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    세포침투성 ＡＭＰ-활성화 단백질 키나아제 및 그 용도
    52.
    发明公开
    세포침투성 ＡＭＰ-활성화 단백질 키나아제 및 그 용도 无效
    细胞转导激活的蛋白激酶及其用途

    公开(公告)号：KR1020110061668A

    公开(公告)日：2011-06-10

    申请号：KR1020090118135

    申请日：2009-12-02

    Applicant: 한림대학교 산학협력단 ,  대한민국(농촌진흥청장)

    Inventor： 권해용 ,  이광길 ,  강석우 ,  여주홍 ,  조유영 ,  최수영 ,  조용준 ,  장상호 ,  음원식 ,  김대원 ,  박진서 ,  조성민 ,  신승훈

    IPC: C12N9/12 ,  C07K19/00 ,  A61K38/45 ,  C12N15/54

    Abstract: PURPOSE: An AMP-activated protein kinase fusion protein is provided to suppress inflammation by intracellular concentration-dependent and time-dependent introduction. CONSTITUTION: A cell permeable AMP-activated protein kinase fusion protein has a protein transport domain which is bound to at least one terminal of the AMP-activated protein kinase. The protein transport domain is PEP-1 peptide. The AMP-activated protein kinase has an amino acid of sequence number 7. A cosmetic composition contains the AMP-activated protein kinase as an active ingredient. A pharmaceutical composition for treating inflammation including type 2 diabetes, obesity, skin cancer, and atopic inflammation contains the AMP-activated protein kinase as an active ingredient and pharmaceutically acceptable carrier.

    Abstract translation: 目的：提供AMP激活的蛋白激酶融合蛋白，以通过细胞内浓度依赖性和时间依赖性介导来抑制炎症。 构成：细胞可渗透的AMP激活蛋白激酶融合蛋白具有蛋白转运结构域，其结合AMP活化蛋白激酶的至少一个末端。 蛋白质转运结构域是PEP-1肽。 AMP活化蛋白激酶具有序列号7的氨基酸。化妆品组合物含有AMP活化蛋白激酶作为活性成分。 用于治疗包括2型糖尿病，肥胖症，皮肤癌和特应性炎症的炎症的药物组合物含有AMP活化蛋白激酶作为活性成分和药学上可接受的载体。

    봉독을 유효성분으로 하는 여드름 예방 및 치료용 조성물
    54.
    发明公开
    봉독을 유효성분으로 하는 여드름 예방 및 치료용 조성물 有权
    包含用于治疗ACNE的BEE​​-VENOMS的组合物

    公开(公告)号：KR1020110011334A

    公开(公告)日：2011-02-08

    申请号：KR1020090068925

    申请日：2009-07-28

    Applicant: 대한민국(농촌진흥청장) ,  동성제약주식회사

    Inventor： 한상미 ,  이광길 ,  여주홍 ,  이양구 ,  한충섭

    IPC: A61K35/64 ,  A61K8/98 ,  A61Q19/08 ,  A61Q19/10

    CPC classification number: A61Q19/00 ,  A61K8/987 ,  A61K35/63 ,  A61Q19/08 ,  A61Q19/10

    Abstract: PURPOSE: A composition containing bee venom for preventing and treating acne is provided to ensure antibacterial activity to Propionibacterium acnes and to help regeneration of skin cells. CONSTITUTION: A composition for preventing or treating acne contains bee venom as an active ingredient. The concentration is 0.0001-10%(w/v). A cosmetic composition for preventing or treating acne contains bee venom as an active ingredient. A body cleansing instrument for preventing or treating acne contains bee venom as an active ingredient. The composition is manufactured in a form of liquids, creams, pastes, or solids. The composition additionally contains aqueous ingredient, oil ingredient, surfactant, moisturizer, tackifier, antiseptic and perfume.

    Abstract translation: 目的：提供含有预防和治疗痤疮的蜂毒组合物，以确保对丙酸杆菌的抗菌活性，并有助于皮肤细胞的再生。 构成：用于预防或治疗痤疮的组合物含有蜂毒作为活性成分。 浓度为0.0001-10％（w / v）。 用于预防或治疗痤疮的化妆品组合物含有蜂毒作为活性成分。 用于预防或治疗痤疮的身体清洁仪器含有蜂毒作为活性成分。 组合物以液体，霜剂，糊剂或固体的形式制造。 该组合物还含有水成分，油成分，表面活性剂，保湿剂，增粘剂，防腐剂和香料。

    저분자 실크 프로테인을 함유하는 화장품 조성물
    58.
    发明公开
    저분자 실크 프로테인을 함유하는 화장품 조성물 有权
    含有丝蛋白的化妆品组合物

    公开(公告)号：KR1020020096607A

    公开(公告)日：2002-12-31

    申请号：KR1020010035294

    申请日：2001-06-21

    Applicant: 대한민국(농촌진흥청장) ,  오마샤리프화장품 주식회사

    Inventor： 여주홍 ,  이광길 ,  이용우 ,  김선여 ,  한충섭 ,  이정호 ,  박창재

    IPC: A61K8/64 ,  A61Q19/00 ,  A61Q19/10

    CPC classification number: A61K8/64 ,  A61K8/987 ,  A61Q19/00 ,  Y10S514/847

    Abstract: PURPOSE: A cosmetic composition with silk protein having excellent absorption properties, water vapor barrier properties, air permeability, etc. is provided which is excellent in product stability and long-term stability as well as a moisturizing effect and gives a natural, non-sticky feel during use. CONSTITUTION: The cosmetic composition contains 0.5 to 10.0% by weight of silk protein. The silk protein is low molecular silk protein obtained by removing soluble sericin, dissolving with a neutral salt and then hydrolyzing polymeric silk protein with protease such as actinase and/or neutrase after removing the salt. The composition is formulated into toilet soap, skin lotion, lotion, cream, pearl-off pack or bathing agent.

