公开(公告)号：WO1983000970A1

公开(公告)日：1983-03-17

申请号：PCT/US1982001220

申请日：1982-09-09

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  LEDLEY, Robert, S.

IPC: H04N05/32

CPC classification number: A61B6/487 ,  A61B6/481 ,  G06F19/00 ,  H04N5/3205

Abstract: A digital fluorographic method and system calls for digitizing and storing first and second x-ray picture information derived prior to and after, respectively, injection of a contrast medium into the subject. The first and second x-ray picture information are digitized, stored and processed to develop first and second processed picture data, respectively, and the first and second processed picture data are subtractively combined to produce picture data corresponding to a pictorial representation of differences between the x-ray picture information prior to and after, respectively, the injection of the contrast medium. The method and system call for various combinations of the following operations: averaging one or both of the x-ray picture data; convolution of the picture data derived prior to the injection of the contrast medium; pre-enhancement of one or both of the x-ray picture data; and post-enhancement of the picture data corresponding to the pictorial representation of the differences between the x-ray pictures prior to and after, respectively, the injection of the contrast medium. The inventive system includes a plurality of storage units and display units, in conjunction with an image processor, for rapidly operating on (whole-picture processing) the various x-ray picture data provided to the system.

公开(公告)号：WO1998002176A1

公开(公告)日：1998-01-22

申请号：PCT/US1997012501

申请日：1997-07-16

Applicant: GEORGETOWN UNIVERSITY ,  UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE

Inventor： GEORGETOWN UNIVERSITY ,  UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE ,  KING, C., Richter ,  SASTRY, Lakshmi ,  KRAG, David ,  OLIGINO, Lyn

IPC: A61K38/02

CPC classification number: C07K14/4702

Abstract: A non-phosphorylated peptide or functionally equivalent composition binds to an SH2 domain of a signal transduction protein with high affinity. In particular, the composition binds to the SH2 domain with an affinity similar to that of at least one phosphorylated peptide that is a natural target for the protein. The inhibition of a signal transduction process can be accomplished by administering a non-phosphorylated peptide or functionally equivalent composition.

Abstract translation: 非磷酸化肽或功能上等同的组合物以高亲和力结合信号转导蛋白的SH2结构域。 特别地，组合物以与蛋白质的天然靶标的至少一种磷酸化肽的亲和力相似的亲和力结合SH2结构域。 信号转导过程的抑制可以通过施用非磷酸化肽或功能等同的组合物来实现。

公开(公告)号：WO1997026911A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001395

申请日：1997-01-29

Applicant: GEORGETOWN UNIVERSITY ,  DAVIDSON, Eugene, A. ,  YANG, Shutong

Inventor： GEORGETOWN UNIVERSITY

IPC: A61K39/00

CPC classification number: C07K16/205 ,  A61K39/00 ,  C07K14/445 ,  C07K2319/00 ,  C12N2799/023 ,  Y02A50/412 ,  Y10S977/804

Abstract: The present invention relates to a malaria chimeric peptide comprising a vaccinia virus system which expresses a protein corresponding substantially to the major merozoite surface antigen 1 (MSA1) of Plasmodium flaciparum or an immunogenic portion, thereof. In preferred embodiments, the MSA1 peptide is a 593 amino acid peptide corresponding to amino acids 1047 to 1640 of MSA1 and is combined with a signal peptide and/or an anchor peptide. Chimeric peptides having both signal and anchor sequences in combination with MSA1 sequences were the most effective in eliciting an immunogenic response from a vaccinated host.

Abstract translation: 本发明涉及疟疾嵌合肽，其包含痘苗病毒系统，其表达基本上与疟原虫的主要裂殖子表面抗原1（MSA1）相对应的蛋白质或免疫原性 部分。 在优选的实施方案中，MSA1肽是对应于MSA1的氨基酸1047至1640的593个氨基酸的肽，并与信号肽和/或锚肽组合。 具有与MSA1序列组合的信号和锚定序列的嵌合肽在从接种疫苗的宿主引起免疫原性应答方面是最有效的。

公开(公告)号：WO1996021144A1

公开(公告)日：1996-07-11

申请号：PCT/US1995016904

申请日：1995-12-27

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  HAN, Myun, Ki ,  LEE, S., Paul ,  CHIRIKJIAN, Jack, G.

