroformate using pyridine or N-methyl morpholine as a solvent to covert the acid into an anhydrous compound; and (d) reacting the anhydrous compound with hydroxyl amine chloride or N-methyl hydroxyl amine chloride at a temperature of 0-10 deg.C using pyridine or N-methyl morpholine as a solvent to obtain the product of the formula(1). An agent for anti-obese, treating diabetes or hyperlipidemia comprises the hydroxamic acid.
Abstract translation: 提供异羟肟酸衍生物以诱导与能量代谢相关的IDH3α和CPT1的每种启动子的活性增加，从而有效地用于预防或治疗与脂肪血症如肥胖症，高脂血症和糖尿病有关的疾病。 异羟肟酸由式（1）表示，其中R1是CONH，NHCO，CONR4或NR4CO（其中R4是H或C1-10烷基）; R2是 - （CH2）n-（其中n是0或1）; 并且R 3是H或C 1-10烷基。 制备异羟肟酸的方法包括以下步骤：（a）使吡啶或N-甲基吗啉作为溶剂与4-氨基苯甲酸甲酯或4-氨基苯基乙酸反应，使氯甲酸乙酯与胡椒酸反应合成的无水化合物 乙酯，使用吡啶或N-甲基吗啉作为溶剂，在10-20℃的温度下制备苯甲酰胺化合物; （b）使苯甲酰胺与选自溴甲烷，溴乙烷，溴丙烷，溴异丙烷，溴丁烷和溴叔丁烷的烷基卤反应，以苯甲酰胺与烷基取代; （c）水解由步骤（a）获得的苯甲酰胺中的甲酯或由步骤（b）获得的苯甲酰胺化合物制备酸，并使用吡啶或N-甲基吗啉作为溶剂使酸与氯甲酸乙酯反应，从而使 将酸变成无水化合物; 和（d）使用吡啶或N-甲基吗啉作为溶剂，在0-10℃的温度下使无水化合物与羟胺或N-甲基羟胺氯化物反应，得到式（1）的产物。 用于抗肥胖，治疗糖尿病或高脂血症的药物包括异羟肟酸。
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公开(公告)号：KR100837186B1
公开(公告)日：2008-06-13
申请号：KR1020060095279
申请日：2006-09-29
Applicant: (주)아모레퍼시픽
IPC: C07C233/11 , C07C233/21
Abstract: 본 발명은 하기 화학식 1로 표시되는 항노화 효과를 나타내는 레티노익산(Retinoic acid) 유도체 및 이의 제조방법에 관한 것이다:
[화학식 1]
[상기 화학식 1에서, R
1 은 수소, 직쇄 또는 분쇄의 (C
1 -C
7 )알킬 또는 (C
3 -C
7 )시클로알킬이고; R
2 는 히드록시, 1~4개의 히드록시기가 치환된 직쇄 또는 분쇄의 (C
1 -C
7 )알킬 또는 히드록시피라논이 치환된 직쇄 또는 분쇄의 (C
1 -C
5 )알킬이다.]
또한 본 발명은 상기 화학식 1의 레티노익산 유도체를 유효성분으로 함유하는 피부노화 방지용 피부 외용제 조성물에 관한 것이다.
레티노익산 * 레티노익산 수용체 * 항노화 * 콜라겐 * 콜라게나아제 발현억제 * 주름 개선 * 피부 외용제-
58.发明公开카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含皮肤抑制剂G抑制剂以防止皮肤老化的筛选组合物和用于开发抗病材料的筛选方法
公开(公告)号：KR1020080040612A
公开(公告)日：2008-05-08
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: A skin external composition comprising a cathepsin G inhibitor is provided to prevent an adhesion protein from being degraded by intrinsic aging and photo-aging, reduce the production of metalloproteinase and inhibit the activity of metalloproteinase, thereby being more potent anti-aging substance than existing anti-aging substances. A method for screening anti-aging materials is provided to develop the anti-aging materials which effectively inhibit the quantitative and qualitative increase of metalloproteinase, resulting from the degradation of an adhesion protein by cathepsin G in skin cells without direct UV irradiation. A skin external composition for preventing skin aging comprises 0.01-10 wt% a cathepsin G inhibitor as an effective ingredient, wherein the cathepsin G inhibitor is at least one selected from the group consisting of compounds represented by formulae(1) to (4). The composition is formulated into skin lotion, astringent lotion, milk lotion, nourishing cream, essence, massage cream, eye cream, pack, body lotion, body cream, body oil or body essence. A method for screening an anti-aging material comprises the steps of: (a) adding an anti-aging candidate material to a substrate in the presence of cathepsin G enzyme; and (b) measuring the inhibition of activity of the cathepsin G enzyme. Further, the measure of the inhibition of activity of the cathepsin G enzyme is performed by measuring a concentration of a produced metalloprotease.
