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51.发明公开폴리에틸렌글리콜-폴리에틸렌이민-비이온성 폴리아미노산을 포함하는 양친성 공중합체, 이의 제조방법 및 상기 공중합체를 포함하는 약물 전달체 조성물 有权包含聚乙烯醇 - 聚乙烯胺 - 非离子型聚氨酯酸的聚合共聚物，包含共聚物的方法和药物递送组合物
公开(公告)号：KR1020110011129A
公开(公告)日：2011-02-08
申请号：KR1020090068631
申请日：2009-07-28
Applicant: 가톨릭대학교 산학협력단
Abstract: PURPOSE: An amphiphilic copolymer is provided to enable use as a drug delivery composition stable for ionic strength and to control hydrophobicity of the copolymer according to the content of non-ionic amino acids. CONSTITUTION: A method for preparing a polyethyleneglycol-polyethylenimine-nonionic poly amino acid comprises the steps of: (i) covalently bonding polyethyleneglycol and polyethylenimine; (ii) synthesizing non-ionic amino acid N-carboxy anhydride by reacting non-ionic amino acid with a solution in which a triphosgene catalyst is dissolved in a 1,4-dioxane solvent; and (iii) synthesizing an nonionic polyamino acid by reacting the covalently-bonded polyethyleneglycol-polyethylenimine and the synthesized non-ionic amino acid N-carboxy anhydride in an organic solvent.
Abstract translation: 目的：提供两亲性共聚物，以使其能够用作对于离子强度稳定的药物递送组合物，并根据非离子氨基酸的含量来控制共聚物的疏水性。 构成：制备聚乙二醇 - 聚乙烯亚胺 - 非离子聚氨基酸的方法包括以下步骤：（i）共聚键合聚乙二醇和聚乙烯亚胺; （ii）通过使非离子氨基酸与三光气催化剂溶解在1,4-二恶烷溶剂中的溶液反应合成非离子氨基酸N-羧酸酐; 和（iii）通过共价键合的聚乙二醇 - 聚乙烯亚胺和合成的非离子氨基酸N-羧酸酐在有机溶剂中反应来合成非离子聚氨基酸。
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公开(公告)号：KR1020100100495A
公开(公告)日：2010-09-15
申请号：KR1020090019415
申请日：2009-03-06
Applicant: 가톨릭대학교 산학협력단
IPC: A61K9/14 , B82Y5/00 , B82Y30/00 , A61K31/737
CPC classification number: A61K9/14 , A61K9/0019 , A61K31/737 , B82Y5/00
Abstract: PURPOSE: A nanoparticle formed of alkanoylated sulfate-containing polysaccharide is provided to ensure biocompatibility without toxicity and to reduce aggregation of nanoparticles. CONSTITUTION: A nanoparticle is formed by autoagglutination of alkanoylated and amphipathic sulfate group-containing polysaccharide and drug. The sulfate group-containing polysaccharide is chondroitin sulfate, dermatan sulfate, heparan sulfate or sulfuric acid curdlan. The sulfate group-containing polysaccharide is acetylated. A method for preparing the nanoparticles comprises: a step of dissolving sulfate group-containing polysaccharide and C2-C4 alkanoic acid anhydride in a solvent to obtain C2-C4 alkanoylate-sulfate group-containing polysaccharide product; a step of mixing the product with water to precipitate C2-C4 alkanoylated sulate group-containing polysaccharide; a step of dissolving polysaccharide and drug in the drug; a step of forming nanoparticles by autoagglutination; a step of freeze-drying the nanoparticles; and a step of collecting the nanoparticles.
Abstract translation: 目的：提供由含链烷酰化硫酸盐的多糖形成的纳米颗粒，以确保生物相容性，无毒性，并减少纳米颗粒的聚集。 构成：通过烷基化和两性硫酸酯基多糖和药物的自凝集形成纳米颗粒。 含硫酸基团的多糖是硫酸软骨素，硫酸皮肤素，硫酸乙酰肝素或硫酸凝乳胶。 含硫酸基团的多糖被乙酰化。 制备纳米颗粒的方法包括：将含硫酸酯基的多糖和C 2 -C 4链烷酸酐溶解在溶剂中以得到含C 2 -C 4链烷酰硫酸酯基的多糖产物的步骤; 将产物与水混合以沉淀出C2-C4烷酰基化的含有多糖的多糖的步骤; 将多糖和药物溶解在药物中的步骤; 通过自凝集形成纳米颗粒的步骤; 冷冻干燥纳米颗粒的步骤; 和收集纳米颗粒的步骤。
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公开(公告)号：KR1020100084023A
公开(公告)日：2010-07-23
申请号：KR1020090003411
申请日：2009-01-15
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K9/1617 , A61K31/40 , B82Y5/00
Abstract: PURPOSE: A lipid nano microsphere containing hydrophobic photosensitizer is provided to prevent side effect by fluorescence and to enable diagnosis and treatment by photosensitizer. CONSTITUTION: A lipid nano microsphere containing hydrophobic photosensitizer with saturated lipid and unsaturated lipid by biocompatible surfactant. The hydrophobic photosensitizer shows fluorescence in near infrared ray. The biocompatible surfactant has hydrophobic tumor targeting material which is bound to biocompatible aqueous polymer. The hydrophobic tumor targeting material is folic acid, antibody, cobalamin, vitamin A, vitamin C, or vitamin B12.