IPC: G01N21/64

CPC classification number: C12Q1/6818 ,  C12Q1/44 ,  C12Q1/68 ,  C12Q1/6823 ,  C12Q2563/107 ,  C12Q2521/301 ,  C12Q2565/101

Abstract: A method of detecting an enzyme-mediated DNA cleavage reaction in a fluorometric assay is provided. The method can be used to detect DNA cleavage caused by restriction endonucleases, retroviral integrase enzymes, DNases, RNases, or enzymes utilized in other strand separating processes in molecular biology.

Abstract translation: 提供了在荧光测定中检测酶介导的DNA切割反应的方法。 该方法可用于检测由限制性内切核酸酶，逆转录病毒整合酶，DNA酶，核糖核酸酶或分子生物学中其他链分离过程中使用的酶引起的DNA切割。

公开(公告)号：WO1995034684A1

公开(公告)日：1995-12-21

申请号：PCT/US1994006631

申请日：1994-06-10

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  NATARAJAN, Venkatachala ,  SALZMAN, Norman, P.

IPC: C12Q01/70

CPC classification number: C12Q1/703 ,  C07K14/005 ,  C12N2740/16222 ,  C12Q1/6851 ,  C12Q2545/101

Abstract: The invention relates generally to the quantitation of virus and viral nucleic acid. The invention relates to methods for quantitating an amount of virus present in a sample, comprising introducing into the sample a composition comprising a genetically tagged viral nucleic acid, isolating said wild type and said tagged nucleic acid, and quantitating said wild type and said tagged nucleic acid. The invention also relates to genetically tagged retroviral nucleic acid comprising a tag sequence, including insertions and deletions.

Abstract translation: 本发明一般涉及病毒和病毒核酸的定量。 本发明涉及用于量化样品中存在的病毒量的方法，包括向样品中引入包含遗传标记的病毒核酸的组合物，分离所述野生型和所述标记的核酸，并定量所述野生型和所述标记的核酸 酸。 本发明还涉及包含插入和缺失的标签序列的遗传标记的逆转录病毒核酸。

公开(公告)号：WO1994016700A1

公开(公告)日：1994-08-04

申请号：PCT/US1994000920

申请日：1994-01-27

Applicant: SEPRACOR, INC. ,  GEORGETOWN UNIVERSITY

Inventor： SEPRACOR, INC. ,  GEORGETOWN UNIVERSITY ,  GRAY, Nancy, M. ,  WOOSLEY, Raymond, L.

IPC: A61K31/495

CPC classification number: A61K31/495

Abstract: Methods and compositions are disclosed utilizing the optically pure (2R,4S) isomer of itraconazole. This compound is a potent drug for the treatment of local and systemic fungal, yeast, and dermatophyte infections, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of itraconazole.

Abstract translation: 公开利用伊曲康唑的光学纯的（2R，4S）异构体的方法和组合物。 该化合物是治疗局部和全身真菌，酵母和皮肤癣菌感染的有效药物，同时避免与伊曲康唑外消旋混合物相关的副作用的伴随责任。

公开(公告)号：WO1994014446A1

公开(公告)日：1994-07-07

申请号：PCT/US1993012327

申请日：1993-12-17

Applicant: SEPRACOR, INC. ,  GEORGETOWN UNIVERSITY

Inventor： SEPRACOR, INC. ,  GEORGETOWN UNIVERSITY ,  GRAY, Nancy, M. ,  WOOSLEY, Raymond, L.

IPC: A61K31/495

CPC classification number: A61K31/495

Abstract: Methods and compositions are disclosed utilizing the optically pure (+) isomer of ketoconazole. This compound is a potent drug for the treatment of local and systemic fungal, yeast, and dermatophyte infections, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ketoconazole.

