세포침투성 AMP-활성화 단백질 키나아제 및 그 용도
    3.
    发明公开
    세포침투성 AMP-활성화 단백질 키나아제 및 그 용도 无效
    细胞转导激活的蛋白激酶及其用途

    公开(公告)号:KR1020110061668A

    公开(公告)日:2011-06-10

    申请号:KR1020090118135

    申请日:2009-12-02

    Abstract: PURPOSE: An AMP-activated protein kinase fusion protein is provided to suppress inflammation by intracellular concentration-dependent and time-dependent introduction. CONSTITUTION: A cell permeable AMP-activated protein kinase fusion protein has a protein transport domain which is bound to at least one terminal of the AMP-activated protein kinase. The protein transport domain is PEP-1 peptide. The AMP-activated protein kinase has an amino acid of sequence number 7. A cosmetic composition contains the AMP-activated protein kinase as an active ingredient. A pharmaceutical composition for treating inflammation including type 2 diabetes, obesity, skin cancer, and atopic inflammation contains the AMP-activated protein kinase as an active ingredient and pharmaceutically acceptable carrier.

    Abstract translation: 目的:提供AMP激活的蛋白激酶融合蛋白,以通过细胞内浓度依赖性和时间依赖性介导来抑制炎症。 构成:细胞可渗透的AMP激活蛋白激酶融合蛋白具有蛋白转运结构域,其结合AMP活化蛋白激酶的至少一个末端。 蛋白质转运结构域是PEP-1肽。 AMP活化蛋白激酶具有序列号7的氨基酸。化妆品组合物含有AMP活化蛋白激酶作为活性成分。 用于治疗包括2型糖尿病,肥胖症,皮肤癌和特应性炎症的炎症的药物组合物含有AMP活化蛋白激酶作为活性成分和药学上可接受的载体。

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