公开(公告)号：NZ619642A

公开(公告)日：2016-04-29

申请号：NZ61964212

申请日：2012-07-13

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D

IPC: A61K31/52 ,  A61K31/433 ,  A61P17/00 ,  A61P29/00 ,  C07D473/32 ,  C07D473/34

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

公开(公告)号：AU2013215166B2

公开(公告)日：2016-04-21

申请号：AU2013215166

申请日：2013-01-30

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  LOURY DAVID J ,  YAN SHUNQI ,  WANG LONGCHENG ,  FRYE LEAH LYNN

IPC: C07D473/32 ,  A61K31/52 ,  A61P35/00 ,  A61P37/00

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：CA3154024A1

公开(公告)日：2011-12-08

申请号：CA3154024

申请日：2011-06-03

Applicant: PHARMACYCLICS LLC

Inventor： BUGGY JOSEPH J ,  ELIAS LAURENCE ,  FYFE GWEN ,  HEDRICK ERIC ,  LOURY DAVID J ,  MODY TARAK D

IPC: A61K31/519 ,  A61P35/00

Abstract: Disclosed herein are uses of a compound (ibrutinib) for treating follicular lymphoma, wherein the compound has the structure: