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51.发明公开
公开(公告)号：KR1020140007218A
公开(公告)日：2014-01-17
申请号：KR1020120074685
申请日：2012-07-09
Applicant: 제주대학교 산학협력단
CPC classification number: A61K36/04 , A61K8/9706 , A61Q17/04 , Y10S514/886
Abstract: The present invention relates to a composition for protecting and treating skin against ultraviolet rays, comprising a Lomentaria hakodatensis extract, and a product for protecting and treating skin against ultraviolet rays, containing the composition. More specifically, the composition for protecting and treating skin against ultraviolet rays, comprising a Lomentaria hakodatensis extract according to the present invention contains a Lomentaria hakodatensis extract which has scavenging activity of intracellular reactive oxygen species (ROS) generated by peroxide (H_2O_2) and UVB radiation, superoxide anions generated by a xanthine/xanthine oxidase system, and hydroxyl radicals generated by Fenton reaction (FeSO_4+H_2O_2), absorbs UVB, and mitigates or reduces the damage to cellular components (e.g., lipid, protein, and DNA) and apoptosis due to oxidative stress that may be caused by UVB, thereby effectively protecting skin cells from the UVB damage. Therefore, the composition according to the present invention can be useful as a raw material of a functional cosmetic composition or a pharmaceutical composition for protecting skin against ultraviolet rays.
Abstract translation: 本发明涉及一种用于保护和治疗紫外线的皮肤的组合物，其包含一种含有所述组合物的洛氏根真菌提取物和用于保护和治疗紫外线的皮肤的产品。 更具体地说，本发明的含有本实用新型的龙胆草提取物的紫外线保护和治疗用组合物含有具有由过氧化物（H_2O_2）和UVB辐射产生的细胞内活性氧（ROS）的清除活性的龙胆 ，由黄嘌呤/黄嘌呤氧化酶系统产生的超氧阴离子和通过Fenton反应（FeSO 4 + H 2 O 2）产生的羟基自由基吸收UVB，减轻或减少对细胞成分（例如脂质，蛋白质和DNA）的损伤和凋亡 可能由UVB引起的氧化应激，从而有效地保护皮肤细胞免受UVB损伤。 因此，根据本发明的组合物可用作功能性化妆品组合物的原料或用于保护皮肤免受紫外线的药物组合物的作用。
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52.发明公开참곱슬이 추출물을 유효성분으로 포함하는 염증질환 또는 면역질환의 예방 및 치료용 조성물 无效用于预防和治疗包含PLOCAMIUM TELFAIRIAE EXTRACT的炎症或免疫疾病的组合物
公开(公告)号：KR1020130117491A
公开(公告)日：2013-10-28
申请号：KR1020120040201
申请日：2012-04-18
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
Abstract: PURPOSE: A composition for preventing and treating inflammatory diseases or immune disease is provided to suppress NO generation and to develop a therapeutic agent for treating inflammatory diseases and immune diseases caused by excessive inflammation. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory diseases or immune diseases contains 5-10 ug/ml of a Plocamium telfairiae extract as an active ingredient. The extract is an ethanol extract. The extract suppresses the generation of IL-12, IL-6, and TNF-alpha and the activities of MAPK and NF-kappaB. The composition suppresses NO generation.
Abstract translation: 目的：提供一种用于预防和治疗炎性疾病或免疫疾病的组合物，以抑制NO产生并开发用于治疗炎性疾病和由过度炎症引起的免疫疾病的治疗剂。 构成：用于预防和治疗炎症性疾病或免疫疾病的药物组合物含有5-10μg/ ml的Pelfamium telfairiae提取物作为活性成分。 提取物是乙醇提取物。 提取物抑制IL-12，IL-6和TNF-α的产生以及MAPK和NF-κB的活性。 该组合物抑制NO产生。
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53.发明公开
公开(公告)号：KR1020130050495A
公开(公告)日：2013-05-16
申请号：KR1020110115586
申请日：2011-11-08
Applicant: 제주대학교 산학협력단
CPC classification number: A61K36/04 , A61K8/9706 , A61Q17/04 , Y10S514/886
Abstract: PURPOSE: A composition containing a Polysiphonia morrowii Harvey extract as an active ingredient is provided to absorb UV rays, to remove intracellular free radicals, and to suppress cell apoptosis due to the irradiation of UV rays. CONSTITUTION: A pharmaceutical composition for suppressing skin damages due to UV rays and treating skin contains a Polysiphonia morrowii Harvey extract as an active ingredient. The extract is prepared by using water, an organic solvent, or a mixture thereof. The extract is an ethanol extract. The extract absorbs UV rays, removes free radicals, and suppresses apoptosis induced by UV rays. The pharmaceutical composition is manufactured in the form of an external use skin formulation selected from the group consisting of cream, gel, a patch, a spray, an ointment, a liniment, a lotion, pasta, and cataplasma.
