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    METHODS AND SYSTEMS FOR MONITORING AND OBTAINING INFORMATION OF AT LEAST ONE PORTION OF A SAMPLE USING CONFORMAL LASER THERAPY PROCEDURES, AND PROVIDING ELECTROMAGNETIC RADIATION THERETO
    61.
    发明申请
    METHODS AND SYSTEMS FOR MONITORING AND OBTAINING INFORMATION OF AT LEAST ONE PORTION OF A SAMPLE USING CONFORMAL LASER THERAPY PROCEDURES, AND PROVIDING ELECTROMAGNETIC RADIATION THERETO 审中-公开
    用于使用合格激光治疗程序监测和获取至少一个样品的样品的信息的方法和系统，并提供电磁辐射

    公开(公告)号：WO2007143236A2

    公开(公告)日：2007-12-13

    申请号：PCT/US2007061463

    申请日：2007-02-01

    Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SHISHKOV MILLEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J

    Inventor： TEARNEY GUILLERMO J ,  SHISHKOV MILLEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J

    CPC classification number: A61B18/22 ,  A61B5/0066 ,  A61B5/0086 ,  A61B5/0088 ,  A61B2017/22051 ,  A61B2018/2272

    Abstract: In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro- magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.

    Abstract translation: 在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。 例如，可以在样品的部分中引起温度变化。 至少一个第一电磁辐射可以转发到样品附近或部分的部分。 可以在多个深度处识别该部分的变形，作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。 在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。 例如，可以以特定波长向样品中的部分提供电磁辐射。 当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。

    SYSTEM AND METHOD FOR PROVIDING CELL SPECIFIC LASER THERAPY OF ATHEROSCLEROTIC PLAQUES BY TARGETING LIGHT ABSORBERS IN MACROPHAGES
    63.
    发明申请
    SYSTEM AND METHOD FOR PROVIDING CELL SPECIFIC LASER THERAPY OF ATHEROSCLEROTIC PLAQUES BY TARGETING LIGHT ABSORBERS IN MACROPHAGES 审中-公开
    用于通过将光吸收剂靶向在宏观物体中提供细胞特异性激光治疗动脉粥样硬化斑块的系统和方法

    公开(公告)号：WO2007103721A3

    公开(公告)日：2007-11-08

    申请号：PCT/US2007063058

    申请日：2007-03-01

    Applicant: GEN HOSPITAL CORP ,  NADKARNI SEEMANTINI K ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  ANDERSON RICHARD ROX

    Inventor： NADKARNI SEEMANTINI K ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  ANDERSON RICHARD ROX

    IPC: A61N5/06

    CPC classification number: A61B18/245 ,  A61N5/0601 ,  A61N5/062

    Abstract: An apparatus and method according to the present invention can be provided, e.g., for a cell specific laser therapy of atherosclerotic plaques, particularly to systems and methods for targeting endogenous light absorbers present within plaque macrophages and exogenous nanoparticle targeting. In one exemplary embodiment, an electro-magnetic radiation can be forwarded to an anatomical structure. The electro-magnetic radiation may have at least one property configured to (a) modify at least one characteristic of at least one first cell, and (b) minimize any modification of and/or modify at least one characteristic of at least second cell. The first and second cells may be different from one another, the characteristics of the first and second cells can be different from one another, and the first cell and/or the second cell may have at least one macrophage feature, and the characteristic of the at least one first cell and/or the at least one second cell can be temperature. According to still another exemplary embodiment, a location associated with the first cell and the second cell can be determined. For example, the electro-magnetic radiation can be forwarded in a vicinity of the location.

