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    1-Benzoxepin-5 (2H)-one derivatives and pharmaceutical compositions
    61.
    发明授权
    1-Benzoxepin-5 (2H)-one derivatives and pharmaceutical compositions 失效
    1-苯并恶庚英-5（2H） - 酮衍生物和药物组合物

    公开(公告)号：US4279905A

    公开(公告)日：1981-07-21

    申请号：US173076

    申请日：1980-07-28

    Applicant: Heinrich-Wilhelm Ohlendorf ,  Klaus-Ullrich Wolf ,  Wilhelm Kaupmann

    Inventor： Heinrich-Wilhelm Ohlendorf ,  Klaus-Ullrich Wolf ,  Wilhelm Kaupmann

    IPC: A61K31/335 ,  A61K31/37 ,  A61P1/00 ,  A61P1/14 ,  C07D313/08

    CPC classification number: C07D313/08

    Abstract: Novel, 3-amino-1-benzoxepin-5 (2H)-one derivatives and methods for their production are disclosed. These derivatives correspond to the Formula I: ##STR1## wherein: R.sub.1 and R.sub.2 independently of one another arehydrogen,C.sub.1 -C.sub.5 alkyl,C.sub.1 -C.sub.5 alkyl substituted with a terminal phenyl, or a phenyl containing one or two halogens, methyl or methoxy groups, a 3,4-methylenedioxy or a 3,4-ethylenedioxy group,C.sub.2 -C.sub.5 alkyl substituted with terminal hydroxy or methoxy or,C.sub.3 -C.sub.4 alkenyl; orone of R.sub.1 and R.sub.2 are hydrogen or a C.sub.1 -C.sub.5 alkyl and the other is a C.sub.2 -C.sub.5 alkyl substituted with a terminal NR.sub.5 R.sub.6 ;R.sub.5 and R.sub.6 independently of one another are hydrogen or C.sub.1 -C.sub.5 alkyl; orR.sub.5 and R.sub.6 are together a 5 to 7 member ring, orR.sub.5 and R.sub.6 are together a 5 to 7 member ring having heterogeneous oxygen, sulfur or nitrogen;R.sub.1 and R.sub.2 are together a 5 to 7 member ring, orR.sub.1 and R.sub.2 are together a 5 to 7 member ring having heterogeneous oxygen, sulfur or NR.sub.7 ;R.sub.7 is hydrogen, methyl, benzyl or phenyl;R.sub.3 and R.sub.4 independently of one another are hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio; orone of R.sub.3 and R.sub.4 is trifluoromethyl or nitro and the other is hydrogen;and the acid addition salts thereof. These compounds have a favorable effect on the treatment of spasms of the stomach-intestinal tract and, therefore, constitute the active ingredient of pharmaceutical compositions and methods for the treatment of disorders of the stomach and intestinal tract. Processes for the preparation of the derivatives and their acid addition salts and intermediate products for their preparation are also descrived.

    Abstract translation: 公开了3-氨基-1-苯并氧杂-5（2H） - 酮衍生物及其生产方法。 这些衍生物对应于式I：其中：R 1和R 2彼此独立地是氢，C 1 -C 5烷基，被末端苯基取代的C 1 -C 5烷基或含有一个或两个卤素的苯基，甲基或 甲氧基，3,4-亚甲二氧基或3,4-亚乙二氧基，被末端羟基或甲氧基取代的C 2 -C 5烷基或C 3 -C 4烯基; 或R 1和R 2中的一个为氢或C 1 -C 5烷基，另一个为被末端NR 5 R 6取代的C 2 -C 5烷基; R 5和R 6彼此独立地是氢或C 1 -C 5烷基; 或R 5和R 6一起为5至7元环，或者R 5和R 6一起为具有异质的氧，硫或氮的5至7元环; R 1和R 2一起为5至7元环，或者R 1和R 2一起为具有异质氧，硫或NR 7的5至7元环; R7是氢，甲基，苄基或苯基; R 3和R 4彼此独立地是氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基或C 1 -C 4烷硫基; 或者R 3和R 4中的一个是三氟甲基或硝基，另一个是氢; 及其酸加成盐。 这些化合物对胃肠道痉挛的治疗具有有利的作用，因此构成了用于治疗胃肠道疾病的药物组合物和方法的活性成分。 还描述了制备衍生物及其酸加成盐和中间产物用于其制备的方法。

    Front panel and partition holder for display shelf
    65.
    发明授权
    Front panel and partition holder for display shelf 失效
    展示架前面板和分隔架

    公开(公告)号：US3862784A

    公开(公告)日：1975-01-28

    申请号：US41473873

    申请日：1973-11-12

    Applicant: HEINRICH WILHELM

    Inventor： HEINRICH WILHELM

    IPC: A47F3/12 ,  A47F3/00 ,  A47B9/00

    CPC classification number: A47F3/12

    Abstract: Means for mounting front panels and partitions on storage and display shelves comprising an extension laterally arranged on the shelf employing a recess for receiving an inserted attachment which attachment is grooved to support the front panels and the partitions.

    Abstract translation: 用于在存储和展示架上安装前面板和隔板的装置，其包括横向布置在搁架上的延伸部，其采用用于接收插入附件的凹部，该附接件被开槽以支撑前面板和隔板。

    1-phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them
    68.
    发明授权
    1-phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them 失效
    1-苯基-2-氨基羰基吲哚化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US4924004A

    公开(公告)日：1990-05-08

    申请号：US264049

    申请日：1988-10-28

    Applicant: Heinrich-Wilhelm Ohlendorf ,  Wilhelm Kaupmann ,  Ulrich Kuehl ,  Gerd Buschmann ,  Stephen Magda

    Inventor： Heinrich-Wilhelm Ohlendorf ,  Wilhelm Kaupmann ,  Ulrich Kuehl ,  Gerd Buschmann ,  Stephen Magda

    IPC: C07D209/14 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P9/06 ,  C07D209/24 ,  C07D209/42

    CPC classification number: C07D209/42

    Abstract: New 1-phenyl-2-aminocarbonylindole compounds are described which have the general formula I ##STR1## where R.sub.1 is a hydrogen atom, or a lower alkyl, alkenyl, cycloalkyl or cycloalkylalkyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, R.sub.3 is a hydrogen or halogen atom, or a lower alkyl, hydroxyl or lower alkoxy radical, R.sub.4 is a hydrogen or halogen atom, or a lower alkyl, hydroxyl or lower alkoxy radical, or, if R.sub.3 is a hydrogen atom, R.sub.4 may be a nitro or trifluoromethyl radical, or R.sub.3 and R.sub.4 together denote a methylenedioxy or ethylenedioxy radical, R.sub.5 has the meanings given for R.sub.3, R.sub.6 has the meanings given for R.sub.4, R.sub.7 is a hydrogen atom or, if R.sub.5 and R.sub.6 are lower alkoxy radicals, R.sub.7 may also be a lower alkoxy radical, R.sub.8 and R.sub.9 are each a hydrogen atom or a lower alkyl radical or, together with the nitrogen atom, form a heterocyclic group, and Z is a alkylene chain which is optionally substituted by hydroxyl. The compounds have pharmacological properties, in particular antiarrhythmic properties. The compounds may be in the form of the free base or acid addition salts. Pharmaceutical compositions containing these compounds are described as is a method of preparing them.Valuable intermediates for the production of these compounds and methods of preparing the intermediates are also described.

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