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    51.
    发明专利
    未知

    公开(公告)号：AT328877T

    公开(公告)日：2006-06-15

    申请号：AT01990455

    申请日：2001-11-29

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

    IPC: C07D339/04

    Abstract: The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO 2 -R' and R and R' independently of one another are C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.

    54.
    发明专利
    未知

    公开(公告)号：DK1317264T3

    公开(公告)日：2004-11-29

    申请号：DK01963002

    申请日：2001-09-11

    Applicant: BASF AG

    Inventor： HASSELWANDER OLIVER ,  BALDENIUS KAI-UWE ,  KRAEMER KLAUS ,  KLATT MARTIN JOCHEN ,  SCHWEIKERT LONI

    IPC: A61K31/381 ,  A23L1/30 ,  A61K31/00 ,  A61K31/202 ,  A61K31/385 ,  A61P3/10 ,  A61P9/10 ,  A61P13/12 ,  A61P25/02 ,  A61P27/02

    Abstract: The present invention relates to the use of lipoic acid, a physiologically acceptable derivative or salt thereof and one compound of the formula I H3C-(CH2)n1-(CH=CH)n3-(CH2)n2-COOH I in which n1, n2 have, independently of one another, the value of an integer from 3 to 9, n3 has the value of an integer from 2 to 6, and the number of carbon atoms is 18, 20 or 22, a physiologically acceptable derivative or salt thereof, for nutritional supplementation, in functional foods and for therapeutic purposes in the treatment of diabetic disorders. Compositions having a corresponding active ingredient combination, and compositions in the form of commercial packs with corresponding combination products or single-drug products for combined use are also described.

    55.
    发明专利
    未知

    公开(公告)号：DE50201156D1

    公开(公告)日：2004-11-04

    申请号：DE50201156

    申请日：2002-11-13

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  ERHARDT MELANIE

    IPC: C07D339/04 ,  C07C67/30 ,  C07C67/31 ,  C07C67/317 ,  C07C67/32 ,  C07C69/66 ,  C07C69/675

    Abstract: Production of dihydroxycarboxylic acid esters, by reaction of hydroxycarboxylic acid diesters with complex hydrides, is conducted in the absence of a solvent. Production of dihydroxycarboxylic acid esters of formula (I) by reaction of hydroxycarboxylic acid diesters of formula (II) with complex hydrides is conducted in the absence of a solvent. n = 1, 2, 3, 4, 5, 6 or 7; and R and R = optionally substituted 1-20C alkyl, 2-20C alkenyl or alkynyl, 3-8C cycloalkyl, aralkyl, aryl, hetarylalkyl or hetaryl An Independent claim is included for production of R-(+)- alpha -lipoic acid of formula (III) from (I) obtained as above (i.e. in the absence of solvent) by: (1) converting (I) to its bis-sulfonic ester by reaction in an organic solvent with a sulfonic acid chloride and a tertiary nitrogen base; (2) converting the ester thus obtained to R- alpha -lipoic acid ester by reaction in a polar solvent with sulfur and an alkali metal disulfide; and then (3) converting the ester to the required product.

    56.
    发明专利
    未知

    公开(公告)号：DE10318045A1

    公开(公告)日：2004-11-04

    申请号：DE10318045

    申请日：2003-04-17

    Applicant: BASF AG

    Inventor： KLATT MARTIN JOCHEN ,  HAUNERT FRANK ,  KRAEMER KLAUS

    IPC: A23K1/16 ,  A23L1/30 ,  A61K8/36 ,  A61K8/49 ,  A61Q19/00 ,  C07D213/38 ,  C07D339/04 ,  C07D213/02 ,  C07D213/52 ,  A61K31/4425 ,  A61K7/00

    Abstract: The invention relates to ammonium salts of alpha-liponic acid of general formula (I): (Lp) (A), formed from alpha-liponic acid (Lp) and amino compounds (A)=of general formula (II) or general formula (III). The invention also relates to a method for producing said salts, and to the use of said salts as constituents in pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements. The invention also relates to pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements in which the inventive salts are used.

    57.
    发明专利
    未知

    公开(公告)号：DK1318138T3

    公开(公告)日：2004-10-25

    申请号：DK02025292

    申请日：2002-11-13

    Applicant: BASF AG

    Inventor： ERHARDT MELANIE ,  KLATT MARTIN JOCHEN ,  NIEBEL MARKUS

    IPC: C07D339/04 ,  C07C67/30 ,  C07C67/31 ,  C07C67/317 ,  C07C67/32 ,  C07C69/66 ,  C07C69/675

    Abstract: Production of dihydroxycarboxylic acid esters, by reaction of hydroxycarboxylic acid diesters with complex hydrides, is conducted in the absence of a solvent. Production of dihydroxycarboxylic acid esters of formula (I) by reaction of hydroxycarboxylic acid diesters of formula (II) with complex hydrides is conducted in the absence of a solvent. n = 1, 2, 3, 4, 5, 6 or 7; and R and R = optionally substituted 1-20C alkyl, 2-20C alkenyl or alkynyl, 3-8C cycloalkyl, aralkyl, aryl, hetarylalkyl or hetaryl An Independent claim is included for production of R-(+)- alpha -lipoic acid of formula (III) from (I) obtained as above (i.e. in the absence of solvent) by: (1) converting (I) to its bis-sulfonic ester by reaction in an organic solvent with a sulfonic acid chloride and a tertiary nitrogen base; (2) converting the ester thus obtained to R- alpha -lipoic acid ester by reaction in a polar solvent with sulfur and an alkali metal disulfide; and then (3) converting the ester to the required product.

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