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公开(公告)号：KR101271696B1
公开(公告)日：2013-06-05
申请号：KR1020110009823
申请日：2011-01-31
Applicant: 고려대학교 산학협력단
CPC classification number: A61M5/1723 , A61K41/0052 , A61M31/002 , H01P11/003 , H01Q1/22 , H01Q17/002 , Y10T29/49016
Abstract: 본 발명은 나노 안테나를 포함하는 구조체, 이의 제조 방법, 이를 포함하는 약물 전달체, 온열 치료용 복합체, 약물 치료 장치 및 온열 치료 장치에 관한 것이다. 본 발명의 구조체는, 다공성 마이크로 컨테이너의 외부 표면에 나노 안테나 패턴이 형성되어 있어, 외부에서 무선으로 제어가 가능하고, 이를 약물 전달체 및 온열 치료용 복합체로서 활용하는 경우, 생체 내부의 원하는 적용 부위에서 원하는 시간에 따라 약물 치료 및 온열 치료를 할 수 있다. 또한, 본 발명의 구조체는 나노 안테나를 통해 외부 제어부와 무선 신호의 송신 및 수신이 가능하므로, 생체 내부의 신호를 감지하여 외부 제어부에 전송하고, 외부 제어부로터 전송된 대응 신호에 따라 약물 또는 나노 와이어 등을 방출할 수 있다.
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公开(公告)号：KR1020120089211A
公开(公告)日：2012-08-09
申请号：KR1020120009965
申请日：2012-01-31
Applicant: 고려대학교 산학협력단
CPC classification number: A61K41/0052 , A61B18/18 , A61B34/73 , A61B2017/00345 , A61K9/70 , A61L31/16 , A61N1/40 , A61N2/06
Abstract: PURPOSE: A rotating nano wire and a method for inducing cell eradication using the same are provided to rotates the nano wire inserted in the cell in a magnetic field application process by using a magnetic nano wire with a dipole. CONSTITUTION: A composition for cell eradication includes a magnetic nano wire with a dipole. The nano wire is composed of a metal nano wire or a magnetic material nano wire. The metal is formed by gold, platinum, palladium, copper, aluminum or their alloy. The magnetic material is composed of nickel, cobalt, iron, gadolinium, their alloy or their oxide. The dipole is formed on both ends of the nano wires.
Abstract translation: 目的：提供旋转的纳米线和使用其的诱导细胞消除的方法，以通过使用具有偶极子的磁性纳米线来使插入细胞的纳米线在磁场施加过程中旋转。 构成：用于细胞消除的组合物包括具有偶极子的磁性纳米线。 纳米线由金属纳米线或磁性材料纳米线组成。 金属由金，铂，钯，铜，铝或其合金形成。 磁性材料由镍，钴，铁，钆，它们的合金或其氧化物组成。 偶极子形成在纳米线的两端。
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公开(公告)号：KR1020110049724A
公开(公告)日：2011-05-12
申请号：KR1020100108877
申请日：2010-11-03
Applicant: 서울대학교산학협력단 , 고려대학교 산학협력단
CPC classification number: C07K7/08 , A61K38/00 , A61K39/0011 , A61K2039/55555 , C07K7/06 , C07K14/001 , C07K14/47 , A61K47/50 , C07K17/14
Abstract: PURPOSE: A composite of zinc oxide nanoparticles and proteins containing zinc oxide-binding peptides is provided to modify biocompatibility of zinc oxide nanoparticles. CONSTITUTION: A composite of proteins contains zinc oxide-binding peptides and zinc oxide nanoparticles. The zinc oxide-binding peptide has a structure of [(Arg-X_1-X_2-Arg)_m-linker]_n, [(Arg-X_1-X_2-Arg-Lys)_m-linker]_n. In the formula, X_1 is Pro, Ala, Thr, Gln, or Ile; X_2 is His, Ile, Asn, or Arg. The zinc oxide-binding peptide has an amino acid sequence selected from the sequence numbers 1-4.
