公开(公告)号：ES2149159T3

公开(公告)日：2000-11-01

申请号：ES92102197

申请日：1992-02-10

Applicant: HOECHST AG

Inventor： SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JORG ,  KOLAR CENEK ,  HOFFMANN DIETER ,  SEDLACEK HANS-HARALD

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K1/113 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/15 ,  C12N9/24 ,  C12N15/56 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

公开(公告)号：DK0501215T3

公开(公告)日：2000-09-18

申请号：DK92102197

申请日：1992-02-10

Applicant: HOECHST AG

Inventor： SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG ,  KOLAR CENEK ,  HOFFMANN DIETER ,  SEDLACEK HANS-HARALD

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K1/113 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/15 ,  C12N9/24 ,  C12N15/56 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  C07K15/00

公开(公告)号：IE62873B1

公开(公告)日：1995-03-08

申请号：IE399089

申请日：1989-12-13

Applicant: HOECHST AG

Inventor： KOLAR CENEK ,  KOENIG WOLFGANG ,  SANDOW JUERGEN KURT

IPC: A61K38/04 ,  A61K38/00 ,  A61P5/00 ,  C07K7/23 ,  C07K7/06 ,  C07K99/56

Abstract: Peptides of the formula Ac-D-Nal(2)-D-Phe-D-Phe-Ser-X-D-Ser(Rha)-Leu-Arg-Pro-Y in which X represents Tyr or His and Y represents Gly-NH2, D-Ala-NH2, Azgly-NH2 or NH-C2H5 are competitive antagonists of Gn-RH. They are used for the treatment of gonadotropin- and steroid-dependent diseases and are prepared by known methods of peptide chemistry.

公开(公告)号：FI86863B

公开(公告)日：1992-07-15

申请号：FI874401

申请日：1987-10-07

Applicant: HOECHST AG

Inventor： KOENIG WOLFGNG ,  SANDOW JUERGEN KURT ,  KOLAR CENEK

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575

Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.

公开(公告)号：PT85881B

公开(公告)日：1990-07-31

申请号：PT8588187

申请日：1987-10-08

Applicant: HOECHST AG

Inventor： KOLAR CENEK ,  KONIG WOLFGANG ,  SANDOW JURGEN KURT

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  A61K37/02

Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.

公开(公告)号：ZA877561B

公开(公告)日：1988-05-25

申请号：ZA877561

申请日：1987-10-08

Applicant: HOECHST AG

Inventor： KOENIG WOLFGANG ,  WOLFGANG KOENIG ,  SANDOW JUERGEN KURT ,  JUERGEN KURT SANDOW ,  KOLAR CENEK ,  CENEK KOLAR

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K ,  A61K

Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.

公开(公告)号：AU7945987A

公开(公告)日：1988-04-14

申请号：AU7945987

申请日：1987-10-08

Applicant: HOECHST AG

Inventor： KONIG WOLFGANG ,  SANDOW JURGEN KURT ,  KOLAR CENEK

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K7/20 ,  A61K37/43

Abstract: The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.

公开(公告)号：AT193326T

公开(公告)日：2000-06-15

申请号：AT92102197

申请日：1992-02-10

Applicant: HOECHST AG

Inventor： SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG ,  KOLAR CENEK ,  HOFFMANN DIETER ,  SEDLACEK HANS-HARALD

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K1/113 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/15 ,  C12N9/24 ,  C12N15/56 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

公开(公告)号：PT98533B

公开(公告)日：1999-01-29

申请号：PT9853391

申请日：1991-08-01

Applicant: HOECHST AG

Inventor： KOLAR CENEK ,  KONIG WOLFGANG ,  SANDOW JURGEN

IPC: A61K38/00 ,  A61P5/00 ,  A61P5/24 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K14/00 ,  A61K38/04

Abstract: Peptides of the formula in which X is alkanoyl, A is optionally substituted D-Na(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser(R ), F is Leu, Trp or Phe, G is L-Ser(R ), H is Gly-NH2, D-Ala-NH2 or azagly-NH2 and R is a glycosyl radical, have inhibitory effects on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testosterone and oestrogen. A process for the preparation of these peptides is described.

公开(公告)号：CA1314656C

公开(公告)日：1993-03-16

申请号：CA548918

申请日：1987-10-08

Applicant: HOECHST AG

Inventor： KOENIG WOLFGANG ,  SANDOW JUERGEN K ,  KOLAR CENEK

IPC: A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P9/12 ,  C07K7/06 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K7/20 ,  A61K37/43

Abstract: HOE 86/F 253 of the disclosure: Analogs of gonadoliberin with improved solubility, methods for their preparation, agents containing them and their use The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, dehydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; .beta. is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg or His; E is D-Ser(R1), .beta.Asn, .beta.-Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NHalkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.