公开(公告)号：EP1951187A4

公开(公告)日：2011-07-06

申请号：EP06836523

申请日：2006-10-25

Applicant: ADA FOUNDATION

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO

IPC: A61K8/21 ,  A61K8/00

CPC classification number: A61Q11/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24

公开(公告)号：EP1715829A2

公开(公告)日：2006-11-02

申请号：EP04812355.8

申请日：2004-11-29

Applicant: ADA FOUNDATION

Inventor： CHOW, Laurence , C. ,  TAKAGI, Shozo

IPC: A61K6/00

CPC classification number: A61L24/02 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/033 ,  A61K6/0625 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61K6/097 ,  A61L27/12 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  C04B2103/10 ,  C04B2111/00836 ,  C04B14/28 ,  C04B20/008 ,  C04B22/064 ,  C04B22/143 ,  C04B24/003 ,  C04B24/06 ,  C04B38/02 ,  C04B40/0028 ,  C04B40/0082 ,  C04B40/0259 ,  C04B2103/42 ,  C04B2103/445 ,  C04B24/38 ,  C04B24/383 ,  C04B22/085 ,  C04B22/122 ,  C04B24/04 ,  C08L5/08 ,  C08L5/04 ,  C08L1/286 ,  C08L1/284

Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.

公开(公告)号：EP1641426A1

公开(公告)日：2006-04-05

申请号：EP04756561.9

申请日：2004-07-02

Applicant: ADA FOUNDATION

Inventor： DICKENS, Sabine, H. ,  EICHMILLER, Frederick, C.

IPC: A61K6/083 ,  A61K6/00

CPC classification number: A61K6/06 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/083 ,  A61K6/09 ,  C08L33/00 ,  C08L75/16

Abstract: Remineralizing dental cements contain source(s) of calcium and phosphate ions, adhesive resin monomers, reinforcing base resin monomers, and catalysts able to initiate the polymerization of the adhesive and reinforcing base resin monomers. Such dental cements can be used as orthodontic cements, crown and bridge cements, adhesives, sealants, cavity liners, and protective coatings. The release of calcium and phosphate ions and, optionally, fluoride ions, protects tooth structure from demineralization, a precursor of tooth decay.

公开(公告)号：EP3341426A1

公开(公告)日：2018-07-04

申请号：EP16852442.9

申请日：2016-09-28

Applicant: ADA Foundation

Inventor： SUN, Jirun

IPC: C08F20/56

CPC classification number: C08F220/68 ,  A61K6/0023 ,  A61K6/0052 ,  A61K6/083 ,  B33Y70/00 ,  C08F216/125 ,  C08F222/1006 ,  C08K3/36 ,  C09D11/101 ,  C09D11/107 ,  C09D129/10 ,  C09D133/14 ,  C09J129/10 ,  C09J133/14

Abstract: A composition of matter includes a mixture of styrene derivative monomers and methacrylate/acrylate derivative monomers, which have one or more urethane, carbamate, amide, and/or amine functional groups, and initiators, and the compositions are used to achieve composition control of the forming polymer, with the mole fraction of acrylate/methacrylate and styrene moieties in the forming polymer determined preferably by the chemistry and composition of the feeding monomers rather than the viscosity of the monomers.

公开(公告)号：EP1715829B1

公开(公告)日：2011-10-26

申请号：EP04812355.8

申请日：2004-11-29

Applicant: ADA FOUNDATION

Inventor： CHOW, Laurence , C. ,  TAKAGI, Shozo

IPC: A61L27/10 ,  A61L27/58 ,  A61L24/02

CPC classification number: A61L24/02 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/033 ,  A61K6/0625 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61K6/097 ,  A61L27/12 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  C04B2103/10 ,  C04B2111/00836 ,  C04B14/28 ,  C04B20/008 ,  C04B22/064 ,  C04B22/143 ,  C04B24/003 ,  C04B24/06 ,  C04B38/02 ,  C04B40/0028 ,  C04B40/0082 ,  C04B40/0259 ,  C04B2103/42 ,  C04B2103/445 ,  C04B24/38 ,  C04B24/383 ,  C04B22/085 ,  C04B22/122 ,  C04B24/04 ,  C08L5/08 ,  C08L5/04 ,  C08L1/286 ,  C08L1/284

Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.

