公开(公告)号：WO1996035789A1

公开(公告)日：1996-11-14

申请号：PCT/US1996006911

申请日：1996-05-10

Applicant: THE WOMEN'S RESEARCH INSTITUTE ,  UNIVERSITY OF FLORIDA ,  BAZER, Fuller, Warren ,  JOHNSON, Howard, Marcellus ,  PONTZER, Carol, Hanlon ,  OTT, Troy, Lee ,  VAN HEEKE, Gino ,  IMAKAWA, Kazuhiko

Inventor： THE WOMEN'S RESEARCH INSTITUTE ,  UNIVERSITY OF FLORIDA

IPC: C12N15/20

CPC classification number: C07K14/555 ,  A61K38/212 ,  C07K14/56 ,  C07K16/249 ,  C07K2319/00 ,  C07K2319/02

Abstract: The present invention describes the isolation and characterization of multiple forms of human interferon- tau . Protein and nucleic acid coding sequences for the multiple forms are disclosed. In further aspects, the invention relates to methods of producing and using human interferon- tau molecules.

Abstract translation: 本发明描述了多种形式的人干扰素的分离和表征。 公开了多种形式的蛋白质和核酸编码序列。 在另外的方面，本发明涉及生产和使用人类干扰素tau分子的方法。

公开(公告)号：WO1994013812A2

公开(公告)日：1994-06-23

申请号：PCT/US1993011907

申请日：1993-12-07

Applicant: UNIVERSITY OF FLORIDA ,  MOYER, Richard, W. ,  HALL, Richard, L. ,  GRUIDL, Michael, E.

Inventor： UNIVERSITY OF FLORIDA

IPC: C12N15/40

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N9/1211 ,  C12N15/65 ,  C12N15/85 ,  C12N2710/24022 ,  C12N2710/24043 ,  C12N2710/24143

Abstract: The subject invention pertains to novel Entomopoxvirus (EPV) polynucleotide sequences free from association with other viral sequences with which they are naturally associated, recombinant polynucleotide vectors containing the sequences, recombinant viruses containing the sequences, and host cells infected with the recombinant viruses are provided herein, as well as methods for use thereof in the expression of heterologous proteins in both insect and mammalian host cells.

Abstract translation: 本发明涉及与其与天然结合的其他病毒序列无关的新型昆虫痘病毒（EPV）多核苷酸序列，本文提供了含有该序列的重组多核苷酸载体，含有该序列的重组病毒以及用重组病毒感染的宿主细胞 ，以及用于在昆虫和哺乳动物宿主细胞中表达异源蛋白质的方法。

公开(公告)号：WO1994013698A1

公开(公告)日：1994-06-23

申请号：PCT/US1992010584

申请日：1992-12-11

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BOROVSKY, Dov ,  CARSLON, David, A.

IPC: C07K07/06

CPC classification number: C07K7/06 ,  A01N43/36

Abstract: The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example, inhibit the formation of progeny in blood-ingesting insects, since trypsin is an essential enzyme for food digestion which provides the essential building blocks for egg development in such insects.

Abstract translation: 本发明涉及具有干扰胰蛋白酶的生物合成的性质的新型肽。 这种性质使得能够使用这些肽例如抑制摄入昆虫中的后代的形成，因为胰蛋白酶是食物消化的必需酶，其为这种昆虫中的卵发育提供了基本的构建模块。

公开(公告)号：WO1994010313A2

公开(公告)日：1994-05-11

申请号：PCT/US1993010016

申请日：1993-10-19

Applicant: UNIVERSITY OF FLORIDA ,  THE WOMEN'S RESEARCH INSTITUTE

Inventor： UNIVERSITY OF FLORIDA ,  THE WOMEN'S RESEARCH INSTITUTE ,  BAZER, Fuller, Warren ,  JOHNSON, Howard, Marcellus ,  PONTZER, Carol, Hanlon ,  OTT, Troy, Lee ,  VAN HEEKE, Gino ,  IMAKAWA, Kazuhiko

IPC: C12N15/20

CPC classification number: C07K14/555 ,  A61K38/00 ,  C07K16/249 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/61 ,  C07K2319/75

Abstract: The present invention describes the production of interferon- tau proteins and polypeptides derived therefrom. The antiviral and anticellular proliferation properties of these proteins and polypeptides are disclosed. One advantage of the proteins of the present invention is that they do not have cytotoxic side-effects when used to treat cells. Structure/function relationships for the interferon- tau protein are also described.

Abstract translation: 本发明描述了由其衍生的干扰素tau蛋白和多肽的产生。 公开了这些蛋白质和多肽的抗病毒和抗细胞增殖性质。 本发明的蛋白质的一个优点是当它们用于治疗细胞时它们不具有细胞毒性副作用。 还描述了干扰素-τ蛋白的结构/功能关系。

公开(公告)号：WO1993015134A3

公开(公告)日：1993-08-05

申请号：PCT/US1993000015

申请日：1993-01-08

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  HARMON, Julianne, P.