    Abstract translation: 目的：提供具有优异的吸收性，水蒸气阻隔性，透气性的丝蛋白的化妆品组合物，其产品稳定性和长期稳定性以及保湿效果优异，赋予天然，不粘 使用感觉 构成：化妆品组合物含有0.5-10.0重量％的丝蛋白。 丝蛋白是通过去除可溶性丝胶蛋白得到的低分子丝蛋白，用中性盐溶解，然后除去盐后用蛋白酶如肌动蛋白酶和/或中性粒子水解聚合丝蛋白。 将组合物配制成香皂，皮肤洗剂，洗剂，奶油，珍珠粉或洗浴剂。

    겔 여과법에 의한 고순도 실크 펩타이드 제조방법
    59.
    发明公开
    겔 여과법에 의한 고순도 실크 펩타이드 제조방법 有权
    使用凝胶过滤生产高纯度丝胶蛋白的方法

    公开(公告)号：KR1020010038269A

    公开(公告)日：2001-05-15

    申请号：KR1019990046185

    申请日：1999-10-23

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 여주홍 ,  이광길 ,  이용우

    IPC: C07K1/16

    CPC classification number: C07K1/16 ,  C07K1/34 ,  C07K14/43586

    Abstract: PURPOSE: A method for producing high purity silk peptides using gel filtration is provided. The silk peptide solution or powder is applied to cosmetics, and food additives and hydrolyzed using protease to prepare silk peptide as pure as oligopeptide of hundreds-thousands units. CONSTITUTION: The method for producing high purity silk peptide comprises the steps of: obtaining silk fibroin from silk proteins under high temperature and pressure to remove sericin from silk proteins; dissolving silk fibroin in 50% CaCl2·H2O·ethanol solution at 95 deg. C for 5 hours; subjecting the silk fibroin solution to gel filtration chromatography packed with 1 to 150 micrometer, preferably 20 to 80 micrometer bead sized media, sephadex G-10 or G-25; and freeze-drying or spray drying the purified silk peptide solution by using a freezing dryer or spray dryer.

    Abstract translation: 目的：提供使用凝胶过滤生产高纯度丝肽的方法。 将丝肽溶液或粉末用于化妆品和食品添加剂，并使用蛋白酶水解制备丝素肽，纯度为数十万单位的寡肽。 构成：生产高纯度丝肽的方法包括以下步骤：在高温高压下从丝蛋白中获得丝心蛋白，从丝蛋白中去除丝胶蛋白; 将丝素蛋白溶解在95％的50％CaCl2·H2O·乙醇溶液中。 C 5小时; 将丝素蛋白溶液经1〜150微米，优选20〜80微米珠粒度培养基，sephadex G-10或G-25填充凝胶过滤色谱; 并使用冷冻干燥器或喷雾干燥器冷冻干燥或喷雾干燥纯化的丝肽溶液。

    실크아미노산 수용액을 이용한 간장류의 제조방법
    60.
    发明公开
    실크아미노산 수용액을 이용한 간장류의 제조방법 有权
    使用丝氨酸酸溶液的制造方法

    公开(公告)号：KR1020010018963A

    公开(公告)日：2001-03-15

    申请号：KR1019990035142

    申请日：1999-08-24

    Applicant: 대한민국(농촌진흥청장) ,  홍영식품 주식회사

    Inventor： 여주홍 ,  이광길 ,  이용우 ,  정인모 ,  임수호 ,  정운영

    IPC: A23L1/238

    Abstract: PURPOSE: A method for manufacturing soy sauce by using silk amino acid solution is provided to increase sugar content of soy sauce by including high concentration silk amino acid and free amino acid of 97.6% in the soy sauce. CONSTITUTION: A variety of soy sauce by using silk amino acid solution comprises the steps of: (1) gaining silk fibroin protein by removing sericin; (2) hydrolyzing the silk fibroin protein to be 50% of the concentration by adding 25% of hydrochloric acid to the silk fibroin protein at 98deg.C for 48hours, and gaining silk amino acid solution of pH 5.0-5.5 by adding sodium hydroxide of 9M; (3) decoloring and deodorizing the silk amino acid solution; and (4) passing the silk amino acid solution through an electric dialyzer or gel filtration. A mixing soy sauce is mixed 40% of brewed soy sauce and 45% of soybean acid-decomposed soy sauce with 15% of the silk amino acid solution, and aged at 90deg.C for 24hours.

    Abstract translation: 目的：提供使用丝氨酸溶液制造酱油的方法，通过在酱油中含有高浓度丝氨酸和97.6％的游离氨基酸来提高酱油的含糖量。 构成：使用丝氨酸溶液制成的各种酱油包括以下步骤：（1）通过去除丝胶蛋白获得丝素蛋白; （2）通过在98℃下向丝蛋白中加入25％的盐酸48小时将丝蛋白蛋白水解成浓度的50％，通过加入氢氧化钠，得到pH5-5-5的丝氨基酸溶液 9M; （3）丝绸氨基酸溶液脱色除臭; 和（4）使丝氨基酸溶液通过电透析器或凝胶过滤。 混合酱油混合40％的酿造酱油和45％的大豆酸分解酱油与15％丝氨基酸溶液混合，并在90℃下老化24小时。

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