公开(公告)号：WO1995034904A1

公开(公告)日：1995-12-21

申请号：PCT/US1995007335

申请日：1995-06-09

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： CASE WESTERN RESERVE UNIVERSITY ,  MEHREGANY, Mehran ,  GOLDMAN, Kenneth, G. ,  DHULER, Vijayakumar, R.

IPC: H01H09/20

CPC classification number: G01P15/0891 ,  G01P15/0802 ,  G01P2015/0814 ,  H01H1/0036 ,  H01H35/14 ,  H01H35/34 ,  H01H37/52 ,  H01H37/74 ,  H01H61/02 ,  H01H2001/0047 ,  H01H2037/008 ,  H01H2061/006

Abstract: A micromechanical memory sensor includes a latch member assembly (20, 30) mechanically latching upon detection of a threshold value of a variable condition (ambient temperature, acceleration, pressure). The mechanical latching is detected by circuitry of a readout mechanism (21, 22). The sensor further includes a resetting mechanism such as a thermal resistor (24), proof mass (52, 101) or electrostatic combing drive (170, 175) for electrically unlatching the latch member assembly whereby the sensor is latched purely mechanically in its operative states and is electrically reset for repeat use.

Abstract translation: 微机械存储器传感器包括在检测到可变状态（环境温度，加速度，压力）的阈值时机械地闭锁的闩锁构件组件（20,30）。 机械闭锁由读出机构（21,22）的电路检测。 传感器还包括复位机构，例如热电阻器（24），防爆质量块（52,101）或静电梳理驱动器（170,175），用于电解锁闩构件组件，由此传感器以机械方式闩锁在其操作状态 并重复使用。

公开(公告)号：WO1994011411A1

公开(公告)日：1994-05-26

申请号：PCT/US1993011210

申请日：1993-11-18

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： CASE WESTERN RESERVE UNIVERSITY ,  MARCHANT, Roger, E. ,  YUAN, Shengmei ,  SZAKALAS-GRATZL, Gyongyl

IPC: C08F293/00

CPC classification number: C08B37/0075 ,  A61L33/0029 ,  A61L33/08 ,  C08B37/0021 ,  C08B37/0063 ,  C08B37/0069 ,  Y10S525/937 ,  C08L79/02 ,  C08L5/08 ,  C08L5/02 ,  C08L5/10

Abstract: Triblock polymers comprised of polysaccharide, such as heparin or dextran, and a hydrocarbon chain, have been prepared. The triblock polymer adsorbs strongly on the surface of hydrophobic polymer substrates such as polyethylene, through hydrophobic interaction between the polymer and the hydrophobic hydrocarbon chain of the triblock polymer. The surface adsorbed with triblock polymer is resistant to protein deposition, which renders the surface nonthrombogenic.

Abstract translation: 已经制备了由多糖如肝素或葡聚糖组成的三嵌段聚合物和烃链。 三嵌段聚合物通过聚合物和三嵌段聚合物的疏水性烃链之间的疏水相互作用，强烈吸附在疏水聚合物基材如聚乙烯的表面上。 吸附三嵌段聚合物的表面对蛋白质沉积具有抗性，这使得表面不产生血栓形成。

公开(公告)号：WO1994010938A1

公开(公告)日：1994-05-26

申请号：PCT/US1993011213

申请日：1993-11-18

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： CASE WESTERN RESERVE UNIVERSITY ,  MARCHANT, Roger, E.

IPC: A61F02/04

CPC classification number: A61L33/0094 ,  A61L33/0029 ,  Y10S514/822

Abstract: The present invention provides a method for surface modifying a substrate, such as an implant, to provide the substrate with anticoagulant activity and resistance to the deposition of plasma proteins; and the resulting substrate. The surface of the substrate is modified by first depositing a film of a plasma polymer such as plasma polymerized N-vinyl-2-pyrrolidone or allyl alcohol on the surface of the substrate. Optionally, a neutral hydrophilic spacer molecule is attached to the plasma polymer. An anticoagulant, such as heparin, is attached either directly to the substrate or indirectly to the substrate via attatchment to the spacer molecule, when such spacer molecule is present.

Abstract translation: 本发明提供了一种用于表面改性诸如植入物的底物以提供底物抗凝血活性和抵抗血浆蛋白沉积的方法; 和所得到的底物。 通过在衬底的表面上首先沉积诸如等离子体聚合的N-乙烯基-2-吡咯烷酮或烯丙醇之类的等离子体聚合物的膜来改变衬底的表面。 任选地，中性亲水间隔分子连接到等离子体聚合物上。 当存在这种间隔分子时，抗凝血剂（例如肝素）直接连接到基质上，或者通过粘附到间隔分子间接附着到基质上。

公开(公告)号：WO1992020797A1

公开(公告)日：1992-11-26

申请号：PCT/US1992004260

申请日：1992-05-20

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： CASE WESTERN RESERVE UNIVERSITY ,  LARGE, Thomas, H.

IPC: C12N15/12

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K16/22 ,  Y02A50/473

Abstract: A new neurotrophic factor named herein neurotrophin-4 or NT-4 is disclosed. The neurotrophic factor was deduced from the screening of frog genomic DNA by polymerase chain reaction (PCR) with primers to conserved amino acid sequences in nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). The new neurotrophic factor is believed to be distinct as it exhibits limited structural homology with any of the known neurotrophic factors. DNA sequences encoding NT-4, methods for their production and the production of recombinant DNA molecules, and both diagnostic and therapeutic methods and materials are disclosed.

Abstract translation: 公开了一种称为神经营养因子-4或NT-4的新型神经营养因子。 通过聚合酶链反应（PCR）对引导到神经生长因子（NGF）和脑源性神经营养因子（BDNF）中的保守氨基酸序列的引物进行青蛙基因组DNA的筛选，推导出神经营养因子。 认为新的神经营养因子是不同的，因为它与任何已知的神经营养因子具有有限的结构同源性。 公开了编码NT-4的DNA序列，其生产方法和重组DNA分子的生产，以及诊断和治疗方法和材料。

公开(公告)号：WO1992002114A1

公开(公告)日：1992-02-06

申请号：PCT/US1991005213

申请日：1991-07-23

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： CASE WESTERN RESERVE UNIVERSITY ,  MARCHANT, Roger, E.

IPC: H05F03/00

CPC classification number: A61L33/0088 ,  C08F8/04 ,  C08F26/10

Abstract: The present invention is directed to a process for synthesizing hydroxylated plasma-polymerized films, as well as the hydroxylated plasma-polymerized films produced by the process of the invention. In addition, the present invention is directed to the use of hydroxylated plasma-polymerized films produced by the process of the invention for enhancing the compatibility and/or implantability of biomedical implants and/or devices.