公开(公告)号：AU2007319811A1

公开(公告)日：2008-05-22

申请号：AU2007319811

申请日：2007-11-15

Applicant: CODA THERAPEUTICS INC

Inventor： GREEN COLIN R ,  BECKER DAVID L ,  DUFT BRADFORD J

IPC: A61K38/18 ,  A61K31/711

Abstract: Methods and compositions comprising combinations of one or more anti-connexin agents and one or more other agents useful for the promotion and/or improvement of wound healing and/or tissue repair.

公开(公告)号：WO2016029191A2

公开(公告)日：2016-02-25

申请号：PCT/US2015/046425

申请日：2015-08-21

Applicant: AUCKLAND UNISERVICES LIMITED ,  CODA THERAPEUTICS, INC.

Inventor： GREEN, Colin Richard ,  KIM, Yeri ,  PHILLIPS, Anthony ,  DUFT, Bradford James

IPC: A61K38/16

CPC classification number: C12N15/113 ,  A61K9/0048 ,  A61K31/167 ,  A61K31/195 ,  A61K31/352 ,  A61K31/382 ,  A61K31/498 ,  A61K31/5377 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/575 ,  A61K31/713 ,  A61K38/08 ,  A61K38/10 ,  A61K38/39 ,  A61K45/06 ,  A61P27/02 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/3231 ,  A61K2300/00

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract translation: 本发明涉及包含连接蛋白调节剂，潘尼辛调节剂，间隙连接调节剂，半通道调节剂和潘尼辛通道调节剂的组合物和制品，以及它们单独或组合用于治疗眼部和其它疾病的用途。

公开(公告)号：WO2009085274A3

公开(公告)日：2009-10-01

申请号：PCT/US2008014025

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  DUFT BRADFORD J

Inventor： DUFT BRADFORD J

IPC: A61K38/17 ,  A61L24/00 ,  A61P17/02 ,  A61P43/00 ,  C12N15/113

CPC classification number: A61K38/10 ,  A61K9/0014 ,  A61K31/713 ,  A61K38/177 ,  A61K47/38 ,  A61L15/44 ,  A61L26/0066 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  C07K7/08 ,  C07K14/78 ,  C12N15/1138 ,  C12N2310/11 ,  A61K2300/00

Abstract: Methods and compositions comprising combinations and uses of a first anti-connexin agent and a second anti-connexin agent, for example, one or more anti-connexin polynucleotides and one or more anti-connexin peptides or peptidomimetics, are provided for the treatmen or prevention of abnormal or excessive scarring.

Abstract translation: 提供了包含第一抗连接蛋白剂和第二抗连接蛋白剂的组合和用途的方法和组合物，例如一种或多种抗连接蛋白多核苷酸和一种或多种抗连接蛋白肽或肽模拟物，用于治疗或预防 异常或过度瘢痕形成。

公开(公告)号：WO2009097077A2

公开(公告)日：2009-08-06

申请号：PCT/US2009/000129

申请日：2009-01-07

Applicant: CODA THERAPEUTICS, INC. ,  MORI, Ryoichi ,  MARTIN, Paul ,  DUFT, Bradford, J. ,  SHAW, Tanya

Inventor： MORI, Ryoichi ,  MARTIN, Paul ,  DUFT, Bradford, J. ,  SHAW, Tanya

IPC: C12N15/11 ,  A61K48/00

CPC classification number: C12N15/1136 ,  C12N2310/11 ,  C12N2310/14

Abstract: Methods and compositions comprising an anti-ostepontin agent and/or a PDGF receptor blocker or antagonist, alone or in combination with one or more anti-connexin agents, for example, one or more anti-connexin polynucleotides and/or one or more anti-connexin peptides or peptidomimetics, are provided for the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.

Abstract translation: 包含单独或与一种或多种抗连接蛋白试剂，例如一种或多种抗连接蛋白多核苷酸和/或一种或多种抗连接蛋白多核苷酸组合的抗 - 奥替替药物和/或PDGF受体阻断剂或拮抗剂的方法和组合物， 连接蛋白肽或肽模拟物用于促进和/或改善伤口愈合和/或组织修复，以及用于抗瘢痕形成，抗炎，抗纤维化和抗粘连的适应症。

公开(公告)号：WO2009085275A3

公开(公告)日：2009-07-09

申请号：PCT/US2008/014026

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  DUFT, Bradford, J.

Inventor： DUFT, Bradford, J.

IPC: A61K38/17 ,  C12N15/11 ,  A61L24/00 ,  A61P17/02 ,  A61P43/00

Abstract: Compositions, articles, devices and methods for the treatment of fibrosis and fibrotic diseases, disorders, and conditions in humans and non-human animals.

