公开(公告)号：AU2012201856A1

公开(公告)日：2012-04-19

申请号：AU2012201856

申请日：2012-03-29

Applicant: ABBVIE DEUTSCHLAND ,  ABBOTT LAB

Inventor： STRIEBINGER ANDREAS ,  LABKOVSKY BORIS ,  EBERT ULRICH ,  KELLER PATRICK ,  BARGHORN STEFAN ,  HILLEN HEINZ

IPC: C07K16/18 ,  A61K38/04 ,  C07K14/47

Abstract: ANTI-As GLOBULOMER ANTIBODIES, ANTIGEN-BINDING MOIETIES THEREOF, CORRESPONDING HYBRIDOMAS, NUCLEIC ACIDS, VECTORS, HOST CELLS, METHODS OF PRODUCING SAID ANTIBODIES, COMPOSITIONS COMPRISING SAID ANTIBODIES, USES OF SAID ANTIBODIES AND METHODS OF USING SAID ANTIBODIES Abstract Anti-A globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-Ap globulomer antibodies having a binding affinity to AD(20 42) globulomer that is greater than the binding affinity of the antibody to A3 (1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses. (6090564_1):GGG

公开(公告)号：BRPI0619249A2

公开(公告)日：2011-09-20

申请号：BRPI0619249

申请日：2006-11-30

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： BARGHORN STEFAN ,  EBERT ULRICH ,  HILLEN HEINZ ,  KELLER PATRICK ,  STRIEBINGER ANDREAS ,  LABKOVSKY BORIS

IPC: C07K16/18 ,  A61K38/04 ,  C07K14/47

Abstract: Anti-A² globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-A² globulomer antibodies having a binding affinity to A²(20-42) globulomer that is greater than the binding affinity of the antibody to A²(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.

公开(公告)号：AU2006252098B2

公开(公告)日：2011-02-24

申请号：AU2006252098

申请日：2006-12-18

Applicant: ABBOTT LAB

Inventor： MANKOVICH JOHN ,  GHAYUR TARIQ ,  SHORROCK CELIA ELIZABETH ,  BROCKLEHURST SIMON MARK ,  DUNCAN ALEXANDER ROBERT ,  LENNARD SIMON NICHOLAS ,  THOMPSON JULIA ELIZABETH ,  SALFELD JOCHEN ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  ROGUSKA MIKE ,  DIXON RICHARD W

IPC: C12N15/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

公开(公告)号：CA2687414A1

公开(公告)日：2008-12-11

申请号：CA2687414

申请日：2008-05-30

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： HINTON PAUL R ,  HILLEN HEINZ ,  BARGHORN STEFAN ,  LABKOVSKY BORIS ,  KELLER PATRICK ,  STRIEBINGER ANDREAS R ,  EBERT ULRICH ,  JUAN VERONICA M

IPC: C07K16/18 ,  A61P25/28

Abstract: The present invention relates to binding proteins and, in particular, hum anized antibodies that may be used, for example, in the diagnosis, treatment and prevention of Alzheimer's Disease and related conditions.

公开(公告)号：CA2687411A1

公开(公告)日：2008-12-11

申请号：CA2687411

申请日：2008-05-30

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： LABKOVSKY BORIS ,  HINTON PAUL R ,  STRIEBINGER ANDREAS R ,  JUAN VERONICA M ,  EBERT ULRICH ,  HILLEN HEINZ ,  BARGHORN STEFAN ,  KELLER PATRICK

IPC: C07K16/18

Abstract: The present invention relates to binding proteins and, in particular, hum anized antibodies that may be used, for example, in the diagnosis, treatment and prevention of Alzheimer's Disease and related conditions.

公开(公告)号：AU2006252098A1

公开(公告)日：2007-01-11

申请号：AU2006252098

申请日：2006-12-18

Applicant: ABBOTT LAB

Inventor： MANKOVICH JOHN ,  GHAYUR TARIQ ,  SHORROCK CELIA ELIZABETH ,  BROCKLEHURST SIMON MARK ,  DUNCAN ALEXANDER ROBERT ,  LENNARD SIMON NICHOLAS ,  THOMPSON JULIA ELIZABETH ,  SALFELD JOCHEN ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  ROGUSKA MIKE ,  DIXON RICHARD W

IPC: C12N15/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

公开(公告)号：CA2543920A1

公开(公告)日：2005-05-26

申请号：CA2543920

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： VOSS JEFFREY W ,  LABKOVSKY BORIS ,  GHAYUR TARIQ ,  KANG JASPAL SINGH ,  GREEN LARRY ,  HEDBERG BRAD ,  BABCOOK JOHN ,  JIA XIAO-CHI ,  WIELER JAMES

IPC: C12N15/13 ,  A61K39/395 ,  A61P37/00 ,  C07K16/24 ,  C12N1/11 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  G01N33/68

Abstract: The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

公开(公告)号：BG107045A

公开(公告)日：2003-05-30

申请号：BG10704502

申请日：2002-09-02

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  SALFELD JOCHEN G ,  DUNCAN ALEXANDER R ,  BROCKLEHURST SIMON M ,  MANKOVICH JOHN ,  SHORROCK CELIA P ,  THOMPSON JULIA E ,  LENNARD SIMON N

IPC: C12N15/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K16/00

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof., Methods of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g. in a human subject suffering from a disorder in which hIL-18 activity is detrimental. 60 claims, 5 figures

公开(公告)号：BR0108188A

公开(公告)日：2003-02-25

申请号：BR0108188

申请日：2001-02-09

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  DIXON RICHARD W ,  ROGUSKA MIKE ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  SALFELD JOCHEN ,  DUNCAN ALEXANDER ROBERT ,  BROCKLEHURST SIMON MARK ,  MANKOVICH JOHN ,  SHORROCK CELIA PATRICIA ,  THOMPSON JULIA ELISABETH ,  LENNARD SIMON NICHOLAS

IPC: C12N15/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K16/00

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

公开(公告)号：NO20023788D0

公开(公告)日：2002-08-09

申请号：NO20023788

申请日：2002-08-09

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  DIXON RICHARD WOODWARD ,  ROGUSKA MICHAEL ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  SALFELD JOCHEN G ,  DUNCAN ALEXANDER R ,  BROCKLEHURST SIMON MARK ,  MANKOVICH JOHN A ,  SHORROCK CELIA PATRICIA ,  THOMPSON JULIA ELIZABETH ,  LENNARD SIMON NICHOLAS

IPC: A61K39/395 ,  A61K45/00 ,  C12N15/02 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.