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    Method of manufacturing hollow micro-needle structures
    51.
    发明申请
    Method of manufacturing hollow micro-needle structures 有权
    中空微针结构的制造方法

    公开(公告)号：US20070275521A1

    公开(公告)日：2007-11-29

    申请号：US11798884

    申请日：2007-05-17

    Applicant: Chien-Chung Fu

    Inventor： Chien-Chung Fu

    IPC: H01L21/8234 ,  H01L21/336

    CPC classification number: B29C35/0894 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C2035/0827 ,  B81B2201/055 ,  B81C1/00111

    Abstract: A method of manufacturing a hollow micro-needle structure includes the steps of: disposing a first mask layer and a second mask layer respectively aside a first substrate and aside a rear surface of the first substrate, wherein the first substrate is transparent to predetermined light; forming a photoresist layer on the front surface of the first substrate and the first mask layer; providing the predetermined light to illuminate the first substrate in a direction from the rear surface to the front surface so as to expose the photoresist layer to form an exposed portion and an unexposed portion; and removing the unexposed portion to form the micro-needle structure, which is formed by the exposed portion. The micro-needle structure has an inclined sidewall and a through hole surrounded by the inclined sidewall.

    Abstract translation: 一种中空微针结构体的制造方法，其特征在于，包括：将第一掩模层和第二掩模层分别配置在第一基板的外侧，将第一基板的背面放置在第一基板的背面， 在所述第一基板和所述第一掩模层的前表面上形成光致抗蚀剂层; 提供所述预定光以在从所述后表面到所述前表面的方向上照亮所述第一基板，以暴露所述光致抗蚀剂层以形成暴露部分和未曝光部分; 并且去除未曝光部分以形成由暴露部分形成的微针结构。 微针结构具有倾斜侧壁和由倾斜侧壁包围的通孔。

    Flexible substrate structure for microneedle arrays and its manufacturing method
    52.
    发明授权
    Flexible substrate structure for microneedle arrays and its manufacturing method 有权
    微针阵列柔性基片结构及其制造方法

    公开(公告)号：US07273474B2

    公开(公告)日：2007-09-25

    申请号：US10462628

    申请日：2003-06-17

    Applicant: Kai-Cheng Chang ,  Guang-Chyeng Fan

    Inventor： Kai-Cheng Chang ,  Guang-Chyeng Fan

    IPC: A61M5/32

    CPC classification number: B81C1/00111 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  B81B2201/055

    Abstract: The present invention is related to a flexible substrate structure for microneedle arrays and its manufacturing method, whose structure mainly comprising: tapered shape objects and flexible substrate. Wherein, structure of the tapered shape object is composed of a tip, sidewalls, and a base. Meanwhile, the flexible substrate winds tightly around sidewalls of tapered shape objects and is set up on, yet covers the base surface of tapered shape object which faces the tip of tapered shape object. Because the structure applies a flexible substrate along with tapered shape objects, hence, the fit-to-body capability is increased and allows thereof more appropriate for backside drug delivery, as well as sufficiently bring the characteristic of large-area manufacturing into full play.

    Abstract translation: 本发明涉及一种用于微针阵列的柔性衬底结构及其制造方法，其结构主要包括：锥形形状物体和柔性衬底。 其中，锥形物体的结构由尖端，侧壁和基部构成。 同时，柔性基板紧紧地卷绕在锥形形状物体的侧壁周围，并且被设置在其上，同时覆盖面对锥形物体的尖端的锥形物体的基面。 由于该结构与锥形物体一起应用柔性基板，因此，适合身体的能力增加，并且允许其适合于背侧药物递送，并且充分地充分发挥了大面积制造的特征。

    Intracutaneous microneedle array apparatus
    54.
    发明授权
    Intracutaneous microneedle array apparatus 有权