公开(公告)号：WO2009085274A2

公开(公告)日：2009-07-09

申请号：PCT/US2008/014025

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  DUFT, Bradford, J.

Inventor： DUFT, Bradford, J.

IPC: A61K48/00

CPC classification number: A61K38/10 ,  A61K9/0014 ,  A61K31/713 ,  A61K38/177 ,  A61K47/38 ,  A61L15/44 ,  A61L26/0066 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  C07K7/08 ,  C07K14/78 ,  C12N15/1138 ,  C12N2310/11 ,  A61K2300/00

Abstract: Methods and compositions comprising combinations and uses of a first anti-connexin agent and a second anti-connexin agent, for example, one or more anti-connexin polynucleotides and one or more anti-connexin peptides or peptidomimetics, are provided for the treatmen or prevention of abnormal or excessive scarring.

Abstract translation: 提供了包含第一抗连接蛋白剂和第二抗连接蛋白剂的组合和用途的方法和组合物，例如一种或多种抗连接蛋白多核苷酸和一种或多种抗连接蛋白肽或肽模拟物，用于治疗或预防 异常或过度瘢痕形成。

公开(公告)号：WO2015130840A2

公开(公告)日：2015-09-03

申请号：PCT/US2015/017595

申请日：2015-02-25

Applicant: CODA THERAPEUTICS, INC.

Inventor： PHILLIPS, Anthony ,  BANNAN, Scott ,  MATSUOKA, Grove ,  DUFT, Bradford

IPC: A01H5/00 ,  C12N15/82

CPC classification number: C12N15/113 ,  C12N2310/11

Abstract: Connexin protein modulation methods and compositions are provided for the healing of resistant lesions, including lesions on subjects with multiple venous leg ulcers or multiple diabetic foot ulcers, and other responder subjects. Also provided are kits and articles of manufacture comprising a connexin protein modulating agent, for example, a connexin 43 modulating agent for use in the healing of resistant lesions.

公开(公告)号：WO2009097077A9

公开(公告)日：2009-08-06

申请号：PCT/US2009/000129

申请日：2009-01-07

Applicant: CODA THERAPEUTICS, INC. ,  MORI, Ryoichi ,  MARTIN, Paul ,  DUFT, Bradford, J. ,  SHAW, Tanya

Inventor： MORI, Ryoichi ,  MARTIN, Paul ,  DUFT, Bradford, J. ,  SHAW, Tanya

IPC: C12N15/11 ,  A61K48/00

Abstract: Methods and compositions comprising an anti-ostepontin agent and/or a PDGF receptor blocker or antagonist, alone or in combination with one or more anti-connexin agents, for example, one or more anti-connexin polynucleotides and/or one or more anti-connexin peptides or peptidomimetics, are provided for the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.

公开(公告)号：WO2009075882A2

公开(公告)日：2009-06-18

申请号：PCT/US2008/013656

申请日：2008-12-11

Applicant: CoDa Therapeutics, Inc. ,  DUFT, Bradford, J.

Inventor： DUFT, Bradford, J.

IPC: A61K48/00

CPC classification number: C12N15/1138 ,  A61K38/10 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/31 ,  A61K2300/00

Abstract: Methods and compositions comprising combinations and uses of a first anti-connexin agent and a second anti-connexin agent, for example, one or more anti-connexin polynucleotides and one or more anti-connexin peptides or peptidomimetics, are provided for therapeutic use including uses for the promotion and/or improvement of wounds and wound healing and/or tissue repair.

Abstract translation: 包含第一抗连接蛋白剂和第二抗连接蛋白剂的组合和用途的方法和组合物，例如一种或多种抗连接蛋白多核苷酸和一种或多种抗连接蛋白肽或肽模拟物 提供用于治疗用途，包括用于促进和/或改善伤口和伤口愈合和/或组织修复。

公开(公告)号：WO2009075881A2

公开(公告)日：2009-06-18

申请号：PCT/US2008013655

申请日：2008-12-11

Applicant: CODA THERAPEUTICS INC ,  BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

Inventor： BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

IPC: C07K16/18 ,  A61K38/02 ,  C07K2/00

CPC classification number: C07K14/78

Abstract: Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incompletely healing wounds, and dehiscent wounds in a subject in need thereof.

Abstract translation: 方法，化合物，组合物，试剂盒和制品，其包含一种或多种间隙连接调节剂，用于治疗以预期速率不愈合的伤口，包括慢性伤口，延迟愈合伤口，不完全愈合的伤口和受试者的开裂伤口 需要。