公开(公告)号：KR1020110035195A

公开(公告)日：2011-04-06

申请号：KR1020090092811

申请日：2009-09-30

Applicant: 숙명여자대학교산학협력단

Inventor： 전라옥 ,  류재하 ,  김국화 ,  이다연

IPC: C07C335/32 ,  A61K31/155 ,  C07D209/88 ,  A61P17/06

Abstract: PURPOSE: A phenylisothiourea derivative is provided to enable use as a material for the development of therapeutic agents for diseases caused by excessive formation of NO. CONSTITUTION: A phenylisothiourea derivative or pharmaceutically is represented by chemical formula 1. In chemical formula 1, R^1 is C1~10 alkyl, aryl, C1~10 alkoxy, hydroxyl, halogen or carbazolylethoxy; R^2 is C1~10 alkyl, benzyl or substituted benzyl; R^3 is H or C1~10 alkyl. A method for synthesizing the phenylisothiourea derivative comprises the steps of: (i) polycondensing p-substituted aniline as a starting material with isocyanate to obtain phenylthiourea; and (ii) introducing alkyl or aryl group to phenylthiourea.

Abstract translation: 目的：提供苯基异硫脲衍生物，以使其能够用于开发过量形成NO引起的疾病的治疗剂。 构成：苯基异硫脲衍生物或药学上由化学式1表示。在化学式1中，R 1是C 1-10烷基，芳基，C 1-10烷氧基，羟基，卤素或咔唑基聚乙氧基; R 2是C 1-10烷基，苄基或取代的苄基; R 3是H或C 1-10烷基。 合成苯基异硫脲衍生物的方法包括以下步骤：（i）使用异氰酸酯作为起始原料缩聚对取代的苯胺，得到苯基硫脲; 和（ii）将烷基或芳基引入苯基硫脲。