Abstract translation: 提供包含组织蛋白酶G抑制剂的皮肤外用组合物，以防止粘附蛋白由于内在老化和光老化而降解，减少金属蛋白酶的产生并抑制金属蛋白酶的活性，从而比现有的抗老化物质更有效的抗衰老物质 化学物质。 提供了一种筛选抗衰老材料的方法，以开发有效抑制金属蛋白酶定量和定性增加的抗衰老材料，这是由皮肤细胞中组织蛋白酶G在组织蛋白酶G中的降解引起的，而不需要直接的紫外线照射。 用于防止皮肤老化的皮肤外用组合物包含0.01-10重量％的组织蛋白酶G抑制剂作为有效成分，其中组织蛋白酶G抑制剂是选自由式（1）至（4）表示的化合物中的至少一种。 该组合物配制成皮肤洗剂，收敛剂，乳液，滋养霜，精华液，按摩霜，眼霜，包装，身体乳液，身体霜，身体油或身体精华。 用于筛选抗衰老材料的方法包括以下步骤：（a）在组织蛋白酶G酶存在下将抗老化候选材料加入到底物中; 和（b）测量组织蛋白酶G酶的活性的抑制。 此外，组织蛋白酶G酶的活性的抑制的测量是通过测量产生的金属蛋白酶的浓度进行的。
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59.发明授权엘라스테아제 저해 효과를 갖는 3,5-디히드록시벤조산유도체 화합물과 그 제조방법 및 이를 함유하는 항노화화장료 조성물 有权,5-라스테아제저해효과를갖갖갖는,5- ,5- 3 3 3 3 3 3 3 3 3 3 3 3
公开(公告)号：KR100726280B1
公开(公告)日：2007-06-11
申请号：KR1020060035603
申请日：2006-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C233/65 , C07C235/64
Abstract: Provided is a 3,5-dihydroxybenzoic acid derivative, which shows an elastase inhibitory effect and an excellent effect of scavenging free radicals generated by UV irradiation, has an excellent anti-aging effect, and is useful for an anti-aging cosmetic composition. The 3,5-dihydroxybenzoic acid derivative is a compound represented by a formula 1, substituted with hydroxyl groups at 3,5-position thereof and the amide group being substituted with a bulky substituent. The 3,5-dihydroxybenzoic acid derivative is obtained by the method comprising the steps of: (A) reacting 3,5-dihydroxybenzoic acid with acetic anhydride to form 3,5-diacetyloxybenzoic acid; (B) forming an amide compound from the 3,5-diacetyloxybenzoic acid by using ethyl chloroformate and an oleophilic group; and (C) hydrolyzing the acetyl group of the amide compound to provide a 3,5-dihydroxybenzoic acid derivative.
Abstract translation: 本发明提供一种3,5-二羟基苯甲酸衍生物，其显示出弹性蛋白酶抑制作用，并且通过UV照射产生的清除自由基的优异效果，具有优异的抗老化作用，并且可用于抗老化化妆品组合物。 3,5-二羟基苯甲酸衍生物是由式3表示的化合物，其3,5-位被羟基取代且酰胺基被大体积取代基取代。 3,5-二羟基苯甲酸衍生物通过包括以下步骤的方法获得：（A）使3,5-二羟基苯甲酸与乙酸酐反应形成3,5-二乙酰氧基苯甲酸; （B）通过使用氯甲酸乙酯和亲油基团由3,5-二乙酰氧基苯甲酸形成酰胺化合物; 和（C）水解酰胺化合物的乙酰基得到3,5-二羟基苯甲酸衍生物。
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公开(公告)号：KR1020070039668A
公开(公告)日：2007-04-13
申请号：KR1020050094794
申请日：2005-10-10
Applicant: (주)아모레퍼시픽
CPC classification number: C01B33/18 , A61K8/0279 , A61K8/25 , A61Q19/007 , C01P2004/61 , C01P2006/12 , C01P2006/16
Abstract: 본 발명은 펜타에리스리톨 유도체가 포집된 메조포러스 다공성 실리카 복합 분체 및 그 제조방법에 관한 것으로서, 보다 상세하게는 높은 흡유량을 가진 다공성 실리카에 피부 각질층의 수분 유지 능력을 향상시키고, 특히 건조환경에서도 높은 보습력을 보이는 펜타에리스리톨 유도체가 포집된 메조포러스 다공성 실리카 복합 분체 및 그 제조방법에 관한 것이다.
펜타에리스리톨 유도체, 수분유지능력, 보습력, 다공성 실리카
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