公开(公告)号：WO2003026380A2

公开(公告)日：2003-04-03

申请号：PCT/US2002/029943

申请日：2002-09-20

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: B05B1/32 ,  B05B1/34 ,  B05B11/00

CPC classification number: B05B11/0067 ,  B05B1/3436 ,  B05B11/0043 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3094

Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol. The aerosol tip mechanism provides for long-term sterility of the stored fluid, which in turn allows for preservation of the sterility of non-chemically preserved formulations, which may be in the form of suspension or liquid gels.

Abstract translation: 用于分配液体内容物的气溶胶型分配器的气溶胶喷嘴机构具有柔性外壳，由下部和上部组成的刚性盖部分，以及刚性喷嘴部分，其具有容纳在柔性外壳的出口部分内的刚性轴 。 刚性轴与外壳的出口部分接合，形成第一常闭单向阀。 刚性盖部分的下部和上部形成适于容纳柔性外壳的出口部分的靴子，靴子因此约束外壳的出口部分的横向运动，并且将出口部分对称地对准刚性轴 的喷嘴。 刚性喷嘴部分包括多个液体通道，用于将液体从储存器输送到限定在刚性帽部分内的旋转室，该液体通道被配置为使液体的能量损失最小化，并促进分配的更均匀的流体颗粒尺寸 气雾剂。 气溶胶末端机构提供储存的流体的长期无菌性，这又允许保持非化学保存的制剂的无菌性，其可以是悬浮液或液体凝胶的形式。

公开(公告)号：WO2002064439A1

公开(公告)日：2002-08-22

申请号：PCT/US2001/040134

申请日：2001-02-16

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: B65D39/04

CPC classification number: A61L2/081 ,  A61J1/1468 ,  A61J1/18 ,  A61L2202/121 ,  A61M2207/00 ,  B65B3/003 ,  B65D39/007 ,  B65D51/002

Abstract: A resealable cap (110, 210) for a medicament vial (114, 214) has a base portion (112, 212) formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion (126, 226) overlying the base portion. The resealable portion (126, 226) is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member (140, 282) for dispensing medicament into the vial (114, 214). Prior to filling, the cap (110, 210) is assembled to the vial (114, 214) and the cap/vial assembly is sterilized. Then, a needle (140, 282) is inserted through the cap (110, 210) and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle (140, 282), the penetrated region of the cap (248) is fused by laser (276) or direct heat sealing (264) to hermetically seal the needle hole (294) in the cap.

Abstract translation: 用于药物小瓶（114,214）的可重新密封的帽（110,210）具有由硫化橡胶或类似材料形成的基部（112,212），其已知用于为容纳在小瓶内的药物提供稳定的环境，并且可重新密封 覆盖基部的部分（126,226）。 可再密封部分（126,226）由低密度聚乙烯或类似材料制成，并且可以被针或类似的注射构件（140,282）刺穿，用于将药物分配到小瓶（114,214）中。 在填充之前，将帽（110,210）组装到小瓶（114,214）上，并且帽/瓶组件被灭菌。 然后，将针（140,282）插入穿过盖（110,210），药物通过针引入并进入小瓶。 在针（140,282）取出时，帽（248）的穿透区域通过激光（276）或直接热密封（264）熔合，以密封帽中的针孔（294）。

公开(公告)号：WO2013110003A1

公开(公告)日：2013-07-25

申请号：PCT/US2013/022320

申请日：2013-01-18

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: B05B11/00 ,  F16K15/14 ,  B65D47/34

CPC classification number: A61F9/0008 ,  B05B11/0056 ,  B05B11/0062 ,  B05B11/0067 ,  B05B11/007 ,  B05B11/0097 ,  B23P15/001 ,  B65D83/0022 ,  Y10T29/49412

Abstract: A device has a first part with a valve seat and storage chamber, and a second part with a flexible valve cover and actuator. The flexible valve cover and valve seat form a normally closed valve seam there between. The valve cover is movable in response to fluid at an inlet to the seam exceeding a valve opening pressure of the one-way valve between (i) a normally closed position with valve cover and valve seat in contact with each other and defining the normally closed seam, and (ii) a second position with at least a portion of the valve cover spaced away from the valve seat to allow the fluid to pass through the seam.

