Abstract:
The present invention relates generally to the field of diabetes. More particularly, it concerns the identification of genes responsible for NIDDM1 for use in diagnostic and therapeutic applications. The present invention demonstrates that the NIDDM1 locus is, in fact, the calpain 10 gene. The invention further relates to the discovery that analysis of mutations in calpain genes and gene products can be diagnostic for type 2 diabetes. The invention also contemplates methods of treating diabetes in view of the fact that calpain mutations can cause diabetes. Further, the invention relates to novel polynucleotides of the NIDDM1 locus and polypeptides encoded by such polynucleotides.
Abstract:
A method and system for monitoring a process and determining its condition. Initial data is sensed, a first set of virtual data is produced by applying a system state (20) analyzation to the initial data, a second set of virtual data is produced by applying a neural network (40) analyzation to the initial data and a parity space (50) analyzation is applied to the first and second set of virtual data and also to the initial data to provide a parity space (50) decision about the condition of the process. A logic test (60) can further be applied to produce a further system decision about the state of the process.
Abstract:
The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious side effects are minimized and treatment of metastatic melanomas are surprisingly and dramatically improved.
Abstract:
The invention is a method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a learned states (40), a frequency domain transformation carried out for the system signal and reference signal, and a frequency domain difference function is established. The process is then repeated until a full range of data is accumulated over the time domain and an SPRT methodology (50) is applied to determine a three-dimensional surface plot (60) characteristic of the operating state of the system under surveillance.
Abstract:
A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium. The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carrying out this process and a process for the therapeutic use thereof are also disclosed.
Abstract:
The present invention provides isolated and purified polynucleotides that encode plant and cyanobacterial polypeptides that participate in the carboxylation of acetyl-CoA. Isolated cyanobacterial and plant polypeptides that catalyze acetyl-CoA carboxylation are also provided. Processes for altering acetyl-CoA carboxylation, increasing herbicide resistance of plants and identifying herbicide resistant variants of acetyl-CoA carboxylase are also provided.
Abstract:
The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.
Abstract:
PROBLEM TO BE SOLVED: To precisely detect a small node from a chest X-ray image. SOLUTION: In a computer supported diagnostic method for detecting a lung small node in a digitized chest image, this method takes the difference between the signal emphasized image and the signal suppressed image of the chest image to generate a difference picture (a), repeats the threshold value processing of the difference picture by plural threshold values concerning gradation while changing a threshold value, executes a prescribed morphological test to a pixel group with a value larger than each threshold value to specify the candidate of the small node (b), executes plural regular tests to the prescribed feature of the image appearing at the difference image and the chest image by corresponding spatially to excludes the small nodes of pseudo positive reaction from the candidates of the small nodes (c), and additionally excludes the small nodes of pseud positive reaction from the candidates of the residual small nodes at the step (c) by an artificial neural network to specify the residual candidates of the small nodes as the candidates of the true small nodes (d).
Abstract:
PROBLEM TO BE SOLVED: To provide the shift unchanged artificial neural network for detecting disease in a digital image. SOLUTION: This network includes an input layer and at least hidden layer and an output layer includes at least one neuron. Each hidden layer includes at least one hidden group. Each hidden group having at least one hidden unit includes at least one neuron. For learning using error back propagation algorithm so that the mean weight of a group becomes substantially zero, respective neurons need to be equal in connection weight between two groups in adjacent layers. A digital image of a patient is obtained to extract a suspicious area of interest and this area of interest is converted into numeric data, which are inputted to the neural network after the learning to detect a fine calcare part.
Abstract:
PURPOSE: To provide a computerized method and device for improving the precision of diagnosis through the use of a picture emphasized for detecting secular change between hourly consecutive digital medical picture. CONSTITUTION: A pair of pictures are digitized (steps 10 and 20) and in order to make corresponding positions at the two pictures equal, the positioning of the pictures including the distortion of one of the pictures to be nonlinear is executed (step 40). After this, the distorted picture and the other picture are subtraction-processed (step 50). A slightly opaque part existing at a picture photographed later is detected at a subtraction picture.