    Abstract translation: 可以提供根据本发明的设备和方法，例如用于动脉粥样硬化斑块的细胞特异性激光治疗，特别是用于靶向存在于斑块巨噬细胞内的内源光吸收剂和外源纳米颗粒靶向的系统和方法。 在一个示例性实施例中，电磁辐射可被转发至解剖结构。 电磁辐射可以具有至少一种性质，其被配置为（a）修改至少一个第一电池的至少一个特性，并且（b）最小化至少第二电池的任何修改和/或修改至少一个特性。 第一和第二细胞可以彼此不同，第一和第二细胞的特征可以彼此不同，并且第一细胞和/或第二细胞可以具有至少一个巨噬细胞特征，并且第一和第二细胞的特征 至少一个第一电池和/或至少一个第二电池可以是温度。 根据又一示例性实施例，可以确定与第一小区和第二小区相关联的位置。 例如，可以在该位置附近发送电磁辐射。

    SYSTEMS AND PROCESSES FOR PROVIDING ENDOGENOUS MOLECULAR IMAGING WITH MID-INFARED LIGHT
    64.
    发明申请
    SYSTEMS AND PROCESSES FOR PROVIDING ENDOGENOUS MOLECULAR IMAGING WITH MID-INFARED LIGHT 审中-公开
    提供具有中间入射光的内源分子成像的系统和过程

    公开(公告)号：WO2007084933A2

    公开(公告)日：2007-07-26

    申请号：PCT/US2007/060657

    申请日：2007-01-18

    Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

    Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

    CPC classification number: G01N21/3563 ,  G01J3/02 ,  G01J3/021 ,  G01J3/42 ,  G01N21/031 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787

    Abstract: Exemplary systems and processes for generating information associated with at least one portion of a sample are provided. In one exemplary embodiment, at least one electro-magnetic radiation can be received from the at least one portion, whereas the electro-magnetic radiation has a wavenumber that is between approximately 5,000 cm -1 and 600 cm -1 . The information can be generated which includes structural data, molecular data and/or chemical data of the portion. The information can be generated based on (a) at least one phase of the at least one electro-magnetic radiation, and/or (b) at least one refractive index of the at least one portion. According to another exemplary embodiment, the electro-magnetic radiation having a first wavenumber can be transmitted to the portion which has at least two substances, whereas a refractive index of one of the substances at a second wavenumber is approximately the same as a refractive index of another one of the substances at the second wavenumber. The electro-magnetic radiation can be controlled such that the first wavenumber substantially matches the first wavenumber to reduce scattering within the portion.

    Abstract translation: 提供了用于生成与样本的至少一部分相关联的信息的示例性系统和过程。 在一个示例性实施例中，可以从至少一个部分接收至少一个电磁辐射，而电磁辐射具有介于约5000cm -1与600cm -1之间的波数， SUP> -1 。 可以生成包括该部分的结构数据，分子数据和/或化学数据的信息。 可以基于（a）至少一个电磁辐射的至少一个相位，和/或（b）至少一个部分的至少一个折射率来生成信息。 根据另一个示例性实施方式，具有第一波数的电磁辐射可以被传送到具有至少两种物质的部分，而第二波数处的物质之一的折射率近似等于 另一种是第二种波数的物质。 可以控制电磁辐射，使得第一波数基本上匹配第一波数以减少该部分内的散射。

    METHOD AND APPARATUS FOR IMAGING OF VESSEL SEGMENTS
    65.
    发明申请
    METHOD AND APPARATUS FOR IMAGING OF VESSEL SEGMENTS 审中-公开
    用于成像船舶部分的方法和装置

    公开(公告)号：WO2006024015A1

    公开(公告)日：2006-03-02

    申请号：PCT/US2005/030295

    申请日：2005-08-24

    Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E.

    Inventor： TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E.

    IPC: A61B5/00

    CPC classification number: A61B5/6852 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007

    Abstract: An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (208) (e.g., a housing), a fluid delivery arrangement and an imaging arrangement (204). The housing includes an aperture (221) formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated (BY A Pullback device -215) along the surface of the structure while imaging the surface of the structure.

    Abstract translation: 提供了一种用于对与不透明流体接触的结构的表面进行成像的装置，方法和软件装置。 该装置包括制品（208）（例如，壳体），流体输送装置和成像装置（204）。 壳体包括形成在制品中的孔（221）。 流体输送装置构造成将一定体积的基本上透明的流体输送到形成在壳体中的孔。 成像装置被配置为在将透明流体的体积传送到孔之后使用成像模态来对结构的表面进行成像，其中成像装置和/或制品被翻译（通过回抽装置-215） 沿着结构的表面，同时对结构的表面进行成像。

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