Abstract translation: 装置具有带阀座和储存室的第一部分，以及具有柔性阀盖和致动器的第二部分。 柔性阀盖和阀座之间形成常闭阀门。 所述阀盖可响应于在所述接缝的入口处的流体在所述单向阀的打开压力之间（i）与阀盖的常闭位置和彼此接触的阀座之间，限定常闭 接缝，和（ii）第二位置，其中阀盖的至少一部分与阀座间隔开，以允许流体穿过接缝。

公开(公告)号：WO2012145434A1

公开(公告)日：2012-10-26

申请号：PCT/US2012/034127

申请日：2012-04-18

Applicant: DR. PY INSTITUTE, LLC ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61M5/32

CPC classification number: B65B3/003 ,  B65B39/004 ,  B65B39/12

Abstract: A needle has a hollow shaft, a tip formed at one end of the shaft, one or more ports in fluid communication with the interior of the hollow shaft, and a closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s).

Abstract translation: 针具有中空轴，形成在轴的一端的尖端，与中空轴的内部流体连通的一个或多个端口和闭合件。 所述封闭件和/或所述轴可在（i）第一位置和第二位置之间移动，所述第一位置是所述封闭件关闭所述端口，以及（ii）打开所述端口的第二位置。

公开(公告)号：WO2012054890A1

公开(公告)日：2012-04-26

申请号：PCT/US2011/057376

申请日：2011-10-21

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: B67D1/00

CPC classification number: B67D3/043 ,  B67B7/24

Abstract: A pouch connector includes a safety cap having a cap base portion and a main connector disposed opposite the safety cap. The main connector and safety cap are configured to receive a portion of a pouch therebetween. The main connector includes a piercing member for piercing the pouch, an actuating portion for actuating the piercing member and a main connector base portion. The piercing member is configured to pierce through a portion of the pouch so as to provide fluid communication between a substance inside the pouch and the interior of the main connector. A polymeric membrane is coupled to at least one of the cap base portion and the main connector base portion.

Abstract translation: 小袋连接器包括具有帽基部的安全帽和与安全帽相对设置的主连接器。 主连接器和安全帽被配置为在其间容纳一部分袋。 主连接器包括用于刺穿小袋的刺穿构件，用于致动刺穿构件的致动部分和主连接器基部。 穿刺构件被构造成穿过袋的一部分，以便在袋内的物质和主连接器的内部之间提供流体连通。 聚合物膜联接到帽基部和主连接器基部中的至少一个。

公开(公告)号：WO2012024624A1

公开(公告)日：2012-02-23

申请号：PCT/US2011/048483

申请日：2011-08-19

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61M1/00 ,  F16L37/28 ,  A61B19/00

CPC classification number: F16L37/36 ,  A61M39/10 ,  A61M2039/1027 ,  F16L2201/44 ,  Y10T29/49826 ,  Y10T137/87925 ,  Y10T137/9029

Abstract: A connector for transferring a fluid includes a first connector and a second connector. Each connector includes a first outer portion including a first obstructive portion and defining a first fluid passageway for receiving a fluid therein. Each connector further includes a first central nozzle coupled to the first outer portion. The central nozzle includes a first engagement member. The first central nozzle is movable between a first position and a second position with rotation of the first outer portion. In the first position, the first obstructive portion and the first engagement portion substantially overlap to impede fluid flow through the first fluid passageway. In the second position, at least one of the first engagement member and the first obstructive member is displaced to allow fluid flow through the first fluid passageway.

Abstract translation: 用于传送流体的连接器包括第一连接器和第二连接器。 每个连接器包括第一外部部分，其包括第一阻塞部分并且限定用于在其中接收流体的第一流体通道。 每个连接器还包括联接到第一外部部分的第一中心喷嘴。 中心喷嘴包括第一接合构件。 第一中心喷嘴可以在第一外部部分旋转的同时在第一位置和第二位置之间移动。 在第一位置，第一阻塞部分和第一接合部分基本上重叠以阻止流体流过第一流体通道。 在第二位置，第一接合构件和第一阻塞构件中的至少一个被移位以允许流体流过第一流体通道。

公开(公告)号：WO2011127074A1

公开(公告)日：2011-10-13

申请号：PCT/US2011/031280

申请日：2011-04-05

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61M39/14 ,  A61M39/00 ,  A61M3/00