Abstract translation: 目的：提供氧化锌纳米粒子和含有氧化锌结合肽的蛋白质复合物，以改善氧化锌纳米粒子的生物相容性。 构成：蛋白质复合物含有氧化锌结合肽和氧化锌纳米粒子。 氧化锌结合肽具有[（Arg-X_1-X_2-Arg）_m-接头] n，[（Arg-X_1-X_2-Arg-Lys）-m-接头]]的结构。 在该式中，X_1为Pro，Ala，Thr，Gln或Ile; X_2是His，Ile，Asn或Arg。 氧化锌结合肽具有选自序列号1-4的氨基酸序列。
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公开(公告)号：KR100759716B1
公开(公告)日：2007-10-04
申请号：KR1020060093351
申请日：2006-09-26
Applicant: 고려대학교 산학협력단
CPC classification number: B82Y25/00 , B22F1/02 , B22F9/24 , B22F2998/00 , C22C2202/02 , H01F1/0054 , Y10T428/2991 , B22F1/0018
Abstract: A bifunctional nanoparticles consisting of magnetic core-semiconductor shell structure, and a method of manufacturing the particles are provided for improving degree of chrystallization and chemical stability of the nanoparticles. A bifunctional nanoparticles consists of a magnetic core and a semiconductor shell. A method of manufacturing the bifunctional nanoparticles consisting of magnetic core-semiconductor shell structure comprises steps of: mixing a magnetic core matter precursor[for example, Fe(III)(acac)3, 0.5mmol and a reductant for the core matter followed by a solvent for the reductant to form the first mixture solution; heating the first mixture solution up to the first temperature and then cooling the solution to form a magnetic core; mixing a semiconductor shell matter precursor[for example, cadmium acetate(0.7mmol) and selenium(1mmol) in trioctyl phosphine(99.9%, ~3mL] and a reductant for the semiconductor shell matter precursor followed by a solvent for reductant to form the second mixture solution; heating the solution up to the second temperature and then cooling it; and coating the magnetic core with the produced semiconductor shell matter during the reduction reaction. A surfactant is added in the mixture solutions for improving the surface properties of the core and the shell. Among surfactants, tri-block copolymer, PEO-PPO-PEO is preferable. For the precipitation of the nanoparticles, ethanol is added, and then the precipitated nanoparticles are collected by centrifugation.
Abstract translation: 提供由磁芯 - 半导体壳结构组成的双官能纳米颗粒和制造颗粒的方法，用于提高纳米颗粒的结晶度和化学稳定性。 双功能纳米颗粒由磁芯和半导体外壳组成。 制备由磁芯 - 半导体壳结构构成的双功能纳米颗粒的方法包括以下步骤：将磁性核物质前体[例如Fe（III）（acac）3，0.5mmol）和用于核心物质的还原剂 用于还原剂的溶剂以形成第一混合物溶液; 将第一混合物溶液加热至第一温度，然后冷却溶液以形成磁芯; 将半胱氨酸壳质物质前体[例如，乙酸镉（0.7mmol）和硒（1mmol）在三辛基膦（99.9％，〜3mL）中混合，并将半导体壳物质前体的还原剂混合，然后用还原剂溶剂形成第二 混合溶液;将溶液加热至第二温度，然后冷却;在还原反应过程中用生产的半导体壳物质涂覆磁芯，在混合溶液中加入表面活性剂以改善芯的表面性能， 在表面活性剂中，优选三嵌段共聚物PEO-PPO-PEO，为了沉淀纳米颗粒，加入乙醇，然后通过离心收集沉淀的纳米颗粒。
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公开(公告)号：KR20210019767A
公开(公告)日：2021-02-23
申请号：KR20190098793
申请日：2019-08-13
Applicant: 고려대학교 산학협력단
IPC: G01N33/543 , G01N21/65 , G01N33/553
Abstract: 본발명은자성-광학복합나노구조체에관한것으로, 자성-광학복합나노구조체는제 1 코어-쉘나노입자및 제 2 코어-쉘나노입자의이종나노입자들로구성되어자성과광학기능을동시에구현할수 있다.
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公开(公告)号：KR102034381B1
公开(公告)日：2019-10-18
申请号：KR1020180051740
申请日：2018-05-04
Applicant: 고려대학교 산학협력단 , 서울대학교산학협력단
IPC: G01N33/543 , G01N33/553 , G01N33/58 , G01N33/569
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公开(公告)号：KR101916588B1
公开(公告)日：2018-11-07
申请号：KR1020170059757
申请日：2017-05-15
Applicant: 고려대학교 산학협력단
CPC classification number: C25D1/006 , B82B1/002 , B82B3/0023 , F16F1/021 , F16F1/06 , F16F2224/0208 , F16F2226/00
Abstract: 본발명의일 실시예에따른금속나노스프링의제조방법은, 나노기공을가지며, 일면에작업전극을가지는나노템플릿(nano template)을준비하는단계; 아스코르브산 (Ascorbic acid; CHO), 바나듐(IV) 옥사이드설페이트(VOSO·xHO) 및증착하고자하는금속을포함하는금속전구체용액을포함하는제1 금속전구체혼합액을준비하는단계; 상기제1 금속전구체혼합액에질산(Nitric acid; HNO)을혼합하여제2 금속전구체혼합액을준비하는단계; 상기제2 금속전구체혼합액에상기나노템플릿을침지하고, 상기제2 금속전구체혼합액에삽입된상대전극(counter electrode)과상기작업전극사이에전류를인가하여전기도금방식으로상기나노기공에금속나노스프링을증착시키는단계; 및상기금속나노스프링이증착된나노템플릿에서상기작업전극및 상기나노템플릿을선택적으로제거하는단계;를포함한다.
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