Abstract translation: 利用酮康唑的旋光纯（+）异构体公开了方法和组合物。 该化合物是用于治疗局部和全身真菌，酵母和皮肤癣菌感染的有效药物，同时避免与酮康唑外消旋混合物相关的副作用的伴随责任。

公开(公告)号：WO1994011760A1

公开(公告)日：1994-05-26

申请号：PCT/US1993010921

申请日：1993-11-10

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  MOSCOVITCH, Marko

IPC: G01T01/00

CPC classification number: G01T1/04 ,  G01T1/026 ,  G01T3/08

Abstract: A dosimetry method, dosimeter and system characterized by the steps of storing information in a three dimensional optical memory element, then exposing the optical memory element to neutron or other high LET radiation to alter the information stored in the optical memory element as a function of the radiation to which the optical memory element is exposed, and then retrieving the altered information from the optical memory elements for subsequent analysis. The altered information is used to provide a measure of both the radiation dose and energy. In a preferred embodiment, the optical memory device of the dosimeter (18) is a 3-D ORAM (20) comprising a volume of a transparent polymer doped with a light sensitive chemical and, in particular, spirobenzopyran. The dosimeter (18) further has a holder (22) with a case (24) for the ORAM (20) and a carrier (26) for the case (24).

Abstract translation: 一种剂量测定方法，剂量计和系统，其特征在于以下步骤：将信息存储在三维光学存储元件中，然后将所述光学存储元件暴露于中子或其它高LET辐射，以将存储在所述光学存储器元件中的信息作为 光存储器元件暴露于其中的辐射，然后从光学存储器元件检索改变的信息以用于随后的分析。 改变的信息用于提供辐射剂量和能量的量度。 在优选实施例中，剂量计（18）的光学存储装置是包含一定体积的掺有光敏化学品，特别是螺苯并吡喃的透明聚合物的3-D ORAM（20）。 剂量计（18）还具有一个具有用于ORAM（20）的壳体（24）和用于壳体（24）的托架（26）的保持器（22）。

公开(公告)号：WO1994007495A1

公开(公告)日：1994-04-14

申请号：PCT/US1993008349

申请日：1993-09-03

Applicant: SEPRACOR INC. ,  GEORGETOWN UNIVERSITY

Inventor： SEPRACOR INC. ,  GEORGETOWN UNIVERSITY ,  WOOSLEY, Raymond, L. ,  ABERG, A., K., Gunnar

IPC: A61K31/445

CPC classification number: A61K31/445 ,  A61K31/454 ,  A61K2300/00 ,  A61K31/00

Abstract: A pharmaceutical composition comprising the compound of formula (I) or a pharmaceutically acceptable salt thereof, for use in an anti-histaminic treatment which does not induce any significant cardiac arrhythmia, comprising administering a therapeutically effective amount of the compound of formula (I) to a human patient.

Abstract translation: 一种药物组合物，其包含式（I）化合物或其药学上可接受的盐，用于不诱导任何明显心律不齐的抗组胺治疗，包括给予治疗有效量的式（I）化合物至 一个人的病人。

公开(公告)号：WO1994005259A1

公开(公告)日：1994-03-17

申请号：PCT/US1993008032

申请日：1993-09-01

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  RAHMAN, Aquilur ,  THIERRY, Alain ,  DRITSCHILO, Anatoly

IPC: A61K09/127

CPC classification number: A61K31/70 ,  A61K9/1278

Abstract: A method of preparing a liposomal anthracycline glycoside composition, which entails forming cardiolipin-containing liposomes by drying a lipid mixture containing cardiolipin, and then introducing an aqueous solution, and mixing the cardiolipin-containing liposomes with a solution of anthracycline glycoside.

Abstract translation: 一种制备脂质体蒽环苷糖苷组合物的方法，其通过干燥含有心磷脂的脂质混合物，然后引入水溶液，并将含心磷脂的脂质体与蒽环类苷的溶液混合来形成含有心磷脂的脂质体。