Abstract translation: 目的：提供含有疏水性光敏剂的脂质纳米微球，以防止荧光发生副作用，并可通过光敏剂进行诊断和治疗。 构成：通过生物相容性表面活性剂含有饱和脂质和不饱和脂质的疏水性光敏剂的脂质纳米微球。 疏水性光敏剂在近红外线中显示出荧光。 生物相容性表面活性剂具有与生物相容性水性聚合物结合的疏水性肿瘤靶向材料。 疏水性肿瘤靶向物质是叶酸，抗体，钴胺素，维生素A，维生素C或维生素B12。
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公开(公告)号：KR100964372B1
公开(公告)日：2010-06-17
申请号：KR1020070124918
申请日：2007-12-04
Applicant: 가톨릭대학교 산학협력단
Abstract: 본 발명은 폴리에틸렌이민 또는 폴리에틸렌이민이 레티놀, 담즙산, 콜레스테롤, 토코페롤, 칼시페롤, 및 비타민 K로 구성된 그룹에서 선택된 소수성 분자와의 아미드 결합에 의해 형성된 양친매성 물질로 형성된 미셀 형태의 나노 입자가 암세포가 분비하는 가수분해 효소에 의해 생분해될 수 있는 음이온성 고분자 물질로 코팅된 암 치료용 복합체, 그 제조방법, 그 암 치료용 복합체를 포함하는 주사제를 제공한다.
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公开(公告)号：KR1020090058233A
公开(公告)日：2009-06-09
申请号：KR1020070124918
申请日：2007-12-04
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K47/36 , A61K9/0019 , A61K31/785 , A61K2121/00
Abstract: A complex for treating cancer is provided to reduce side effect by coating a polyethyleneimine with anion polymer and improve the anticancer effect. A polyethyleneimine of complex for treating cancer is coated with anionic polymer. The anionic polymer is biodegraded by hydrolase. An amphiphilic derivative of polyethyleneimine is formed by the amide bond between the polyethyleneimine and hydrophobic molecule. The hydrophobic molecule is selected from a group of retinol, bile acid, cholesterol, tocopherol, antirhachitic vitamin and vitamin K.
Abstract translation: 提供了用于治疗癌症的复合物，以通过用阴离子聚合物涂覆聚乙烯亚胺来降低副作用，并提高抗癌作用。 用于治疗癌症的复合物的聚乙烯亚胺包被阴离子聚合物。 阴离子聚合物被水解酶生物降解。 聚乙烯亚胺的两亲性衍生物由聚乙烯亚胺与疏水性分子之间的酰胺键形成。 疏水性分子选自视黄醇，胆汁酸，胆固醇，生育酚，抗穿心素维生素和维生素K.
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Patent Agency Ranking
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公开(公告)号：KR102007278B1
公开(公告)日：2019-08-06
申请号：KR1020180006044
申请日：2018-01-17
Applicant: 가톨릭대학교 산학협력단
IPC: G01N33/569 , G01N33/545 , A61K41/00
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公开(公告)号：KR101886132B1
公开(公告)日：2018-08-07
申请号：KR1020130146359
申请日：2013-11-28
Applicant: 가톨릭대학교 산학협력단
Abstract: 본발명은흡수촉진제가함유된약물방출용스텐트코팅용조성물, 상기조성물로코팅된약물방출용스텐트및 상기스텐트의제조방법에관한것이다. 본발명에따른흡수촉진제가함유된약물방출용스텐트코팅용조성물로코팅된스텐트는코팅된피막으로부터약물과흡수촉진제가동시에방출가능한효과가있고, 조직내부로약물의침투율을증진시킬수 있는효과가있어종래의료용스텐트에비해치료효과를향상시킬수 있다.
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公开(公告)号：KR101797873B1
公开(公告)日：2017-11-14
申请号：KR1020160115673
申请日：2016-09-08
Applicant: 가톨릭대학교 산학협력단
Abstract: 본발명은고분자또는지질, α-리포익산, 광감작제및 약물을포함하는약물전달체에관한것으로, 보다상세하게는상기약물전달체에광원조사시, 광감작제가활성산소종인일항산소를발생시키고, 상기발생된일항산소를약물전달체에포함된α-리포익산이소거하면서약물이방출되는것이확인됨에따라, 상기약물전달체는α-리포익산의항산화능과광감작제의활성산소종생성능을동시에나타낼수 있으므로, 선택적인활성산소종의발생및 소거과정을이용하여약물방출이조절되는신규한약물전달체로제공될수 있다.
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