    公开(公告)号：US06931277B1

    公开(公告)日：2005-08-16

    申请号：US09580819

    申请日：2000-05-26

    Applicant: Vadim Vladimirovich Yuzhakov ,  Faiz Feisal Sherman ,  Grover David Owens ,  Vladimir Garstein

    Inventor： Vadim Vladimirovich Yuzhakov ,  Faiz Feisal Sherman ,  Grover David Owens ,  Vladimir Garstein

    IPC: A61M5/00 ,  A61M5/172 ,  A61M37/00 ,  A61N1/30 ,  A61M5/32

    CPC classification number: B81C99/0085 ,  A61M5/1723 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61N1/30 ,  B81B2201/055

    Abstract: Improved microneedle arrays are provided having a sufficiently large separation distance between each of the individual microneedles to ensure penetration of the skin while having a sufficiently small separation distance to provide high transdermal transport rates. A very useful range of separation distances between microneedles is in the range of 100–300 microns, and more preferably in the range of 100–200 microns. The outer diameter and microneedle length is also very important, and in combination with the separation distance will be crucial as to whether or not the microneedles will actually penetrate the stratum corneum of skin. For circular microneedles, a useful outer diameter range is from 20–100 microns, and more preferably in the range of 20–50 microns. For circular microneedles that do not have sharp edges, a useful length for use with interstitial fluids is in the range of 50–200 microns, and more preferably in the range of 100–150 microns; for use with other biological fluids, a useful length is in the range of 200 microns–3 mm, and more preferably in the range of 200–400 microns. For circular microneedles having sharp side edges, a useful length for use with interstitial fluids is in the range of 50–200 microns, and more preferably in the range of 80–150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns–3 mm, and more preferably in the range of 200–400 microns. For solid microneedles having a star-shaped profile with sharp edges for its star-shaped blades, a useful length for use with interstitial fluids is in the range of 50–200 microns, and more preferably in the range of 80–150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns–3 mm, and more preferably in the range of 200–400 microns, while the radius of each of its blades is in the range of 10–50 microns, and more preferably in the range of 10–15 microns.

    Microneedles for minimally invasive drug delivery
    56.
    发明申请
    Microneedles for minimally invasive drug delivery 失效
    用于微创药物递送的微针

    公开(公告)号：US20040186419A1

    公开(公告)日：2004-09-23

    申请号：US10767485

    申请日：2004-01-29

    Inventor： Steve T. Cho

    IPC: A61M005/00

    CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150282 ,  A61B5/150748 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/157 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053 ,  B81B2201/055

    Abstract: The present invention provides a microneedle incorporating a base that is broad relative to a height of the microneedle, to minimize breakage. The microneedle further includes a fluid channel and a beveled non-coring tip. Preferably arrays of such microneedles are fabricated utilizing conventional semiconductor derived micro-scale fabrication techniques. A dot pattern mask is formed on an upper surface of a silicon substrate, with each orifice of the dot pattern mask corresponding to a desired location of a microneedle. Orifices are formed that pass completely through the substrate by etching. A nitride pattern mask is formed to mask all areas in which a nitride layer is not desired. A nitride layer is then deposited on the bottom of the silicon substrate, on the walls of the orifice, and on the top of the silicon substrate around the periphery of the orifice. The nitride layer around the periphery of the orifice is offset somewhat, such that one side of the orifice has a larger nitride layer. Anisotropic etching is used to remove a substantial portion of the substrate, creating a plurality of angular, blunt, and generally pyramidal-shaped microneedles. A subsequent removal of the nitride layer, followed by an isotropic etching step, softens and rounds out the blunt angular microneedles, providing generally conical-shaped microneedles. The uneven nitride layer adjacent the orifice ensures that the microneedles will include a beveled tip. Such microneedle arrays are preferably incorporated into handheld diagnostic and drug delivery systems.