CPC classification number: F16L41/02 ,  A61M39/18 ,  A61M39/26 ,  A61M2039/267 ,  Y10T29/49826 ,  Y10T137/0318 ,  Y10T137/87925 ,  Y10T137/87949 ,  Y10T137/87957

Abstract: An aseptic fluid connector having a first connector including a first fluid passageway for receiving a fluid therein; a first port in fluid communication with the first fluid passageway for passage of the fluid therethrough; and a first deflecting member. The first deflecting member includes a first engaging portion radially spaced relative to the first port, and a first valve movable between a closed position and an open position with movement of the first engaging portion between a non-deflected position and a deflected position, respectively, in the non- deflected position, the first valve is located in the closed position forming a fluid-tight seal between the first valve and first port and preventing the passage of fluid therethrough, and in the deflected position, the first valve is located in the open position allowing the aseptic passage of fluid through the first port.

Abstract translation: 一种无菌流体连接器，其具有包括用于在其中接收流体的第一流体通道的第一连接器; 与第一流体通道流体连通以使流体通过其中的第一端口; 和第一偏转构件。 第一偏转构件包括相对于第一端口径向间隔开的第一接合部分，以及第一阀，其可在关闭位置和打开位置之间移动，其中第一接合部分分别在非偏转位置和偏转位置之间移动， 在非偏转位置，第一阀位于关闭位置，在第一阀和第一端口之间形成流体密封，并防止流体通过，并且在偏转位置，第一阀位于 打开位置允许流体通过第一端口的无菌通道。

公开(公告)号：WO2011044531A1

公开(公告)日：2011-04-14

申请号：PCT/US2010/052102

申请日：2010-10-08

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: B65D47/04

CPC classification number: B65D47/2081 ,  B05B11/047 ,  B29B11/08 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14053 ,  B29B2911/14066 ,  B29B2911/1408 ,  B29B2911/14093 ,  B29B2911/14106 ,  B29B2911/14113 ,  B29B2911/14133 ,  B29B2911/1414 ,  B29B2911/14326 ,  B29B2911/14333 ,  B29B2911/1442 ,  B29B2911/14473 ,  B29B2911/1452 ,  B29C49/06 ,  B29C73/025 ,  B29K2023/12 ,  B29K2067/00 ,  B29K2105/258 ,  B65B51/023 ,  B65B55/08 ,  B65D51/002 ,  B65D83/0061 ,  F16K15/147 ,  Y10T137/7837

Abstract: A device includes a first part having a co-molded first support, valve cover and elastic actuator, and a second part having an injection molded second support, valve seat, and variable- volume storage chamber pre-form. The pre-form is blow molded into a flexible pouch defining the variable-volume storage chamber. The one-way valve includes a semi-annular, curvilinear, relatively rigid valve seat defining axially-extending, opposing first marginal portions, and an axially-extending first mid-portion angularly extending between the opposing first marginal portions. A flexible valve member is superimposed on the valve seat and defines axially- extending, opposing second marginal portions fixedly secured on or adjacent to respective first marginal portions of the valve seat, and an axially-extending second mid-portion angularly extending between the opposing first marginal portions and superimposed onto the first mid- portion of the valve seat. The flexible valve cover and valve seat form a normally closed axially and angularly extending valve seam therebetween.

Abstract translation: 装置包括具有共模塑的第一支撑件，阀盖和弹性致动器的第一部件，以及具有注射成型的第二支撑件，阀座和可变容积存储室预成型件的第二部件。 预成型件吹塑成定义可变容积储存室的柔性袋。 单向阀包括限定轴向延伸的相对的第一边缘部分的半环形曲线的相对刚性的阀座，以及在相对的第一边缘部分之间成角度地延伸的轴向延伸的第一中间部分。 柔性阀构件叠加在阀座上并且限定轴向延伸的相对的第二边缘部分，其固定地固定在阀座的相应的第一边缘部分上或邻近阀座的相应的第一边缘部分，以及轴向延伸的第二中间部分，其在相对的第一 边缘部分并重叠在阀座的第一中间部分上。 柔性阀盖和阀座在其间形成一个常闭轴向和角度延伸的阀接缝。

公开(公告)号：WO2007133297A2

公开(公告)日：2007-11-22

申请号：PCT/US2007/000419

申请日：2007-01-05

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian, V. ,  ADAMO, Benoit ,  HOULE, Nathaniel