公开(公告)号：EP1885650A4

公开(公告)日：2011-01-05

申请号：EP05812423

申请日：2005-09-16

Applicant: ADA FOUNDATION

Inventor： CHOW LAURENCE C ,  SUN LIMIN

IPC: C01B25/16

CPC classification number: C01F11/22 ,  C01B25/322 ,  C01B25/455 ,  C01B33/24

Abstract: Nano-particles of calcium and phosphorous compounds are made in a highly pure generally amorphous state by spray drying a weak acid solution of said compound and evaporating the liquid from the atomized spray in a heated column followed by collection of the precipitated particles. Hydroxyapatite (HA) particles formed by such apparatus and methods are examples of particle manufacture useful in bone and dental therapies. Dual nozzle spraying techniques are utilized for generally insoluble compounds.

公开(公告)号：EP2266634A2

公开(公告)日：2010-12-29

申请号：EP10010701.0

申请日：2004-11-29

Applicant: ADA FOUNDATION

Inventor： The designation of the inventor has not yet been filed

IPC: A61L27/10 ,  A61L27/58 ,  A61L24/02

CPC classification number: A61L24/02 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/033 ,  A61K6/0625 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61K6/097 ,  A61L27/12 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  C04B2103/10 ,  C04B2111/00836 ,  C04B14/28 ,  C04B20/008 ,  C04B22/064 ,  C04B22/143 ,  C04B24/003 ,  C04B24/06 ,  C04B38/02 ,  C04B40/0028 ,  C04B40/0082 ,  C04B40/0259 ,  C04B2103/42 ,  C04B2103/445 ,  C04B24/38 ,  C04B24/383 ,  C04B22/085 ,  C04B22/122 ,  C04B24/04 ,  C08L5/08 ,  C08L5/04 ,  C08L1/286 ,  C08L1/284

Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and salt solutions with a cationic component other than calcium and an anionic component that forms strong calcium complexes in the solution, or is insoluble with calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.

Abstract translation: 糊状形式的骨或牙科植入材料包括磷酸钙和/或含钙粉末和盐溶液与除了钙之外的阳离子组分和在溶液中形成强钙络合物的阴离子组分的盐溶液的混合物，或者是 不溶于钙。 糊状物是稳定的，耐冲洗，并且将形成羟基磷灰石并相对于水泥硬化。

公开(公告)号：EP1715829A4

公开(公告)日：2008-03-05

申请号：EP04812355

申请日：2004-11-29

Applicant: ADA FOUNDATION

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO

IPC: A61L27/10 ,  A61K6/00 ,  A61K6/097 ,  A61L24/02 ,  A61L27/12 ,  A61L27/58 ,  C04B28/34

CPC classification number: A61L24/02 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/033 ,  A61K6/0625 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61K6/097 ,  A61L27/12 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  C04B2103/10 ,  C04B2111/00836 ,  C04B14/28 ,  C04B20/008 ,  C04B22/064 ,  C04B22/143 ,  C04B24/003 ,  C04B24/06 ,  C04B38/02 ,  C04B40/0028 ,  C04B40/0082 ,  C04B40/0259 ,  C04B2103/42 ,  C04B2103/445 ,  C04B24/38 ,  C04B24/383 ,  C04B22/085 ,  C04B22/122 ,  C04B24/04 ,  C08L5/08 ,  C08L5/04 ,  C08L1/286 ,  C08L1/284

Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.

公开(公告)号：EP1885650A1

公开(公告)日：2008-02-13

申请号：EP05812423.1

申请日：2005-09-16

Applicant: ADA FOUNDATION

Inventor： CHOW, Laurence, C. ,  SUN, Limin

IPC: C01B25/16

CPC classification number: C01F11/22 ,  C01B25/322 ,  C01B25/455 ,  C01B33/24

Abstract: Nano-particles of calcium and phosphorous compounds are made in a highly pure generally amorphous state by spray drying a weak acid solution of said compound and evaporating the liquid from the atomized spray in a heated column followed by collection of the precipitated particles. Hydroxyapatite (HA) particles formed by such apparatus and methods are examples of particle manufacture useful in bone and dental therapies. Dual nozzle spraying techniques are utilized for generally insoluble compounds.

公开(公告)号：EP3526193A1

公开(公告)日：2019-08-21

申请号：EP17860318.9

申请日：2017-10-05

Applicant: ADA Foundation ,  Sun, Jirun

Inventor： SUN, Jirun

IPC: C07C245/06 ,  A61K31/655