    Abstract translation: 本发明提供了一种结合了相对于微针的高度宽的基底的微针，以使破损最小化。 微针还包括流体通道和倾斜的非取心尖端。 优选地，使用常规的半导体衍生的微尺度制造技术制造这种微针的阵列。 在硅基板的上表面上形成点阵图案掩模，点图案掩模的每个孔口对应于微针的期望位置。 形成通过蚀刻完全通过基板的孔。 形成氮化物图案掩模以掩盖不需要氮化物层的所有区域。 然后将氮化物层沉积在硅衬底的底部，孔的壁上，以及围绕孔的周边的硅衬底的顶部上。 围绕孔的周边的氮化物层稍微偏移，使得孔的一侧具有较大的氮化物层。 使用各向异性蚀刻去除基本部分的大部分，产生多个角，钝，通常为锥形的微针。 随后去除氮化物层，随后进行各向同性的蚀刻步骤，软化和圆化钝角微针，提供大致锥形的微针。 邻近孔口的不均匀氮化物层确保了微针将包括一个倾斜尖端。 这种微针阵列优选并入手持诊断和药物输送系统中。

    Method for manufacturing microstructures having multiple microelements with through-holes
    57.
    发明申请
    Method for manufacturing microstructures having multiple microelements with through-holes 有权
    具有多个具有通孔的微量元素的微结构的制造方法

    公开(公告)号：US20040164454A1

    公开(公告)日：2004-08-26

    申请号：US10373251

    申请日：2003-02-24

    Applicant: The Procter & Gamble Company

    Inventor： Vladimir Gartstein ,  Faiz Feisal Sherman

    IPC: B29C043/22

    CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B26F1/24 ,  B26F1/26 ,  B81B2201/055 ,  B81C2201/034 ,  B81C2201/036

    Abstract: A method is provided for manufacturing microstructures of the type which contain a substrate and an array of protruding microelements with through-holes, which are used in penetrating layers of skin. The microelements are embossed or pressed into an initial substrate structure, which in some embodiments is formed from extruded polymeric material, and in some cases from two layers of polymer that are co-extruded. The through-holes are formed from filled through-cylinders of a second material that is removed after the embossing or pressing step; in other instances, the through-holes are left hollow during the embossing or pressing step.

    Abstract translation: 提供了一种用于制造包含基底的微结构的方法和具有通孔的突出微元件阵列，其用于穿透皮肤层。 微元件被压花或压制成初始的基底结构，其在一些实施方案中由挤出的聚合物材料形成，并且在一些情况下由共挤出的两层聚合物形成。 通孔由在压花或压制步骤之后被去除的第二材料的填充的通孔形成; 在其他情况下，在压花或压制步骤期间，通孔留空。

    Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
    59.
    发明授权
    Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems 有权
    用于通过生物屏障运输流体的系统和方法以及用于这种系统的生产技术

    公开(公告)号：US06558361B1

    公开(公告)日：2003-05-06

    申请号：US09589369

    申请日：2000-06-08

    Applicant: Yehoshua Yeshurun

    Inventor： Yehoshua Yeshurun

    IPC: A61M3700

    CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150984 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055

    Abstract: A device for the transport of fluids through a biological barrier includes a number of microneedles projecting from the front face of a substrate. A conduit is associated with each of the microneedles to provide a fluid flow path for transport of fluid through a hole in the biological barrier formed by the corresponding microneedle. Each of the microneedles is configured to provide a penetrating tip, and each conduit terminates at an opening which is proximal with respect to the microneedle tip. Also described are microneedle-based devices with integrated MEMS pumping configurations for withdrawal and/or delivery of fluids, and remote healthcare systems based on such devices.

    Abstract translation: 用于通过生物屏障输送流体的装置包括从基板的前表面突出的许多微针。 导管与每个微针相关联以提供流体流动路径，用于将流体输送通过由相应的微针形成的生物屏障中的孔。 每个微针构造成提供穿透尖端，并且每个导管终止于相对于微针尖端近端的开口。 还描述了具有用于取出和/或输送流体的集成MEMS泵送配置的基于微针的装置，以及基于这种装置的远程保健系统。

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