IPC: C08K05/10

公开(公告)号：WO1993015134A2

公开(公告)日：1993-08-05

申请号：PCT/US1993000015

申请日：1993-01-08

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  HARMON, Julianne, P.

IPC: C08K05/10

CPC classification number: B29C71/04 ,  B29C35/0866 ,  B29K2025/00 ,  B29K2033/12

Abstract: A method of enhancing the ionizing irradiation sterilization stability of an optically transparent, rigid, heat processible thermoplastic polymer comprising modifying the polymer to decrease the glass transition temperature thereof to a value such that: a) the glass transition temperature of the modified polymer is above the desired end-use temperature; b) the modified polymer remains optically transparent, rigid and heat processible; and c) the modified polymer recovers from the discolorization effects produced by exposure to ionizing sterilizing irradiation at a temperature below the glass transition temperature thereof.

Abstract translation: 一种提高光学透明，刚性，可热加工的热塑性聚合物的电离辐射灭菌稳定性的方法，包括改性聚合物以将其玻璃化转变温度降低到以下值：a）改性聚合物的玻璃化转变温度高于 期望最终使用温度; b）改性聚合物保持光学透明，刚性和热可加工性; 和c）所述改性聚合物在低于其玻璃化转变温度的温度下通过暴露于电离灭菌辐射产生的变色效果而恢复。

公开(公告)号：WO1993008745A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009429

申请日：1992-10-30

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  MACMILLAN, Michael

IPC: A61B17/00

CPC classification number: A61B17/7055 ,  A61B17/1757 ,  A61B17/6408

Abstract: A method for percutaneously fixing and fusing the lumbosacral joint and a guide device for accurate placement of instrumentation to effect the fixation or fusion. The inventive method comprises placement of pins along bony canals leading bilateral of the spine from the pelvis to the S1 pedicles and then the vertebral body of L5.

公开(公告)号：WO1993007103A1

公开(公告)日：1993-04-15

申请号：PCT/US1992008216

申请日：1992-10-02

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  TOREKI, William ,  BATICH, Christopher, D.

IPC: C04B35/52

CPC classification number: C04B35/571 ,  C04B35/62281

Abstract: A method of preparing preceramic SiC fibers having a very low oxigen content by forming fibers from a solution of a polycarbosilane and vinylic SiC precursor in a mutual volatile solvent, heating fibers in an oxygen-free inert atmosphere to effect a cross-linking reaction therebetween. Also disclosed is a method of preparing SiC fibers having superior high temperature properties and a very low oxygen content comprising heating the above-described cross-linked preceramic fibers in an inert atmosphere substantially free of oxygen for a time and at a temperature sufficient to pyrolyze the cross-linked fibers to SiC fibers. The disclosure also describes the novel fibers produced by the above-described methods.

公开(公告)号：WO1993004178A1

公开(公告)日：1993-03-04

申请号：PCT/US1992007063

申请日：1992-08-21

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  VASIL, Indra, K. ,  VASIL, Vimla

IPC: C12N15/82

CPC classification number: A01H5/10 ,  C12N15/8207 ,  C12N15/8277

Abstract: The subject invention pertains to a novel method for producing transgenic wheat plants. The transgenic plants are produced by delivering appropriate DNA to a specific callus type.

Abstract translation: 本发明涉及一种生产转基因小麦植物的新方法。 通过将适当的DNA递送到特定的愈伤组织类型来产生转基因植物。

公开(公告)号：WO1992010561A1

公开(公告)日：1992-06-25

申请号：PCT/US1991008835

申请日：1991-12-04

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  INGRAM, Lonnie, O. ,  OHTA, Kazuyoshi

IPC: C12N01/00

CPC classification number: C12N9/0006 ,  C12N9/88 ,  C12N15/01 ,  C12N15/70 ,  C12N15/74 ,  C12N15/902 ,  C12P7/065 ,  Y02E50/17

Abstract: Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

Abstract translation: 获得重组宿主细胞，其包含（A）编码染色体的异源，多肽编码多核苷酸片段，其处于内源性启动子的转录控制下，（B）产生异源片段表达增加的突变，得到 在不存在突变的情况下，通过宿主细胞增强由该片段编码的每种多肽的产生，相对于宿主细胞每种多肽的产生。 在没有选择用于显示这种增加的表达的细胞的条件的情况下，保留了如此实现的增加的表达。 当整合片段包括例如来自有效乙醇生产​​者的乙醇生产基因如运动发酵单胞菌，本发明中的重组大肠杆菌和其它肠道细菌细胞能够将大范围的生物质衍生的糖有效转化为乙醇。