Inventor： PY, Daniel ,  CHAN, Julian, V. ,  ADAMO, Benoit ,  HOULE, Nathaniel

IPC: H01L21/44

CPC classification number: B67D1/0004 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D2001/0827 ,  F16K15/145

Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a Flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat. A valve cover is mounted on the valve body, and includes an axially-extending portion formed of an elastic material overlying the valve seat and covering a substantial axially-extending portion thereof. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define an axially-extending seam therebetween forming a normally closed, axially-extending valve opening, and the valve portion is movable radially between (i) a normally closed position with the valve portion engaging the valve seat, and (ii) an open position with at least a segment of the valve portion spaced radially away from the valve seat to connect the valve opening in fluid communication with the at least one flow aperture and thereby allow the passage of substance from the variable-volume storage chamber through the valve opening. In the normally closed and open positions, the one-way valve maintains substance remaining in the variable- volume storage chamber in an aseptic condition and sealed with respect to the ambient atmosphere.

Abstract translation: 提供了一种柔性袋和阀组件，用于无菌存储物质，从其中分配多部分储存物质，并将残留在袋中的物质保持在相对于环境大气密封的无菌状态。 柔性袋和阀组件可接收在相对刚性的壳体内，并且适于与泵协作，用于泵送物质的离散部分并且通过单向阀从其分配物质。 组件包括柔性袋，其中限定有相对于环境大气密封的可变容积存储室，用于将物质的多个部分无菌存储。 组件的单向阀包括限定轴向延伸的阀座的阀体和延伸穿过阀体和/或阀座的至少一个流动孔。 阀盖安装在阀体上，并且包括由弹性材料形成的轴向延伸部分，该弹性材料覆盖在阀座上并覆盖其基本上轴向延伸的部分。 阀部分限定预定的径向厚度并与阀座形成过盈配合。 阀部分和阀座在其间限定了一个轴向延伸的接缝，形成一个常闭的，轴向延伸的阀门开口，阀部分在（i）与阀座接合的阀部分的常闭位置和 （ii）打开位置，其中所述阀部分的至少一个段与所述阀座径向间隔开，以将所述阀开口与所述至少一个流动孔流体连通，从而允许所述物质从所述可变容积存储器 室通过阀门开口。 在常开和常开位置，单向阀将物质保持在可变容积的储存室中，处于无菌状态，并相对于环境大气密封。

公开(公告)号：WO2007047902A2

公开(公告)日：2007-04-26

申请号：PCT/US2006/041002

申请日：2006-10-17

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B29C45/00

CPC classification number: B29C45/1701 ,  B29C37/0007 ,  B29C45/006 ,  B29C45/1753 ,  B29C45/40 ,  B29C45/42 ,  B29C2045/1797 ,  B29C2791/005

Abstract: An apparatus and method are provided for molding sterile parts. The apparatus has a first mold portion and a second mold portion. At least one of the first and second mold portions defines a mold cavity configured to receive a molten plastic and form therefrom at least one molded part At least one of the first and second mold portions is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the first and second mold portions and permitting the passage of a fluid sterilant therein. A fluid source that contains or otherwise generates a fluid sterilant, such as vaporized hydrogen peroxide, is connectable in fluid communication with the fluid passageway for introducing the sterilant into the fluid passageway with at least one of the first and second mold portions in the open position, and in turn contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.

Abstract translation: 提供了用于模制无菌部件的装置和方法。 该装置具有第一模具部分和第二模具部分。 第一模具部分和第二模具部分中的至少一个限定了模腔，其被构造成接收熔融塑料并从其形成至少一个模制部件。第一模具部分和第二模具部分中的至少一个可相对于彼此移动， 用于密封模腔或空腔并在其中模制至少一个部件的位置，以及（ii）在第一和第二模具部分之间限定流体通道并允许其中的流体灭菌剂通过的打开位置。 包含或以其他方式产生流体灭菌剂的流体源例如蒸发的过氧化氢可连接到流体通道，用于将灭菌剂引入流体通道，其中第一和第二模具部分中的至少一个处于打开位置 ，并且还与灭菌剂接触形成第一和第二模具部分的表面，形成流体通道并且位于与至少一个模具腔相邻但不与模腔内的模制部件的内表面接触，以消除 暴露的模具表面，从而防止模制部件的污染。