公开(公告)号：DK630289A

公开(公告)日：1990-06-15

申请号：DK630289

申请日：1989-12-13

Applicant: HOECHST AG

Inventor： KOLAR CENEK ,  KOENIG WOLFGANG ,  SANDOW JUERGEN KURT

IPC: A61K38/04 ,  A61K38/00 ,  A61P5/00 ,  C07K7/23 ,  C07K7/06 ,  A61K37/02 ,  C07K1/00

Abstract: Peptides of the formula Ac-D-Nal(2)-D-Phe-D-Phe-Ser-X-D-Ser(Rha)-Leu-Arg-Pro-Y in which X represents Tyr or His and Y represents Gly-NH2, D-Ala-NH2, Azgly-NH2 or NH-C2H5 are competitive antagonists of Gn-RH. They are used for the treatment of gonadotropin- and steroid-dependent diseases and are prepared by known methods of peptide chemistry.

公开(公告)号：AU595383B2

公开(公告)日：1990-03-29

申请号：AU7945987

申请日：1987-10-08

Applicant: HOECHST AG

Inventor： KONIG WOLFGANG ,  SANDOW JURGEN KURT ,  KOLAR CENEK

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K7/20 ,  A61K37/43

Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.

公开(公告)号：FI874401A

公开(公告)日：1988-04-10

申请号：FI874401

申请日：1987-10-07

Applicant: HOECHST AG

Inventor： KOENIG WOLFGNG ,  SANDOW JUERGEN KURT ,  KOLAR CENEK

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K

Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.

公开(公告)号：DK527187D0

公开(公告)日：1987-10-08

申请号：DK527187

申请日：1987-10-08

Applicant: HOECHST AG

Inventor： KOENIG WOLFGANG ,  SANDOW JUERGEN KURT ,  KOLAR CENEK

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K7/20

Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.