公开(公告)号：KR20180030730A

公开(公告)日：2018-03-23

申请号：KR20187007316

申请日：2013-01-30

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  LOURY DAVID J ,  YAN SHUNQI ,  WANG LONGCHENG ,  FRYE LEAH LYNN

IPC: C07D473/32 ,  A61K31/52

CPC classification number: C07D473/34

Abstract: 브루톤티로신키나제(Btk)와공유결합을형성하는화합물이본원에개시되어있다. Btk의비가역적억제제도기재되어있다. 또한, Btk의가역적억제제도기재되어있다. 상기화합물을포함하는약학조성물도개시되어있다. 자가면역질환또는병태, 이종면역질환또는병태, 림프종을포함하는암, 및염증성질환또는병태의치료를위해 Btk 억제제를단독으로또는다른치료제와함께사용하는방법이개시되어있다.

Abstract translation: 本文公开了与布鲁顿酪氨酸激酶（Btk）形成共价键的化合物。 还描述了Btk的不可逆抑制剂。 另外，还描述了Btk的可逆抑制剂。 还公开了包含该化合物的药物组合物。 单独或与其他治疗剂组合使用Btk抑制剂的方法用于治疗自身免疫疾病或病症，异质性免疫疾病或病症，癌症（包括淋巴瘤）和炎性疾病或病症。

公开(公告)号：KR20180021740A

公开(公告)日：2018-03-05

申请号：KR20177037849

申请日：2016-06-02

Applicant: PHARMACYCLICS LLC

Inventor： ATALLAH GORDANA BABIC ,  CHEN WEI ,  JIA ZHAOZHONG J ,  POZZAN ALFONSO ,  RAVEGLIA LUCAL FRANCESCO ,  ZANALETTI RICCARDO

IPC: C07D417/14 ,  A61K31/497 ,  A61K31/53 ,  A61P19/02 ,  A61P19/10 ,  A61P35/00 ,  C07D401/14

CPC classification number: C07D417/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08

Abstract: 브루톤티로신키나제 (Btk)의가역적및 비가역적억제제가본 명세서에서개시된다. 상기화합물을포함하는약제학적조성물이또한개시된다. 상기 Btk 억제제를사용하는방법은자가면역질환또는병태, 이종면역질환또는병태, 림프종을포함하는암, 및염증성질환또는병태의치료를위해, 단독으로또는다른치료제와함께기재된다.

Abstract translation: 说明书中公开了bruton酪氨酸激酶（Btk）的可逆和不可逆抑制剂。 还公开了包含这些化合物的药物组合物。 描述了单独或与其他治疗剂组合用于治疗自身免疫疾病或病症，异源免疫疾病或病症，包括淋巴瘤的癌症和炎性疾病或病症的Btk抑制剂的使用方法。

公开(公告)号：WO2016196776A3

公开(公告)日：2017-01-05

申请号：PCT/US2016035489

申请日：2016-06-02

Applicant: PHARMACYCLICS LLC

Inventor： ATALLAH GORDANA BABIC ,  CHEN WEI ,  JIA ZHAOZHONG J ,  POZZAN ALFONSO ,  RAVEGLIA LUCAL FRANCESCO ,  ZANALETTI RICCARDO

IPC: C07D403/12 ,  A61K31/497 ,  A61K31/53

CPC classification number: C07D417/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08

Abstract: Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are describeded, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract translation: 本文公开了可逆和不可逆的Bruton酪氨酸激酶（Btk）抑制剂。 还公开了包含化合物的药物组合物。 描述了使用Btk抑制剂单独或与其它治疗剂组合用于治疗自身免疫疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症的方法。

公开(公告)号：WO2016004305A3

公开(公告)日：2016-03-03

申请号：PCT/US2015038986

申请日：2015-07-02

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  YAN SHUNQI ,  WANG LONGCHENG ,  LOURY DAVID J ,  JIA ZHAOZHONG J ,  FRYE LEAH LYNN ,  GREENWOOD JEREMY ROBERT ,  SHELLEY MEE YOO ,  ATALLAH GORDANA BABIC ,  ZANALETTI RICCARDO ,  CATALANI MARIA PIA ,  RAVEGLIA LUCA FRANCESCO

IPC: A61K31/437

CPC classification number: C07D471/04 ,  C07D471/06 ,  C07D487/04 ,  C07D519/00

Abstract: Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract translation: 本文公开了抑制Bruton酪氨酸激酶（Btk）的化合物。 还描述了Btk的不可逆抑制剂。 此外，还描述了Btk的可逆抑制剂。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

公开(公告)号：WO2016019237A2

公开(公告)日：2016-02-04

申请号：PCT/US2015043102

申请日：2015-07-31

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  WANG LONGCHENG ,  JIA ZHAOZHONG J ,  PALMER JAMES T

IPC: A61K31/53 ,  A61K31/522

CPC classification number: A61K9/0031 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/006 ,  A61K9/0078 ,  A61K9/4866 ,  C07D487/04

Abstract: Described herein are cyano containing heteroaryl compounds as kinase inhibitors. Methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases described.

Abstract translation: 本文描述的是含有氰基的杂芳基化合物作为激酶抑制剂。 合成这些抑制剂的方法，以及使用这些抑制剂治疗所述疾病的方法。

公开(公告)号：WO2016004280A2

公开(公告)日：2016-01-07

申请号：PCT/US2015038947

申请日：2015-07-02

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  JIA ZHAOZHONG J

IPC: F24J2/04

CPC classification number: A61K31/4166

Abstract: Described herein are heteroaryl compounds as kinase inhibitors. Methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases are also described.

Abstract translation: 本文描述的是作为激酶抑制剂的杂芳基化合物。 还描述了合成这种抑制剂的方法，以及在治疗疾病中使用这些抑制剂的方法。

公开(公告)号：EP3174539A4

公开(公告)日：2017-12-13

申请号：EP15827550

申请日：2015-07-31

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  WANG LONGCHENG ,  JIA ZHAOZHONG J

IPC: C07D487/00 ,  A61K31/519 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D487/04 ,  A61K31/4162

Abstract: Disclosed herein are amido compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：EP3016953A4

公开(公告)日：2017-03-01

申请号：EP14819592

申请日：2014-06-30

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  JIA ZHAOZHONG J ,  LOURY DAVID J

IPC: C07D473/34 ,  A61K31/52 ,  A61P19/02 ,  A61P37/00

CPC classification number: C07D473/34 ,  A61K31/52

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：MX375752B

公开(公告)日：2025-03-06

申请号：MX2016007111

申请日：2016-06-01

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  THOMAS WILLIAM D ,  JIA ZHAOZHONG J

IPC: C07D403/12 ,  A61K31/497 ,  A61K31/53 ,  A61P19/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Se describen aquí inhibidores de tirosina quinasa de Bruton (Btk) reversibles y irreversibles. También se describen composiciones farmacéuticas que incluyen los compuestos. Se describen métodos para utilizar los inhibidores de Btk, solos o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o afecciones autoinmunes, enfermedades o afecciones heteroautoinmunes, cáncer, que incluye linfoma, y enfermedades o afecciones inflamatorias.

公开(公告)号：ES2590905T8

公开(公告)日：2020-12-09

申请号：ES13166272

申请日：2010-10-12

Applicant: PHARMACYCLICS LLC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10