Abstract translation: 目的：提供含有Polysiphonia morrowii Harvey提取物作为活性成分的组合物，以吸收紫外线，去除细胞内自由基，并抑制紫外线照射引起的细胞凋亡。 构成：用于抑制由紫外线引起的皮肤损伤和处理皮肤的药物组合物含有作为活性成分的Polysiphonia morrowii Harvey提取物。 提取物通过使用水，有机溶剂或其混合物制备。 提取物是乙醇提取物。 提取物吸收紫外线，去除自由基，抑制紫外线诱导的凋亡。 药物组合物以选自霜，凝胶，贴片，喷雾剂，软膏，搽剂，洗剂，面食和粘膜的外用皮肤制剂的形式制造。
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公开(公告)号：KR1020110067807A
公开(公告)日：2011-06-22
申请号：KR1020090124561
申请日：2009-12-15
Applicant: 제주대학교 산학협력단 , 충남대학교산학협력단
IPC: C07J9/00 , A61K31/704 , A61P35/00
CPC classification number: C07J17/005 , A23L33/10 , A23V2002/00 , A23V2200/308 , A61K31/575 , A61K31/58 , C07J9/00
Abstract: PURPOSE: Gypenoside, a producing method thereof, and the use thereof are provided to offer the excellent anti-cancer effect of the gypenoside to users to increase the chemotherapy treatment efficiency of cancer. CONSTITUTION: Gypenoside includes R1, R2, R3 and R4. The R1 includes substituents selected from hydroxy or halogen marked with A. The substituents are substituted or non-substituted linear or branched chain type C1~6 alkyl. The R2 and R3 are hydrogen or the hydroxyl, separately. The R4 includes the hydrogen, substituted or non-substituted linear or branched chain type C1~8 alkenyl.
Abstract translation: 目的：提供山梨醇苷及其制备方法及其用途，为用户提供优异的抗癌作用，提高癌症的化疗治疗效率。 构成：Gypenoside包括R1，R2，R3和R4。 R1包括选自用A标记的羟基或卤素的取代基。取代基是取代或未取代的直链或支链C 1-6烷基。 R2和R3分别是氢或羟基。 R4包括氢，取代或未取代的直链或支链C1〜8链烯基。
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公开(公告)号：KR101037237B1
公开(公告)日：2011-05-25
申请号：KR1020090035814
申请日：2009-04-24
Applicant: 제주대학교 산학협력단 , 충남대학교산학협력단
Abstract: 본 발명은 문주란으로부터 분리되는 노르갈란타민(Norgalanthamine) 화합물을 유효성분으로 함유하는 탈모 질환의 예방 및 치료를 위한 조성물에 관한 것으로, 상세하게는 본 발명의 노르갈란타민 화합물이 모발의 성장에 중요한 역할을 하는 모유두세포(Dermal papilla cell)의 성장 증식을 촉진하여 모낭의 성장기를 유도하는 효과를 나타내므로, 탈모 질환의 예방 및 치료에 유용한 약학조성물 및 건강기능식품에 이용될 수 있다.
노르갈란타민, Norgalanthamine, 모낭, 탈모, 모유두세포-
Patent Agency Ranking
公开(公告)号：KR101037235B1
公开(公告)日：2011-05-25
申请号：KR1020090035815
申请日：2009-04-24
Applicant: 제주대학교 산학협력단 , 충남대학교산학협력단
Abstract: 본 발명은 문주란으로부터 분리되는 노르갈란타민(Norgalanthamine) 화합물을 유효성분으로 함유하는 탈모 방지 및 모발 생장 촉진 효과를 갖는 조성물에 관한 것으로, 상세하게는 본 발명의 노르갈란타민 화합물이 모발의 성장에 중요한 역할을 하는 모유두세포(Dermal papilla cell)의 성장 증식을 촉진하여 모낭의 성장기를 유도하는 효과를 나타내므로, 탈모 방지 및 발모 개선용 피부외용 약학 조성물 및 화장료 조성물로 이용될 수 있다.
노르갈란타민, Norgalanthamine, 모낭, 탈모, 모유두세포-
公开(公告)号：KR1020100117198A
公开(公告)日：2010-11-03
申请号：KR1020090035814
申请日：2009-04-24
Applicant: 제주대학교 산학협력단 , 충남대학교산학협력단
Abstract: PURPOSE: A composition containing norgalanthamine isolated from Crinum asiaticum var. japonicum for preventing and treating hair loss is provided to promote dermal pailla cell proliferation. CONSTITUTION: A pharmaceutical composition for preventing and treating hair loss contains 0.1-50 weight% of norgalanthamine compound of formula I as an active ingredient. A health food for preventing and treating hair loss contains norgalanthamine compound as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule or beverage.
Abstract translation: 目的：一种含有从Crinum asiaticum var。 提供用于预防和治疗脱发的日本专利以促进皮肤细胞增殖。 构成：用于预防和治疗脱发的药物组合物含有0.1-50重量％的作为活性成分的式I的恶唑烷胺化合物。 一种用于预防和治疗脱发的保健食品含有作为活性成分的诺嘉胺化合物。 保健食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。
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公开(公告)号：KR1020050031054A
公开(公告)日：2005-04-01
申请号：KR1020040075381
申请日：2004-09-21
Applicant: 제주대학교 산학협력단
Abstract: An extract of Eurya emarginata, and a composition comprising a compound isolated from the same extract are provided, which Eurya emarginata extract and compound isolated therefrom have antioxidative and anti-inflammatory activity, so that they can be useful in pharmaceutical composition and health food for prevention and treatment of diseases associated with inflammation. The composition for prevention and treatment of diseases associated with inflammation comprises the organic solvent extract of Eurya emarginata having antioxidative and anti-inflammatory activity as an effective component, and pharmaceutically acceptable carriers, wall materials or diluents, wherein the organic solvent is polar solvent including methanol, ethanol and butanol, nonpolar solvent including hexane, ethylacetate, acetone, chloroform and methylene chloride, and mixed solvents thereof. The composition for prevention and treatment of diseases associated with inflammation comprises Eutigoside of formula (I), and pharmaceutically acceptable carriers, wall materials or diluents, wherein R is H or OH; and the diseases associated with inflammation is rheumatic arthritis, asthma, acute pain, chronic pain, neuropatic pain, pain after operation, migraine, neuropathy, neural damage, irritable bowel syndrome, shock by endotoxin or inflammatory bowel disease.
Abstract translation: 提供Eurya emarginata的提取物和包含从相同提取物分离的化合物的组合物，其中Eurya emarginata提取物和从其分离的化合物具有抗氧化和抗炎活性，使得它们可用于药物组合物和保健食品中的预防 和治疗与炎症相关的疾病。 用于预防和治疗与炎症相关疾病的组合物包括具有抗氧化和抗炎活性作为有效成分的Eurya emarginata的有机溶剂提取物和药学上可接受的载体，壁材料或稀释剂，其中有机溶剂是包括甲醇的极性溶剂 乙醇和丁醇，非极性溶剂，包括己烷，乙酸乙酯，丙酮，氯仿和二氯甲烷，以及它们的混合溶剂。 用于预防和治疗与炎症有关的疾病的组合物包括式（I）的尤特糖苷和药学上可接受的载体，壁材料或稀释剂，其中R是H或OH; 与炎症相关的疾病是风湿性关节炎，哮喘，急性疼痛，慢性疼痛，神经性疼痛，手术后疼痛，偏头痛，神经病，神经损伤，肠易激综合征，内毒素或炎性肠病的休克。
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